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Inter-Fraction and Intra-Fraction Variation in the Absorbed-Dose Delivery during Interstitial High Dose Rate Brachytherapy—A Study Using MicroMOSFET <i>In-Vivo</i>Dosimeter

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 445-456页

作者： Seenisamy Ramapandian Vivekanandan nagarajan Ashutosh Mukherji Parthasarathy Vedasoundaram K. S. Reddy Vivekanandam Singhavajala Vijayaprabhu Neelakandan Department of Radiotherapy RCC JIPMER Pondicherry India Department of Medical Physics Cancer Institute Chennai India Department of Oncology MGMC & RI Puducherry India

Background: The delivered dose has to be checked and verified with planned dose since precise and accurate dose delivery is essential in Brachytherapy. Sources of uncertainty during Brachytherapy are intra-fraction, inter-fraction and inter-application variations. In-vivo dosimetry is the direct method to monitor the radiation dose delivered to a patient during radiotherapy. In this study, assessment of the inter-fraction and intra-fraction variations in the interstitial Brachytherapy was done with microMOSFET. Aim: To analyze the inter-fraction variations in dose delivery during interstitial HDR Brachytherapy and to compare the measured point dose with the TPS-calculated point dose, intra-fraction variation, using the microMOSFET in-vivo dosimeter. Materials and Methods: From May 2014 to February 2016, 22 patients with Head and Neck cancers and 8 patients with Soft-Tissue Sarcomas (STS) were selected for this study. All these patients underwent CT imaging more than 24 hours after the application. Brachyvision 3DTPS and GammaMed Plus iX HDR unit were used for treatments. MicroMOSFET in-vivo dosimeter after calibration was used for the measurements of dose inside the treated volume. Intra & Inter-fraction variations were analyzed and reported. Results: The SD of inter-fraction variation among 22 Head & Neck patients ranges from 2.14% to 14.26%. Minimum & maximum dose variation with first fraction dose of patients ranged from -22.33% to +26.71% and the mean doses were -6.42% to +19.76%. Differences of TPS dose and microMOSFET measured first fraction dose, intra-fraction variation, ranged from -12.36% to +5.05%. The SD of inter-fraction variation for 8 STS patients was from 2.81% to 14.43%. Minimum and maximum doses vary from -38.72% to +25.74% and mean dose varies from -21.5% to +12.53%. Differences of point doses of TPS and measured, intra-fraction variation, were from -5.86% to 4.88%. Conclusions: MicroMOSFET has the potential to minimize the gross errors during mul

关键词： MicroMOSFET Interstitial Brachytherapy MicroMOSFET in Brachytherapy In-Vivo Dosimetry in Brachytherapy Dose Verification in Brachytherapy

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An <i>In-Vivo</i>Study during Combined Intracavitary and Interstitial Brachytherapy of Gynaecological Malignancies Using microMOSFET

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第2期6卷 162-173页

作者： Ramapandian Seenisamy Vivekanandan nagarajan Ashutosh Mukherji Parthasarathy Vedasoundaram K. S. Reddy Vivekanandam Singhavajala Vijayaprabhu Neelakandan Department of Radiotherapy RCC JIPMER Puducherry India Department of Medical Physics Cancer Institute Adyar Chennai India Department of Oncology MGMC & RI Puducherry India

Aim: To analyze the inter-fraction, intra-fraction uncertainties and to verify the delivered total dose with planned dose in the combined intracavitary-interstitial brachytherapy of gynaecological cancer patients using microMOSFET in-vivo dosimeter. Materials and Methods: Between May 2014 and March 2016, 22 patients who underwent brachytherapy treatments with an applicator combination of CT/MR compatible tandem, ring and Syed-Neblett template-guided rigid needles were included in this study. Specially designed microMOSFET, after calibration, was used to analyze the variations in dosimetry of combined intracavitary-interstitial application. Results: The standard deviation for Inter-fraction variation among 22 combined intracavitary interstitial applications ranged between 0.86% and 10.92%. When compared with the first fraction dose, the minimum and maximum dose variations were −9.5% and 26.36%, respectively. However, the mean doses varied between −5.95% and 14.49%. Intra-fraction variation, which is the difference of TPS calculated dose with first fraction microMOSFET-measured dose ranges from −6.77% to 8.68%. The variations in the delivered total mean dose in 66 sessions with planned doses were −3.09% to 10.83%. Conclusions: It is found that there was a gradual increase in microMOSFET measured doses as compared to the first fraction with that of subsequent fractions in 19 out of 22 applications. Tumor deformation and edema may be the influencing factors, but the applicator movements played a major role for the variations. We find that the microMOSFET is an easy and reliable system for independent verification of uncertainties during ICBT-ISBT treatments.

