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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 331-340页

作者： nahid ghaedi Iran Pouraboli Mansour Mirtadzadini Mohammad-mehdi Moeini-aghtaie Department of Biology Faculty of SciencesShahid Bahonar University of KermanKermanIran Department of Pathology Pathology and Stem Cell Research CenterAfzalipour Medical FacultyKerman University of Medical SciencesKermanIran

Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced ***:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then rats received a single dose of CCl4(2.5 mL/kg,50%v/v in liquid paraffin).Biochemical and histopathological assays were performed to assess the effects of the extract on liver function and ***,antioxidant and oxidative markers as well as inflammatory and fibrotic indicators were ***:Pretreatment with Levisticum officinale extract significantly mitigated CCl4-induced damage to liver structure,improved serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,urea,total bilirubin,and total protein,enhanced glutathione content and superoxide dismutase and catalase activities in the liver,as well as decreased plasma and hepatic malondialdehyde *** results demonstrated that the extract reduced Ki-67 andα-SMA expression and Masson’s trichrome staining revealed decreased liver collagen in rats treated with Levisticum officinale ***,Levisticum officinale extract markedly decreased the gene expressions of TNF-α,IL-6,TGF-β1,MCP-1,and ***:Levisticum officinale extract exerts hepatoprotective effects on CCl4-induced hepatotoxicity through antioxidant,anti-inflammatory,and anti-fibrotic activities.

关键词： Levisticum officinale CCl4 Inflammation Liver toxicity Antioxidant

Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition

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Neural Regeneration Research 2025年第11期20卷 3225-3226页

作者： Mahboubeh Ahmadi nahid Rouhi Javad Mirnajafi-Zadeh Bechara J.Saab Department of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Interactive Pte.Ltd. SingaporeRepublic of Singapore

Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain *** dopamine is primarily associated with pleasure,reward,and motivation,its effects can be quite complex;and this complexity is further compounded when examining how dopamine functions in typical versus disease-affected neural *** pa rticula r,epilepsy,characte rized by heightened brain excitability,is linked to cognitive dysfunction,and dopamine is implicated in elements of both its pathology and *** has been successful in describing the synaptic abnormalities believed to contribute to memory issues in epilepsy,aiding in the search for effective therapies for what persists as a major medical issue.

关键词： dopamine epilepsy primarily

Electron beams probe quantum coherence

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Light(Science & Applications) 2024年第4期13卷 596-597页

作者： nahid Talebi Institute for Experimental and Applied Physics Kiel University24118 KielGermany

Scientists have traditionally employed superimposed mutually-coherent electron beams for holography and phase retrieval of electron ***,recent theoretical exploration delves into the interaction of superposed electron beams with the *** investigation aims to elucidate long-range Coulomb correlations and quantum decoherence phenomena when electrons interact with their environment.

关键词： quantum mutually Electron

Comparative Study of Micro and Nano Size WO3/E44 Epoxy Composite as Gamma Radiation Shielding Using MCNP and Experiment

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Chinese Physics Letters 2017年第10期34卷 92-94页

作者： Shahryar Malekie nahid Hajiloo Radiation Application Research School Nuclear Science and Technology Research Institute Karaj 31485-498 Iran

The radiation shielding characteristics of 50wt% WO3/E44 epoxy composite in various gamma energies from 80 keV to 1.33 MeV are investigated via the MCNP code. Thus two scales are considered for WOa filler particles： micro and nano with sizes of i #m and 5Onto, respectively. The simulation results show that W03 nano particles exhibit a larger increase in linear attenuation coefficient in comparison with micro size particles. Finally, validation of simulation results with the published experimental data shows a good agreement.

