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Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases

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World Journal of Gastroenterology 2022年第18期28卷 1934-1945页

作者： Wynne sim Wei-Meng Lim Ling-Wei Hii Chee-Onn Leong Chun-Wai Mai School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia School of Pharmacy International Medical UniversityKuala Lumpur 57000Malaysia Center for Cancer and Stem Cell Research Institute for ResearchDevelopmentand InnovationInternational Medical UniversityKuala Lumpur 57000Malaysia AGTC Genomics Kuala Lumpur 57000Malaysia State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical Chemistry Faculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor ***,it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses,thus allowing continuous tumor growth and *** evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic *** with other cancers,pancreatic cancer has a tumor microenvironment that can resist most treatment modalities,including emerging ***,the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients,suggesting that pancreatic cancer has successfully evaded *** this review,we summarize the impact of genetic alteration and epigenetic modification(especially histone deacetylases,HDAC)on immune evasion in pancreatic *** overexpression significantly suppresses tumor suppressor genes,contributing to tumor growth and *** review the evidence on HDAC inhibitors in tumor eradication,improving T cells activation,restoring tumor immunogenicity,and modulating programmed death 1 *** provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.

关键词： Histone acetylation Histone deacetylases inhibitors Immune evasion Pancreatic cancers Pancreatic ductal adenocarcinoma

Accuracy of tree mapping based on hand-held laser scanning comparing leaf-on and leaf-off conditions in mixed forests

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Journal of Forestry Research 2024年第5期35卷 14-25页

作者： Frederico Tupinambá-simões Adrián Pascual Juan Guerra-Hernández Cristóbal Ordóñez Tiago de Conto Felipe Bravo iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Department of Geographical Sciences University of MarylandCollege ParkMD 20742USA Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile laser scanning to survey forest ecosystems is a promising,scalable technology to describe forest 3D structures at high *** confirm the con-sistency in the retrieval of forest structural parameters using hand-held laser scanning(HLS),before operationalizing the method,confirming the data is *** analyzed the per-formance of tree-level mapping based on HLS under differ-ent phenology conditions on a mixed forest in western Spain comprising Pinus pinaster and two deciduous species,Alnus glutinosa and Quercus *** area was surveyed twice during the growing season(July 2022)and once in the deciduous season(February 2022)using several scan-ning *** reference data(418 trees,15 snags)was used to calibrate the HLS data and to assess the influence of phenology when converting 3D data into tree-level attrib-utes(DBH,height and volume).The HLS-based workflow was robust at isolating tree positions and recognizing stems despite changes in ***-six percent of all pairs matched below 65 *** DBH,phenology barely altered *** observed a strong agreement when comparing HLS-based tree height *** values exceeded 2 m when comparing height measurements,confirming height data should be carefully used as reference in remote sensing-based inventories,especially for deciduous *** volume was more precise for pines(r=0.95,and rela-tive RMSE=21.3–23.8%)compared to deciduous species(r=0.91–0.96,and relative RMSE=27.3–30.5%).HLS data and the forest structural complexity tool performed remark-ably,especially in tree positioning considering mixed forests and mixed phenology conditions.

关键词： Precision forestry Forest monitoring Mobile laser scanning Forest inventory

Mobility of Arsenic and Heavy Metals in a Sandy-Loam Textured and Carbonated Soil

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Pedosphere 2009年第2期19卷 166-175页

作者： I. GARC íA M. DIEZ F. MART íN M. simóN C. DORRONSORO Departamento Edafologia y Quimica Agricola CITE IIB Carretera Sacramento s/n 04120 University of Almeria (Spain) Departamento Edafologia y Quimica Agricola Campus Fuentenueva s/n 18002 University of Granada (Spain)

The continued effect of the pyrite-tailing oxidation on the mobility of arsenic, lead, zinc, cadmium, and copper was studied in a carbonated soil under natural conditions, with the experimental plot preserved with a layer of tailing covering the soil during three years. The experimental area is located in Southern Spain and was affected by a pyrite-mine spill. The climate in the area is typically Mediterranean, which determines the rate of soil alteration and element mobility. The intense alteration processes that occurred in the soil during three years caused important changes in its morphology and a strong degradation of the main soil properties. In this period, lead concentrated in the first 5 mm of the soil, with concentrations higher than 1500 mg kg?1, mainly associated to the neoformation of plumbojarosite. Arsenic was partially leached from the first 5 mm and mainly concentrated between 5–10 mm in the soil, with maximum values of 1239 mg kg-1; the retention of arsenates was related to the neoformation of iron hydroxysulfates (jarosite, schwertmannite) and oxyhydroxides (goethite, ferrihydrite), both with a variable degree of crystallinity. The mobility of Zn, Cd, and Cu was highly affected by pH, producing a stronger leaching in depth; their retention was related to the forms of precipitated aluminium and, in the case of Cu, also to the neoformation of hydroxysulfate.

