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Modulatory Effects and Action Mechanisms of Tryptanthrin on Murine Myeloid Leukemia Cells

Cellular & Molecular Immunology 2009年第5期6卷 335-342页

作者： Hoi-Ling Chan Hon-Yan Yip nai-ki mak Kwok-Nam Leung Department of Biochemistry The Chinese University of Hong Kong Shatin HKSAR China Department of Food and Nutritional SciencesProgramme The Chinese University of Hong Kong Shatin HKSAR China Department of Biology Hong Kong Baptist University Kowloon TongHKSAR China Department of Biochemistry and Food and Nutritional Sciences Programme The Chinese University of Hong Kong Shatin HKSAR China

Leukemia is the disorder of hematopoietic cell development and is characterized by an uncoupling of cell proliferation and differentiation. There is a pressing need for the development of novel tactics for leukemia therapy as conventional treatments often have severe adverse side effects. Tryptanthrin （6,12-dihydro-6,12-dioxoindolo- （2,1-b）-quinazoline） is a naturally-occurring, weakly basic alkaloid isolated from the dried roots of medicinal indigo plants （Ban-Lan-Gen）. It has been reported to have various biological and pharmacological activities, including anti-microbial, anti-inflammatory, immunomodulatory and anti-tumor effects. However, its modulatory effects and action mechanisms on myeloid cells remain poorly understood. In this study, tryptanthrin was shown to suppress the proliferation of the murine myeloid leukemia WEHI-3B JCS cells in a dose- and time-dependent manner. It also significantly reduced the growth of WEHI-3B JCS cells in vivo in syngeneic BALB/c mice. However, it exhibited no significant direct cytotoxicity on normal murine peritoneal macrophages. Flow cytometric analysis showed an obvious cell cycle arrest of the tryptanthrin-treated WEHI-3B JCS cells at the G0/G1 phase. The expression of cyclin D2, D3, Cdk 2, 4 and 6 genes in WEHI-3B JCS cells was found to be down-regulated at 24 h as measured by RT-PCR. Morphological and functional studies revealed that tryptanthrin could induce differentiation in WEHI-3B JCS cells, as shown by the increases in vacuolation, cellular granularity and NBT-reducing activity in tryptanthrin-treated cells. Collectively, our findings suggest that tryptanthrin might exert its anti-tumor effect on the murine myelomonocytic leukemia WEHI-3B JCS cells by causing cell cycle arrest and by triggering cell differentiation.

关键词： Ban-Lan-Gen tryptanthrin myeloid leukemia cell differentiation

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Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein–Barr virus-infected nasopharyngeal carcinoma cells

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Cellular & Molecular Immunology 2010年第4期7卷 323-326页

作者： Ho-Kee Koon Kwok-Wai Lo Kwok-Nam Leung Maria Li Lung Chris Chi-Kwong Chang Ricky Ngok-Shun Wong Wing-Nang Leung nai-ki mak Department of Biology Hong Kong Baptist UniversityKowloonHong Kong Department of Anatomical and Cellular Biology and State Key Laboratory in Oncology in South China Prince of Wales HospitalShatinHong Kong Department of Biochemistry and Food and nutritional Sciences Programme The Chinese University of Hong KongShatinHong Kong Department of Biology Hong Kong University of Science and TechnologyHong Kong Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong Kong School of Chinese Medicine The Chinese University of Hong KongShatinHong Kong

Nasopharyngeal carcinoma(NPC)is a malignant disease associated with Epstein–Barr virus(EBV)*** study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-AM photodynamic therapy(PDT)*** were treated with the photosensitiser Zn-BC-AM for 24 h before light *** ELISA was used to evaluate the production of *** the same experimental condition,HK-1-EBV cells produced a higher basal level of IL-1a(1561 pg/ml),IL-1b(16.6 pg/ml)and IL-8(422.9 pg/ml)than the HK-1 *** the light dose of 0.25–0.5 J/cm2,Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1a and IL-1b than the HK-1 *** production of IL-1b appeared to be mediated via the IL-1b-converting enzyme(ICE)-independent *** contrast,the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-AM *** results suggest that Zn-BC-AM PDT might indirectly reduce tumour growth through the modulation of cytokine production.

关键词： Photodynamic therapy nasopharyngeal carcinoma cytokines Epstein-Barr virus

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Immunosuppressive and immunodulatory effects of anti-inflammatory protein,Sj16,of ***

Immunosuppressive and immunodulatory effects of anti-inflamm...

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全国寄生虫学与热带医学学术研讨会

作者： Ming Chiu Fung nai ki mak Department of Biology the Chinese University of Hong Kong Department of Biology Hong Kong Baptist University

Schistosoma japonicum is the parasite causing schistosomiasis in *** with schistosome does not arouse significant inflammatory response in *** the parasite can escape from the host immune attack and inhibit dermatitis is the major focus of many *** we have reported the molecular cloning and characterization of the anti-inlfammatory protein, Sj16,of *** recombinant Sj16,rSj16,can inhibit thioglycollate-induced inflammation in mice and suppress the expression of the pro-inflammatory cytokine IL-1 beta and chemokine MIP-2 in peritoneal exudes *** we report on the studies of the effects of rSj16 on host immune system and hematopoiesis.

