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苝类化合物研究与应用

化学进展 2015年第6期27卷 704-743页

作者：王辉 Ponmani Jeyakkumar Sangaraiah nagarajan 孟江平周成合西南大学化学化工学院生物有机与药物化学研究所重庆市高校应用化学重点实验室重庆400715 重庆文理学院材料与化工学院环境材料与修复技术重庆市重点实验室重庆402160

苝类化合物具有大的共轭体系,易于进行结构修饰,可引入各种功能性基团,这种奇特结构赋予了苝类化合物优良的理化性质和特殊功能,在材料科学、超分子化学、生物、药学、医学等领域具有宽广的应用潜力,尤其在苝类有机光电材料已得到广泛... 详细信息

苝类化合物具有大的共轭体系,易于进行结构修饰,可引入各种功能性基团,这种奇特结构赋予了苝类化合物优良的理化性质和特殊功能,在材料科学、超分子化学、生物、药学、医学等领域具有宽广的应用潜力,尤其在苝类有机光电材料已得到广泛的研究,取得了许多重要成就。尤其是近来越来越多的研究致力于开发苝类化合物其它可能的应用,已延伸到诸多领域,特别是相关生物医药的应用研究已成为近几年来异常活跃的新兴研究领域,引起广泛关注,进展迅速。本文结合课题组的研究工作,参考国内外近五年文献,首次系统地综述了苝类化合物在有机光电材料、纳米材料、生物医药光敏剂、生物荧光标记和成像、药物载体、人工诊断剂、人工离子受体和荧光分子探针等材料、生物、医药领域应用研究新进展。文中注重强化了化合物结构对苝类化合物性质和应用的影响。对未来苝类化合物研究与应用的发展趋势作了展望。

关键词：苝材料科学超分子识别

End-to-end computational approach to the design of RNA biosensors for detecting miRNA biomarkers of cervical cancer

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Synthetic and Systems Biotechnology 2022年第2期7卷 802-814页

作者： Priyannth Ramasami S.Baabu Shivaramakrishna Srinivasan Swetha nagarajan Sangeetha Muthamilselvan Thamarai Selvi Raghavv R.Suresh Ashok Palaniappan Department of Bioinformatics School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavurTamil Nadu 613401India Department of Bioengineering School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavurTamil Nadu613401India School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Life Sciences Division TCS ResearchTata Consultancy ServicesChennaiTamil Nadu600042India

Cervical cancer is a global public health subject as it affects women in the reproductive ages,and accounts for the second largest burden among cancer patients worldwide with an unforgiving 50%mortality *** scant awareness and limited access to effective diagnosis have led to this enormous disease burden,calling for point-of-care,minimally invasive diagnosis ***,an end-to-end quantitative unified pipeline for diagnosis has been developed,beginning with identification of optimal biomarkers,concurrent design of toehold switch sensors,and finally simulation of the designed diagnostic circuits to assess *** miRNA expression data in the public domain,we identified miR-21-5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic *** riboregulators called toehold switches specific to the biomarker panel were then *** predict the dynamic range of toehold switches for use in genetic circuits as biosensors,we used a generic grammar of these switches,and built a neural network model of dynamic range using thermodynamic features derived from mRNA secondary structure and ***-generation toehold switches were used to overcome the design challenges associated with miRNA *** resultant model yielded an adj.R^(2)~0.71,outperforming earlier models of toehold-switch dynamic *** kinetics modelling was performed to predict the sensitivity of the second-generation toehold switches to the miRNA *** showed a linear response between 10 nM and 100 nM before *** study demonstrates an end-to-end computational workflow for the efficient design of genetic circuits geared towards the effective detection of unique genomic/nucleic-acid *** approach has the potential to replace iterative experimental trial and error,and focus time,money,and *** software including the toehold grammar parser,neu

关键词： Cervical cancer biosensor miRNA biomarker Synthetic toehold switches Genetic circuit design Reaction network modelling Toehold efficacy modelling Toehold switch grammar Machine learning

Well selection in depleted oil and gas fields for a safe CO_(2) storage practice: A case study from Malaysia

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Petroleum 2017年第1期3卷 167-177页

作者： Arshad Raza Raoof Gholami Reza Rezaee Chua Han Bing Ramasamy nagarajan Mohamed Ali Hamid Department of Petroleum Engineering Curtin UniversityMalaysia Department of Petroleum Engineering Curtin UniversityAustralia Department of Chemical Engineering Curtin UniversityMalaysia Department of Applied Geology Curtin UniversityMalaysia

