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Cardiac ryanodine receptor gene(hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope

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Chinese Medical Journal 2006年第24期119卷 2129-2133页

作者： Ngai-Shing Mok Ching-Wan Lam nai-chung fong Yim-Wo Hui Yuen-Choi Choi Kwok-Yin Chan Department of Medicine & Geriatrics Princess Margaret Hospital Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Paediatrics Princess Margaret Hospital Hong Kong China

Sudden cardiac death （SCD） in children and adolescents is uncommon and yet it is devastating for both victim＇s family and the society. Recently, it was increasingly recognized that SCD in young patients with structurally normal heart may be caused by inheritable primary electrical diseases due to the malfunction of cardiac ion channels, a disease entity known as the ion channelopathies. Catecholaminergic polymorphic ventricular tachycardia （CPVT） is a specific form of ion channelopathy which can cause cardiac syncope or SCD in young patients by producing catecholamine-induced bi-directional ventricular tachycardia （BiVT）, polymorphic VT and ventricular fibrillation （VF） during physical exertion or emotion. We reported here an index case of CPVT caused by cardiac ryanodine receptor gene （hRyR2） mutation which presented as cardiac syncope and sudden cardiac arrest in a Chinese adolescent female.

关键词： cardiac ryanodine receptor catecholaminergic polymorphic ventricular tachycardia Chinese sudden death

Self-Cognizant Bionic Liquid Sensor for Pathogen Diagnosis

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Cyborg and Bionic Systems 2021年第1期2021卷 184-191页

作者： B.fong Providence University Taiwan(Province of China)

As observed in the outbreaks of SARS and swine flu,as well as many other infectious diseases,the huge volume of human traffic across numerous enclosed public venues has posed immense challenges to preventing the spread of communicable *** is an urgent need for effective disease surveillance management in public areas under pandemic *** physicochemical properties associated with ionic liquids make them particularly suited for molecular communications in sensing networks where low throughput is quite adequate for pathogen *** paper presents a self-cognizant system for rapid diagnosis of infectious disease using a bionic sensor such that testing can be supported without collecting a fluid sample from a subject through any invasive *** system is implemented for testing the performance of the proposed bionic liquid sensing network.

关键词： testing diagnosis networks

Waste Foundry Sand Reused as Clay Replacement for Tile Manufacture

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International Journal of Transportation Science and Technology 2014年第4期3卷 339-351页

作者： Huan-Lin Luo Deng-fong Lin Mei-Ling chung Lisa Y.Chen Department of Civil and Ecological Engineering I-Shou UniversityNo.1Sec.1Syuecheng Rd.Dashu DistrictKaohsiung City 84001TaiwanR.O.C Department of Information Management I-Shou UniversityNo.1Sec.1Syuecheng Rd.Dashu DistrictKaohsiung City 84001TaiwanR.O.C

In an effort to extend the reutilization of waste foundry sand(WFS),we evaluated the use of WFS as a replacement for clay in tile *** effects of WFS addition on the properties of clay tile specimens were investigated at six different levels of WFS replacement:0,10,15,20,40,and 60%.These specimens were fired at one of three different kiln temperatures:1,000,1,050,and 1,100º*** physical analyses were performed to determine the properties of the finished *** results of this study indicate that the properties of the tile specimens were improved by WFS supplementation and that the optimal clay replacement level was 15%WFS.

关键词： finished replacement optimal

A FRAMEWORK OF SETTING UP GOAL CONTROL LIMITS OF TARGET COSTING FOR NON-NORMAL DISTRIBUTIONS

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Journal of Systems Science and Systems Engineering 2007年第4期16卷 424-433页

作者： Hsin-Hung WU fong-Jung YU Department of Business Administration National Changhua University of Education Changhua Taiwan China Department of Industrial Engineering and Technology Management Da-Yeh University Changhua Taiwan China

This study provides a framework of target costing to extend its original scope when the underlying distribution is non-normal. The new specification limits can be derived by listening to the market price from Taguchi loss function. Later, the new specification limits can be linked through the non-normality-based C^^pk value along with non-normality-based X^^-Rcontrol charts to derive goal control limits. Moreover, an example is provided to illustrate the usefulness of the proposed framework of target costing by relentlessly reducing cost and improving product quality to gain competitiveness in the marketplace.