关键词： Comparative Study of Micro and Nano Size WO3/E44 Epoxy Composite as Gamma Radiation Shielding Using MCNP and Experiment

Modulating microRNAs in cancer: next-generation therapies

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Cancer Biology & Medicine 2022年第3期19卷 289-304页

作者： nahid Arghiani Khalid Shah Center for Stem Cell and Translational Immunotherapy(CSTI) Harvard Medical SchoolBostonMA 02115USA Department of Neurosurgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Harvard Stem Cell Institute Harvard UniversityCambridgeMA 02138USA

MicroRNAs(miRNAs)are a class of endogenously expressed non-coding regulators of the genome with an ability to mediate a variety of biological and pathological *** is growing evidence demonstrating frequent dysregulation of microRNAs in cancer cells,which is associated with tumor initiation,development,migration,invasion,resisting cell death,and drug *** have shown that modulation of these small RNAs is a novel and promising therapeutic tool in the treatment of a variety of diseases,especially cancer,due to their broad influence on multiple cellular ***,suboptimal delivery of the appropriate miRNA to the cancer sites,quick degradation by nucleases in the blood circulation,and off target effects have limited their research and clinical ***,there is a pressing need to improve the therapeutic efficacy of miRNA modulators,while at the same time reducing their *** delivery vehicles for miRNA modulators have been shown to be effective in vitro and in *** this review,we will discuss the role and importance of miRNAs in cancer and provide perspectives on currently available carriers for miRNA *** will also summarize the challenges and prospects for the clinical translation of miRNAbased therapeutic strategies.

关键词： MiRNAs dysregulation delivery systems cancer therapy clinical translation

Quantum optics with swift electrons

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Light(Science & Applications) 2021年第5期10卷 717-719页

作者： nahid Talebi Institute for Experimental and Applied Physics Kiel University24118 KielGermany

Stimulated and spontaneous interactions of electron wavepackets with optical near fields were explored with complementary *** striking agreement with theory,scientists have demonstrated the dependence of spontaneous a... 详细信息

关键词： optics complementary quantum

Management of chronic heart failure in the older population

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Journal of Geriatric Cardiology 2014年第4期11卷 329-337页

作者： nahid Azad Genevieve Lemay Ottawa Hospital Civic Campus Geriatric Assessment Unit 1053 Carling Avenue Box 678 Ottawa ON K1Y 4E9 Canada

Chronic heart failure （CHF） is the leading cause of hospitalization for those over the age of 65 and represents a significant clinical and economic burden. About half of hospital re-admissions are related to co-morbidities, polypharmacy and disabilities associated with CHF. Moreover, CHF also has an enormous cost in terms of poor prognosis with an average one year mortality of 33%–35%. While more than half of patients with CHF are over 75 years, most clinical trials have included younger patients with a mean age of 61 years. Inadequate data makes treatment decisions challenging for the providers. Older CHF patients are more often female, have less cardiovascular diseases and associated risk factors, but higher rates of non-cardiovascular conditions and diastolic dysfunction. The prevalence of CHF with reduced ejection fraction, ischemic heart disease, and its risk factors declines with age, whereas the prevalence of non-cardiac co-morbidities, such as chronic renal failure, dementia, anemia and malignancy increases with age. Diabetes and hypertension are among the strongest risk factors as predictors of CHF particularly among women with coronary heart disease. This review paper will focus on the specific consideration for CHF assessment in the older population. Management strategies will be reviewed, including non-pharmacologic, pharmacologic, quality care indicators, quality improvement in care transition and lastly, end-of-life issues. Palliative care should be an integral part of an interdiscipli-nary team approach for a comprehensive care plan over the whole disease trajectory. In addition, frailty contributes valuable prognostic in-sight incremental to existing risk models and assists clinicians in defining optimal care pathways for their patients.

