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Giant Magnetoresistance Effect of [bcc-Fe(M)/Cu](M=Co,Ni) Multilayers

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Journal of Materials Science & Technology 2000年第2期16卷 186-190页

作者： M.Matsui, M.Doi and N.Shimizu (Department of Crystalline Materials Science and Engineering, nagoya university, Chikusa-ku, nagoya 464-8603, Japan Department of Crystalline Materials Science and Engineering Nagoya University Chikusa-ku Nagoya 464-8603 Japan

GMR effect of multilayers of bcc-Fe(M)(M=Co, Ni) alloy and Cu layers has been investigated. The maximum MR ratio is found at 1.1 nm Fe(Co) and 1.3～1.4 nm Cu layer thickness in [Fe(Co)/CuJ, and at 1.6 nm Fe(Ni) and 1.4 nm Cu layer thickness in [Fe(Ni)/Cu]. Under the optimum annealing condition, the MR ratio increases up to 50% and 38% for Fe(Co) and Fe(Ni) systems, respectively. The origin of the increase of GMR is discussed, taking the progress of preferred orientation of Fe(Co)[100] or Fe(Ni)[100] by anneahng into account.

关键词： Giant Magnetoresistance Effect of M=Co,Ni Multilayers Cu bcc-Fe

Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity

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Cell research 2004年第2期14卷 148-154页

作者： Jun DU~(1,2*), Shao Hui CAI~(3,4), Zhe SHI~3, Fumihiko NAGASE~1 ~1Department of Medical Technology, nagoya university School of Health Sciences, Aichi 461-8673, Japan. ~2School of Pharmaceutical Science, Sun Yat-Sen university, Guangzhou, 510089, China. ~3Department of Immunology, nagoya university Graduate and Faculty School of Medicine, Aichi, 466-8550, Japan. ~4College of Pharmacy, Jinan university, Guangzhou, 510632, China. Department of Medical Technology Nagoya University School of Health Sciences Aichi Japan School of Pharmaceutical Science Sun Yat-Sen University Guangzhou China Department of Immunology Nagoya University Graduate and Faculty School of Medicine Aichi Japan College of Pharmacy Jinan University Guangzhou China

H-Ras is well known as one of the essential components of Ras/Raf/MEK/ERK cascade, which is a critical prosurvival signaling mechanism in most eukaryotic cells. Ras targets Raf/MEK/ERK cascade by integrating and transmitting extracellular signals from growth factor receptors to Raf, leading to the propagation of signals to modulate a serious of cellular survival events. Apoptosis signal-regulating kinasel (ASK1) serves as a general mediator of cell death because it is responsive to a variety of death signals. In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo, which was reversed only partially by addition of RafS621A, an antagonist of Raf, whereas MEK inhibitor, PD98059, and PI3K inhibitor, LY294002, did not disturb the inhibitory effect of H-Ras on ASK-1-induced apoptosis. Furthermore, by means of immunoprecipitate and kinase assays, we demonstrated that the interaction between H-Ras and ASK1 as well as the inhibition

关键词： H-Ras ASK1 apoptosis binding activity.

STUDY ON SELECTIVE DISSOLUTION OF GOLD IN ALKALINE THIOUREA MEDIA

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Journal of Central South university 1997年第2期9卷 79-83页

作者： Chai Liyuan Zhong Haiyun Zhang Chuanfu (Department of Nonferrous Metallurgy, Central South university of Technology, Changsha 410083, China)Masazumi kido Ryouichi Ichino(center for Integrated researchin Science and Engineering nagoya university,nagoya 4 Department of Nonferrous Metallurgy Central South University of Technology Changsha 410083 China center for Integrated research in Science and Engineering Nagoya University Nagoya 464 Japan

Gold dissolves easily in an alkaline thiourea solution with Na2SO3 and Na2S2O8, where the accompanied elements of Au, such as Ag, Cu, Ni and Fe can hardly dissolve. It was considered that electrochemical reduction and catalytic action of SO32- prevent thiourea from decomposing irreversibly and accelerates dissolution of *** S2O82- as an oxidant can control the potential so that formamidine disulfide may form efficiently. The dissolution of gold is mainly through oxidation of Au by formamidine disulfide and complexation of thiourea with An+,and not direct oxidation of S2O82-. Thus,sufficient formamidine disulfide is necessary to accelerate the dissolution of gold. The reason for Ag, Cu hardly being dissoluble is that the black layers of Ag2S and Cu1.92S form on the surface of Ag and Cu. The metal Ni and Fe do not dissolve in the alkaline media due to their sulfide films passivation samely.

