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World Journal of Gastroenterology 2013年第44期19卷 7880-7888页

作者： Mortada Hassan El-Shabrawi naglaa mohamed kamal alanani Pediatrics and Pediatric Hepatology Faculty of MedicineCairo University Giza 12411 Egypt

Hepatitis C virus(HCV)is a major health burden infecting 170-210 million people *** 3-4millions are newly-infected *** of pediatric infection varies from 0.05%-0.36%in the United States and Europe;up to 1.8%-5.8%in some developing *** highest prevalence occurs in Egypt,sub-Saharan Africa,Amazon basin and *** has been present in some populations for several centuries,notably genotypes 1 and 2 in West *** anti-schistosomal therapy practiced in the 1960s until the early 1980s had spread HCV infection throughout *** acquisition of HCV remains a major route for infection among Egyptian *** screening of transfusions,unsterilized injection equipment and re-used needles and syringes continue to be major routes of HCV transmission in developing countries,whereas vertical transmission and adolescent high-risk behaviors(e.g.,injection drug abuse)are the major routes in developed *** risk of vertical transmission from an infected mother to her unborn/newborn infant is approximately 5%.Early stages of HCV infection in children do not lead to marked impairment in the quality of life nor to cognitive,behavioral or emotional dysfunction;however,caregiver stress and family system strain may *** slowly progresses to serious complications as cirrhosis(1%-2%)and hepatocellular carcinoma(HCC)especially in the presence of risk factors as hemolytic anemias,obesity,treated malignancy,and concomitant human immune deficiency and/or hepatitis B virus *** vaccine remains elusive to *** the immune mechanisms in patients who successfully cleared the infection is essential for vaccine *** pediatric standard of care treatment consists of pegylated interferon-α2a or b plus ribavirin for 24-48 *** new oral direct acting antivirals,approved for adults,need further evaluation in *** virologic response varies depending on the viral lo

关键词： Hepatitis C virus Burden Genotypes Cost Pediatrics

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Wood By-Products as UV Protection:A Consequence Review

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Journal of Renewable Materials 2024年第4期12卷 699-720页

作者： naglaa Salem El‑Sayed mohamed Hasanin Samir Kamel Cellulose and Paper Department National Research CentreCairo12622Egypt

In recent decades,the ozone layer has suffered considerable damage,increasing the entry of ultraviolet(UV)light into the atmosphere and reaching the earth’s surface,negatively affecting ***,researchers aimed to solve this problem by synthesizing advanced UV-shielding *** the other hand,developing an easy and green strategy to prepare functional materials with outstanding properties based on naturally abundant and environmentally friendly raw materials is highly desirable for sustainable *** biomass-derived materials are sustainable and biodegradable,they present a promising substitute for petroleum-based *** three main structural constituents of the plant biomass-based materials that are naturally available are cellulose,hemicellulose,and *** review details current developments using wood-based products such as cellulose,hemicellulose,and lignin in UV-shielding *** will start with assembling the structure and chemistry of cellulose,hemicellulose,and lignin,followed by their contributions to preparing UV-shielding ***,it will briefly discuss the different processing methods for the design of UV-shielding *** wood by-products offer additional opportunities to use the whole tree harvest.

关键词： UV-shielding wood cellulose lignin hemicellulose sunlight protection

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Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal Abd El-Salam Marwa mohamed Anwar Rasha Mahmoud Gouda naglaa Abou El Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

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Text-Independent Algorithm for Source Printer Identification Based on Ensemble Learning

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Computers, Materials & Continua 2022年第10期73卷 1417-1436页

作者： naglaa F.El Abady mohamed Taha Hala H.Zayed Department of Computer Science Faculty of Computers and Artificial IntelligenceBenha University13518Egypt School of Information Technology and Computer Science(ITCS) Nile University12677Egypt

Because of the widespread availability of low-cost printers and scanners,document forgery has become extremely *** or signatures are used to protect important papers such as certificates,passports,and identification *** the origins of printed documents is helpful for criminal investigations and also for authenticating digital versions of a document in today’s *** printer identification(SPI)has become increasingly popular for identifying frauds in printed *** paper provides a proposed algorithm for identifying the source printer and categorizing the questioned document into one of the printer classes.A dataset of 1200 papers from 20 distinct(13)laser and(7)inkjet printers achieved significant identification results.A proposed algorithm based on global features such as the Histogram of Oriented Gradient(HOG)and local features such as Local Binary Pattern(LBP)descriptors has been proposed for printer *** classification,Decision Trees(DT),k-Nearest Neighbors(k-NN),Random Forests,Aggregate bootstrapping(bagging),Adaptive-boosting(boosting),Support Vector Machine(SVM),and mixtures of these classifiers have been *** proposed algorithm can accurately classify the questioned documents into their appropriate printer *** adaptive boosting classifier attained a 96%*** proposed algorithm is compared to four recently published algorithms that used the same dataset and gives better classification accuracy.

