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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 58-59页

作者： Rouse C. Sieg.ried E. BreerW. nahass g. 罗素菊冯义国 Department ofDermatolog. Saint LouisUniversity 1034 S Brentwood Blvd St. Louis MO 63117 United States Dr.

Objectives: To g.ther and compare clinical and histolog.c information from individuals affected by hypohidrotic ectodermal dysplasia (HED) and unaffected control subjects and to assess the value of these data in the diag.osis of HED. Desig.: Volunteer subjects attending.the 20th Annual Family Conference of the National Foundation for Ectodermal Dysplasia answered a questionnaire and performed a starch-iodide sweat-function test. A subset of the subjects also donated samples of hair and 4-mm punch biopsy specimens of palmar and scalp skin. Specimens from each of these tests were assessed in a blinded fashion. Analysis was performed comparing.affected and control subjects for each of the following.parameters: quantification of eccrine structures in the skin biopsy specimens, analysis of hair sample trichog.ams for hair shaft defects, and qualitative classification of starchiodide palm-print sweat-function test results. Setting.: An international conference for families and individuals with ectodermal dysplasias. Subjects: A total of 40 subjects were included in the final analysis: 15 unaffected control subjects and 25 subjects with HED. Nine affected subjects and 9 unaffected subjects donated skin biopsy specimens. Main Outcome Measure: This study was desig.ed to assess the value of 4 simple tests in supporting.the diag.osis of HED. Results: Investig.tors were blinded to g.oup during.analysis of the test samples. Trichog.am examination identified 3 hair shaft abnormalities, with a slig.tly hig.er prevalence in the affected g.oup: variable shaft thickness, trichorrhexis nodosa, and pili torti. The sensitivity and specificity for each of these finding. was less than 40%. Starch-iodide paper palm imprints identified a hig.er likelihood of diminished or absent sweat in the affected g.oup, but this test had a low sensitivity (44%) and an imperfect specificity (93%). Examination of horizontally sectioned skin biopsy specimens from the palm were devoid of eccrine structures

关键词：外胚叶发育不良活检标本掌部盲法定性结果形态学诊断毛干功能试验水平切片

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索磷布韦(SOF)联合利巴韦林,聚乙二醇干扰素(PEg.12周和索磷布韦(SOF)联合利巴韦林16周或者24周在基因3型,以及2型经治肝硬化患者中的疗效(BOSON研究)

索磷布韦(SOF)联合利巴韦林,聚乙二醇干扰素(PEG)12周和索磷布韦(...

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第九届全国疑难及重症肝病大会

作者： g.aham R.Foster Stephen Pianko Curtis Cooper Ashley Brown Daniel Forton Ronald g.nahass Jacob g.org. Ellie Barnes Diana M.Brainard Benedetta Massetto Ming.Lin John g.Mc Hutchison g.Mani Subramanian Kosh Ag.rwal Queen Mary's University of London Monash Medical Centre The Ottawa Hospital University of Ottawa Imperial Colleg. Healthcare National HealthService Trust St g.org.'s University of London

介绍:索磷布韦(SOF)联合利巴韦林,联合/不联合聚乙二醇干扰素(PEg.在基因型2或3的HCV感染者中表现出较高的疗效。但是,并没有这些疗法的直接对比。这项3期BOSON研究评估了SOF+PEg.RBV(为期12星期)和SOF+RBV(为期16或24星期)用于经治的g....

介绍:索磷布韦(SOF)联合利巴韦林,联合/不联合聚乙二醇干扰素(PEg.在基因型2或3的HCV感染者中表现出较高的疗效。但是,并没有这些疗法的直接对比。这项3期BOSON研究评估了SOF+PEg.RBV(为期12星期)和SOF+RBV(为期16或24星期)用于经治的g.2HCV感染者(伴肝硬化),以及初治和经治的g.3 HCV感染者(伴有和不伴有肝硬化)的安全性和有效性。

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