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Effect of Disinfectants on Elastic Modulus, Flexural Strength and Color Stability of Denture Base Resins

Open Journal of Stomatology 2018年第4期8卷 135-148页

作者： Tobias Bensel Jens J. Bock Lisa Zumpe Sonia Mansour nadine blümel Julia Seeliger Arne F. Boeckler Department of Prosthodontics University of Halle Halle Germany Private Orthodontic Practice Fulda Germany Department of Prosthodontics Gerodontology and Craniomandibular Disorders Charité-University Medicine Berlin Berlin Germany Department of Orthodontics Technical University Dresden Dresden Germany

Objective: Infection control protocols dictate the disinfection of dentures. There are no products available which are designed for the specific use of disinfecting dentures. The objective of this study was to investigate the impact of chemical disinfectants on elastic modulus, flexural strength and color stability of denture base resins. Methods: 256 specimens from four acrylic denture base resins were manufactured. Two cold-curing denture base resins: PalaXpress (Heraeus Kulzer, Hanau, Germany), Futura Gen (Schuetz Dental, Roßbach, Germany) and two heat-curing denture base resins: Paladon 65 (Heraeus Kulzer, Hanau, Germany), FuturAcryl 2000 (Schuetz Dental, Roßbach, Germany) were used. Three chemical disinfecting agents were tested: Impresept, D050 Instru-Gen, Stammopur DR. Specimens were stored in distilled water and in chemical disinfecting agents. They were divided randomly into groups. E-Modulus and flexural strength were measured using the three-point bending test. Color changes (ΔE) were determined spectrophotometrically. Results: The disinfection agents showed no significant influence on the E-modulus compared to distilled water (Acrylic vs. distilled water from (Futura Gen) 2688.80 ± 230.78 vs. 2766.60 ± 91.22 MPa to (PalaXpress) 3004.20 ± 26.40 vs. 2851.00 ± 95.23 MPa). Flexural strength after storage in distilled water and disinfection did not differ significantly (Acrylic vs. distilled water from (Paladon65) 27.28 ± 1.30 vs. 28.42 ± 0.84 N/mm2, (p > 0.05) to (PalaXpress) 30.88 ± 0.25 vs. 29.68 ± 0.79 N/mm2, p < 0.001). Disinfection caused a significant color change with Impresept of Paladon 65 (p ≤ 0.001), FuturaAcryl 2000 with Stammopur DR and D 050 Instru-Gen (p ≤ 0.001). Conclusions: The investigated disinfection agents did not influence elastic modulus and flexural strength of denture base resins negatively. ΔE-values were in a range of 1 to 2. Thus, the detected color changes may be marginal. Clinical relevance: Single use disinfections

关键词： Cross Infection Chemical Disinfectants Denture Base Resins Material Characteristics Disinfection

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Cas13d-mediated gene knockdown in CAR T cells:towards off-the-shelf cancer treatment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1796-1798页

作者： Midori Johnston nadine Urban Can Dincer FIT Freiburg Centre for Interactive Materials and Bioinspired Technology University of FreiburgFreiburgGermany IMTEK-Department of Microsystems Engineering University of FreiburgFreiburgGermany

In a recent study published in Cell,Tieu et *** RfxCas13d to dynamically enhance performance and longevity of chimeric antigen receptor(CAR)T cells by massively multiplexed gene knockdown and thereby,move the treatmen... 详细信息

关键词： treatment shelf

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A cross-sectional analysis of the effectiveness of a nutritional support programme for people with tuberculosis in Southern Madagascar using secondary data from a non-governmental organisation

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Infectious Diseases of Poverty 2024年第1期13卷 101-102页

作者： Mara Anna Franke Julius Valentin Emmrich Fierenantsoa Ranjaharinony Onja GbrilleRavololohanitra Harizaka Emmanuel Andriamasy Samuel Knauss nadine Muller Global Digital Health Lab at Charité Center for Global Health Charité – Universitätsmedizin Berlin Berlin Germany London School of Hygiene and Tropical Medicine London UK Ärzte Für Madagaskar E.V. Leipzig Germany Heidelberg Institute of Global Health Heidelberg University Heidelberg Germany Berlin Institute of Health at Charité - Universitätsmedizin Berlin Berlin Germany Doctors for Madagascar Antananarivo Madagascar Speciality Network: Infectious Diseases and Respiratory Medicine Charité - Universitätsmedizin Berlin Berlin Germany

