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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 40-49页

作者： Ashwin D Porwal Paresh M Gandhi Deepak k kulkarni Gajanan b bhagwat Pravin P kamble Department of Proctology Healing Hands ClinicMahārāshtraPune 411001India R&D Center Healing Hands and Herbs Pvt.Ltd.MahārāshtraPune 411002India

bACkGROUND Functional constipation(FC)is a common gastrointestinal disorder characterized by abdominal pain and bloating,which can greatly affect the quality of life of *** treatments often yield suboptimal results,leading to the exploration of alternative therapeutic *** To evaluate the efficacy of kiwibiotic in the management of FC and related *** This prospective,interventional,single-center,crossover study compared the safety and effectiveness of kiwibiotic®vs psyllium husk in managing FC,abdominal pain,and *** diagnosed with FC were randomly assigned to receive kiwibiotic or psyllium husk during the two treatment periods,with a 14-day washout period between *** Seventy participants were enrolled,32 of whom received kiwibiotic followed by psyllium husk,and 33 received *** showed superiority over psyllium husk in alleviating abdominal pain and bloating,as evidenced by significantly lower mean ***,kiwibiotic resulted in more than 90.0%of patients experiencing relief from various constipation symptoms,while psyllium husk showed comparatively lower *** kiwibiotic is an effective treatment option for FC,abdominal pain,and bloating,highlighting its potential as a promising alternative therapy for patients with FC and its associated symptoms.

关键词： kiwibiotic Psyllium husk Constipation Abdominal pain bloating

Gastroesophageal reflux following per-oral endoscopic myotomy:Can we improve outcomes?

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World Journal of Gastroenterology 2024年第22期30卷 2834-2838页

作者： Inian Samarasam Raj kumar Joel Anna b Pulimood Department of Surgery Upper Gastrointestinal Surgery UnitChristian Medical College&HospitalVellore 632004TamilnaduIndia Department of Cardiothoracic Surgery Christian Medical College&HospitalVellore 632004TamilnaduIndia Department of Gastrointestinal Sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia

This editorial is an analysis the review article by Nabi et al recently published in this *** Cardia is a disease whose pathophysiology is still *** is known that there is inflammation of unknown aetiology leading to loss of ganglion cells in the muscularis *** end result is lower oesophageal sphincter spasm,loss of receptive relaxation,decreased oesophageal peristalsis,all leading on to varying degrees of *** treatment of this condition is palliative in nature,performed by myotomy of the lower oesophagus either surgically or *** reflux disease(GERD)has been associated with the myotomy performed,particularly with the Peroral Endoscopic Myotomy(POEM)*** et al have provided an excellent overview of the latest developments in predicting,preventing,evaluating,and managing GERD subsequent to *** on this theme,this review article explores the concept of using histology of the oesophageal muscle layer,to grade the disease and thereby help tailoring the length/type of myotomy performed during the POEM *** the future,will a histology based algorithm available preoperatively,help modify the POEM procedure,thereby decreasing the incidence of GERD associated with POEM?

关键词： Achalasia cardia Peroral endoscopic myotomy Laparoscopic Heller’s myotomy Histopathology Histologic grading

Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： SINGH Hardeep TING David S-k READER Graham ESHTIAGHI Nicky ICHIYANAGI Mitsuhisa SUZUkI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

The Making of a Health Profession:How Chinese Medicine became a Nationally Registered Allied Health Profession in Australia

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Chinese Medicine and Culture 2024年第1期7卷 51-62页

作者： John L McDonald Judy b James School of Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Australia Brisbane 4120Australia

In 2012, traditional Chinese medicine(TCM) practitioners in Australia became nationally-registered allied health professionals in three categories: acupuncturist, Chinese herbal medicine practitioner, and Chinese herbal medicine dispenser. Australia was the first Western country to introduce national registration for Chinese medicine, followed by Portugal and, recently, New Zealand. The practice of TCM in Australia can be traced back to the beginning of Chinese immigration to Australia during the Victorian Gold Rush which began in the 1850s. The process which led to national registration commenced in the early 1970s with the establishment of the first acupuncture courses. Decades of gradual development of courses from unaccredited part-time diplomas to accredited bachelor degrees, and the development, by the profession, of national consensus on educational standards were essential elements in the process which led to registration. Professional associations, such as the Australian Acupuncture and Chinese Medicine Association Ltd.(AACMA), also developed a framework of professional selfregulation, including Codes of Ethics, Codes of Conduct, ongoing professional development requirements and Infection Control Guidelines, and provided leadership in the development of the profession. After decades of tribalism and division within the TCM profession, the National Academic Standards Committee brought almost all stakeholders together to reach a consensus on the Australian Guidelines for Traditional Chinese Medicine Education which were published by AACMA in 2001. Professional associations also collaborated on joint submissions to the government in support of registration, which was introduced first in the state of Victoria in 2000, and subsequently became national in 2012. Despite national registration, some barriers still remain, and professional associations continue to lobby the federal government for inclusion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regulation Education Standards Australia TCM