关键词： Heart failure Elderly patient Management Hypertension Coronary artery disease diabetes

Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods

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Chinese Chemical Letters 2007年第4期18卷 427-430页

作者： nahid Ghasemi Ali Niazi Department of Chemistry Faculty of SciencesAzad University of ArakArakIran

Spectrophotometric method has been developed for the direct quantitative determination of captopril in pharmaceutical preparation and biological fluids （human plasma and urine） samples. The method was accomplished based on parallel factor analysis （PARAFAC） and partial least squares （PLS）. The study was carried out in the pH range from 2.0 to 12.8 and with a concentration from 0.70 to 61.50μg mL^-1 of captopril. Multivariate calibration models such as PLS at various pH and PARAFAC were elaborated from ultraviolet spectra deconvolution and captopril determination. The best models for this system were obtained with PARAFAC and PLS at pH 2.0. The applications of the method for determination of real samples were evaluated by analysis of captopril in pharmaceutical preparations and biological fluids with satisfactory results. The accuracy of the method, evaluated through the RMSEE was 0.5801 for captopril with best calibration curve by PARAFAC and 0.6168 for captopril with PLS at pH 2.0 model.

关键词： Captopril Spectrophotometric Parallel factor analysis Partial least squares Pharmaceutical analysis

AN ALGEBRAIC APPROACH TO DEGENERATE APPELL POLYNOMIALS AND THEIR HYBRID FORMS VIA DETERMINANTS

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Acta Mathematica Scientia 2023年第2期43卷 719-735页

作者： Mumtaz RIYASAT Tabinda nahid Subuhi KHAN Department of Applied Mathematics Faculty of Engineering and TechnologyAligarh Muslim UniversityAligarhIndia Department of Mathematics Faculty of ScienceAligarh Muslim UniversityAligarhIndia

It is remarkable that studying degenerate versions of polynomials from algebraic point of view is not limited to only special polynomials but can also be extended to their hybrid *** for the first time,a closed determinant expression for the degenerate Appell polynomials is *** determinant forms for the degenerate Bernoulli and Euler polynomials are also investigated.A new class of the degenerate Hermite-Appell polynomials is investigated and some novel identities for these polynomials are *** degenerate Hermite-Bernoulli and degenerate Hermite-Euler polynomials are considered as special cases of the degenerate Hermite-Appell ***,by using Mathematica,we draw graphs of degenerate Hermite-Bernoulli polynomials for different values of *** zeros of these polynomials are also explored and their distribution is presented.

关键词： degenerate Bernoulli polynomials degenerate Appell polynomials determinant expressions degenerate hybrid Appell polynomials

Biochar alleviates metal toxicity and improves microbial community functions in a soil co-contaminated with cadmium and lead

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Biochar 2021年第4期3卷 485-498页

作者： nahid Azadi Fayez Raiesi Faculty of Agriculture Department of Soil Science and EngineeringShahrekord UniversityP.O.Box 115ShahrekordIran

Soil amendment with biochar alleviates the toxic effects of heavy metals on microbial functions in single-metal contaminated ***,it is unclear how biochar application would improve microbial activity and enzymatic activity in soils co-polluted with toxic *** present research aimed at determining the response of microbial and biochemical attributes to addition of sugarcane bagasse biochar(SCB)in cadmium(Cd)-lead(Pb)co-contaminated ***(400 and 600°C)decreased the available concentrations of Cd and Pb,increased organic carbon(OC)and dissolved organic carbon(DOC)contents in *** decrease of metal availability was greater with 600°C SCB than with 400°C SCB,and metal immobilization was greater for Cd(16%)than for Pb(12%)in co-spiked soils amended with low-temperature *** application improved microbial activity and biomass,and enzymatic activity in the soils co-spiked with metals,but these positive impacts of SCB were less pronounced in the co-spiked soils than in the single-spiked *** decreased the adverse impacts of heavy metals on soil properties largely through the enhanced labile C for microbial assimilation and partly through the immobili-zation of *** analysis further confirmed that soil OC was overwhelmingly the dominant driver of changes in the properties and quality of contaminated soils amended with *** promotion of soil microbial quality by the low-temperature SCB was greater than by high-temperature SCB,due to its higher labile C *** findings showed that SCB at lower temperatures could be applied to metal co-polluted soils to mitigate the combined effects of metal stresses on microbial and biochemical functions.

关键词： Bagasse biochar Microbial activity Soil enzymes Metal co-contamination