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Eosinophilic esophagitis in Egyptian adult patients presenting with upper gastrointestinal symptoms

Open Journal of Gastroenterology 2014年第2期4卷 88-95页

作者： Shereen Shoukry Hunter Dina Omar Helmy naglaa aly zayed Tamer Mohamed El-Tayeb Magdy Amin El-Serafy Endemic Medicine Department and Gastrointestinal Endoscopy and Liver Unit Faculty of Medicine Cairo University Cairo Egypt Endoscopy Unit New Kasr El-Ainy Teaching Hospital Cairo Egypt Pathology Department Faculty of Medicine Cairo University Cairo Egypt

Background and Study Aim: Eosinophilic esophagitis (EoE) is a clinicopathological disease characterized by esophageal dysfunction and marked esophageal eosinophilic infiltration. It shows a marked increase in incidence and prevalence and has been associated with gastroesophageal reflux disease (GERD). The aim of this work was to detect the prevalence of EoE in Egyptian adult patients presenting with upper gastrointestinal symptoms and to clarify its clinical pattern and the possibility of its overlap with GERD. Patients and Methods: The study included 91 adult patients presenting with various upper gastrointestinal symptoms. Upper gastrointestinal endoscopy was done and esophageal biopsies were taken. The presence of >15 eosinophils per high power field together with a history of intake of proton pump inhibitors for at least 3 weeks without improvement was used as prerequisite diagnostic criteria for EoE. Results: Classification of the patients was based on both endoscopic and histo-pathological findings. Accordingly, out of the 91 patients, 70 had GERD (76.9%);58 of them had erosive reflux disease (ERD) and 12 had endoscopically normal esophagus but with histopathological changes compatible with reflux esophagitis and were classified as non erosive reflux disease (NERD). Eighteen patients had normal endoscopic and histopathological esophagus (19.8%), and 3 patients had EoE (3.3%), with an overlap between ERD and EoE in one patient. The mean age of EoE patients was 41.6 ± 11.7 years. Two of them were males and one was a female. All of the 3 patients complained of dysphagia and none complained of heartburn. The endoscopists did not report any endoscopic findings characteristic of EoE. Conclusion: The prevalence of EoE is low in adult Egyptian patients presenting with upper gastrointestinal symptoms. Dysphagia is the main presenting symptom of EoE while heartburn is not characteristic of the disease. Normal esophagus endoscopically does not exclude EoE.

关键词： Eosinophilic Esophagitis (EoE) Adults Gastroesophageal Reflux Disease (GERD) Egypt

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Text-Independent Algorithm for Source Printer Identification Based on Ensemble Learning

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Computers, Materials & Continua 2022年第10期73卷 1417-1436页

作者： naglaa F.El Abady Mohamed Taha Hala H.zayed Department of Computer Science Faculty of Computers and Artificial IntelligenceBenha University13518Egypt School of Information Technology and Computer Science(ITCS) Nile University12677Egypt

Because of the widespread availability of low-cost printers and scanners,document forgery has become extremely *** or signatures are used to protect important papers such as certificates,passports,and identification *** the origins of printed documents is helpful for criminal investigations and also for authenticating digital versions of a document in today’s *** printer identification(SPI)has become increasingly popular for identifying frauds in printed *** paper provides a proposed algorithm for identifying the source printer and categorizing the questioned document into one of the printer classes.A dataset of 1200 papers from 20 distinct(13)laser and(7)inkjet printers achieved significant identification results.A proposed algorithm based on global features such as the Histogram of Oriented Gradient(HOG)and local features such as Local Binary Pattern(LBP)descriptors has been proposed for printer *** classification,Decision Trees(DT),k-Nearest Neighbors(k-NN),Random Forests,Aggregate bootstrapping(bagging),Adaptive-boosting(boosting),Support Vector Machine(SVM),and mixtures of these classifiers have been *** proposed algorithm can accurately classify the questioned documents into their appropriate printer *** adaptive boosting classifier attained a 96%*** proposed algorithm is compared to four recently published algorithms that used the same dataset and gives better classification accuracy.

关键词： Document forensics source printer identification(SPI) HOG LBP principal component analysis(PCA) bagging AdaBoost

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Assessment of Insulin Resistance and Insulin Growth Factor-1 in Egyptian Patients with Chronic Hepatitis C

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Open Journal of Endocrine and Metabolic Diseases 2011年第1期1卷 1-8页

作者： Inas Kostandi Magy Bahgat naglaa zayed Laila Rashed 不详

Introduction: Insulin resistance (IR) is documented in patients with chronic hepatitis C(CHC), plays an important factor in disease progression and predicting poor response to treatment. In chronic liver disease, levels of insulin-like growth factor-1 (IGF-1) were correlated with IR. Aim: To evaluate IR and serum levels of IGF-1 in Egyptian patients with CHC after anti-viral therapy. Patients and Methods: Forty biopsy-proven, non-diabetic, CHC patients, who received combined IFN/ribavirin therapy, in addition to 10 healthy controls were studied. Serum levels of IGF-1, growth hormone (GH) were measured and HOMA-IR(homeostasis model assessment of IR), body mass index (BMI) were calculated. Baseline data, retrieved from patients’ files before initiation of therapy, together with response to antiviral therapy were analyzed with respect to the measured variables. Results: All patients possessed a significant higher HOMA-IR score (p = 0.02), GH levels (p < 0.001) and blood glucose levels (p < 0.001) than controls while significantly lower levels of IGF-1 were found in patients (p = 0.008)with no significant difference between responders and non-responders as regards the previously mentioned variables. HOMA-IR score was significantly correlated with GH levels, p = 0.003 and with IGF-1 levels in both responders and non responders. Low IGF-1 levels were associated with increase in fibrosis stages and were significantly correlated with insulin(r = –0.499, p = 0.001). Conclusion: CHC patients exhibit an increased HOMA-IR score reflecting the existence of IR irrespective of treatment response. Low IGF-1 levels were associated with advanced stages of fibrosis and thus could contribute to the progression of hepatic fibrosis in CHC.