关键词： microMOSFET Intra-Fraction Variations in Brachytherapy Inter-Fraction Variations in Brachytherapy Combined Intracavitary and Interstitial Brachytherapy In-Vivo Dosimetry in Brachytherapy Applicator Displacement Brachytherapy Uncertainties

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Synthesis of the First Phosphonate Bis-tetrazoles as Fluconazole Analogs

Synthesis of the First Phosphonate Bis-tetrazoles as Flucona...

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中国化学会全国第十二届有机合成化学学术研讨会

作者： Gao,Wei-Wei Sangaraiah,nagarajan Syed,Rasheed Zhang,Feng-Xiu Zhou,Cheng-He Laboratory of Bioorganic ＆ Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest University

Fluconazole with two triazole rings has established an exceptional therapeutic record for Candida infections with low toxicity,excellent safety profile and favorable pharmacokinetic ***,the use of Fluconazole is still limited by poor water solubility,narrow antimicrobial spectrum and multidrug ***,there is a real perceived need for the development of novel and more effective antimicrobial *** we would like to develop a class of phosphonates bis-tetrazoles as novel type of fluconazole analogs and evaluate their antifungal activities.

关键词： tetrazole fluconazole phosphate antifungal

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Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing

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National Science Review 2020年第1期7卷 84-91页

作者： Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li Shenzhen Key Laboratory of Nanobiomechanics Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Materials Science and Engineering Xiangtan University School of Materials Science and Engineering University of New South Wales Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemical Physics University of Science and Technology of China Institute for Advanced Materials and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Dongguan Neutron Science Center Department of Physics Southern University of Science and Technology International Center for Quantum Materials and Electron Microscopy Laboratory School of Physics Peking University Hunan Provincial Key Laboratory of Health Maintenance for Mechanical Equipment Hunan University of Science and Technology Department of Physics College of Science National University of Defense Technology Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Songshan Lake Materials Laboratory Dongguan Neutron Science Center

Complex oxides with tunable structures have many fascinating properties, though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach. Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic（1-x）BiTi;/;Fe;Mg;/;O;–（x）CaTiO;（BTFM–CTO） solid solution in large area, confirming its ferroelectricity at the atomic scale with strong spontaneous polarization. Careful compositional tuning leads to a bulk magnetization of 0.07 ± 0.035 μB/Fe at room temperature, enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0 × 10;s/m. This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film, making it possible to explore a much wider space of composition,phase, and structure that can be easily scaled up for industrial applications.

关键词： complex oxide solution method epitaxy multiferroic

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Mosquito larvicidal properties of volatile oil from salt marsh mangrove plant of Sesuvium portulacastrum against Anopheles stephensi and Aedes aegypti

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Journal of Coastal Life Medicine 2013年第1期1卷 66-71页

作者： Mohamed Yacoob Syed Ali Venkatraman Anuradha SyedAbudhair Sirajudeen Prathasarathy Vijaya nagarajan Yogananth Ramachandran Rajan Peer Mohamed Kalitha Parveen PG&Research Department of Biotechnology Mohamed Sathak College of Arts&ScienceSholinganallurChennai-600119Tamil NaduIndia Center for Marine Fisheries Research Institute Mandapam CampTamil NaduIndia

Objective:To identify the larvicidal activity of the volatile oil from Sesuvium portulacastrum(***)against Anopheles stephensi and Aedes ***:Volatile oil extract of *** was prepared in a graded series of *** test for the larvicidal effect of volatile oil against mosquitos larvae was conducted in accordance with the WHO standard *** of 25 early 4th instar larvae of two mosquitoes were transferred to 250 mL enamel bowl containing 199 mL of distilled water and 1 mL of plant *** experiment was conducted with triplicate with concurrent a control ***:Volatile oil extract of *** showed toxicity against 4th instar larvae of Aedes aegypti and Anopheles stephensi with equivalent LC50 value[(63±7.8)μL/mL,LCL-UCL=55.2-64.0]and LC90 value[(94.2±3.9)μL/mL]in maximum activity with minimum concentration(200μL/mL)of volatile oil and followed by maximum activity of 250μL concentration showed LC50 value=(68.0±8.2)μL/mL,LCL-UCL=66.26-69.2 and LC50 value of(55.2±2.8)μL/mL,LCL-UCL=53.7-56.9,LC90=(95.2±1.25)μL/mL and followed by 250μL of oil extract against 4th instar larvae of Aedes aegypti ***:It is inferred from the present study that,the extracts from salt marsh mangrove plan of *** are identified as a potential source of safe and efficacious mosquito control agents for the management of vector borne diseases of malaria and dengue.

