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Prevelance of Bovine Cyst.cercosis in Egypt.and t.e Cyst.cidal Effect.of t.o Ext.act. Obt.ined from.Balanit.s aegypt.aca and m.ringa oleifera on m.ce m.del Affect.d wit. t. saginat. Cyst.cerci

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Open Journal of Anim.l Sciences 2024年第2期14卷 39-55页

作者： Om.ia m. Kandil Noha m. F. Hassan Doaa Sedky Hat.m.A. Shalaby Heba m. Ashry nadia m. t. abu el ezz Sahar m. Kandeel m.ham.d S. Abdelfat.ah L. Ying Ebt.sam.m. Al-Olayan Parasit.logy and Anim.l Diseases Depart.0}nt Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chem.st.y of Nat.ral Com.ounds Depart.0}nt Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chem.st.y Depart.0}nt Faculty of Science Helwan University Cairo Egypt St.t. Key Laborat.ry of Plat.au Ecology and Agricult.re Qinghai University Xining China College of Agricult.re and Anim.l Husbandry Qinghai University Xining China Depart.0}nt.of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

t.e aim.of t.e present.st.dy was t. det.rm.ne t.e prevalence of bovine cyst.cercosis in bot. cat.le and buffloas, in Egypt.and t. assess t.e cyst.cidal efficacy of Balanit.s aegypt.aca fruit. (B. aegypt.aca) and m.ringa oleifera seeds (m. oleifera) ext.act. in experim.nt.lly infect.d m.ce. t.e st.dy det.ct.d t.e level of t.m.r necrosis fact.r (t.F-α) t. m.nit.r t.e im.une and inflam.at.ry responses of experim.nt.lly infect.d m.ce. t.rough m.at.inspect.on, a t.t.l num.er of 2125 m.le bovine, 2 t. 5 years old, (1125 cat.le and 1000 buffloes) were exam.ned under t.e aut.orit. of Albsat.ne and Alwaraq official abat.oirs in Cairo Governorat., Egypt.covering t.e period ext.nded from.m.rch 2022 t. April 2023. t.e overall prevalence of t.e disease am.ng bovine was 7.8% (6.31% of cat.le and 9.5% of buffloes). Besides, B. aegypt.aca and m. oleifera ext.act. showed cyst.cidal act.vit. in experim.nt.lly infect.d m.ce. A decrease in t.e num.ers of cyst.cerci was found in all t.eat.d m.ce groups, and up t. 88% reduct.on was achieved in t.e B. aegypt.aca-t.eat.d group;higher t.an t.at.was recorded in bot. m. oleifera (72.23%) and albendazole-t.eat.d ones (80.56%). Post.0}rt.m.findings proved t.at.m. oleifera and B. aegypt.aca reduced cyst.cerci num.ers com.arable t. a com.ercial ant.elm.nt.c. t.e st.dy showed a significant.decrease (P 0.001) in t.F-α levels aft.r t.eat.0}nt.wit. Balanit.s and m.ringa ext.act., com.ared wit. t.e unt.eat.d cont.ol and t.e albendazole-t.eat.d groups.

关键词： Prevalence Balanit.s aegypt.aca m.ringa oleifera m.ce t. saginat. Cyst.cerci

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Sm.rt.predict.on of liquefact.on-induced lat.ral spreading

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Journal of Rock m.chanics and Geot.chnical Engineering 2024年第6期16卷 2310-2325页

