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Rare tumor of the ovary: Primitive choriocarcinoma

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 448-450页

作者： Sanaa Errarhay Najia Hmidani Samia Mahmoud Hind El Fatemi Hanane Saadi Omar El Mesbahi nadia squalli Chahrazed Bouchikhi Amarti Afaf Abdelaziz Banani Department of Gynecology and Obstetrics University Hospital of Fez Fez Morocco Department of Oncology University Hospital of Fez Fez Morocco Department of Pathology University Hospital of Fez Fez Morocco Department of Radiology University Hospital of Fez Fez Morocco

We report the case of a patient of 30 years with primary choriocarcinoma of the ovary. This patient referred for abdomino-pelvic mass suspected clinically and sonographically. Exploratory laparotomy was performed with the presence of two latero-uterine mass adherents to the highly vascularised uterus and difficult to resects deep plane with a mass left hepatic bleeding. A biopsy of both masses was performed and histological examination with immunehistochemical study returned for a primary ovarian non-gestational choriocarcinoma and the patient received 4 cycles of chemotherapy after hepatic artery embolization with good clinical, biological and radiological evaluation.

关键词： Germinal Ovarian Tumour Ovarian Choriocarcinoma Chemotherapy

Phytochemical analysis,antioxidant,acetylcholinesterase,andα-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese Medicine 2024年第3期44卷 496-504页

作者： Naila Sher Mushtaq Ahmed nadia Mushtaq Department of Biotechnology University of Science and Technology Bannu-KPK 28100Pakistan Department of Botany University of Science and Technology Bannu-KPK 28100Pakistan

OBJECTIVE:To investigate the effects of Hippeastrum hybridum(HH)as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase(α-amylase)and acetylcholinesterase(AChE).METHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be(78.52±0.69)mg GAE/g,(2.01±0.04)mg RUE/g,and(58.12±0.23)mg TAE/g of plant extract respectively.28.02%±0.02%alkaloid and 2.02%±0.05%saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50(50%inhibition)of(151.01±0.13)(HH),(79.01±0.04)(Ascorbic acid)for ferric reducing,(91.48±0.13)(HH),(48.02±0.11)(Ascorbic acid)against Ammonium molybdenum,(156.02±0.31)(HH),(52.38±0.21)(Ascorbic acid)against DPPH,136.01±0.21(HH),52.02±0.31(Ascorbic acid)against H_(2)O_(2),and 154.12±0.03(HH),(40.05±0.15)(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition ofα-amylase(V_(max)remained constant and Km increases from 10.65 to84.37%)while Glucophage caused the un-competitive type of inhibition i-e both Km and V_(max)decreased from40.49 to 69.15%and 38.86 to 69.61%*** K_(i),(inhibition constant);K_(I),(dissociation constant),K_(m),(Michaelis-Menten constant),and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while V_(max)decreases from 60.5%to74.1%.The calculated K_(i),K_(I),K_(m),and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidant

关键词： Hippeastrum hybridum phytochemicals antioxidant alpha-amylase acetylcholinesterase

ANonmonotone Projected Gradient Method for Multiobjective Problems on Convex Sets

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Journal of the Operations Research Society of China 2024年第2期12卷 410-427页

作者： Gabrie Anibal Carrizo nadia Soledad Fazzio Maria Laura Schuverdt Department of Mathematics National University of the SouthBahia BlancaArgentina Department of Mathematics University of La PlataLa PlataArgentina

In this work we consider an extension of the classical scalar-valued projected gradient method for multiobjective problems on convex *** in Fazzio et al.(Optim Lett 13:1365-1379,2019)a parameter which controls the step length is considered and an updating rule based on the spectral gradient method from the scalar case is *** the present paper,we consider an extension of the traditional nonmonotone approach of Grippo et al.(SIAM J Numer Anal 23:707-716,1986)based on the maximum of some previous function values as suggested in Mita et al.(J Glob Optim 75:539-559,2019)for unconstrained multiobjective optimization *** prove the accumulation points of sequences generated by the proposed algorithm,if they exist,are stationary points of the original *** experiments are reported.