Effect of cylinder wall parameters on the final packing density of mono-disperse spheres subject to three-dimensional vibrations Author links open overlay panel

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Particuology 2024年第8期91卷 211-225页

作者： Jack R.Grogan Andrei L.Nicuşan Christopher R.k.Windows-Yule School of Chemical Engineering The University of BirminghamEdgbastonBirminghamB152TTUK

Achieving densely packed particles is desirable within the industries of ceramics,pharmaceuticals,defence and additive *** this work,we use the discrete element method(DEM)to determine the effect of wall parameters on the final packing density of mono-disperse spheres subject to 4 varying three-dimensional vibration and fill *** focus specifically on the impact of the container wall parameters on the particles'final packing *** on from the validation of the DEM simulation the particle-wall coefficient of restitution,the particle-wall coefficient of rolling friction and the particle-wall coefficient of sliding friction were varied individually and the effect on the final packing density *** relatively low particle-particle friction glass beads,the effect of these wall properties had no discernible effect on the final packing density *** on from these findings the particle-wall properties were varied at the extreme values of particle-particle coefficient of rolling friction and particle-particle coefficient of sliding *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of restitution resulted in a minor increase in the final packing density of particles though this was not statistically *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of rolling friction resulted in a minor decrease in the final packing density of the particles though again not to a degree where the trend can,with complete certainty,be distinguished from the random error across the ***,when the particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of sliding friction resulted in a significant decrease in the final packing density of *** decrease was attributed to the propagation of force chains throughout the *** significant decrease in final packing density with

关键词： Vibropacking Packing Densification Vibration Discrete element method Friction Wall friction Restitution

Data error propagation in stacked bioclimatic envelope models

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Integrative Zoology 2024年第2期19卷 262-276页

作者： Xueyan LI babak NAIMI Peng GONG Miguel b.ARAÚJO Guangdong Provincial key Laboratory of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of ScienceGuangzhouChina ‘Rui Nabeiro’biodiversity Chair CHANGE-MED InstituteUniversity ofÉvoraÉvoraPortugal Department of Geography and Department of Earth Sciences University of Hong KongHong KongChina Department of biogeography and Global Change National Museum of Natural SciencesCSICMadridSpain

Stacking is the process of overlaying inferred species potential distributions for multiple species based on outputs of bioclimatic envelope models(bEMs).The approach can be used to investigate patterns and processes of species *** data limitations on individual species distributions are inevitable,but how do they affect inferences of patterns and processes of species richness?We investigate the influence of different data sources on estimated species richness gradients in *** fitted bEMs using species distributions data for 334 bird species obtained from(1)global range maps,(2)regional checklists,(3)museum records and surveys,and(4)citizen science data using presence-only(Mahalanobis distance),presence-background(MAXENT),and presence–absence(GAM and bRT)*** species predictions were stacked to generate species richness ***,we show that different data sources and bEMs can generate spatially varying gradients of species *** environmental predictors that best explained species distributions also differed between data *** using citizen-based data had the highest accuracy,whereas those using range data had the lowest *** richness patterns estimated by GAM and bRT models were robust to data *** multiple data sets exist for the same region and taxa,we advise that explicit treatments of uncertainty,such as sensitivity analyses of the input data,should be conducted during the process of modeling.

关键词： richness patterns species distribution stacked bioclimatic envelope models uncertainty

Reactions induced by 30 MeV 3He beam on 9be:cluster transfer reactions

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Chinese Physics C 2024年第1期48卷 61-70页

作者： b.A.Urazbekov T.Issatayev S.M.Lukyanov A.Azhibekov A.S.Denikin k.Mendibayev D.M.Janseitov Yu E.Penionzhkevich k.A.kuterbekov T.k.Zholdybayev Gumiliyev Eurasian National University 2 Satpayev StrAstanaKazakhstan Institute of Nuclear Physics 1 Ibragimov StrAlmatyKazakhstan bogolubov Laboratory of Theoretical Physics JINR20 Joliot Curie StrDubnaRussia Flerov Laboratory of Nuclear Reactions JINR20 Joliot Curie StrDubnaRussia korkyt-ata State University 29A Aiteke-Byi StrKyzylordaKazakhstan Dubna State University 19 Universitetskaya StrDubnaRussia Al-Farabi kazakh National University AlmatyKazakhstan

An experiment was conducted for studying the cluster structure of be induced by He ions at an energy of 30 *** results of the nuclear reaction^(3)He+^(9)be,the differential cross sections for the exit channels–elastic,inelastic,α+^(8)be,^(6)He+^(6)be,^(6)Li+^(6)Li,and^(7)be+^(5)He–were *** and inelastic scattering data were treated within both the optical model and coupled channel method.A new set of optical potentials was considered for the elastic *** deformation parameter was established for the transition 3/2→5/*** transfer reactions were analyzed via the coupled reaction channel *** nuclear reactions with the exit channels^(6)He+^(6)be,^(6)Li+^(6)Li,and^(7)be+^(5)He were complemented by two-step transfer *** contribution of each reaction mechanism were shown and compared with the findings of other authors.