关键词： mechanism selective dissolution of gold alkaline thiourea electrochemical reduction and catalytic action formamidine disulfide mix potential

Isolation of a choline monooxygenase cDNA clone from Amaranthus tricolor and its expressions under stress conditions

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Cell research 2001年第3期11卷 187-193页

作者： MENG YU LING, YU MEI WANG, DA BING ZHANG, NAOSUKE NII Faculty of Agriculturs, Meijo university, Tempaku-ku, nagoya, Aichi. 468-8502 Japan Yingdong College of Biotechnology, Shaoguan university, Datang Road, Shaoguan 512005, China Agro-Biotech center of Sh Faculty of Agriculture Meijo University Tempaku-ku Nagoya Japan Yingdong College of Biotechnology Shaoguan University Shaoguan China Agro-Biotech center of Shanghai Academy of Agricultural Sciences Shanghai Key Laboratory of genetic breeding Shanghai China

Plants synthesize the osmoprotectant glycine betaine (GB) via choline→betaine aldehyde→glycine be- taine[1]. Two enzymes are involved in the pathway choline monooxygenase (CMO) and betaine aldehyde dehydrogenase (BADH). A full length CMO cDNA (1,643bp) was cloned from Amaranthus tricolor. The open reading frame encoded a 442-amino acid polypeptide, which showed 69% identity with CMOs in Spina- cia oleracea L. and Beta vulgaris L. DNA gel blot analysis indicated the presence of one copy of CMO gene in the A. tricolor genome. The expressions of CMO and BADH proteins in *** leaves significantly increased under salinization, drought and heat stress (42℃), as determined by immunoblot analysis, but did not respond to cold stress (4℃), or exogenous ABA application. The increase of GB content in leaves was parallel to CMO and BADH contents.

关键词： Amaranthus tricolor betaine aldehyde dehydrogenase(BADH) choline monooxygenase (CMO) glycine betaine (GB) stress.

SELECTIVE DISSOLUTION OF GOLD IN AN ALKALINETHIOUREA SOLUTION BY ELECTROLYSIS

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Journal of Central South university 1997年第2期9卷 73-78页

作者： Zhang Chuanfu Chai Liyuan Zhong Haiyun (Department of Nonferrous Metallurgy, Central South university of Technology, Changsha 410083, China)Masazumi Okido RyouichiIchino(center erforIntegratedresearchinScienceandEngineering nagoyauniversity,nagoya464,Ja Department of Nonferrous Metallurgy Central South University of Technology Changsha 410083 China center for Integrated research in Science and Engineering Nagoya University Nagoya 464 Japan

Anodic polarization behavior of gold, silver, copper, nickel and iron in potentiostatic condition has been examined in an alkaline aqueous thiourea solution, where gold is hardly dissoluble normally. The addition of Na2SO3 into the solution can accelerate anodic dissolution of gold. The factors affecting selective dissolution of gold in the alkaline thiourea solution by electrolysis have been studied, and the optimum condition was obtained. In 0.1 mol/L thiourea solution of pH 12. 5 containing 0. 5 mol/L Na2SO3 and 2. 5% acetone, at the potential of 0. 34 V vs NHE, at the temperature of 323 K, the dissolved mass of gold anode with the exposed area of 1. 0 cm2 reached more than 300 mg·dm-3 within 30 min, and other metals such as silver, copper, nickel and iron could hardly dissolve.

关键词： polarization behavior selective dissolution of gold electrolysis alkaline thiourea solution sodium sulfite

In situ synthesis of DNA micro-arrays using typography technique

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Science China Chemistry 2007年第1期50卷 75-83页

作者： TANG JianXin 1,2 ,HE NongYue 1,2,3 &LI Song 1 1State Key Laboratory of Bioelectronics,Southeast university,Nanjing 210096,China 2Key Laboratory of Green Packaging and Application of Biological nanotechnology of Hunan Province,Hunan university of Tech- nology,Zhuzhou 412008,China 3Zhongshan Huoju Polytechnic,Zhongshan 528436,China State Key Laboratory of Bioelectronics Southeast University Nanjing China Key Laboratory of Green Packaging and Application of Biological nanotechnology of Hunan Province Hunan University of Technology Zhuzhou China Zhongshan Huoju Polytechnic Zhongshan China