作者： m.ham.ad Noum.n Am.ad Raja t.rek Abdoun Waleed el-Sekelly New York Universit.(NYU)abu Dhabi Abu Dhabi129188United Arab Emirates Universit. of m.nagem.nt.and t.chnology Lahore54372Pakistan Depart.0}nt.of Civil and Environm.nt.l Eng. Rensselaer Polytechnic Institute(RPI)1108th StreetJEC 4049TroyNY12180USA Depart.0}nt.of St.uct.ral Engineering Mansoura UniversityMansoura35516Egypt

t.e predict.on of liquefact.on-induced lat.ral spreading/displacem.nt.Dh)is a challenging t.sk for civil/geot.chnical *** t.is st.dy,a new approach is proposed t. predict.Dh using gene expression program.ing(GEP).Based on st.t.st.cal reasoning,individual m.dels were developed for t.o t.pographies:free-face and gent.y sloping *** wit. a com.arison wit. convent.onal approaches for predict.ng t.e Dh,four addit.onal regression-based soft.com.ut.ng m.dels,*** process regression(GPR),relevance vect.r m.chine(RVm.,sequent.al m.nim.l opt.m.zat.on regression(Sm.R),and m.-t.ee,were developed and com.ared wit. t.e GEP *** result. indicat. t.at.t.e GEP m.dels predict.Dh wit. less bias,as evidenced by t.e root.m.an square error(Rm.E)and m.an absolut. error(m.E)for t.aining(i.e.1.092 and 0.815;and 0.643 and 0.526)and for t.st.ng(i.e.0.89 and 0.705;and 0.773 and 0.573)in free-face and gent.y sloping ground t.pographies,*** overall perform.nce for t.e free-face t.pology was ranked as follows:GEP>RVm.m.-t.ee>GPR>Sm.R,wit. a t.t.l score of 40,32,24,15,and 10,*** t.e gent.y sloping condit.on,t.e perform.nce was ranked as follows:GEP>RVm.GPR>m.-t.ee>Sm.R wit. a t.t.l score of 40,32,21,19,and 8,***,t.e result. of t.e sensit.vit. analysis showed t.at.for bot. free-face and gent.y sloping ground,t.e liquefiable layer t.ickness(t.(15))was t.e m.jor param.t.r wit. percent.ge det.riorat.on(%D)value of 99.15 and 90.72,respect.vely.

关键词： Lat.ral spreading Int.lligent.m.deling Gene expression program.ing(GEP) Closed-form.solut.on Feat.re im.ort.nce

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Exom. sequencing ident.fies a likely causat.ve variant.in 53%of fam.lies wit. ciliopat.y-relat.d feat.res on renal ult.asound aft.r excluding NPHP1 delet.ons

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konst.nt.n Deut.ch Verena Klam.t.t.om.s m.Kit.ler t.lm.n Jobst.Schwan Ronen Schneider Florian Buerger St.ve Selt.sam.Sherif el Desoky Jam.ela A.Kari Farkhanda Hafeez m.ria Szczepanska Loai A.Eid Hazem.S.Awad m.na Al-Saffar Neveen A.Solim.n Velibor t.sic Cam.lle Nicolas-Frank Kirollos Yousef Luca m.Schierbaum.Sophia Schneider Abdul Halawi Izzeldin elm.barak Kat.arina Lem.erg Shirlee Shril Shrikant.m.m.ne Nancy Rodig Friedhelm.Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Depart.0}nt.of Pediat.ic Gast.oent.rology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Inst.t.t. of Healt. at.Charit.e Universit.t.m.dizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Depart.0}nt.of Nephrology and Hypert.nsion FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Depart.0}nt.of Pediat.ics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Depart.0}nt.of Pediat.ic Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Depart.0}nt.of Pediat.ics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospit.l and Al-Jalila Children’s Specialt. Hospit.l Kidney Center of ExcellenceDubai 4545United Arab Emirates Depart.0}nt.of Genet.cs and Genom.cs UAE UniversityAbu Dhabi 15551United Arab Emirates Depart.0}nt.of Pediat.ics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Depart.0}nt.of Pediat.ics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt.Cent.r for Research and Regenerat.ve m.dicine(ECRRm. Cairo 11511Egypt m.dical Facult. Skopje University Children’s HospitalSkopje 1000North Macedonia Depart.0}nt.of Genet.cs Yale University School of MedicineNew HavenCT 06520USA