Background There is a strong,bi-directional link between tuberculosis(TB)and undernutrition:TB often causes undernutrition,and undernourished people are more likely to contract TB and experience worse ***,several TB nutritional support programmes exist;however,evidence on their effectiveness is limited and *** study evaluates the effect of a nutritional support programme implemented for people with TB in the Atsimo-Andrefana region,Madagascar in *** this programme,undernourished people with TB[with a body mass index(BMI)ofble oil and 6.0 kg of a soy-wheat blend per month throughout their TB *** We analysed secondary non-governmental organisation data collected between January and Novem-ber 2022 in the Atsimo-Andrefana region,Southern Madagascar,including information on an individual's medical conditions(e.g.,type of TB,treatment outcomes)and nutritional status measured prior to,during,and after comple-tion of treatment(e.g.,height,weight,mid-upper arm circumference).We conducted descriptive analyses of patient baseline characteristics and outcomes to assess the impact of the provided nutritional support on the BMI of people With *** A total of 1310 people with TB were included in the study[9.9%(130)children under the age of 5,32.1%(420)children between 5 and 18 years,58.0%(760)adults].55.4% of children under 5,28.1% of children between ages 5 and 18,and 81.3%of adults were undernourished at treatment initiation.42.3%(55/130)of children under 5 experi-enced severe acute malnutrition at treatment *** the average BMl of adults with TB receiving food support increased over time,from 17.1 kg/m^(2)(interquartile range:15.8-18.3,range:10.3-22.5)to 17.9 kg/m^(2)(interquartile range:16.6-19.1,range:11.9-24.1),most adults remained undernourished even after completing TB *** The current TB nutritional support programme falls short of sufficiently increasing the BM

关键词： Tuberculosis Sub-Saharan Africa Undernutrition Nutritional support

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Artificial Intelligence Adoption for Cybersecurity in Africa

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Journal of Information Security 2024年第2期15卷 134-147页

作者： nadine Nibigira Vincent Havyarimana Zhu Xiao School of Engineering Sciences University of Burundi Doctoral School Bujumbura Burundi Department of Applied Sciences Burundi Higher Institute of Education (ENS) Bujumbura Burundi College of Computer Science and Electronic Engineering Hunan University Yongzhou Hunan

Legacy-based threat detection systems have not been able to keep up with the exponential growth in scope, frequency, and effect of cybersecurity threats. Artificial intelligence is being used as a result to help with the issue. This paper’s primary goal is to examine how African nations are utilizing artificial intelligence to defend their infrastructure against cyberattacks. Artificial intelligence (AI) systems will make decisions that impact Africa’s future. The lack of technical expertise, the labor pool, financial resources, data limitations, uncertainty, lack of structured data, absence of government policies, ethics, user attitudes, insufficient investment in research and development, and the requirement for more adaptable and dynamic regulatory systems all pose obstacles to the adoption of AI technologies in Africa. The paper discusses how African countries are adopting artificial intelligence solutions for cybersecurity. And it shows the impact of AI to identify shadow data, monitor for abnormalities in data access and alert cyber security professionals about potential threats by anyone accessing the data or sensitive information saving valuable time in detecting and remediating issues in real-time. The study finds that 69.16% of African companies are implementing information security strategies and of these, 45% said they use technologies based on AI algorithms. This study finds that a large number of African businesses use tools that can track and analyze user behaviour in designated areas and spot anomalies, such as new users, strange IP addresses and login activity, changes to permissions on files, folders, and other resources, and the copying or erasure of massive amounts of data. Thus, we discover that just 18.18% of the target has no national cybersecurity strategy or policy. The study proposes using big data security analytics to integrate AI. Adopting it would be beneficial for all African nations, as it provides a range of cyberattack defense techn

关键词： Artificial Intelligence (AI) Cybersecurity Cyberattacks Cybercriminals

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Sensitive Information Security Based on Elliptic Curves

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World Journal of Engineering and Technology 2024年第2期12卷 274-285页

The elliptic curve cryptography algorithm represents a major advancement in the field of computer security. This innovative algorithm uses elliptic curves to encrypt and secure data, providing an exceptional level of security while optimizing the efficiency of computer resources. This study focuses on how elliptic curves cryptography helps to protect sensitive data. Text is encrypted using the elliptic curve technique because it provides great security with a smaller key on devices with limited resources, such as mobile phones. The elliptic curves cryptography of this study is better than using a 256-bit RSA key. To achieve equivalent protection by using the elliptic curves cryptography, several Python libraries such as cryptography, pycryptodome, pyQt5, secp256k1, etc. were used. These technologies are used to develop a software based on elliptic curves. If built, the software helps to encrypt and decrypt data such as a text messages and it offers the authentication for the communication.