A novel typography technique was developed to in situ synthesize oligonucleotide arrays on glass slide,which has the celerity,high spatial resolution,lower cost,reliable operation,and high synthetic *** principle and process of the typography technique for fabricating gene-chips have been described in detail.A suit of poly(terafluoroethylene)devices for synthesizing oligonucleotide arrays were designed and prepared,and the fiber tubes with a number of nano-or micron-channels were em- *** oligonucleotide arrays of 16 and 160 features with four different probes were synthesized using the typography *** four specific oligonucleotide probes including the matched and the mismatched by the fluorescent target sequence gave obviously different hybridization fluorescent *** was indicated that the gene-chip fabricated by the typography method could be used to rapidly screen single-nucleotide polymorphisms(SNP)and to detect mutations.

关键词： typography oligonucleotide in situ synthesis DNA microarrays

Preparation of liposomal brucine and its pharmaceutical/pharmacody-namic characterization

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Acta Pharmacologica Sinica 2007年第11期28卷 1851-1858页

作者： Xiang-qi QIN~2,Yuan YUAN~2,Chang-sheng LIU~(2,4),Qiu-yun WANG~3,Xi SHEN~2,Bai-can YANG~3~2 Key Laboratory for Ultrafine Materials of Ministry of Education,and Engineering research center for Biomedical Materials of Ministrv ofEducation,East China university of Science and Technology,Shanghai 200237,China ~3 Pharmacy Department of Traditional ChineseMedicine,Shanghai university of Traditional Chinese Medicine,Shanghai 201203,China Key Laboratory for Ultrafine Materials of Ministry of Education and Engineering Research Center for Biomedical Materials of Ministry of Education East China University of Science and Technology Shanghai China Pharmacy Department of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

Aim:To prepare a novel transdermal preparation of liposomal brucine （LB） andinvestigate its pharmaceutical/pharmacodynamic ***:LBwas prepared by a modified ethanol-dripping *** drug encapsulationefficiency （EE）,particle size,in vitro release,and skin permeation were ***,a safety evaluation and pharmacodynamic analysis of LB,includingacute dermal toxicity,skin irritation,and analgesic and anti-inflammatory effectswere ***:the EE of LB was 72% and the mean particle size ofthe liposomes was 55.4 *** in vitro release profile indicated that less than68% of the encapsulated brucine was released in 10 h.A skin permeation studyshowed that compared with the free brucine,LB exhibited higher cumulative drugpermeation through the skin and lower drug accumulation in skin tissue,indica-tive of an obvious promotion of skin permeation with liposomal *** acute dermal LD50of LB was greater than 100 mg/kg （brucine content） andskin irritation tests revealed that LB had no irritation to both integrity and brokenskin.A pharmacodynamic evaluation of LB was performed by xylene-inducedmouse ear edema test and acetic acid-induced writhing test at the dosage of 1.5,3,and 6 mg/kg,*** results showed that anti-inflammatory activitiesand analgesic effects of brucine encapsulated were significantly higher than thatof the free brucine （P<0.01）.Moreover,LB maintained a remarkably longer anti-inflammatory and analgesic ***:It can be proposed that LBprepared here could represent a safe,effective and promising transdermal formu-lation for analgesic and anti-inflammatory effects.

关键词： liposomal brucine traasdermal formulation attenuation synergia sustained release analgesic anti-inflammatory

THE NUMERICAL STABILITY OF THE θ-METHOD FOR DELAYDIFFERENTIAL EQUATIONS WITH MANY VARIABLEDELAYS

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Journal of Computational Mathematics 1999年第5期17卷 523-532页

作者： Lin Qiu Taketomo Mitsui(Graduate School of Human Informatics, nagoya university, Face-Cho, Chikusa-km, nagoya,464-8601, Japan)Jiao-xun Kuang(Department of Mathematics, Shanghai Normal university, 100 Guilin Road, Shanghai200234, China) nagoya university 日本上海师范大学数学系上海

This paper deals with the asymptotic stability of theoretical solutions and numerical methods for the delay differential equations(DDEs)where a,b1,b2,. ..,bm and yo ∈ C, 0 < λm ≤ λm-1 ≤ ... ≤λl < 1. A sufficient condition such that the differential equations are asymptotically stable *** it is shown that the linear θ-method is AGPm-stable if and only if1/2≤θ-≤ 1.

关键词： Delay differential equation Variable delays Numerical stability θ-methods

The Triode Carbon Nanotube Composited Field Emission Device

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The Triode Carbon Nanotube Composited Field Emission Device