Nephronopht.isis-relat.d ciliopat.ies(NPHP-RC)represent.one of t.e m.st.com.on causes of chronic kidney disease in t.e first.t.ree decades of life and are charact.rized by a broad genet.c and clinical het.rogeneit..1 t. dat.,m.re t.an 90 genes have been ident.fied t.at.cause aut.som.lrecessive NPHP-RC if m.t.t.d,account.ng for up t. 60%of cases.1 Am.ng t.ese,hom.zygous delet.ons of NPHP1 are t.e m.st.com.on *** genes localize t. prim.ry cilia,basal bodies,or t.e cent.osom. and lead t. a prim.ry ciliary disrupt.on if m.t.t.d,t.ereby causing a broad phenot.pical spect.um.1 Pat.ent. t.at.suffer from.NPHP-RC can eit.er have an isolat.d renal phenot.pe,such as polyuria,polydipsia,decreased urinary concent.at.on abilit.,and secondary enuresis due t. loss of t.bular funct.on,or present.wit. ext.arenal sym.t.m. including ret.nal degenerat.on,cerebellar verm.s hypoplasia,or hepat.c *** are oft.n diagnosed in early adolescence,reaching end-st.ge renal disease before 25 years of age,but.early onset.and rapidly progressive form. of NPHP-RC also exist.1 Renal ult.asound indicat.s kidneys of norm.l or reduced renal lengt. wit. increased echogenicit. and cort.com.dullary cyst..

关键词： degenerat.on urinary likely

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Synt.esis, in vit.o ant.t.m.r act.vit. and m.lecular m.deling st.dies of a new series of benzot.iazole Schiff bases

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Chinese Chem.cal Let.ers 2016年第3期27卷 380-386页

作者： m.ust.fa t.Gabr nadia S.el-Gohary Em.n R.el-Bendary m.ham.d m.el-Kerdawy Nant.ng Ni Depart.0}nt.of m.dicinal Chem.st.y Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Depart.0}nt.of Chem.st.y Ceorgia State University Atlanta CA 30303 USA

A new series of benzot.iazole Schiff bases 3–29 was synt.esized and screened for ant.t.m.r act.vit. against.cervical cancer（Hela） and kidney fibroblast.cancer（COS-7） cell lines. Result. indicat.d t.at.com.ounds 3, 14, 19, 27 and 28 have prom.sing act.vit. against.Hela cell line wit. IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 m.ol/L, respect.vely, in com.arison t. doxorubicin as a reference ant.t.m.r agent.IC50 2.05 m.ol/L）. In addit.on, com.ound 3 displayed excellent.act.vit. against.COS-7 cell line wit. IC50 value of 4.31 m.ol/L in com.arison t. doxorubicin（IC50 3.04 m.ol/L）. In t.e present.work,st.uct.re based pharm.cophore m.pping, m.lecular docking, prot.in-ligand int.ract.on, fingerprint. and binding energy calculat.ons were em.loyed in a virt.al screening st.at.gy t. ident.fy t.e int.ract.on bet.een t.e com.ounds and t.e act.ve sit. of t.e put.t.ve t.rget. EGFR t.rosine kinase. m.lecular propert.es, t.xicit., drug-likeness, and drug score profiles of com.ounds 3, 14, 19, 27, 28 and 29 were also assessed.

关键词： Benzot.iazole Schiff bases Ant.t.m.r act.vit. m.lecular m.deling In silico st.dies

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Synt.esis,ant.m.crobial, ant.quorum.sensing and cyt.t.xic act.vit.es of new series of benzot.iazole derivat.ves

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Chinese Chem.cal Let.ers 2015年第12期26卷 1522-1528页

作者： m.ust.fa t.Gabr nadia S.el-Gohary Em.n R.el-Bendary m.ham.d m.el-Kerdawy Nant.ng Ni m.na I.Shaaban Depart.0}nt.of m.dicinal Chem.st.y Faculty of Pharmacy Mansoura University Depart.0}nt.of Chem.st.y Georgia State University Depart.0}nt.of m.crobiology Faculty of Pharmacy Mansoura University Depart.0}nt.of m.crobiology College of Pharmacy Taibah University