关键词： Cryptography Elliptic Curves Digital Security Data Sensitive Data Implementation

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Identification of Microorganisms in Poultry Farms in N’djamena and the Border Areas of Hadjer-Lamis and Chari-Baguirmi Chad

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Journal of Agricultural Chemistry and Environment 2024年第2期13卷 223-234页

作者： Abakar Abbo Zakaria Bebanto Antipas Ban-Bo nadine Terei Bongo Naré Richard Gandolo Abdelsalam Adoum Doutoum Labortoire de Rattachement IRED (Institut de Recherches en Elevage pour le Dé veloppement) University of N&#8217Djamena N&#8217Djamena Chad Laboratory of Biochemistry-Cellular and Molecular Biology-Microbiology (L2BCM) Faculty of Exact and Applied Sciences University of N&#8217Djamena N&#8217Djamena Chad Livestock Research Institute for Development (IRED) N&#8217Djamena Chad Adam Barka University of Abé ch&#233 Ab&#233ch&#233 Chad

Introduction: On the outskirts of Ndjamena, semi-industrial poultry farming and traditional poultry farming are practised informally on almost all poultry farms in Chad. This type of poultry farming is faced with real health problems attributable to a lack of monitoring of the vaccination schedule, inadequate compliance with biosecurity measures and poor application of the Ichikawa rule based on the 5 M’s. Objective: The aim of this article is to identify the microorganisms responsible for contamination of poultry farms in the study area. Method: The study was carried out from 28/04/2022 to 31/01/2023 on the basis of 300 samples taken from feed, drinking water, droppings and scrapings from poultry housing surfaces in the 30 farms that served as a framework for our research. Sampling was of the simple random type, and farms were selected on the basis of the farmers’ consent. The data were recorded on pre-established survey forms. Our study was cross-sectional, descriptive and prospective. Bacteria were isolated using the reference method NF EN ISO 6579 for Salmonella spp. and cultured on the specific medium eosin methylene blue (EMB) for Escherichia coli, Pseudomonas and Citrobacter freundii. Results: The following results emerged from this study: Escherichia coli (5.33%), Pseudomonas (1.33%), Citrobacter freundii (12%) and Salmonella paratyphi (21.68%). Conclusion: Of the 300 samples analysed, 121 (40.33%) were contaminated with pathogens. This high level of contamination is a health problem. The study shows that biosecurity is less satisfactory on the farms visited. Nevertheless, farms with a very satisfactory level of biosafety ensure food safety and variety for the population.

关键词： Microorganisms Identification Poultry Farms N’Djamena Hadjer-Lamis Chari-Baguirmi(Chad)

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Laparoscopic Orchidopexy after 4 Weeks of Testicular Traction with Preservation of blood Supply: A New Concept for the Treatment of Intra-Abdominal Cryptorchidism: Original Article

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Open Journal of Pediatrics 2024年第2期14卷 205-217页

作者： Ntsobe Tobie Eric Haijin Liu Nyanit Bob Dorcas Wei Peng Feng Chen Ndikontar Raymond Kouna Tsala Irene nadine Qian Liu Surgery Department Garoua General Hospital Garoua Cameroon Paediatric Surgery Department First Affiliated Hospital of Gannan Medical College Ganzhou China Paediatric Surgery Department China Medical University Shenyang China Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Paediatric Surgery Department Yaounde Central Hospital Yaounde Cameroon China Traditional Medicine University Nanchang China

Background: Testicular atrophy is recurrent after orchidopexy for intra-abdominal cryptorchidism due to damage to vessels. Fowlers-Stephens and Shehata methods proposed staged orchidopexy, but are still associated to a rate of atrophy greater than 10%. Purpose: We set out to present a new technique that preserves testicular vessels. Our study is aimed at investigating testicular vitality after surgery. Patients and Method: We reviewed files of boys who underwent orchidopexy for 2 years in our department. Those who have been operated for intra-abdominal cryptorchidism with the new technique and aged between 6 months and 14 years old were included in our study. We excluded boys who have been operated before 6 months and after 14 years old and those who did not respect their follow-up plane. Ultrasound (US) outcomes were used to measure testicular volumes and blood flow at each postoperative visit. The Sample population was divided into group A and group B representing testes that were followed respectively for 12 and 24 months. Results: 22 boys with 25 testes were included in our study;11 testes in group A and 14 testes in group B. In each group, we noted a significant difference of UDT volumes from the third month after surgery with respective P-values 0.05. There was no statistical difference between UDT and contra lateral testes volumes 12 months after surgery in group A and 24 months in group B with respective P-values of 0.07 and 0.72. All volume differential indexes were Conclusion: This method offers a new perspective in performing safe orchidopexy for intra abdominal undescended testes.