关键词： Document forensics source printer identification(SPI) HOG LBP principal component analysis(PCA) bagging AdaBoost

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Rooted Tree Optimization for Wind Turbine Optimum Control Based on Energy Storage System

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Computers, Materials & Continua 2023年第2期74卷 3977-3996页

作者： Billel Meghni Afaf Benamor Oussama Hachana Ahmad Taher Azar Amira Boulmaiz Salah Saad El-Sayed M.El-kenawy Nashwa Ahmad kamal Suliman mohamed Fati naglaa K.Bahgaat Department of Electrical Engineering Badji Mokhtar UniversityLSEM LaboratoryAnnaba23000Algeria Department of Electrical Engineering Biskra UniversityLGEB LaboratoryBiskra07000Algeria Department of Drilling and Rig Mechanics Ksadi Merbah UniversityOuargla30000Algeria College of Computer and Information Sciences Prince Sultan UniversityRiyadh11586Saudi Arabia Faculty of Computers and Artificial Intelligence Benha UniversityBenha13518Egypt Department of Electronics University of Badji MokhtarLERICA LaboratoryAnnaba23000Algeria Delta Higher Institute for Engineering&Technology(DHIET) Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Faculty of Engineering Cairo UniversityGiza12613Egypt Department of Communications and Electronics Engineering Faculty of EngineeringCanadian International College(CIC)ElShiekh ZayedEgypt

The integration of wind turbines(WTs)in variable speed drive systems belongs to the main factors causing lowstability in electrical ***,in order to avoid this issue,WTs hybridization with a storage system is a *** paper investigates WT system operating at variable *** system contains of a permanent magnet synchronous generator(PMSG)supported by a battery storage system(BSS).To enhance the quality of active and reactive power injected into the network,direct power control(DPC)scheme utilizing space-vector modulation(SVM)technique based on proportional-integral(PI)control is ***,to improve the rendition of this method(DPC-SVM-PI),the rooted tree optimization technique(RTO)algorithm-based controller parameter identification is used to achieve PI optimal *** compare the performance ofRTO-based controllers,they were implemented and tested along with some other popular controllers under different working *** obtained results have shown the supremacy of the suggested PIRTO algorithm compared to competing controllers regarding total harmonic distortion(THD),overshoot percentage,settling time,rise time,average active power value,overall efficiency,and active power steadystate error.

关键词： Rooted tree optimization(RTO)method direct power control(DPC) wind turbine(WT) proportional integral(PI) PMSG

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Efficient Hardware Design of a Secure Cancellable Biometric Cryptosystem

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Intelligent Automation & Soft Computing 2023年第4期36卷 929-955页

作者： Lamiaa A.Abou Elazm Walid El-Shafai Sameh Ibrahim mohamed G.Egila H.Shawkey mohamed K.H.Elsaid naglaa F.Soliman Hussah Nasser AlEisa Fathi E.Abd El-Samie Department of Microelectronics Electronics Research InstituteAlnozhaEgypt Department of Electronics and Electrical Communications Engineering Ain Shams UniversityCairoEgypt Department of Electronics and Electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Security Engineering Laboratory Department of Computer SciencePrince Sultan UniversityRiyadh 11586Saudi Arabia Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia

Biometric security is a growing trend,as it supports the authentication of persons using conﬁdential biometric *** of the transmitted data in multi-media systems are susceptible to attacks,which affect the security of these *** systems provide sufﬁcient protection and privacy for *** recently-introduced cancellable biometric recognition systems have not been investigated in the presence of different types of *** addition,they have not been studied on different and large biometric *** point that deserves consideration is the hardware implementation of cancellable biometric recognition *** paper presents a suggested hybrid cancellable biometric recognition system based on a 3D chaotic *** rationale behind the utilization of the 3D chaotic cryptosystem is to guarantee strong encryption of biometric templates,and hence enhance the security and privacy of *** suggested cryptosystem adds signiﬁcant permutation and diffusion to the encrypted biometric *** introduce some sort of attack analysis in this paper to prove the robustness of the proposed cryptosystem against *** addition,a Field Programmable Gate Array(FPGA)implementation of the pro-posed system is *** obtained results with the proposed cryptosystem are compared with those of the traditional encryption schemes,such as Double Random Phase Encoding(DRPE)to reveal superiority,and hence high recogni-tion performance of the proposed cancellable biometric recognition *** obtained results prove that the proposed cryptosystem enhances the security and leads to better efﬁciency of the cancellable biometric recognition system in the presence of different types of attacks.