New series of benzot.iazole derivat.ves were designed and synt.esized. t.e newly synt.esized com.ounds were screened for t.eir ant.bact.rial act.vit. against.Escherichia coli, St.phylococcus aureus and Bacillus cereus. Com.ounds 6j and 6o showed t.e highest.act.vit. against.E. coli and S. aureus. t.e ant.fungal act.vit. of t.ese com.ounds was also t.st.d against.Candida albicans and Aspergillus fum.gat.s293. Com.ounds 4c, 4g and 6j exhibit.d t.e highest.act.vit. against.C. albicans. In addit.on, com.ounds4 a and 6j displayed prom.sing act.vit. against.A. fum.gat.s 293. t.e sam. com.ounds were exam.ned for t.eir ant.quorum.sensing act.vit. against.Chrom.bact.rium.violaceum.At.C 12472, whereas com.ounds4 a, 6j and 6p showed m.derat. act.vit.. t.e in vit.o cyt.t.xicit. t.st.ng of t.e synt.esized com.ounds was perform.d against.cervical cancer（Hela） and kidney fibroblast.cancer（COS-7） cell lines. Result. indicat.d t.at.all t.st.d com.ounds have IC50 values 〉50 m.ol/L against.bot. cell lines. m.lecular propert.es, t.xicit.es, drug-likeness, and drug score profiles of com.ounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： ant.bact.rial m.iet. ant.fungal ant.m.crobial cyt.t.xic screened m.derat. subst.t.ent.Candida albicans

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t.ends and out.om.s of pancreat.coduodenect.m. for periam.ullary t.m.rs: A 25-year single-cent.r st.dy of 1000 consecut.ve cases

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World Journal of Gast.oent.rology 2017年第38期23卷 7025-7036页

作者： aym.n el nakeeb waleed askar ehab at.f ehab el hanafy ahm.d m.sult.n t.rek salah ahm.d sheht. m.ham.d el sorogy em.d ham.y m.ham.d el hem.y ahm.d a el-geidi t.arwat.kandil m.ham.d el shobari t.laat.abd allah am.ad fouad m.st.fa abu zeid ahm.d abu el eneen nabil gad el-hak gam.l el ebidy om.r fat.y ahm.d sult.n m.ham.d abdel wahab gast.oent.rology surgical cent.r mansoura university

AIm.t. evaluat. t.e evolut.on, t.ends in surgical approaches a n d r e c o n s t.r u c t.i o n t.e c h n i q u e s, a n d i m.p o r t.a n t.lessons learned from.perform.ng 1000 consecut.ve pancreat.coduodenect.m.es(PDs) for periam.ullary *** t.is is a ret.ospect.ve review of t.e dat. of all pat.ent. who underwent.PD for periam.ullary t.m.r during t.e period from.January 1993 t. April 2017. t.e dat. were cat.gorized int. t.ree periods, including early period(1993-2002), m.ddle period(2003-2012), and lat. period(2013-2017).RESULt. t.e frequency showed PD was increasingly perform.d aft.r t.e year 2000. Wit. t.m., elderly, cirrhot.c and obese pat.ent., as well as pat.ent. wit. uncinat. process carcinom. and borderline t.m.r were increasingly select.d for PD. t.e m.dian operat.ve t.m. and post.perat.ve hospit.l st.y decreased significant.y over t.e periods. Hospit.l m.rt.lit. declined significant.y, from.6.6% t. 3.1%. Post.perat.ve com.licat.ons significant.y decreased, from.40% t. 27.9%. t.ere was significant.decrease in post.perat.ve pancreat.c fist.la in t.e second 10 years, from.15% t. 12.7%. t.ere was a significant.im.rovem.nt.in m.dian survival and overall survival am.ng t.e *** Surgical result. of PD significant.y im.roved, wit. m.rt.lit. rat. nearly reaching 3%. Pancreat.c reconst.uct.on following PD is st.ll debat.ble. t.e survival rat. was also im.roved but.t.e rat. of recurrence is st.ll high, at.36.9%.

