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Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal Abd el-Salam Marwa Mohamed Anwar Rasha Mahmoud Gouda naglaa abou el fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

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Effect of Doum Fruit (Hyphaene Thebaica) Extract on Some Biochemical Parameters, Enzyme Activities and Histopathological Changes of Pancreas in Alloxan Induced Diabetic Rats

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Food and Nutrition Sciences 2020年第3期11卷 207-219页

作者： naglaa Abd fattah Abd el Halim Hassan Department of Home Economics Faculty of Agriculture Alexandria University Alexandria Egypt

Medicinal plants have been used in the treatment of some diseases like diabetes. One of them is doum fruit extract. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Animals were allocated into five groups of rats, two groups, several as control (one normal and one diabetic rats) and the other three groups were induced diabetic with doum extract (0.5, 1 and 2 g/kg b·wt) which were given every other day by stomach tube for 6 weeks. Evaluation was made for glucose, insulin, lipid profile, enzyme activities, antioxidant activity and histopathological changes of pancreas. The results showed that doum fruit extract decreased blood glucose, insulin, total cholesterol (TC), triglyceride (TG), total lipid (TL), low-density lipoprotein cholesterol (LDL-C), lactate dyhadreygenase (LDH), alanine and aspartate amino transferase (ALT, AST), alkaline phosphatase (ALP) and Malondialdehyde (MDA) while plasma catalase activity and high density lipoprotein cholesterol (HDL-C) were significantly (p 0.05) increased. Therefore, the results of this study demonstrated that the active compounds present in the doum extract have a positive effect on the biochemical parameters of diabetic rats.

关键词： Doum Fruit Extract Alloxan Histopathological MDA Biochemical Parameters

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Efficient Hardware Design of a Secure Cancellable Biometric Cryptosystem

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Intelligent Automation & Soft Computing 2023年第4期36卷 929-955页

作者： Lamiaa A.abou elazm Walid el-Shafai Sameh Ibrahim Mohamed G.Egila H.Shawkey Mohamed K.H.elsaid naglaa F.Soliman Hussah Nasser AlEisa Fathi E.Abd el-Samie Department of Microelectronics Electronics Research InstituteAlnozhaEgypt Department of electronics and electrical Communications Engineering Ain Shams UniversityCairoEgypt Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Security Engineering Laboratory Department of Computer SciencePrince Sultan UniversityRiyadh 11586Saudi Arabia Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia

Biometric security is a growing trend,as it supports the authentication of persons using conﬁdential biometric *** of the transmitted data in multi-media systems are susceptible to attacks,which affect the security of these *** systems provide sufﬁcient protection and privacy for *** recently-introduced cancellable biometric recognition systems have not been investigated in the presence of different types of *** addition,they have not been studied on different and large biometric *** point that deserves consideration is the hardware implementation of cancellable biometric recognition *** paper presents a suggested hybrid cancellable biometric recognition system based on a 3D chaotic *** rationale behind the utilization of the 3D chaotic cryptosystem is to guarantee strong encryption of biometric templates,and hence enhance the security and privacy of *** suggested cryptosystem adds signiﬁcant permutation and diffusion to the encrypted biometric *** introduce some sort of attack analysis in this paper to prove the robustness of the proposed cryptosystem against *** addition,a Field Programmable Gate Array(FPGA)implementation of the pro-posed system is *** obtained results with the proposed cryptosystem are compared with those of the traditional encryption schemes,such as Double Random Phase Encoding(DRPE)to reveal superiority,and hence high recogni-tion performance of the proposed cancellable biometric recognition *** obtained results prove that the proposed cryptosystem enhances the security and leads to better efﬁciency of the cancellable biometric recognition system in the presence of different types of attacks.

关键词： Information security cancellable biometric recognition systems cryptanalysis 3D chaotic map encryption FPGA

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