关键词： Target costing Taguchi loss function goal control limit process capability index non-normal distribution

Innovative chest wall reconstruction with a locking plate and cement spacer after radical resection of chondrosarcoma in the sternum: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2302-2311页

作者： chung-Wei Lin Tsung-Yu Ho Chen-Wei Yeh Hsien-Te Chen I-Ping Chiang Yi-Chin fong Department of Orthopedic Surgery China Medical University HospitalChina Medical UniversityTaichung City 40454Taiwan Department of Education China Medical University HospitalChina Medical UniversityTaichung City 40447Taiwan Department of Sports Medicine College of Health CareChina Medical UniversityTaichung City 40402Taiwan Spine Center China Medical University HospitalChina Medical UniversityTaichung City 40454Taiwan Department of Pathology China Medical University HospitalChina Medical UniversityTaichung 40454Taiwan Department of Orthopedic Surgery China Medical University Beigang HospitalYunlin County 65152Taiwan

BACKGROUND Chondrosarcoma,a cartilage matrix producing tumor,is the second most commonly observed primary bone tumor after osteosarcoma,accounting for 15%of all chest wall *** herein report the case of a patient with chondrosarcoma of the sternum and our management of the chest wall defects that presented following radical tumor *** SUMMARY A 31-year-old patient presented to our hospital with dull pain and a protruding mass overlying the chest for 3 *** presence of nocturnal pain and mass size progression was reported,as were overhead arm elevation-related *** tomography showed a focal osteoblastic mass in the sternum with bony exostosis and adjacent soft tissue *** emission tomography-computed tomography revealed hypermetabolic activity with a mass located over the upper *** resonance imaging showed a focal illdefined bony mass of the sternum with cortical destruction and periosteal *** biopsy showed a consistent result with chondrosarcoma with immunohistochemical positivity for S100 and focal positivity for *** grade II chondrosarcoma diagnosis was confirmed by postoperative *** patient underwent radical tumor resection and chest wall reconstruction with a locking plate and cement *** patient was discharged 1 wk after surgery without any *** the 1-year follow-up,there was no local recurrence on *** functional scores,including Constant Score,Nottingham Clavicle Score,and Oxford Shoulder Score,showed the absence of pain in the performance of daily activities or substantial functional *** The diagnosis of chondrosarcoma must be considered when chest wall tumors are *** surgical reconstructive materials,with a locking plate and cement spacer,used in our study are cost-effective and readily-available for the sternum defect.

关键词： Chondrosarcoma Sternum Chest wall Cement Reconstruction Case report

Effects of Nitridation Temperature on Characteristics of Gallium Nitride Thin Films Prepared Via Two-Step Method

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 362-366页

作者： Chee Yong fong Sha Shiong Ng fong Kwong Yam Haslan Abu Hassan Zainuriah Hassan Nano-Optoelectronics Research and Technology Laboratory School of PhysicsUniversiti Sains Malaysia

In this research,the growth of GaN thin films on c-plane sapphire（0001） substrates via two-step method without the assist of buffer layer and catalysts was ***,gallium oxide（Ga_2O_3） thin films were deposited on sapphire substrates by radio frequency magnetron sputtering *** deposited Ga_2O_3 thin films were then nitridated at various *** this research,attention is focused on the influence of nitridation temperatures on the structural and optical properties of the synthesized GaN thin *** is revealed that 950 ℃ is the optimal nitridation temperature for synthesizing hexagonal wurtzite GaN thin film with preferential（0002） growth direction.