Carbon capture and sequestration technology is recognized as a successful approach taken to mitigate the amount of greenhouse gases released into the ***,having a successful storage practice requires wise selection of suitable wells in depleted oil or gas fields to reduce the risk of leakage and contamination of subsurface *** aim of this paper is to present a guideline which can be followed to provide a better understanding of sophisticated wells chosen for injection and storage *** recent studies carried out on different aspects of geosequestration indicated that the fracture pressure of seals and borehole conditions such as cement-sheath integrity,distance from faults and fractures together with the depth of wells are important parameters,which should be part of the analysis for well selection in depleted reservoirs.A workflow was then designed covering these aspects and it was applied to a depleted gas field in *** results obtained indicated that Well B in the field may have the potential of being a suitable conduit for *** more studies are required to consider other aspects of well selections,it is recommended to employ the formation integrity analysis as part of the caprock assessment before making any decisions.

关键词： CO_(2)storage Injection wells Leakage Carbonate reservoir Malaysia

CO_(2) storage in depleted gas reservoirs:A study on the effect of residual gas saturation

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Petroleum 2018年第1期4卷 95-107页

Depleted gas reservoirs are recognized as the most promising candidate for carbon dioxide *** gas production followed by injection of carbon dioxide after depletion is the strategy adopted for secondary gas recovery and storage *** strategy,however,depends on the injection strategy,reservoir characteristics and operational *** have been many studies to-date discussing critical factors influencing the storage performance in depleted gas reservoirs while little attention was given to the effect of residual *** this paper,an attempt was made to highlight the importance of residual gas on the capacity,injectivity,reservoir pressurization,and trapping mechanisms of storage sites through the use of numerical *** results obtained indicated that the storage performance is proportionally linked to the amount of residual gas in the medium and reservoirs with low residual fluids are a better choice for storage ***,it would be wise to perform the secondary recovery before storage in order to have the least amount of residual gas in the *** the results of this study are useful to screen depleted gas reservoirs for the storage purpose,more studies are required to confirm the finding presented in this paper.

关键词： CO_(2)storage Dry gas reservoir Long term reservoir simulation Residual gas saturation

Preliminary assessment of CO_(2) injectivity in carbonate storage sites

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Petroleum 2017年第1期3卷 144-154页

Depleted gas reservoirs are used for a large-scale carbon dioxide(CO_(2))storage and reduction of the greenhouse gas released into the *** identify a suitable depleted reservoir,it is essential to do a preliminary and comprehensive assessment of key storage factors such as storage capacity,injectivity,trapping mechanisms,and ***,there are a limited number of studies providing a preliminary assessment of CO_(2) injectivity potential in depleted gas reservoirs prior to a CO_(2) storage *** aim of this study is to provide a preliminary assessment of a gas field located in Malaysia for its storage potential based on subsurface characterization prior to *** of the reservoir interval based on the facies,cores,and wireline log data of a well located in the field indicated that the pore type and fabrics analysis is very beneficial to identify suitable locations for a successful storage *** the results obtained are promising,it is recommended to combine this preliminary assessment with the fluid-mineral interactions analysis before making any judgment about reliability of storage sites.

关键词： CO_(2)storage Injectivity Carbonate reservoir Lithofacies Petrophysics

Triple-Polarized Multi-User Mimo-Idma System under Correlated Fading Channel

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Circuits and Systems 2016年第8期7卷 1623-1634页

作者： B. Partibane V. nagarajan Department of ECE SSN College of Engineering Chennai India Department of ECE Adhiparasakthi Engineering College Melmaruvathur India

A multiple-input multiple-output interleave division multiple access (MIMO-IDMA) system with Triple Polarized Division Multiplexing (TPDM) is presented in this paper. The present methodology replaces three independent linearly polarized antennas with a single triple polarized antenna at both the transmitter and receiver. The users in the communication link are accommodated and separated using a user-specific interleaver combined with low rate spreading sequence. To eliminate the effects of multi-stream interference (MSI), minimum mean square error (MMSE) algorithm based on successive interference cancellation (SIC) Multi-user detection (MUD) technique is employed at the receiver. Furthermore, log-maximum a posteriori probability (MAPP) decoding algorithm is implemented at the mobile stations (MSs) to overcome the effects of multi-user interference (MUI) effects. The paper also evaluates the effects of coded MIMO-IDMA in the downlink communication by adopting the Stanford University Interim (SUI) and Long-term Evolution (LTE)channel model specifications. In comparison with the traditional uncoded system, the present solution considering turbo coded triple-polarized MIMO-IDMA system with iterative decoding algorithm provides better bit error rate (BER) with reduced signal to noise ratio (SNR). The simulation results also show that though the SNR requirement is higher for the proposed technique compared to the conventional uni-polarized antenna based MIMO-IDMA system, it gives the advantages of achieving higher data rate with reduced cost and space requirements in the context of a downlink (DL).