关键词： Pancreat.coduodenect.m. Pancreat.cogast.ost.m. Pancreat.cojejunost.m. 手术后的胰腺的管 Periam.ullary 肿瘤

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Opt.cal Charact.rizat.on of (t.0})&lt.sub&gt.2&lt./sub&gt.ZnCl&lt.sub&gt.4&lt./sub&gt.Single Cryst.ls in t.e Norm.l Phase

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Open Journal of Applied Sciences 2015年第4期5卷 169-181页

作者： A. abu el-Fadl m. Alm.kht.r A. m. Nashaat Physics Depart.0}nt Faculty of Science Assiut University Assiut Egypt

t.e t.ansm.t.ance (t. and t.e reflect.nce (R) were m.asured for (t.0})2ZnCl4 single cryst.ls and hence t.e absorpt.on coefficient.(α), ext.nct.on coefficient.(Kex.), refract.ve index (n), real and im.aginary dielect.ic const.nt. (ε', ε") of (t.0})2ZnCl4 cryst.ls were calculat.d as a funct.on of phot.n energy. t.e analysis of t.e spect.a behavior of t.e absorpt.on coefficient.in t.e absorpt.on region revealed indirect.t.ansit.on. t.e dispersion of t.e refract.ve index is discussed in t.rm. of t.e sin-gle oscillat.r Wem.le-DiDom.nico m.del. t.e single oscillat.r energy (E0), t.e dispersion energy (Ed), t.e lat.ice dielect.ic const.nt.(εL) and t.e rat.o of free charge carrier concent.at.on t. t.e ef-fect.ve m.ss (N/m.) were est.m.t.d. t.e Ft.R spect.a were recorded t. st.dy t.e funct.onal groups of t.e as grown and annealed sam.les.

关键词： (t.0})2ZnCl4 Single Cryst.ls Opt.cal Band Gap Refract.ve Index Dispersion Param.t.rs Ft.R Spect.oscopy

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t.e Role of &lt.i&gt.Helicobact.r pylori&lt./i&gt.Infect.on, and m.lnut.it.on am.ng t.pe 2 Diabet.c m.dical Services Pat.ent. in t.e Gaza St.ip

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Int.rnat.onal Journal of Clinical m.dicine 2013年第12期4卷 556-560页

作者： m.zen A. el-Sakka Ekt.m.l m. abu Jabal Luay m. Nasser m.dical Service Gaza Palestine Nut.it.on Depart.0}nt Ministry of National Economy Gaza Palestine Pharm.cognosy Depart.0}nt Faculty of Pharmacy Al Azhar University-Gaza Gaza Palestine

Background: Diabet.s m.ans t.e blood glucose, which is t.o high or t.o low. Wit. t.pe 2 Dm. t.e m.re com.on t.pe, t.e body does not.m.ke or use insulin well. In pat.ent. wit. Dm. Helicobact.r pylori is one of t.e m.st.com.on infect.ons worldwide. Available dat. on t.e possible associat.on bet.een H. pylori infect.on and Dm.are cont.adict.ry. t.ere are a few st.dies in t.e m.ddle East. and t.is st.dy is t.e pioneer st.dy, in t.e m.dical Services Clinics in Gaza st.ip. Aim.: t.is st.dy was conduct.d t. reveal t.e prevalence of H. pylori infect.on, m.lnut.it.on, insulin resist.nce am.ng t.Dm.pat.ent., t. describe t.e diet.ry requirem.nt. of t.Dm.pat.ent., finally t. evaluat. t.e current.inform.t.on about.diet. and lifest.le in t.e prevent.on of H. pylori, and m.lnut.it.on. m.t.odology: A cross-sect.onal st.dy was conduct.d in t.e m.dical Services Clinics in Gaza St.ip, and t.ere were 129 pat.ent. included in t.is st.dy. Dat. were collect.d t.rough hem.t.logical inform.t.on and st.uct.red int.rview quest.onnaire. Result.: Highly significant.percent.ge of H. pylori (70%) am.ng t.e Dm.pat.ent. includes in t.e st.dy, but.not.indicat.s any significant.associat.on bet.een gender and H. pylori st.t.s. Conclusion: H. pylori pat.ent. should updat. t.eir sugar level values in t.e record, and should get.exercise and diet.plan for every m.al.

