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Numerical Study on Transonic Flow with Local Occurrence of Non-Equilibrium Condensation

Open Journal of Fluid Dynamics 2013年第2期3卷 42-47页

作者： Shigeru Matsuo Kazuyuki Yokoo Junji nagao Yushiro Nishiyama Toshiaki Setoguchi Heuy Dong Kim Shen Yu Department of Advanced Technology Fusion Saga University Saga Japan Graduate School of Science & Engineering Saga University Saga Japan Institute of Engineering Thermophysics Chinese Academy of Science Beijing China Institute of Ocean Energy Saga University Saga Japan School of Mechanical Engineering Andong National University Andong Korea

Characteristics of transonic flow over an airfoil are determined by a shock wave standing on the suction surface. In this case, the shock wave/boundary layer interaction becomes complex because an adverse pressure gradient is imposed by the shock wave on the boundary layer. Several types of passive control techniques have been applied to shock wave/boundary layer interaction in the transonic flow. Furthermore, possibilities for the control of flow fields due to non-equilibrium condensation have been shown so far and in this flow field, non-equilibrium condensation occurs across the passage of the nozzle and it causes the total pressure loss in the flow field. However, local occurrence of non-equilibrium condensation in the flow field may change the characteristics of total pressure loss compared with that by non-equilibrium condensation across the passage of flow field and there are few for researches of locally occurred non-equilibrium condensation in a transonic flow field. The purpose of this study is to clarify the effect of locally occurred non-equilibrium condensation on the shock strength and total pressure loss on a transonic internal flow field with circular bump. As a result, it was found that shock strength in case with local occurrence of non-equilibrium condensation is reduced compared with that of no condensation. Further, the amount of increase in the total pressure loss in case with local occurrence of non-equilibrium condensation was also reduced compared with that by non-equilibrium condensation across the passage of flow field.

关键词： Compressible Transonic Shock Wave Non-Equilibrium Condensation Simulation

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Early results of Omitting Completion Axillary Lymph Node Dissection in Sentinel Lymph Node Metastasis-Positive Breast Cancer Patients

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Advances in Breast Cancer research 2013年第4期2卷 126-132页

作者： Junko Honda Hisashi Matsuoka Chieko Hirose Taeko nagao Takahiro Yoshida Masako Takahashi Issei Imoto Mitsunori Sasa Department of Human Genetics Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Department of Oncological and regenerative Surgery Institute of Health Biosciences The University of Tokushima Graduate Scholl Tokushima Japan Department of Surgery National Hospital Organization Higashitokushima Medical Center Tokushima Japan Department of Surgery Tokushima Breast Care Clinic Tokushima Japan

Background: We investigated the early results of omitting completion axillary lymph node dissection (ALND) for axillary node metastasis-negative (N0), sentinel node (SN) metastasis-positive breast cancer patients. Patients and Methods: 489 patients had invasive N0 breast cancer treated without completion ALND, regardless of their SN metastasis status. Analyses included the associations between the SN metastasis status, clinicopathological findings and recurrence, between recurrence and clinicopathological findings, and recurrence-free survival. results: 430 patients were SN biopsy (SNB)-negative, and 59 were SNB-positive. The SNB-positive patients received significantly more potent adjuvant therapy than the SNB-negative patients. Median follow-up was 3.7 years, and the axillary node recurrence was seen in 6 patients (1.2%) and recurrence in 21 patients. The SN status showed no associations with the clinicopathological findings or recurrence. Univariate analysis showed recurrence was associated with absence of hormonal therapy, Er-negative, Pgr-negative, HEr2-positive or triple-negative (TNBC) disease, a tumor ≥2.1 cm and higher nuclear grade. Multivariate analysis showed recurrence was associated with absence of hormonal therapy and a tumor ≥2.1 cm. Cox proportional hazards model showed recurrence was extremely early in Er-negative and TNBC patients. Conclusion: Completion ALND can be skipped in N0 breast cancer patients even if they are SNB-positive, but adjuvant therapy is essential.

关键词： Axillary Lymph Node Dissection Breast Cancer Sentinel Node Biopsy

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Effects of Supersonic Nozzle Geometry on Characteristics of Shock Wave Structure

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Open Journal of Fluid Dynamics 2012年第4期2卷 181-186页

作者： Shigeru Matsuo Kousuke Kanesaki Junji nagao Md. Tawhidul Islam Khan Toshiaki Setoguchi Heuy Dong Kim Department of Advanced Technology Fusion Saga University Saga Japan Graduate School of Science & Engineering Saga University Saga Japan Institute of Ocean Energy Saga University Saga Japan School of Mechanical Engineering Andong National University Andong Korea

Interaction between the normal shock wave and the turbulent boundary layer in a supersonic nozzle becomes complex with an increase of a Mach number just before the shock wave. When the shock wave is strong enough to separate the boundary layer, the shock wave is bifurcated, and the 2nd and 3rd shock waves are formed downstream of the shock wave. The effect of a series of shock waves thus formed, called shock train, is considered to be similar to the effect of one normal shock wave, and the shock train is called pseudo-shock wave. There are many researches on the configuration of the shock wave. However, so far, very few researches have been done on the asymmetric characteristics of the leading shock wave in supersonic nozzles. In the present study, the effect of nozzle geometry on asymmetric shock wave in supersonic nozzles has been investigated experimentally.

