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Trends in treatment and overall survival among patients with proximal esophageal cancer

World Journal of Gastroenterology 2019年第47期25卷 6835-6846页

作者： Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch nadia haj mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen Department of Internal Medicine Division of Medical OncologyGROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Research Netherlands Comprehensive Cancer Organization(IKNL)Eindhoven 5612 HZNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Pathology and Data Analytics Leeds Institute of Medical Research at St James”sUniversity of LeedsLeeds LS97TFUnited Kingdom Department of Medical Oncology University Medical Center UtrechtUtrecht 3584 CXNetherlands Department of Radiation Oncology(MAASTRO clinic) GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6229 ETNetherlands Department of Internal Medicine Division of GastroenterologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Radiotherapy RadiotherapiegroepDeventer 7416 SENetherlands Department of Medical Oncology Amsterdam University Medical CentersUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiotherapy Insituut VerbeetenTilburg 5042 SBNetherlands Department of Medical Oncology Leiden University Medical CenterLeiden 2333 ZANetherlands Department of Surgery Catharina Hospital EindhovenEindhoven 5623 EJNetherlands Department of Public Health Erasmus Medical Center RotterdamRotterdam 3015 GDNetherlands

BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital ***-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been *** trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease *** optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life *** To establish trends in treatment and OS in patients with proximal esophageal *** In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer *** proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the *** in radiotherapy,chemotherapy,and surgery,and OS were *** were stratified by presence of distant *** Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment *** In total,2783 patients were *** the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,*** metastatic disease,the use of chemotherapy and radiotherapy increased over *** OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on ***

关键词： Esophagus Esophageal cancer Proximal Cervical Upper thoracic Trends Treatment Survival Outcome

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni nadia D’Ambrosi Department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Application of Modified Silica Coated Magnetite Nanoparticles for Removal of Iodine from Water Samples

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Nano-Micro Letters 2012年第1期4卷 57-63页

作者： Tayyebeh Madrakian Abbas Afkhami mohammad Ali Zolfigol Mazaher Ahmadi nadia Koukabi Faculty of Chemistry Bu-Ali Sina University

The adsorption of iodine onto silica coated magnetite nanoparticles(im-SCMNPs) that modified with imidazole was investigated for removal of high concentrations of iodine from wastewater. Modified silica magnetite nanoparticles showed high efficiency in removing iodine from wastewater samples. The optimum pH for iodine removal was 7.0-8.0. The adsorption capacity was evaluated using both the Langmuir and Freundlich adsorption isotherm models. The size of the produced magnetite nanoparticles was determined by X-ray diffraction analysis and scanning electron microscopy. Synthesized magnetite nanoparticles showed the high adsorption capacity and would be a good method to increase adsorption efficiency for the removal of iodine in a wastewater treatment process. The Langmuir adsorption capacity(qmax) was found to be 140.84 mg/g of the adsorbent.

关键词： Modified silica magnetite nanoparticles Iodine Imidazole Water samples

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Phospholipase C from Pseudomonas aeruginosa and Bacillus cereus:characterization of catalytic activity

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 860-866页

作者： Nooran Sherif Elleboudy mohammad Mabrouk Aboulwafa nadia Abdel-Haleem Hassouna Department of Microbiology and Immunology Faculty of PharmacyAin Shams University

Objective:To study characteristics of phospholipases C(PLCs),their importance for producing microorganisms us well us the potential of their use for industrial ***:PLC from Bacillus cereus(***) D101 was selected as an example of Gram-positive PLCs and PLC from Pseudomanas aeruginosa(***) D183 of Gram-negative *** were partially purified by ammonium sulfate precipitation followed by membrane *** purified preparations were used to study effect of different factors on activities as well as in substrate specificity tests which were conducted using a turbidimetric assay ***:Maximum activity was at pH 7 and 8 and 40 ℃ for *** PLC,and pH 8-10 and 37 ℃ for *** *** PLCs were inhibited by Pi at 5 mM or higher,whereas,PLC from *** only was inhibited by *** of *** PLC was not affected by removing Zn^(2+) ions from reaction mixture or their replacement with Ca^(2+),Ba^(2+),Mg^(2+) or Mn^(2+)***-a-vis,activity of *** PLC was found to be metal ion dependent PLCs from both isolates were relatively thermostable and showed maximum affinity toward *** and phosphatidylethanolamine were not good substrates and phosphatidylinositol,phosphatidylserine,phosphatidylglycerol and cardiolipin could be considered ***:Human body physiological conditions could favor activity of *** and *** *** enzymes may participate in phosphate scavenging and virulence of producing isolates but not in *** from both isolates are potential candidates for industrial use.