关键词： t.pe 2 Diabet.s m.llit.s (t.Dm. Helicobact.r pylori (H. pylori) Insulin Resist.nce (IR) m.lnut.it.on

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Role of m.gm.t.sm.and Relat.d-Exsolved Fluids during t.-Nb-Sn Concent.at.on in t.e Cent.al East.rn Desert.of Egypt.Evidences from.m.neral Chem.st.y and Fluid Inclusions

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Journal of Eart. Science 2023年第3期34卷 674-689页

作者： m.ham.d Abd el m.nsef m.brouk Sam. Fat.0} t.ksoy‐Köksal Rainer Abart.m.rt.n Ondrejka Khaled m.bdelfadil Geology Depart.0}nt Faculty of ScienceTanta University31527 TantaEgypt Geology Depart.0}nt Faculty of ScienceMinia University61519 El-MiniaEgypt Depart.0}nt.of Geological Engineering Middle East Technical University06800 AnkaraTurkey Depart.0}nt.of Lit.ospheric Research University of Vienna1090 ViennaAustria Depart.0}nt.of m.neralogy Petrology and Economic GeologyComenius UniversityBratislavaSlovakia Depart.0}nt.of Geology Faculty of ScienceSohag University82524 SohagEgypt Depart.0}nt.of Physics and Eart. Sciences Jacobs University28759 BremenGermany

t.e rare m.t.ls of abu Dabbab area in t.e Cent.al East.rn Desert.of Egypt.have been invest.gat.d for t.eir m.neralogy and condit.ons of precipit.t.on using com.inat.on of Em.A and fluid inclusions st.dies,in order t. delineat. t.e source,m.chanism.of form.t.on and evolut.onary m.del for t.ese econom.c ***(t.-Nb-Sn)-bearing m.nerals at.t.e abu Dabbab area include colum.it. group m.nerals(CGm.),wodginit. and *** bot. granit.c int.usion and it. enclosed quart. veins,m.st.of zoned CGm. and cassit.rit. grains are com.only charact.rized by a well-developed t.ost.ge ***,colum.it.-(m.)(CGm.Ⅰ)represent. t.e early form.d phase of CGm. t.at.is charact.rized by high m.#values(0.64-0.92)wit. quit. low t.#values(0.13-0.49).It.was invaded by t.-rich phases including t.nt.lit.-(m.)(CGm.Ⅱ;t.#=0.13-0.49)and wodginit.,which cont.in high t._(2)O_(5)and SnO_(2)(17.91 wt.%).In regard t. cassit.rit.,t.ere are dist.nct.com.osit.onal differences bet.een t.e early-phase cassit.rit.(Cst.Ⅰ)and t.e lat.-phase one(Cst.Ⅱ),where t.e lat.er is enriched in t._(2)O_(5),Nb_(2)O_(5)and *** chem.st.y and t.xt.ral crit.ria of t.e early st.ge CGm.Ⅰand Cst.Ⅰ,all are indicat.ve of m.gm.t.c ***,t.e lat.er CGm.Ⅱ,wodginit. and Cst.Ⅱwere influenced by t.e lat. m.gm.t.c t.-rich *** inclusions m.crot.erm.m.t.y shows crit.ria of phase separat.on represent.d by bot. boiling and fluid *** init.al fluid was supposed t. be of m.gm.t.c origin(m.gm.t.c CH4),t.at.was consequent.y influenced by fluid m.xing/dilut.on wit. post.hydrot.erm.l/m.t.oric wat.r wit. respect.t. t.e decom.ression process during *** const.uct.on gave rise t. an est.m.t. P-t.condit.ons(t.330-370℃,P=22-50 m.a).t.e fluid inclusions’m.crot.erm.m.t.y support. a t.ansit.on bet.een m.gm.t.c and lat. t. post.hydrot.erm.l act.vit.es in addit.on t. surface-derived fluid(m.t.oric fluid?)in a part.as m.in source for t.e polym.t.llic deposit..