关键词： Aedes aegypti Anopheles stephensi Larvicidal Oleic acid Sesuvium portulacastrum

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聚合的钙皂分散剂

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日用化学工业译丛 1990年第5期 27-28页

作者： M.K.nagarajan 王璇

用肥皂作为清洁剂可追溯到文明社会初期,长期使用表明它是安全和有效的。然而,肥皂的一个重要缺点是它不溶于含钙、镁盐的水(常称为'硬水')中。众所周知、在硬水中形成的不溶皂往往会絮凝,并形成所谓的'钙皂垢'。

关键词：钙皂分散剂肥皂

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分析与设计边跟踪-边扫描雷达的新方法

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系统工程与电子技术 1988年第9期 32-50页

作者： V.nagarajan ,王连成 ,宗波

一、前言传统的边跟踪一边扫描(TWS)雷达的设计优化方法独立考虑检测和跟踪两种功能。本文提出把两种功能的性能一起优化的一种新方法。在这篇文章中,我们将推导一些解析公式,用以表示输入门限、试验目标门限、航

关键词：概率虚警误警航迹相关方程门限机动目标乘积试验目标

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Nasal Schwannoma—A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 94-98页

作者： A. Ravindran A. Amirthagani Prince Peterdhas S. nagarajan P. Palanivel Rekha Salini A. S. Jagan Department of Otorhonolaryngology Thanjavur Madical College Thanjavur India

According to the literature, half of the schwannoma cases occur in the head and neck areas and only less than 4% occur in the sinonasal tract. In this case, a 50-year-old male patient, Mr. Jeyapal with a-year-long progressive left side nasal obstruction and purulent rhinorrhea, is presented [1]. The CT reveals a mass filling the left nasal cavity. During surgical intervention, the mass is found to originate from the medial side of the septum anteriorly and inferiorly. The pathological examination reveals capsulated tumor with palisading cellular arrangement and high cellular density [2]. The pathological findings and nervous origin of the tumor are discussed after an extensive review of the literature.

关键词： Nasal Schwannoma Chronic Nasal Obstruction Nasal Polyp

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应对高级嵌入式处理器系统调试挑战

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电子设计技术 EDN CHINA 2008年第11期15卷 102-102,104,108页

作者： Jorge Carrillo Raj nagarajan Oliver Oppitz Xilinx公司 Lauterbach公司

FPGA最大的优点在于其灵活性，可激发设计人员创造出无数不同的设计。然而，设计调试通常最后才加以考虑——如果还加以考虑的话，因此调试器通常要适应系统的要求。

关键词：系统调试嵌入式处理器设计人员 FPGA 调试器

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Surgical management of invasive fungal infections in adult leukemia patients:experience from a large tertiary center in Southeast-Asia

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Blood Science 2020年第2期2卷 59-65页

作者： Bryan M.H.Keng Zhi Xuan Ng Yan Chin Tan Thuan Tong Tan Gee Chuan Wong Chandramouli nagarajan Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Haematology Singapore General HospitalSingapore Department of Infectious Diseases Singapore General HospitalSingapore Singhealth Duke-NUS Blood Cancer Centre Singapore

Objectives:Invasive fungal infections(IFIs)are a major cause of morbidity and mortality in acute leukemia patients undergoing chemotherapy or hematopoietic stem cell transplantation(HSCT).Surgical interventions may be necessary to improve the survival outcomes of these *** aim of this study is to report a single-center experience using surgical intervention as adjunctive treatment for IFI in adult leukemia ***:A retrospective review was conducted to obtain clinical characteristics and outcomes of surgically managed IFI patients diagnosed between January 2005 and December 2015 in our ***:Nineteen acute leukemia patients,median age 46 years(range 19–65),underwent 20 surgical procedures as management for *** patients had proven IFI diagnoses prior to *** patients underwent surgery for both diagnostic and therapeutic ***-surgery,the diagnostic yield for proven IFI increased by a factor of 5,and 15 patients had definitive IFI *** complications included 2 pleural effusions,4 pneumothoraxes,and 1 *** median duration of hospitalization for patients with complications was 9 days(range 3–64).Thirteen patients benefited overall from the procedure,3 had temporary clinical benefits,and 2 had progression of *** surgery,the 3-month and 2-year overall survival rates were 89.5%and 57.9%,*** median time from surgery to resumption of chemotherapy or HSCT was 25 ***:Surgical interventions for IFI are feasible in selected leukemia patients,as they yield valuable information to guide antifungal therapy or enable therapeutic outcomes with acceptable risk,thereby allowing patients to proceed with curative chemotherapy and HSCT.

关键词： Invasive fungal infection Leukemia Surgical management

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