关键词： Compressible Flow Asymmetric Shock Wave Supersonic Nozzle Experiment

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应对全球环境危机的生态现代化与生态文明

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江西师范大学学报（哲学社会科学版） 2022年第1期55卷 19-28页

作者： [日]长尾伸一韩丹名古屋大学经济学院日本名古屋4648601

从作为一个根植于中国传统价值与历史文化,以实现新型现代化为目标的政治哲学和政治准则,到作为一个新发展战略指南,生态文明具有多重含义。就其对环境政策的强调以及基于环境的经济与社会发展愿景而言,生态文明可以被视为20世纪末开始... 详细信息

从作为一个根植于中国传统价值与历史文化,以实现新型现代化为目标的政治哲学和政治准则,到作为一个新发展战略指南,生态文明具有多重含义。就其对环境政策的强调以及基于环境的经济与社会发展愿景而言,生态文明可以被视为20世纪末开始的全球趋势的一部分。就经济与环境的关系而言,生态文明建设也是一种通过工业社会的生态转型来应对全球环境危机的战略,与生态现代化契合。长期来看工业化社会将不可避免地逐步进入低增长的稳态社会,然而生态文明所涵盖的目标范围在时间轴上较生态现代化更长远。不仅生态与经济可以双赢,而且环境与福利两者之间普遍存在互补性。为加快生态文明建设,有必要进一步探讨生态福利及其配套制度的建设。

关键词：生态现代化全球环境危机产业社会结构转型生态文明稳态社会

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real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions

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World Journal of Hepatology 2017年第25期9卷 1064-1072页

作者： Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki nagao Toshihide Shima Yoshito Itoh Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Department of Gastroenterology and Hepatology North Medical CenterKyoto Prefectural University of Medicine Department of Internal Medicine Aiseikai Yamashina Hospital Center for Digestive and Liver Diseases Nara City Hospital Department of Gastroenterology and Hepatology Omihachiman Community Medical Center Department of Gastroenterology Otsu Municipal Hospital Department of Gastroenterology Matsushita Memorial Hospital Center of Gastroenterology and Hepatology Saiseikai Suita Hospital

AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(rASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVr) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major rASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVr at 12 wk after treatment completion(SVr12).rESULTS The overall SVr12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVr12. There were no significant differences in SVr12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVr12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of r12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P roup showed a lower SVr12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVr12 and had available pretreatment and post-treatment sera had additional rASs in NS3:D168, NS5:L31, and Y93 substitution at treatment *** Combination of DCV and ASV is associated with a high SVr rate. Baseline rASs should be thoroughly assessed to avoid additional rASs after treatment failure.

关键词： Hepatitis C Asunaprevir Combination therapy resistance-associated substitutions Daclatasvir

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Two Clinoconidium species（Cryptobasidiaceae） producing galls on trees of Cinnamomum in Japan

Two Clinoconidium species（Cryptobasidiaceae） producing gal...

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中国菌物学会第七届全国会员代表大会暨2017年学术年会

作者： Makoto KAKISHIMA Hideyuki nagao Jing-Xin JI Yue SUN Yu LI Cvetomir M.DENCHEV Engineering research Center of Chinese Ministry of Education for Edible and Medicinal Fungi Jilin Agricultural University University of Tsukuba School of Biological Sciences Universiti Sains Malaysia Institute of Biodiversity and Ecosystem research Bulgarian Academy of Sciences

Clinoconidium was established by Patouillard in1898, but, later, it was validated by Saccardo in1902 because of the designation of an illegitimate type species name. This genus was characterized by gastroid sporulation in peripheral lacunae of the host galls and having aseptate, colourless, and globose to ovoid basidiospores. This genus is phylogenetically treated as a member of the Cryptobasidiaceae（Exobasidiales, Exsobasidiomycetes, Ustilaginomycotina, Basidiomycota）（Begerow et al. 2014）. Four species of Clinoconidium have been previously reported on the plants of Lauraceae from mainly tropical and sub-tropical regions in the world. Among them two species have been recorded in Asia;*** on Cinnamomum burmanii from China and C. sawadae on Cinnamomum camphora from Taiwan（Jiang et al. 2016）. Based on morphological examinations and phylogenetic analyses,Clinoconidium globosum, nom. nov. and C. onumae, comb. nov. are proposed to accommodate Sphacelotheca cinnamomi and Ustilago onumae（syn. Melanopsichium onumae）, respectively, from *** first one produces galls on fruits of Cinnamomum daphnoides, whereas the latter one on shoot buds of Cinnamomum tenuifolium.