关键词： Interleave Division Multiple Access (IDMA) Multiple Input Multiple Output (MIMO) Multi-User Interference (MUI) Stanford University Interim (SUI) Channel Model Long Term Evolution (LTE) Channel Model

Improvement of Supplementary Irrigation Water Quality for Rain-Fed Agriculture in the Semi-Arid Region Using Magnetization Techniques

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Journal of Water Resource and Protection 2018年第12期10卷 1198-1209页

作者： Deepak Bornare Ramakrishna nagarajan Rajiv Barge Center of Studies in Resources Engineering Indian Institute of Technology Mumbai India Department of Agriculture Engineering Maharashtra Institute of Technology Aurangabad India Eco Nutrivet Biosolutions Division Pune India

Rain-fed agriculture depends on the groundwater as a supplementary source of irrigation. The poor quality of water from the hard rock area is applied to the crops to save the crop. Continuous irrigation leads to degradation of soil, drip irrigation system as well plants. This study assessed the damages on the drip irrigation system and soil, inflicted by the use of low-quality irrigation water. The quality of water was improved with reference to raw water in terms of pH (1.57% - 5.88%), EC (3.08% - 10.08%), ions (0.96% - 46%) by using magnetization method, without disrupting the existing irrigation system in the basaltic aquifer in semi-arid to the arid condition. This was demonstrated before the farmers in central India.

关键词： Supplementary Irrigation Low Water Quality Hard Rock Aquifer Dissolved Salts Semi-Arid Region Magnetization Method

Influence of Modifiers on Supercritical Fluid Chromatography (SFC) and Supercritical Fluid Extraction (SFE), Part I

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International Journal of Analytical Mass Spectrometry and Chromatography 2017年第2期5卷 17-39页

作者： Ilia Brondz Boris Sedunov nagarajan Sivaraman Norwegian Drug Control and Drug Discovery Institute (NDCDDI) AS Ski Norway The Computer and Information Systems Department of the Russian New University Moscow Russia Fuel Chemistry Division Indira Gandhi Centre for Atomic Research (IGCAR) Kalpakkam India

It is important to understand the mechanism and implications of different modifiers on analytical and preparative processes under chromatography with supercritical fluids (SFs) and under extraction with SFs. Supercritical fluid chromatography (SFC) and supercritical fluid extraction are generally carried out with neat supercritical carbon dioxide (SCCO2) or with SCCO2 containing modifiers (or cosolvents), especially for strongly polar compounds. For example, methanol is added as a cosolvent/modifier to SCCO2 for the extraction/separation of polar compounds. This paper discusses the influence of the modifier on the colligative properties of the principal mobile phase, which may define the situation in the total mobile phase in a chromatography column or in parts of a column under SFC. No colligative behavior of solutions reflects individual properties of the solutes. Their cross-interactions with solvents are discussed.

关键词： Supercritical Fluid (SF) Supercritical Fluid Chromatography (SFC) Supercritical Fluid Extraction (SFE) Modifiers Influence of Modifiers Colligative Properties Thermodynamics-Based Evaluation of Binary Mixtures Phase Equilibria

Classification of human emotion from EEG using discrete wavelet transform

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Journal of Biomedical Science and Engineering 2010年第4期3卷 390-396页

作者： Murugappan Murugappan nagarajan Ramachandran Yaacob Sazali 不详

In this paper, we summarize the human emotion recognition using different set of electroencephalogram (EEG) channels using discrete wavelet transform. An audio-visual induction based protocol has been designed with more dynamic emotional content for inducing discrete emotions (disgust, happy, surprise, fear and neutral). EEG signals are collected using 64 electrodes from 20 subjects and are placed over the entire scalp using International 10-10 system. The raw EEG signals are preprocessed using Surface Laplacian (SL) filtering method and decomposed into three different frequency bands (alpha, beta and gamma) using Discrete Wavelet Transform (DWT). We have used “db4” wavelet function for deriving a set of conventional and modified energy based features from the EEG signals for classifying emotions. Two simple pattern classification methods, K Nearest Neighbor (KNN) and Linear Discriminant Analysis (LDA) methods are used and their performances are compared for emotional states classification. The experimental results indicate that, one of the proposed features (ALREE) gives the maximum average classification rate of 83.26% using KNN and 75.21% using LDA compared to those of conventional features. Finally, we present the average classification rate and subsets of emotions classification rate of these two different classifiers for justifying the performance of our emotion recognition system.

关键词： EEG Human Emotions Discrete Wavelet Transform KNN LDA