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CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的肿瘤进展（英文）

CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的...

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2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：沈月洪陈羽菱林云涛李一村刘朋菲张璧茹王宇帆 king-Chi Chan nai-ki mak Michael Kahn 齐众杨宏宇

Background: Head and neck squamous cell carcinoma(HNSCC) is a highly aggressive and frequently lethal malignancy. The 5-year survival rate of patients with HNSCC has remained low due to the tumor recurrence, metastasis, and treatment resistance. CDK5RAP2 is a microtubule regulatory protein. The role and underlying molecular mechanism of CDK5RAP2 in HNSCC are ***: CDK5RAP2 expression was examined using qRT-PCR and database analysis, and the biological role of CDK5RAP2 in HNSCC were investigated using colony formation assays,transwell assays, sphere formation assays, and in vivo tumorigenesis assays. Drug treatment,chromatin immunoprecipitation, and luciferase reporter assays were used to determine the regulation of CDK5RAP2 expression by the Wnt signaling pathway. Moreover, the gene expression profiles of CDK5RAP2-depleted cells were identified through RNA-sequencing and bioinformatics analyses. Lastly, spindle orientation was investigated through ***: CDK5RAP2 expression was upregulated in HNSCC tumor tissues and cells, and CDK5RAP2 knockdown inhibited cell tumorigenesis and migration. CDK5RAP2 expression was found to be regulated by the Wnt signaling pathway. Moreover, CDK5RAP2 depletion altered the cancer stem(-like) cell(CSC) signature of HNSCC cells. Notably, CDK5RAP2 was found to regulate spindle orientation in mitotic ***: CDK5RAP2 is identified here as a potential CSC marker of HNSCC that is regulated by the Wnt signaling pathway. CDK5RAP2 plays an indispensable role in HNSCC development and regulates the CSC signature of HNSCC by controlling spindle orientation during mitosis.

关键词： Head and neck squamous cell carcinoma(HNSCC) Wnt signaling pathway Cancer stem(-like) cell(CSC) CDK5RAP2 Spindle orientation

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DIGITAL CIRCUIT MACROMODELING WITH PSPICE

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Journal of Electronics(China) 1999年第3期16卷 269-276页

作者： To Ching nai Chou Sek mak Peng kin(Faculty of Science & Technology, University of Macao, Macao) Faculty of Science & Technology University of Macau Macau

Ordinary algebra is used to represent Boolean algebra on logic variables with states 0 and 1, so to achieve a unify approach to simulated both digital and analog circuit in PSPICE. Result on mixed A/D simulation shows... 详细信息

关键词： Mixed A/D simulation Digital circuit macromodeling

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高共轭性的四苯基卟啉-Ru(Ⅱ)联吡啶配合物的合成、光学性质及光动力抗癌活性

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无机化学学报 2022年第12期38卷 2383-2391页

作者：张劲祥黄伟国黄嘉良麦乃歧韩山师范学院化学与环境工程学院潮州521041 香港浸会大学理学院化学系中国香港999077 香港浸会大学理学院生物系中国香港999077

利用β位吡嗪环共轭连接的卟啉-菲咯啉配体L制备了两亲性的卟啉基-钌配合物PorRu和PorZn-Ru,对其进行了核磁及质谱的表征、线性与非线性光谱分析及光动力抗癌活性研究。实验结果显示所得的2个钌配合物具有高的^(1)O_(2)量子产率(0.93、0... 详细信息

利用β位吡嗪环共轭连接的卟啉-菲咯啉配体L制备了两亲性的卟啉基-钌配合物PorRu和PorZn-Ru,对其进行了核磁及质谱的表征、线性与非线性光谱分析及光动力抗癌活性研究。实验结果显示所得的2个钌配合物具有高的^(1)O_(2)量子产率(0.93、0.82)和较高的双光子吸收截面(619、621 GM),鼻咽癌HK-1细胞株的摄取量可达每10~6个细胞约22 nmol。体外光动力抗癌活性测试显示在2 J·cm^(-2)的光学剂量及4μmol·L^(-1)的给药浓度下,抑制效率分别达到(87.44±2.21)%、(45.03±2.85)%。

关键词：卟啉钌配合物两亲性双光子光动力治疗

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Corrole光敏剂在光动力治疗中的重原子效应

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高等学校化学学报 2006年第7期27卷 1363-1365页

作者：刘海洋郭平叶江柏荣应晓廖世军麦乃歧张启光华南理工大学化学系广州510641 香港科技大学化学系华南理工大学应用物理系广州510641 香港浸会大学生物系

10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole([STHZ]1) was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang *** al.,Proc SPIE,2006,Vol.6139,p268).To explore the heavy-atom effect on corrole photosensitizer,an exact analogue of corole [STHZ]1[STBZ] with the modification of two heavy iodine atoms on its 10-phenyl group,10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole(2),were ***,the photocytoxicity of corrole 2 on NPC cell dropped sharply as compared to corole *** exhibited no significant PDT cytotoxicity even if its concentration reached 2 μmol/*** may be caused by the lowering of its singlet oxygen quantum yield in PDT, although the intersystem crossing of corrole 2 could be enhanced by iodine heavy-atom effect as indicated by the strong decrease of its fluorescence emission.