关键词： arsenic heavy metals oxidation pyrite-tailing soil

An experimental study on tsunami inundation over complex coastal topography

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Theoretical & Applied Mechanics Letters 2013年第3期3卷 40-45页

作者： Shawn Y.sim Zhenhua Huang Adam D.Switzer Earth Observatory of Singapore Nanyang Technological University Division of Earth Science Nanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University

In recent studies, the effects of complex costal topography on tsunami run-up has sparked heated discussion. This study mainly aims at investigating the effects of complex costal topography on the tsunami inundation distance and the effectiveness of sand dunes in dissipating tsunami wave energy. The experiments were carried out in a wave flume to investigate the potential reduction effects of wave run-up by non erodible sand dune like features. The results show that increasing dunes spacing could not significantly affect inundation distance. However, if the height of sand dunes is of the same order of magnitude as the incoming tsunami wave and the gaps between the dunes are large enough, successful tsunami mitigation could also be possible.

关键词： complex topography tsunami inundation tsunami hazard mitigation

Aggregation induced edge sites actuation of 3D MoSe_(2)/rGO electrocatalyst for high-performing water splitting system

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Aggregate

Aggregate 2024年第2期5卷 188-200页

作者： Gnanaprakasam Janani Subramani Surendran Dong-Kyu Lee Sathyanarayanan Shanmugapriya Hyunjung Lee Yuvaraj Subramanian Uk sim Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuJeonnamRepublic of Korea Department of Chemistry University of UlsanDoowang-dongNam-guUlsanRepublic of Korea Research Institute NEEL SciencesINC.NajuRepublic of Korea Center for Energy Storage System Chonnam National UniversityGwangjuRepublic of Korea

2D materials are regarded as promising electrocatalysts for water splitting because of their advances in providing ample active sites and improving electrochemical reaction kinetics.2D MoSe_(2)has a greater intrinsic electrical conductivity and lower Gibbs free energy for reactant ***,there is still room for improvement in the electrocatalytic performance of MoSe_(2)for high-performance electrochemical water splitting ***,the in situ preparation of heterostructure made of covalently bonded MoSe_(2)and rGO is *** obtained electrocatalyst contains the aggregated 3D structured MoSe_(2)over rGO,which is covalently bonded together with more edge *** active edge sites of MoSe_(2)/rGO are dynamically involved in the electrocatalytic activity while facilitating electron ***,the MoSe_(2)/rGO heterostructure requires a low cell voltage of 1.64 V to reach 100 mA cm^(−2)in water splitting with high reaction *** aggregated MoSe_(2)over rGO with more edge sites exposed by the 3D structure of MoSe_(2)and the interfacial covalent bond in between them provides a favorable electronic structure for the HER and OER with low overpotentials and high current densities and enhances the stability of the *** work presents an attractive and cost-effective electrocatalyst suitable for industrial-scale hydrogen fuel production.

关键词： 3D/2D heterostructures aggregation covalent bond edge sites hydrogen production MoSe_(2) rGO

Compensating the impurities on the Cu surface by MOFs for enhanced hydrocarbon production in the electrochemical reduction of carbon dioxide

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Journal of Energy Chemistry 2022年第3期31卷 68-73,I0003页

作者： Shin Joon Kang Jong Ho Won Hansaem Choi Woohyeong sim Mun Kyoung Kim Siraj Sultan Youngkook Kwon Hyung Mo Jeong School of Mechanical Engineering and Department of Smart Fab.Technology Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea Department of Chemistry Kookmin University77 Jeongneung-roSeongbuk-guSeoul 02707Republic of Korea School of Energy and Chemical Engineering Emergent Hydrogen Technology R&D CenterUlsan National Institute of Science and Technology50 UNIST-gilUlsan 44919Republic of Korea

Copper(Cu)provides a cost-effective means of producing value-added fuels through the electrochemical reduction of carbon dioxide(CO_(2)RR).However,we observed the production of hydrocarbons via CO_(2)RR on commercial Cu films is less efficient because of the surface impurities,i.e.,*** monoxide(CO),a reaction intermediate of CO_(2)RR to hydrocarbons,binds strongly to the Fe sites and interrupts the production of hydrocarbons,resulting in an active hydrogen evolution reaction(HER).Herein,we report a method of blocking the effect of Fe impurities on the Cu surface through the preferential growth of nano-sized metal-organic frameworks(MOFs)on Fe *** zirconium(Zr)-based MOFs(UiO-66)forms a compensating layer on Cu film via the terephthalic acid(TPA)-Fe coordination bond,the Ui O-66 coated Cu film(UiO-66@Cu)presents significantly improved hydrocarbon Faradaic efficiency(FE)of 37.59%compared to 14.68%FE on commercial Cu film(99.9%purity)by suppressing *** to X-ray photoelectron spectroscopy(XPS)analysis,the UiO-66 ligand binds to entire metallic Fe site on the Cu surface,while metallic Cu is ***,UiO-66@Cu provides active sites of Cu for CO_(2)RR and leads to highly efficient and selective production of hydrocarbons.