关键词： Laparoscopy Staged-Orchidopexy Testicar Traction Testicular Atrophy

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Investigating Non-Compliance with COVID-19 Vaccination through Hesitancy, Refusal, and Access Limitation: A Community-Based Survey from the Democratic Republic of the Congo

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Journal of Biosciences and Medicines 2024年第9期12卷 280-306页

作者： Nestor Kalala-Tshituka Alain Cimuanga-Mukanya Alain Yamba Mukendi Faustin Ndjibu Mpoji Ghislain Disashi-Tumba Joris Losimba Likwela nadine Kayiba Kalenda Evariste Tshibangu-Kabamba Department of Public Health Faculty of Medicine Pharmacy and Public Health University of Mbujimayi Mbuji-Mayi Democratic Republic of the Congo Department of Public Health Faculty of Medicine and Pharmacy University of Kisangani Kisangani Democratic Republic of the Congo Department of Internal Medicine Faculty of Medicine Pharmacy and Public Health University of Mbujimayi Mbuji-Mayi Democratic Republic of the Congo Department of Environmental and Preventive Medicine Faculty of Medicine Oita University Oita Japan Research Institute of Health and Society Catholic University of Louvain Brussels Belgium

Introduction: Vaccination plays a pivotal role in mitigating the repercussions of the COVID-19 pandemic. However, vaccination campaigns encounter obstacles, especially in developing countries like the Democratic Republic of the Congo (DRC). This study aimed at investigating the roles of vaccine hesitancy, refusal, and access barriers, while identifying individual-level factors associated with non-vaccination in Mbujimayi, DRC. Methods: A community-based cross-sectional survey was conducted in three health districts and included 1496 residents. Attitudes and behaviors related to seeking COVID-19 vaccination were assessed using a standardized questionnaire. Hierarchical logistic regression modeling was used to assess factors potentially affecting non-compliance with vaccination. Results: Among participants (median age = 33, IQR = 23.3, M/F sex ratio = 0.7), 60% displayed misconceptions about COVID-19 or its vaccine, while only 35.2% perceived COVID-19 as a significant health threat. Vaccination coverage was estimated at 49.1% (95% CI: 47.5;52.6), with 71.8% of vaccinated individuals having received one dose. Among the unvaccinated individuals, 50.9% expressed no intention to be vaccinated in the future, citing hesitation (30.4%) or refusal (39.6%) mainly due to side effects or distrust of vaccines. Conversely, 32.7% of the unvaccinated persons expressed access barriers despite willingness to be vaccinated. Misconceptions about COVID-19 and its vaccines were the main drivers of vaccination non-compliance. Conclusion: These findings demonstrate significant vaccine non-compliance driven by hesitancy, refusal, and access barriers. Strategies to enhance vaccination coverage and pandemic preparedness should address misconceptions, sociodemographic barriers, and geographic disparities.

关键词： COVID-19 Vaccination Non-Observance Community Democratic Republic of the Congo

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Jumping on the Bed

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语数外学习(初中版) 2024年第4期 1-1页

作者： nadine Cranenburgh

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The Translational Apparatus of Plastids and Its Role in Plant Development

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Molecular Plant 2014年第7期7卷 1105-1120页

作者： nadine Tiller Ralph Bock Max-Planck-Institut for Molekulare Pflanzenphysiologie Am Muhlenberg 1 D-14476 Potsdam-Golm Germany

Chloroplasts （plastids） possess a genome and their own machinery to express it. Translation in plastids occurs on bacterial-type 70S ribosomes utilizing a set of tRNAs that is entirely encoded in the plastid genome. In recent years, the components of the chloroplast translational apparatus have been intensely studied by proteomic approaches and by reverse genetics in the model systems tobacco （plastid-encoded components） and Arabidopsis （nucleus-encoded components）. This work has provided important new insights into the structure, function, and biogenesis of chloroplast ribosomes, and also has shed fresh light on the molecular mechanisms of the translation process in plastids. In addition, mutants affected in plastid translation have yielded strong genetic evidence for chloroplast genes and gene products influencing plant develop- ment at various levels, presumably via retrograde signaling pathway（s）. In this review, we describe recent progress with the functional analysis of components of the chloroplast translational machinery and discuss the currently available evidence that supports a significant impact of plastid translational activity on plant anatomy and morphology.

关键词： plastid translation ribosome ribosomal protein evolution plastid transformation retrograde signaling leaf development palisade cell.

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