关键词： Corrole 光敏剂鼻咽癌光动力治疗重原子效应

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基于2-可加模糊测度的NPD项目复杂性评价

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运筹与管理 2013年第5期22卷 196-202页

作者：张延禄杨乃定西北工业大学管理学院陕西西安710072

针对NPD项目复杂性各因素间具有的关联性以及传统评价方法的局限性,提出一种基于关联多属性的2-可加模糊测度方法来对NPD项目复杂性进行评价。在界定项目复杂性内涵的基础上,从产品复杂性、环境复杂性、组织复杂性和技术复杂性四个方面... 详细信息

针对NPD项目复杂性各因素间具有的关联性以及传统评价方法的局限性,提出一种基于关联多属性的2-可加模糊测度方法来对NPD项目复杂性进行评价。在界定项目复杂性内涵的基础上,从产品复杂性、环境复杂性、组织复杂性和技术复杂性四个方面构建了NPD项目复杂性评价指标体系。从模糊测度、默比乌斯变换和交互作用系数间的转化关系出发,基于最大Marichal熵原则,提出了一种确定2-可加模糊测度值的新方法。利用Choquet积分作为集结算子,自下而上计算各候选方案的综合评价值。最后,通过具体算例说明了该方法的可行性和有效性。

关键词：复杂性评价关联多属性 2-可加模糊测度 Choquet积分 NPD项目

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Pd/SAPO-5的制备及其在合成甲基正戊基酮中的应用

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精细化工 2018年第10期35卷 1667-1672页

作者：王强王乃威付睿峰王忍青江志东上海交通大学化学化工学院上海市绝缘与老化重点实验室

以三乙胺为模板剂,采用水热法制备了Pd/SAPO-5双功能催化剂,并用H2-TPR,XRD,SEM,XRF,^（29）Si MASNMR等手段对催化剂进行了表征。结果表明：钯的加入并不能改变分子筛的晶体结构;而不同的硅铝比（SiO2与Al2O3的物质的量比,下同）会导致... 详细信息

以三乙胺为模板剂,采用水热法制备了Pd/SAPO-5双功能催化剂,并用H2-TPR,XRD,SEM,XRF,^（29）Si MASNMR等手段对催化剂进行了表征。结果表明：钯的加入并不能改变分子筛的晶体结构;而不同的硅铝比（SiO2与Al2O3的物质的量比,下同）会导致SAPO-5分子筛晶体结构以及形貌上的差异。将所制备的催化剂用于丙酮和丁醛气相一步法合成甲基正戊基酮（mak）的反应中,考察了硅铝比、反应温度和金属负载量对催化活性的影响,在SAPO-5分子筛结构完整的前提下,Pd/SAPO-5催化活性随硅铝比的上升而增加。在硅铝比为1.5、反应温度180℃、w（Pd）=0.25%时,mak的收率最高,可达57.86%,并可运行500 h以上而不明显失活。

关键词： Pd/SAPO-5 双功能催化剂硅铝比一步合成甲基正戊基酮催化技术

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降低出厂水中铝含量的研究与应用

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中国给水排水 2014年第19期30卷 50-53页

作者：李晓华陆庆元关永年沈华高乃云苏州工业园区清源华衍水务有限公司江苏苏州215000 同济大学环境科学与工程学院上海200092

降低出厂水中铝含量,精准控制硫酸铝投加量是生产中的关键和难点。苏州工业园区清源华衍水务有限公司与同济大学合作,开展大量研究工作,根据水厂生产工艺特点,总结出一系列行之有效的降低出厂水铝含量的措施,如:利用计算公式精确计算硫... 详细信息

降低出厂水中铝含量,精准控制硫酸铝投加量是生产中的关键和难点。苏州工业园区清源华衍水务有限公司与同济大学合作,开展大量研究工作,根据水厂生产工艺特点,总结出一系列行之有效的降低出厂水铝含量的措施,如:利用计算公式精确计算硫酸铝投加量、将质量控制点前移等,成功将出厂水中铝含量控制在0.100 mg/L以下,解决了出厂水中铝残留问题,保障了水质安全。采取的措施可操作性强、简单、方便、有效,对自来水生产有较强的指导意义。

关键词：出厂水铝含量硫酸铝精准控制投加量

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