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Bioactive Materials:A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response

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Journal of Bionic Engineering 2019年第4期16卷 563-581页

作者： Shirin Nour nafiseh baheiraei Rana Imam Navid Rabiee Mohammad Khodaei Akram Alizadeh Seyed Mohammad Moazzeni Tissue Engineering Group Biomedical Engineering DepartmentAmirkabir University of Technology(Tehran Polytechnic)TehranIran Tissue Engineering and Applied Cell Sciences Division Department of HematologyFaculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Chemistry Shahid Beheshti UniversityTehranIran Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayeganIran Department of Tissue Engineering and Applied Cell Sciences Faculty of MedicineSemnan University of Medical SciencesSemnanIran Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon ***,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the *** this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent *** the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory ***,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface *** better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed.

关键词： implant bioactive materials cell-biomaterial interactions immune response surface engineering

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Optimization and comparison of two different 3D culture methods to prepare cell aggregates as a bioink for organ printing

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BIOCELL 2012年第1期36卷 37-45页

作者： RANA IMANI SHAHRIAR HOJJATI EMAMI HOSSEIN FAKHRZADEH nafiseh baheiraei ALI M SHARIFI Department of Biomedical Engineering Amirkabir University of TechnologyTehranIran Endocrinology and Metabolism Research Institute Tehran University of Medical SciencesTehranIran Razi Institute for Drug research Department of PharmacologySchool of MedicineTehran University of Medical SciencesTehranIran Department of Tissue Engineering and Cell therapy School of advanced sciences in MedicineTehran University of Medical Sciences.TehranIran

The ultimate goal of tissue engineering is to design and fabricate functional human tissues that are similar to natural cells and are capable of *** of cell aggregates is one of the important steps in 3D tissue engineering technology,particularly in organ *** simple methods,hanging drop(HD)and conical tube(CT)were utilized to prepare cell *** size and viability of the aggregates obtained at different initial cell densities and pre-culture duration were *** proliferative ability of the cell aggregates and their ability to spread in culture plates were also *** both methods,the optimum average size of the aggregates was less than 500μ*** aggregates were smaller than HD aggregates.5,000 cells per drop HD aggregates showed a marked ability to attach and spread on the culture *** proliferative ability reduced when the initial cell density was *** these methods,we found that the HD method having better size controlling ability as well as enhanced ability to maintain higher rates of viability,spreading,and *** conclusion,smaller HD aggregates might be a suitable choice as building blocks for making bioink particles in bioprinting technique.

关键词： tissue engineering hanging drop conical tube bioprinting

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