关键词： colum.it.-group m.nerals wodginit. cassit.rit. m.gm.t.c-hydrot.erm.l fluid inclusion deposit. abu Dabbab

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Cyt.kine profile in Egypt.an hepat.t.s C virus genot.pe-4 in relat.on t. liver disease progression

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World Journal of Gast.oent.rology 2005年第42期11卷 6624-6630页

作者： Abdel-Rahm.n N Zekri m.ham.ed S el-Din Ashour Ahm.d Hassan Hanaa m.Alam.el-Din Am.l m. el-Shehaby m.ha A abu-Shady Virology and Im.unology Unit. Cancer Biology Depart.0}nt National Cancer Institute Cairo University Egypt m.crobiology Depart.0}nt. Facult. of Pharm.cy Azhar University Egypt m.crobiology and Im.unology Depart.0}nt. Sohag Facult. of m.dicine South Valley University Egypt Virology and Im.unology Unit.Cancer Biology Depart.0}nt National Cancer Institute Cairo University Egypt Biochem.st.y Depart.0}nt. el-Kaser el-Aini School of m.dicine Cairo University Egypt

AIm. t. observe t.e im.alance bet.een t.helper cell t.1 and t.2 cyt.kines in several chronic hepat.t.s disease at.different.st.ges of disease ***: We m.asured t.e cyt.kine levels of t.1 (IL-2 and IL-2R), t.2 (IL-10) and t.e pro-inflam.at.ry cyt.kines (IL-6 and IL-6R and t.F and t.F-RⅠ and Ⅱ)by t.e elISA t.chnique in t.e sera of 33 hepat.cellular carcinom. (HCC) pat.ent. and 20 chronic liver disease (CLD) pat.ent.. In addit.on, 20 asym.t.m.t.c hepat.t.s C virus carriers and 20 healt.y subject. negat.ve for hepat.t.s C virus(HCV) m.rkers served as ***: Ant.-HCV ant.bodies were found t. be posit.ve in 94% of HCC cases and 75% of CLD *** t.e ot.er hand, HCV virem.a was det.ct.d using Rt.CR in 67% of HCC cases and 65% of CLD cases. HBsAg was posit.ve in 9% of HCC cases and 30% of CLD *** bilharzial-Ab was posit.ve in 55% of HCC cases,65% of CLD cases and in 70% of asym.t.m.t.c carriers (ASC). HCC pat.ent. had significant.y higher values of IL-2R, t.F-RⅡ (P＜0.001), and t.F-RⅠ (P＞0.05), but.lower t.Fα (P＜0.001) and IL-6 (P = 0.032) in com.arison t. ASC. But. in com.arison t. non-cancer cont.ols, HCC pat.ent. had higher values of IL-2R, IL-6R, t.F-RⅠ and t.F-RⅡ, but.lower t.F-α (P＜0.001). CLD pat.ent. had higher IL-2R, t.F-RⅠ, and t.F-RⅡ (P＜0.001) t.an ASC. But. in com.arison t. non-cancer cont.ols, CLD pat.ent. had higher values of IL-2R, t.F-RⅠ and t.F-RⅡ, but.lower t.F-α (P＜0.001). IL-10 was higher (t.ough not.significant.y) in HCC and CLD pat.ent. t.an in sym.t.m.t.c carriers and non-cancer ***: Liver disease progression from.CLD t. HCC due t. HCV genot.pe-4 infect.on is associat.d wit. an im.alance bet.een t.1 and t.2 cyt.kines. IL-2R,t.F-RⅠ, and t.F-RⅡ could be used as pot.nt.al m.rkers.

关键词：细胞因子埃及丙型肝炎病毒肝疾病

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