关键词： Information security cancellable biometric recognition systems cryptanalysis 3D chaotic map encryption FPGA

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埃及重症监护护士临床领导力行为的调查研究

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International Journal of Nursing Sciences 2022年第3期9卷 357-363,I0004页

作者： Heba mohamed Al Anwer Ashour Maram Ahmed Banakhar naglaa Abd Elaziz Elseesy Nursing Administration Department Faculty of NursingAlexandria UniversityAlexandriaEgypt Department of Public Health Nursing Faculty of NursingKing Abdulaziz UniversityJeddahSaudi Arabia

目的本研究旨在调查埃及医院重症监护护士的临床领导力行为现状,并比较私立和公立医院护士临床领导力水平的差异。方法2019年1—3月,在埃及1所公立教学医院和1所私立医院共选取365名具有护理学学士学位的重症监护护士进行横断面调查。... 详细信息

目的本研究旨在调查埃及医院重症监护护士的临床领导力行为现状,并比较私立和公立医院护士临床领导力水平的差异。方法2019年1—3月,在埃及1所公立教学医院和1所私立医院共选取365名具有护理学学士学位的重症监护护士进行横断面调查。采用社会人口学特征调查表和临床领导力行为问卷(the Clinical Leadership Behaviors Questionnaire,CLB-Q)收集数据,将各维度及总分的条目均分转换为百分制得分,以便进行比较和分析。结果结果显示,护士CLB-Q得分为(77.11±11.87)分,其中沟通维度得分最高(91.84±7.38)。私立医院重症监护护士的CLB-Q得分为(90.48±5.53)分,高于公立教学医院护士得分(68.29±4.21),差异有统计学意义(P<0.001)。有5~10年工作经验的护士在CLB-Q总分及自我认知、倡导和授权、决策、质量与安全、团队合作和临床卓越维度得分较其他组别护士得分高(P<0.01)。单身护士的CLB-Q总分及倡导和授权、决策、质量与安全以及临床卓越维度得分较已婚护士高(P<0.01)。结论护理管理者应促进重症监护护士加强临床实践,鼓励他们参加质量和安全方面的培训项目,以培养其临床领导力。公立医院的重症监护护士尤其需要全面提升临床领导力水平。

关键词：行为横断面研究重症监护病房领导力护士

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Effects of dual sofosbuvir/daclatasvir therapy on, chronic hepatitis C infected, survivors of childhood malignancy

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World Journal of Clinical Cases 2019年第16期7卷 2247-2255页

作者： Mortada HF El-Shabrawi Laila M Sherief Mostafa Yakoot naglaa M kamal mohamed A Almalky Manal M AbdElgawad Aml A Mahfouz Sherine Helmy Enas M kamal Dina Attia Hisham R El-Khayat Paediatric Hepatology Department Cairo Faculty of MedicineCairo 11559Egypt Paediatric Hematology-Oncology Department Zagazig Faculty of MedicineZagazig 21121Egypt Internal medicine Pediatrics and HepatologyGreen Clinic and Research CenterAlexandria UniversityAlexandria 21121Egypt Paediatric Hepatology Department Alexandria Faculty of medicineAlexandria 21121Egypt Innovations & Research Pharco CorporationAlexandria 21121Egypt Endemic medicine and Hepatology Department Minia UniversityMinia 22233Egypt Endemic medicine and Hepatology Department Beni-suef UniversityBeni-suef 62511Egypt Gastroenterology and Endemic Medicine Department Theodore Research InstituteCairo 23323Egypt

