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Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers

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World Journal of Experimental Medicine 2023年第5期13卷 102-114页

作者： Tagreed Qassim Alsbihawi Mojtaba Zare Ebrahimabad Fakhri Sadat Seyedhosseini Homa Davoodi nafiseh abdolahi Alireza Nazari Saeed Mohammadi Yaghoub Yazdani Department of Immunology Faculty of MedicineGolestan University of Medical SciencesGorgan 49341-74515Iran Metabolic Disorders Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Laboratory Sciences Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Immunology Golestan University of Medical SciencesGorgan ***Iran Golestan Rheumatology Research Center Golestan University of Medical SciencesGorgan 49341-74515Iran Department of Surgery Faculty of MedicineRafsanjan University of Medical SciencesRafsanjan ***Iran Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical SciencesGorgan 49341-74515Iran

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder impacting multiple organs,influenced by genetic factors,especially those related to the immune ***,there is a need for new biomarkers in ***-125a(miR-125a)levels are decreased in T cells,B cells,and dendritic cells of SLE ***-125a plays a regulatory role in controlling the levels of tumor necrosis factor-alpha(TNF-α)and interleukin 12(IL-12),which are crucial pro-inflammatory cytokines in SLE *** To assess the levels of miR-125a,IL-12,and TNF-αin SLE patients’plasma,evaluating their diagnostic and prognostic *** The study included 100 healthy individuals,50 newly diagnosed(ND),and 50 SLE patients undergoing *** patients were monitored for a duration of 24 wk to observe and record instances of ***-125a expression was measured using real-time reverse transcription polymerase chain reaction,while ELISA kits were used to assess IL-12 and TNF-α*** The results showed significantly reduced miR-125a expression in SLE patients compared to healthy individuals,with the lowest levels in ND ***-αand IL-12 expression levels were significantly elevated in SLE patients,especially in the early stages of the *** operating characteristic curve analyses,and Cox-Mantel Log-rank tests indicated miR-125a,TNF-α,and IL-12 as proper diagnostic biomarkers for SLE.A negative correlation was found between plasma miR-125a expression and IL-12/TNF-αlevels in SLE *** Decreased miR-125a levels may be involved in the development of SLE,while elevated levels of IL-12 and TNF-αcontribute to immune *** findings offer new diagnostic and prognostic markers for ***,the negative correlation observed suggests an interaction between miR-125a,TNF-α,and *** research is necessary to uncover the underlying mechanisms that govern these relationships.

关键词： Systemic lupus erythematosus microRNA-125a Interleukin-12 Tumor necrosis factor alpha Biomarker

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