关键词： Hepatitis C Insulin Resistance Interferon Ribavirin IGF-1

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Rooted Tree Optimization for Wind Turbine Optimum Control Based on Energy Storage System

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Computers, Materials & Continua 2023年第2期74卷 3977-3996页

作者： Billel Meghni Afaf Benamor Oussama Hachana Ahmad Taher Azar Amira Boulmaiz Salah Saad El-Sayed M.El-kenawy Nashwa Ahmad Kamal Suliman Mohamed Fati naglaa K.Bahgaat Department of Electrical Engineering Badji Mokhtar UniversityLSEM LaboratoryAnnaba23000Algeria Department of Electrical Engineering Biskra UniversityLGEB LaboratoryBiskra07000Algeria Department of Drilling and Rig Mechanics Ksadi Merbah UniversityOuargla30000Algeria College of Computer and Information Sciences Prince Sultan UniversityRiyadh11586Saudi Arabia Faculty of Computers and Artificial Intelligence Benha UniversityBenha13518Egypt Department of Electronics University of Badji MokhtarLERICA LaboratoryAnnaba23000Algeria Delta Higher Institute for Engineering&Technology(DHIET) Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Faculty of Engineering Cairo UniversityGiza12613Egypt Department of Communications and Electronics Engineering Faculty of EngineeringCanadian International College(CIC)ElShiekh ZayedEgypt

The integration of wind turbines(WTs)in variable speed drive systems belongs to the main factors causing lowstability in electrical ***,in order to avoid this issue,WTs hybridization with a storage system is a *** paper investigates WT system operating at variable *** system contains of a permanent magnet synchronous generator(PMSG)supported by a battery storage system(BSS).To enhance the quality of active and reactive power injected into the network,direct power control(DPC)scheme utilizing space-vector modulation(SVM)technique based on proportional-integral(PI)control is ***,to improve the rendition of this method(DPC-SVM-PI),the rooted tree optimization technique(RTO)algorithm-based controller parameter identification is used to achieve PI optimal *** compare the performance ofRTO-based controllers,they were implemented and tested along with some other popular controllers under different working *** obtained results have shown the supremacy of the suggested PIRTO algorithm compared to competing controllers regarding total harmonic distortion(THD),overshoot percentage,settling time,rise time,average active power value,overall efficiency,and active power steadystate error.

关键词： Rooted tree optimization(RTO)method direct power control(DPC) wind turbine(WT) proportional integral(PI) PMSG

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Value of transabdominal bowel ultrasonography and splanchic vascular parameters in the evaluation of inflammatory bowel disease

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Open Journal of Gastroenterology 2013年第2期3卷 99-106页

作者： Manal Kamel Magdy El-Serafy Hussein Attia Hanan Abdeel-Haleem naglaa zayed Maha Hasab-Allah Zakaria Salama Endemic Medicine Department Cairo University Cairo Egypt Gastrointestinal Endoscopy Unit Faculty of Medicine Cairo University Cairo Egypt Radiology Department National Cancer Institute Cairo University Cairo Egypt

Background: Although non-specific, transabdominal bowel ultrasonography, in real time or in color Doppler;has been beneficial in evaluating the location, extent and activity of inflammatory bowel disease (IBD). Aim: To assess the potential role of bowel transabdominal bowel ultrasonography in the diagnosis and follow-up of IBD. Patients and Methods: A cohort of 30 adults histologically-proven active IBD patients;ulcerative colitis (UC) (n = 20), Crohn’s disease (CD) (n = 10) were prospectively assessed in addition to 20 non-IBD participants representing the control group. All participants underwent the full colonoscopy in addition to real time and color Doppler ultrasonography. Bowel wall thickness, peri-enteric changes, and hemodynamic changes in the portal vein and mesenteric arteries were recorded at initial enrollment and after complete remission in 10 IBD patients. Results: Bowel wall was significantly thickened in all active IBD patients with a significant decrease after disease quiescence in CD patients;p value p value

关键词： Bowel Ultrasonography-Inflammatory Bowel Disease Ulcerative Colitis Crohn’s Disease Splanchnic Vessels Doppler

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Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients

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World Journal of Gastroenterology 2016年第34期22卷 7767-7777页

作者： Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem naglaa zayed Ahmed Khairy Mostafa K El Awady Department of Microbial Biotechnology National Research Centre Department of Biochemistry Faculty of ScienceAin Shams University Endemic Medicine Department Faculty of MedicineCairo University

AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype *** This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk *** Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected

关键词： Hepatitis C virus immune response Tumor necrosis factor alpha Single nucleotide polymorphisms Cytokine expression Liver disease progression

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