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提高番木瓜种子发芽率的方法

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热带作物译丛 1988年第5期 27-29页

作者： M.A.nagao 黄守宏

木瓜种子发芽率低,部分原因是约有20％无种胚。用1.097克/毫升的蔗糖溶液分离种子,并经1.0M硝酸钾或600ppm赤霉酸浸泡后,发茅率和发芽速度都提高了。硝酸钾处理的发芽率为87.8％,赤霉酸处理的为80.5％;前者的幼苗生长正常,后者的幼苗茎... 详细信息

木瓜种子发芽率低,部分原因是约有20％无种胚。用1.097克/毫升的蔗糖溶液分离种子,并经1.0M硝酸钾或600ppm赤霉酸浸泡后,发茅率和发芽速度都提高了。硝酸钾处理的发芽率为87.8％,赤霉酸处理的为80.5％;前者的幼苗生长正常,后者的幼苗茎细长。

关键词：种子液面硝酸钾繁殖器官物面土硝种子发芽率赤霉素赤霉酸粒重多年生草本果番木瓜蔗糖溶液

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澳洲坚果的病虫害治理

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热带作物科技 1993年第5期 74-77页

作者： nagao,MA 许成文

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腮腺多形性腺瘤癌变的组织病理研究

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国际口腔医学杂志 1983年第2期 103-104页

作者： Koichi nagao 黄洪章

腮腺良性多形性腺瘤(简称BPA)癌变(简称CPAs)为涎腺上皮性恶性肿瘤之一。作者报告了48例腮腺多形腺瘤癌变的组织病理研究结果,并对CPAs的组织学类型、生物学特点和组织发生学进行了讨论。供光学显微镜检查的组织学标本用10％福尔马林固... 详细信息

腮腺良性多形性腺瘤(简称BPA)癌变(简称CPAs)为涎腺上皮性恶性肿瘤之一。作者报告了48例腮腺多形腺瘤癌变的组织病理研究结果,并对CPAs的组织学类型、生物学特点和组织发生学进行了讨论。供光学显微镜检查的组织学标本用10％福尔马林固定,每例连续切取五个标本,石蜡色埋,每个标本切12张连续片,进行苏木精一伊红染色,Weigert's,PAS—阿利新兰,Masson's三色染色和银染色。2例未分

关键词：腮腺肿瘤癌变病理研究粘液表皮样癌

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Knockdown of Dock7 <i>in vivo</i>specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness

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American Journal of Molecular Biology 2012年第3期2卷 210-216页

作者： Tomohiro Torii Yuki Miyamoto Motoshi nagao Naoko Onami Hideki Tsumura Masahiro Maeda Kazuaki Nakamura Akito Tanoue Junji Yamauchi Department of Pharmacology National Research Institute for Child Health and Development Tokyo Japan Immuno-Biological Laboratories Co. Ltd. Gunma Japan Laboratory Animal resource Facility National Research Institute for Child Health and Development Tokyo Japan The Japan Human Health Sciences Foundation Tokyo Japan

During development of the peripheral nervous system (PNS), Schwann cells (SCs) wrap individual axons to form myelin sheaths, which act as surrounding insulators and markedly enhance the propagation of the action potential. In peripheral neuropathies such as Guillain-Barré syndrome (GBS) and inherited demyelinating Charcot-Marie-Tooth (CMT) disease and diabetic neuropathies, chronic demyelination and defective remyelination are repeated, causing more severe neuropathies. It is thus thought that development of a drug that promotes proper myelination with minimal side effects could provide an effective therapy for these diseases. As yet, however, little is known about therapeutic target molecules and genetically-modified mice for testing such approaches. We previously cloned the dock7 gene and characterized Dock7 as the regulator controlling SC myelination;however, an important issue, whether knockdown of Dock7 specifically affects myelination by SCs but not leaves neurons unaffected, has remained unclear. Here, we generate newly-produced transgenic mice harboring short-hairpin rNA (shrNA) targeting Dock7. We also describe that Dock7 shrNA transgenic mice exhibit enhanced myelin thickness without affecting axon thickness in sciatic nerves of the PNS, as reduced thickness of the axon diameter is the primary indicator of denatured neurons. Similarly, purified in vitro SC-neuronal cocultures established from transgenic mice exhibit enhanced formation of myelin segments, suggesting that knockdown of Dock7 promotes myelination by SCs. Collectively, Dock7 knockdown specifically affects SC myelination in sciatic nerves, providing evidence that Dock7 may be a promising drug-target-specific molecules for developing a therapy for peripheral neuropathies that aims to enhance myeliantion.

关键词： Dock7 Transgenic Mouse Schwann Cell Myelination Axon Diameter

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