关键词： Sputtering Nitridation Gallium oxide Gallium nitride

Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste,with Particular Reference to Southeast Asia

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Journal of Renewable Materials 2022年第4期10卷 909-938页

作者： Hsiao Wei Tan Zhi Yin Joan Lim Nur Airina Muhamad fong fong Liew Institute of Research Management and Services Research and Innovation Management ComplexUniversity of MalayaKuala Lumpur50603Malaysia Department of Restorative Dentistry Faculty of DentistryMAHSA UniversitySaujana Putra CampusJenjarum42610Malaysia Institute of Biological Sciences Faculty of ScienceUniversity of MalayaKuala Lumpur50603Malaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA UniversitySaujana Putra CampusJenjarum42610Malaysia

With a growing population,changes in consumerism behavior and trends in consumption in Indo-Pacific Asia,our seafood processing and consumption practices produce a large volume of waste *** are several advantages in regulating and sustaining shellfish processing *** major advantage of waste management is that it leads to better conservation of natural resources in the long *** shell waste contains useful biomaterials,which are still untapped due to inadequate waste disposal and solid waste ***,the major component of shell waste,can be extracted either chemically or *** chemical extraction approaches,which use acids and alkali,could be an environmental *** the other hand,biological methods can be eco-friendly alternatives for shell waste *** this review,recent trends in management of shellfish waste as sources of chitin,conversion of chitin into chitosan,economic aspects of waste treatment and application of chitosan will be discussed.

关键词： Seafood waste waste management chitin chitosan economic value Southeast Asian fisheries

Biofuel-driven trigeneration systems for non-residential building applications:A holistic assessment from the energy,environmental and economic perspectives

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Building Simulation 2023年第4期16卷 557-576页

作者： K.F.fong C.K.Lee Division of Building Science and Technology College of EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

In the metropolises,it is unlikely to use merely solar and wind energy to pursue zero carbon building ***,it would become possible if biofuel-driven trigeneration systems(BDTS)are *** is thus essential to assess the application opportunity of BDTS in a holistic *** this study,BDTS offered definite primary energy saving of up to 15%and carbon emissions reduction of at least 86%in different types of non-residential buildings as compared to the conventional *** 24/7 operation for the hotel and hospital buildings,the corresponding BDTS could even achieve zero carbon *** the BDTS primed with compression-ignition internal combustion engine were not economically viable even in running cost due to the high local biodiesel price *** BDTS primed with spark-ignition engine and fueled by biogas,however,would have economic merit when carbon price was considered for the conventional systems that fully utilize fossil *** of carbon tax and social cost could have the payback ceilings of 8 years and 2 years respectively for most of building ***,the results could reflect the application potential of BDTS for non-residential buildings,leading the pathway to carbon neutrality for sustainable sub-tropical cities.

关键词： trigeneration biofuel dynamic simulation carbon tax social cost economic analysis

NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

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World Journal of Gastroenterology 2016年第46期22卷 10158-10165页

作者： fong-fong Chu R Steven Esworthy James H Doroshow Binghui Shen Department of Gastroenterology and Hepatology The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope Center for Cancer Research and Division of Cancer Treatment and Diagnosis National Cancer Institute

AIM To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium(S. Tm) in a mouse *** Eight-week-old male wild-type(WT) and Nox1 knockout(KO) C57BL6/J(B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily. The ileum, cecum and colon were removed for sampling at the fourth day post-inoculation. Portions of all three tissues were fixed for histology and placed in RNAlater for m RNA/c DNA preparation and quantitative real-time PCR. The contents of the cecum were recovered for estimation of S. Tm *** We found Nox1-knockout(Nox1-KO) mice were not more sensitive to S. Tm colonization and infection than WT B6 mice. This conclusion is based on the following observations:(1) S. Tm-infection induced similar weight loss in Nox1-KO mice compared to WT mice;(2) the same S. Tm CFU was recovered from the cecal content of Nox1-KO and WT mice regardless of the inoculation dose, except the lowest inoculation dose(2 × 106 CFU) for which the Nox1-KO had one-log lower CFU than WT mice;(3) there is no difference in cecal pathology between WT and Nox1-KO groups; and(4) there are no S. Tm infection-induced changes in gene expression levels(IL-1b, TNF-α, and Duox2) between WT and Nox1-KO groups. The Alpi gene expression was more suppressed by S. Tm treatment in WT than the Nox1-KO cecum. CONCLUSION Nox1 does not protect mice from S. Tm colonization. Nox1-KO provides a very minor protective effect against S. Tm infection. Using NOX1-specific inhibitors for colitis therapy should not increase risks in bacterial infection.

关键词： Knockout mouse NADPH Oxidase-1 Salmonella typhimurium Goblet cells Reactive oxygen species