关键词： Impurity on Cu film Zr-based MOFs Electrocatalysts CO_(2)reduction Hydrocarbon

Biomimetic Fe_(7)S_(8)/Carbon electrocatalyst from[FeFe]-Hydrogenase for improving pH-Universal electrocatalytic hydrogen production Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 451-459页

作者： Dohun Kim Subramani Surendran Sejin Im Jaehyoung Lim Kyoungsuk Jin Ki Tae Nam Uk sim Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science&Technology(DGIST)DaeguRepublic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Department of Chemistry Korea UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

Efficient and cost-effective electrocatalysts that can operate across a wide range of pH conditions are essential for green hydrogen *** by biological systems,Fe_(7)S_(8)nanoparticles incorporated on polydopamine matrix electrocatalyst were synthesized by co-precipitation and annealing *** resulting Fe_(7)S_(8)/C electrocatalyst possesses a three-dimensional structure and exhibits enhanced electrocatalytic performance for hydrogen production across various pH ***,the Fe_(7)S_(8)/C electrocatalyst demonstrates exceptional activity,achieving low overpotentials of 90.6,45.9,and 107.4 mV in acidic,neutral,and alkaline environments,*** impedance spectroscopy reveals that Fe_(7)S_(8)/C exhibits the lowest charge transfer resistance under neutral conditions,indicating an improved proton-coupled electron transfer ***-wave electron paramagnetic resonance results confirm a change in the valence state of Fe from 3+to 1+during the hydrogen evolution reaction(HER).These findings closely resemble the behavior of natural[FeFe]-hydrogenase,known for its superior hydrogen production in neutral *** remarkable performance of our Fe_(7)S_(8)/C electrocatalyst opens up new possibilities for utilizing bioinspired materials as catalysts for the HER.

关键词： biomimetic electrocatalyst hydrogen production renewable energy

Monkeypox awareness,knowledge,and attitude among undergraduate preclinical and clinical students at a Malaysian dental school:An emerging outbreak during the COVID-19 era

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 461-467页

作者： Galvin sim Siang Lin Wen Wu Tan Daryl Zhun Kit Chan Kai Shen Ooi Hasnah Hashim Department of Dental Materials Faculty of DentistryAsian Institute of MedicineScience and Technology(AIMST)University08100BedongKedahMalaysia Department of Dental Public Health Faculty of DentistryAsian Institute of MedicineScience and Technology(AIMST)University08100BedongKedahMalaysia Department of Paediatrics Faculty of MedicineUniversiti Kebangsaan Malaysia Medical Centre56000Kuala LumpurMalaysia

Objective:To evaluate the awareness,knowledge,and attitude on monkeypox viral infection among preclinical and clinical dental students in ***:A cross-sectional study was conducted among 229 preclinical and clinical dental students via an online self-reported *** questionnaire included 3 items on awareness,15 items on knowledge,9 items on attitude and 2 open-ended *** were presented as frequencies and ***-square test was used to compare knowledge and awareness scores between preclinical and clinical dental students and content analysis was performed for open-ended ***:Preclinical and clinical dental students were aware of the existence of monkeypox(89.5%and 94.4%,respectively),that the disease emerged in non-endemic countries(81.0%and 87.1%,respectively)and that it was declared a public health emergency of international concern by the World Health Organization(73.3%and 79.0%,respectively).Clinical dental students’overall knowledge level was significantly higher than preclinical dental students(P=0.014).Both preclinical(95.2%)and clinical(96.8%)dental students demonstrated positive attitudes toward monkeypox with no significant difference(P=0.736)noted between *** themes emerged from the open-ended questions:(1)reimplementation of nationwide lockdown,(2)impact on the economy and health,and(3)disruption to the educational *** also anticipated their face-to-face learning to be reduced should there be a new ***:Both preclinical and clinical dental students showed comparable awareness and attitudes,while the latter demonstrated greater satisfactory knowledge toward the re-emergence of monkeypox during the COVID-19 ***,efforts to improve dental students’understanding of this alarming outbreak are required,to safeguard their health and minimise transmission.

关键词： Communicable disease Monkeypox virus Public health Tropical disease Zoonoses

Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility

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Insect Science 2019年第4期26卷 635-648页

作者： Paola A. Caicedo Idalba Mildred Serrato Shuzhen sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM) Cali Colombia 2W. Harry Feinstone Department of Molecular Microbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland USA Department of Biological Sciences Simon Fraser University Burnaby Canada

Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DENV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (DENV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti.

关键词： Aedes aegypti dengue virus innate immune response knockdown microarray vector competence