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The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 27-31页

作者： Suzanah abdul Rahman Nur Amalina Ahmad nadia hanis abdul samat Syazana Zahri Afif Raihan abdullah Kit-Lam Chan Department of Biomedical Science Kulliyyah of Allied Health SciencesInternational Islamic University Malaysia School of Pharmaceutical Sciences Universiti Sains Malaysia

Objective: To evaluate the effects of Eurycoma longifolia(E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley ***: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 *** smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological ***: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ***: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility.

关键词： Eurycoma longifolia Oestrous cycle Testosterone Oestradiol Progesterone Ovaries

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