关键词： Multiobjective optimization Projected gradient methods Nonmonotone line search Global convergence

Pro-fertility effect of Ficus carica fruit extract in streptozotocin-induced male rats

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Asian pacific Journal of Reproduction 2024年第1期13卷 34-41页

作者： Mat Noor Mahanem Subramaniam Puvaratnesh AbuBakar Umarqayum Shamsusah nadia A Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Institute of Biological Sciences Faculty of ScienceUniversity Malaya50603 Kuala LumpurMalaysia Department of Earth Sciences and Environment Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

Objective:To explore the impact of Ficus carica fruit aqueous extract on fertility parameters in streptozotocin(STZ)-induced male ***:Twenty-four male Sprague-Dawley rats were divided into four different *** groups except a normal control group were induced with 50 mg/kg of streptozotocin(STZ)intravenously to induce diabetes.A positive control group was treated with an antidiabetic drug,metformin(500 mg/kg)whereas a negative control group remained untreated throughout the ***,another diabetic rat group received treatment with 400 mg/kg of aqueous Ficus carica fruit *** in the treatment group were administered Ficus carica fruit aqueous extract daily through forcefeeding via oral gavage for a 21-day *** included the sperm quality(count,motility and morphology),histology of the testes,serum testosterone and fasting blood glucose(FBG)***:The FBG level of the Ficus carica-treated rats exhibited a significant decrease compared to the negative control group(P<0.05).Sperm quality analysis also indicated that the aqueous Ficus carica extract had significant positive effects on sperm count and motility(P<0.05).The histology of the testes in Ficus caricatreated rats revealed an improved cell arrangement in the germinal cell ***,serum testosterone level showed an increment in the Ficus carica treatment group in comparison to the negative control ***:Our findings provide compelling evidence for the profertility and anti-hyperglycemic properties of aqueous Ficus carica fruit extract in diabetic-induced male rats.

关键词： Ficus carica fruit Male fertility parameter Diabetes mellitus Anti-hyperglicemic

Survey of current practices in the management of cervical cancer by Moroccan radiotherapists

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Radiation Medicine and Protection 2024年第2期5卷 124-130页

作者： Bouchra Amaoui Slimane Semghouli Hanane El Kacemi Issam Lalya nadia Benchekroune Fatima Safini Sanae Abbaoui Biotechnology and Medicine(BioMed)Laboratory Faculty of Medicine and PharmacyIbn Zohr UniversityAgadirMorocco Souss Massa University Hospital Center AgadirMorocco Higher Institute of Nursing Professions and Health Techniques AgadirMorocco Mohammed-V University RabatMorocco National Institute of Oncology(INO) RabatMorocco Mohammed-V Military Instruction Hospital RabatMorocco Hassan II University CasablancaMorocco Mohammed VI Oncology Center-Casablanca University Hospital CasablancaMorocco Regional Oncology Center AgadirMorocco

Objective:To assess the applicability degree of the international guidelines by Moroccan radiotherapists,in order to improve the management of cervical cancer(CC),since CC is the second most common cancer for women in ***:This cross-sectional study was carried out using a questionnaire sent online to Moroccan *** questionnaire covered participants'characteristics,initial assessment and treatment preparation,techniques and indications for radiotherapy and brachytherapy,dose and indications,as well as on the protocol adopted in the intermediate stages and the location of adjuvant treatments and assessments'***:74 radiotherapists out of 300 have responded to the *** 27.0%of practitioners reported discussing patient records systematically in a multidisciplinary consultation meeting(MCM).For the initial assessment,77.0%requested pelvic magnetic resonance imaging(MRI).It is significantly less requested in regional oncology centers(ROCs)than in university hospital centers(UHCs)or the private sector(P<0.001).Furthermore,Clinicians in ROCs do not have access to new techniques of *** 83.8%of cases,the most prescribed radiotherapy protocols were 45–46 Gy in 1.8–2 Gy per ***-dimensional gynaecological brachytherapy high-throughput dose guided by dosimetric scanner was available in 75.5%of structures while interstitial gynaecological brachytherapy was only available in 23%of *** two most prescribed dose protocols were 47 Gy and 37 Gy in 74.4%and 21.6%of cases,***,monitoring during the first two years was based mainly on pelvic MRI(82.2%)while PET/CT was recommended by only less than 10%.Conclusions:The findings obtained show that our radiotherapists generally comply with international guidelines for the cervical cancer ***,they should still enhance their practices for the first staging evaluation,the use of systematic MCMs,the doses and treatment techniques used,and