关键词： cluster transfer reaction mechanisms coupled equations

Understanding pediatric surgical needs in North korea: a modeling analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 47-53页

作者： Phillip J Hsu Sangchul Yoon kee b Park University of Michigan Ann ArborMichiganUSA Department of Global Health and Social Medicine Harvard Medical SchoolBostonMassachusettsUSA Department of Medical Humanitiesand Social Sciences Yonsei University SeoulSouth Korea

background Sixty-five percent of children worldwide lack access to surgical care,the majority of whom live in low-income and middle-income countries(LMiCs).Developing surgical infrastructure requires information on surgical need;however,this information is often limited in *** korea(Democratic People's Republic of korea,DPRk)has a low amount of publicly available ***,we analyzed available modeled data to understand the causes of pediatric deaths due to conditions treatable with surgery in *** We used World bank data and models from the Institute for Health Metrics and Evaluation to identify causes of pediatric deaths affecting pediatric patients(agebetween DPRk and countries with similar economic *** between 1990 and 2019,the number of overall pediatric deaths has *** 2019,32.2%of allpediatric deaths in DPRk were caused by surgical *** leading categories of surgical conditions were injuries(53.9%),congenital conditions(34.2%),tumors(8.8%),and abdominal conditions(3.2%).DPRk has a lower relative rate of pediatric deaths compared with other LMICs with similar gross domestic product per ***,it has a higher relative rate of pediatric deaths due to conditions requiring treatment with *** injuries contribute significantly to the high rate of pediatric deaths in *** Although DPRk may be allocating overall resources toward pediatric healthcare more efficiently than economic peers,DPRk may benefit from improvement in pediatric surgical *** availability of data and close international collaboration could be potential solutions to bridge this gap.

关键词： pediatric surgical injuries

Structural failure analysis with CMS-based ground motion selection using innovative cost function and weight factors

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 899-918页

作者： Delbaz Samadian Imrose b.Muhit Nashwan Dawood School of Computing Engineeringand Digital TechnologiesTeesside UniversityMiddlesbrough TS13BXUK

The selection and scaling of ground motion records is considered a primary and essential task in performing structural analysis and *** methods involve using ground motion models and a conditional spectrum to select ground motion records based on the target *** research demonstrates the influence of adopting different weighted factors for various period ranges during matching selected ground motions with the target hazard *** event data from the Next Generation Attenuation West 2(NGA-West 2)database is used as the basis for ground motion selection,and hazard de-aggregation is conducted to estimate the event parameters of interest,which are then used to construct the target intensity measure(IM).The target IMs are then used to select ground motion records with different weighted vector-valued objective *** weights are altered to account for the relative importance of IM in accordance with the structural analysis application of steel moment resisting frame(SMRF)*** of an ordinary objective function for the matching spectrum,a novel model is introduced and compared with the conventional cost *** results indicate that when applying the new cost function for ground motion selection,it places higher demands on structures compared to the conventional cost ***,submitting more weights to the first-mode period of structures increases engineering demand *** demonstrate that weight factors allocated to different period ranges can successfully account for period elongation and higher mode effects.

关键词： weighted objective function ground motion selection steel moment resisting frame hazard analysis

Is salmonid migration at risk from chemical information disruption?

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Aquaculture and Fisheries 2024年第3期9卷 378-387页

作者： keith b.Tierney Gregory G.Pyle biological Sciences College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of Public Health College of Health SciencesEdmontonABT6G 1C9Canada Department of biological Sciences University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the basis for good *** many invaluable salmon species,chemical information is necessary to guide and fine-tune their migrations to and from freshwater mating grounds.A problem is that salmon of the current world are running a gauntlet of toxic chemicals arising from diverse anthropogenic inputs and these chemicals are known to disrupt *** is sufficient evidence that effluents from cities,mines,agriculture and industry contain chemicals that can rapidly,and sometimes irreversibly,impair the olfactory sense that salmon use to gather *** toxic inputs may not only be strong enough to impair migration,but be strong enough to redirect salmon away from their *** is also evidence that some synthetic chemicals may serve as the basis for ‘new’ information and be useful in making correct migratory *** the plus side,there are examples of new regulations that limit the input of chemicals of known olfactory toxicity,but on the minus side,increased urbanization and global climate change will likely increase the number and/or severity of some neurotoxic *** we identify the specific avenues of chemical risks to information disruption and in so doing prioritize and rank the risks to migrating *** data collected here can be used to lay the foundation for modelling the effects of anthropogenic inputs on information disruption in diverse salmonid species from around the world and therefore help secure their longevity in a changing chemical environment.

关键词： Salmon migration Ocean ranching Chemical information disruption Homing disruption Olfactory toxicity