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Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

Genes & Diseases 2017年第3期4卷 170-175页

作者： Samar Samir Abdelmajed Mohamed Youssef Moushira Erfan Zaki naglaa abu-mandil hassan Somaia Ismail October University for Modern Sciences and Arts(MSA) GizaEgypt Organic chemistry Department Faculty of scienceCairo UniversityEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreEgypt Medical Molecular Genetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt

Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes *** genome-wide association studies(GWAS)confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated(FTO)gene and obesity in adults and children in different ethnic *** our study,the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and *** examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases,we used the restriction fragment length polymorphism(RFLP)technique to genotype the *** current study showed that there were no significant differences(P>0.05)between the cases and controls in both variants of rs17817449 and rs9939609 ***,there were significant correlations between rs17817449 and cholesterol and between rs9939609 and *** Current Study although the two variants(rs9939609 and rs17817449)didn’t show an association with obesity,but there was a correlation between the lipid profile and these two variants.

关键词： Children Egyptians Fat mass and obesity associated gene(FTO) Obesity Variants

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