BACKGROUND Childhood cancer survivors are potentially at a higher risk of infection with hepatitis C virus (HCV).The effects of all-oral direct-acting antiviral therapy (DAA) on both the HCV infection as well as the state of cancer remission have not been well investigated in this *** To test the effects of dual sofosbuvir/daclatasvir (SOF/DCV) therapy in the treatment of chronic HCV in survivors of hematologic malignancy in pediatric age *** We conducted a prospective,uncontrolled,open-label multicenter study.A total of 20 eligible,chronic HCV,genotype-4,infected children who had been in continuous complete remission from hematologic cancer (leukemia/lymphoma) for at least one year were included in the *** patients were treated with combined SOF/DCV for 12 *** were monitored throughout the study till 12 wk after end of treatment for safety and efficacy outcomes including the sustained virologic response 12 (SVR12) rate,hematological indices,liver and kidney *** The intent-to-treat SVR12 rate was 20 of 20 (100%;95%CI: 84%-100%).All patients showed normalized liver enzymes from *** hematological indices,liver and kidney functions were kept normal throughout the *** fatalities or treatment-emergent serious or severe adverse events were reported throughout the *** SOF/DCV combined therapy could be used safely and effectively in the treatment of chronic HCV genotype-4 infection in leukemia/lymphoma treated *** relapses were detected during treatment and throughout the follow up period for either the original malignant disease or the HCV infection.

关键词： Chronic hepatitis C Survivors of childhood cancer Sofosbuvir Daclatasvir Efficacy

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Molecular Modeling and Antimicrobial Screening Studies on Some 3-Aminopyridine Transition Metal Complexes

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Open Journal of Inorganic Chemistry 2022年第3期12卷 39-56页

作者： Islam M. I. Moustafa naglaa M. mohamed Sahar M. Ibrahim Chemistry Department Faculty of Science Benha University Benha Egypt

Seven transition metal complexes of Mn2+, Ni2+, Co2+, Cu2+ and Zn2+ with 3-aminopyridine (3-APy) as ligand have been synthesized, characterized by different techniques and their antibacterial activities were studied. Molecular modeling calculations were performed using DMOL3 program in materials studio package which is designed for the realization of large scale density functional theory calculation (DFT). The quantum mechanical and chemical reactivity parameters such as chemical hardness, chemical potential, electronegativity, electrophilicity index and Homo-Lumo energy gap were obtained theoretically and were used to understand the biological activity of the prepared compounds. Some complexes were tested for their in-vitro cytotoxic activity in human lung cancer cell lines (A-549 cell line), and structureactivity relationships were established. In general, the coordination to Co2+ increased the cytotoxicity while the Ni2+ complexes show reduced cytotoxic activity compared to the metal-free 3-aminopyridine.

关键词： 3-Aminopyridine Transition Metal Complexes Biological Cytotoxic Activities Molecular Orbital Calculation Density Functional Theory

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Evaluation of phosphorus bioavailability in El Mex Bay and Lake Mariut sediments

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International Journal of Sediment Research 2017年第3期32卷 432-441页

作者： naglaa F.Soliman Gehan M.El Zokm mohamed A.Okbah Department of Environmental Studies Institute of Graduate Studies and Research University of Alexandria National Institute of Oceanography and Fisheries

Phosphorus(P) fractions and their bioavailability in the sediments from El Mex Bay and Lake Mariut in Egypt were investigated using different chemical extraction methods. Sodium bicarbonate(NaHC03)extractable P(Olsen-P) was the largest fraction(14.42%), followed by algal available P(AAP)(3.56%),water soluble P(WSP)(0.79%), and readily desorbable P(RDP)(0.06%) for El Mex Bay. While AAP contributed 9.94% to total P in sediments from Lake Mariut, Olsen-P 8.53%, WSP 4.11%, and RDP 0.92%.Summation of the bioavailable P fractions didn’t exceed the sediment quality guidelines, and, therefore, P doesn’t represent a danger to marine organisms. Correlation coefficients showed that no apparent relations between total P(TP) and iron(Fe), aluminum(Al), and calcium(Ca) in the sediments. Furthermore, Fe:P ratio was less than 15 indicting that there was not enough Fe in surface sediments to bind to P at most of the sampling sites. The positive correlation between TP and organic matter(OM) for Lake Mariut and El Mex Bay sediments indicated that the organic matter content of the sediment was a useful predictor of the total phosphorus content. Data from this study constitute a baseline of phosphorus bioavailability in sediments from El Mex Bay and Lake Mariut and could be used as a reference for future studies on the changes of bioavailable and residual phosphorus fractions over time.

关键词： Phosphorus bioavailability Sediments El Mex Bay Lake Mariut

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