关键词： Radiotherapy Brachytherapy Cervical cancer Morocco

Nonlinear Study on the Mechanical Performance of Built-Up Cold-Formed Steel Concrete-Filled Columns under Compression

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3435-3465页

作者： Oulfa Harrat Yazid Hadidane S.M.Anas Nadhim Hamah Sor Ahmed Farouk Deifalla Paul O.Awoyera nadia Gouider Civil Engineering Laboratory Faculty of TechnologyDepartment of Civil EngineeringBadji Mokhtar-Annaba UniversityP.O.Box 12Annaba23000Algeria Department of Civil Engineering Faculty of Engineering and TechnologyJamia Millia Islamia(A Central University)New Delhi110025India Civil Engineering Department University of GarmianKalar46021Iraq Department of Civil Engineering Harran UniversitySanliurfa63510Turkey Structural Engineering and Construction Management Department Future University in EgyptNew Cairo11835Egypt Department of Civil Engineering Covenant UniversityOta112233Nigeria

Given their numerous functional and architectural benefits,such as improved bearing capacity and increased resistance to elastic instability modes,cold-formed steel(CFS)built-up sections have become increasingly developed and used in recent years,particularly in the construction *** paper presents an analytical and numerical study of assembled CFS two single channel-shaped columns with different slenderness and configurations(backto-back,face-to-face,and box).These columns were joined by double-row rivets for the back-to-back and box configurations,whereas they were welded together for the face-to-face *** built-up columns were filled with ordinary concrete of good *** element models were applied,using ABAQUS software,to assess mechanical performance and study the influence of assembly techniques on the behavior of cold-formed columns under axial *** approaches based on Eurocode 3 and Eurocode 4 recommendations for un-filled and concrete-filled columns respectively were followed for the numerical analysis,and concrete confinement effects were also considered per American Concrete Institute(ACI)standards for face-to-face and box *** obtained results indicated a good correlation between the numerical results and the proposed analytical methodology which did not exceed 8%.The failure modes showed that the columns failed due to instabilities such as local and global buckling.

关键词： Cold-formed steel built-up sections slenderness rivets welded axial compression analytical approaches confinement buckling

Non-invasive prenatal testing can detect silent cancers in expecting mothers

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Genes & Diseases 2024年第2期11卷 585-588页

作者： Alessandro Ottaiano Monica Ianniello nadia Petrillo Mariachiara Santorsola Luigia De Falco Salvatore Giovanni Castaldi Maria Antonietta Castaldi Valentina Giudice Carmine Selleri Giovanni Savarese Unit of Innovative Therapies for Abdominal Metastases Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy AMES Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specialization School of Clinical Pathology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregnancy and Prenatal Diagnosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hematology and Transplant Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregnancy is a unique physiological state in which several changes *** of the most important aspects is the maternal immune system,which sets to tolerate the presence of thedeveloping fetus(a semi-allogeneic organism),while at the same time providing protection against pathogens.1 Pregnancy has long been known to affect the risk of certain cancers including breast cancer in the short term,gestational trophoblastic disease(GTD),cervical cancer,and melanoma.2,3 The reasons for the increased risk of these cancers during pregnancy are not fully understood,but several hypotheses have been proposed as the hormonal and immune system changes.

关键词： mother cancers fetus

Dual innervation method to preserve erectile function following prostatectomy

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 159-160页

作者： nadia Hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat Wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore Department of Urology Mount Alvernia Hospital Singapore574623Singapore Department of General Surgery Sengkang General Hospital544886Singapore Department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry Dario A.Fioretto Lorenzo M.Procopio Stéphane Monfray Frédéric Boeuf Laurent Vivien Eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine nadia Belabas Institut Polytechnique de Paris LTCI Université Paris-Saclay CNRS Centre for Nanosciences and Nanotechnology Weizmann Institute of Science STMicroelectronics SAS

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability, noise resilience, parallelization, and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave mixing. However, state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation, and efficient photon pair generation. We have developed silicon ring resonators with a footprint below 0.05 mm2providing more than 70 frequency channels separated by 21 GHz. We exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic devices. We fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state tomography. We demonstrate for the first time, we believe, a fully connected five-user quantum network in the frequency domain. These results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology, for applications in quantum computing and secure communications.

关键词： frequency domain integrated photonics quantum gates quantum networks