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Infantile Hemangiopericytoma: Two Cases Report and Literature Review

Surgical Science 2011年第7期2卷 379-384页

作者： Gamal Al-Saied Amin Abokifa Mohamed Al-Saeed Mohamed Abdul Aziz Medhat Ibrahim Moemen Hafez Tharwat Hussain Mohamed Shahin Dalal Nemenqani naglaa fawzy 不详

Hemangiopericytoma is a rare vascular tumour of infants. Although generally considered to be benign, local recurrence and metastases can occur. Herein, we report on two full term girls, delivered with lumbosacral swelling and left thigh swelling respectively. Complete surgical excision with safety margins was performed for each lesion. Histologic examination of both lesions showed picture of infantile hemangiopericytoma. There is no evidence of local recurrence or distant metastasis during last 20 and 17 months for 1st case and 2nd case respectively. In conclusion;most infantile hemangiopericytoma follow a benign course. Rarely these tumours behave aggressively with local infiltration, recurrences and even distant metastases. Careful follow up is therefore essential.

关键词： Infantile Hemangiopericytoma Vascular Tumour

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Infantile Hemangiopericytoma: Two Cases Report and Literature Review

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Surgical Science（外科学） 2011年第7期

作者： Gamal Al-Saied Amin Abokifa Mohamed Al-Saeed Mohamed Abdul Aziz Medhat Ibrahim Moemen Hafez Tharwat Hussain Mohamed Shahin Dalal Nemenqani naglaa fawzy

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Combined Treatment Strategy and Outcome of High Risk Neuroblastoma: Experience of the Children’s Cancer Hospital-Egypt

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Journal of Cancer Therapy 2013年第9期4卷 1435-1442页

作者： Emad Moussa Mohamed fawzy Alaa Younis Maged El Shafei Mohamed Saad Zaghloul naglaa El Kinaai Amal Refaat Noha Atta Alaa El Haddad Department of Pathology National Cancer Institute Cairo University and Children’s Cancer Hospital Egypt Cairo Egypt Department of Pediatric Oncology Children’s Cancer Hospital-Egypt Cairo and Clinical Oncology Department Faculty of Medicine Menufeya University Menufeya Egypt Department of Pediatric Oncology National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Radiodiagnosis National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Radiotherapy National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt Department of Research Children’s Cancer Hospital-Egypt Cairo Egypt Department of Surgical Oncology National Cancer Institute Cairo University and Children’s Cancer Hospital-Egypt Cairo Egypt

Background: Neuroblastoma (NB) is remarkable for its wide spectrum of clinical behavior and biological characteristics in relation to outcome. The use of aggressive therapy, including autologous hematopoietic stem cell transplantation (HSCT) and the addition of isoretionin (cis-Retinoic Acid/cis-RA), has increased survival rates of patients with advanced disease. Methods: Pediatric 271 newly diagnosed high risk NB patients were prospectively enrolled into the study. Patients received neoadjuvant chemotherapy of alternating cycles: [cyclophosphamide, doxorubicin, vincristine (CAdO)] and [etoposide, carboplatin]. Intensification courses of “ICE” (ifosfamide, carboplatin, and etoposide) regimen were administered to patients with bone marrow (BM) residual infiltration. Whenever safely feasible, complete surgical resection or debulking of the primary tumor was attempted for patients achieving partial response. Eligible patients underwent HSCT, while radiation therapy to the primary and metastatic sites, as well as maintenance with cis-RA was given for 6 months. Results: The median age of our patients was 2.8 years with male to female ratio of 1.65:1. At 4 years, the overall and event free survivals were 33.7% and 23.3% for the entire group under study, with significantly higher rates (42.7% and 35.6%, respectively) for HSCT patients (n = 94;p 0.001). The outcome was also significantly correlated with response to induction therapy, pathological subtype, as well as other variables. Conclusion: Myeloablative therapy followed by stem cell rescue is regarded as the most important goal of high risk NB treatment to improve survival till present. Each of consolidation HSCT, post induction disease status, as well as international neuroblastoma pathology classification (INPC) subtype was an independent predictive variable of survival. A collaborative effort with an emphasis on biologic characteristics of aggressive disease and tailored therapy needs to be strengthened to further o

关键词： High-Risk Neuroblastoma Treatment Outcome

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