关键词： Phospholipase C Pseudomonas aeruginosa Bacillus cereus Catalytic activity Substrate specificity

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Predicting groundwater level of wells in the Diyala River Basin in eastern Iraq using artificial neural network

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Journal of Groundwater Science and Engineering 2020年第1期8卷 87-96页

作者： Abdulrahman Th mohammad Qassem H Jalut nadia L Abbas Baqubah Technical Institute Middle Technical University(MTU)BaghdadIraq Department of Civil Engineering College of EngineeringUniversity of DiyalaDiyalaIraq.

Al-Mansourieh zone is a part of Al-Khalis City within the province of Diyala and located in the Diyala River Basin in eastern Iraq with a total area about 830 *** is the main water source for agriculture in this *** well drilling without geological and hydraulic information has led the most of these wells to dry up ***,it is necessary to estimate the levels of groundwater in wells through observed *** this study,Alyuda NeroIntelligance 2.1 software was applied to predict the groundwater levels in 244 wells using sets of measured *** data included the coordinates of wells(x,y),elevations,well depth,discharge and groundwater *** ANN structures(5-3-3-1,5-10-10-1 and 5-11-11-1)were used to predict the groundwater levels and to acquire the best matching between the measured and ANN predicted *** coefficient of correlation,coefficient determination(R2)and sum-square error(SSE)were used to evaluate the performance of the ANN *** to the ANN results,the model with the three structures has a good predictability and proves more effective for determining groundwater level in *** best predictor was achieved in the structure 5-3-3-1,with R2 about 0.92,0.89,0.84 and 0.91 in training,validation,testing and all processes *** minimum average error in the best predictor is achieved in validation and testing processes at about 0.130 and 0.171 *** the other hand,the results indicated that the model has the potential to determine the appropriate places for drilling the wells to obtain the highest level of groundwater.

关键词： Groundwater Well ANN Diyala River

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Effect of Gd3+-,Pr3+-or Sm3+-substituted cobalt-zinc ferrite on photodegradation of methyl orange and cytotoxicity tests

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Journal of Rare Earths 2019年第12期37卷 1288-1295页

作者： Seyed Mahdi Peymani-Motlagh nadia Moeinian Mojtaba Rostami Mahdi Fasihi-Ramandi Ali Sobhani-Nasab Mehdi Rahimi-Nasrabadi mohammad Eghbali-Arani mohammad Reza Ganjali Teofil Jesionowski Hermann Ehrlich mohammad Ali Karimi Narges Ajami Department of Chemistry Imam Hossein UniversityTehran 16765-3454Iran Department of Chemistry Payame Noor UniversityTehran 19395-4697Iran Young Researchers and Elite Club Karaj BranchIslamic Azad UniversityKaraj ***Iran Molecular Biology Research Center Systems Biology and Poisoning InstituteBaqiyatallah University of Medical SciencesTehran ***Iran Social Determinants of Health(SDH)Research Center Kashan University of Medical SciencesKashan ***Iran Core Research Lab Kashan University of Medical SciencesKashan ***Iran Faculty of Pharmacy Baqiyatallah University of Medical SciencesTehran 195163759Iran Department of Physics University of KashanKashan ***Iran Center of Excellence in Electrochemistry Faculty of ChemistryUniversity of TehranTehran ***Iran Institute of Chemical Technology and Engineering Faculty of Chemical TechnologyPoznan University of TechnologyPoznan 60965Poland Institute of Electronic and Sensor Materials TU Bergakademie FreibergFreiberg 09599Germany

Gd3+-,Pr3+-or Sm3+-doped Co-Zn(Co0.5Zn0.5Fe2 O4)magnetic ferrites(i.e.,Co0.5Zn0.5Gd0.1Fe1.9O4,Co0.5Zn0.5Pr0.1Fe1.9O4 and Co0.5Zn0.5Sm0.1Fe1.9O4)were prepared using a facile sol-gel approach,and the structure,surface morphology and chemical composition of the products were studied by means of scanning electron microscopy(SEM),energy dispersive X-ray analysis(EDX),X-ray diffraction(XRD),UVvisible diffuse reflectance spectroscopy(DRS),photoluminescence(PL)spectroscopy,Fourier transform infrared spectroscopy(FT-IR)and vibrating sample magnetometer(VSM)*** patterns show the Co-Zn product is composed of cubic spinel phases with few impurities or secondary phases,and the average crystallite sizes of the samples are determined to be approximately^51—80,~99—181,~68—103 and^83—133 *** the coercivity and remnant and saturation magnetizations,evaluated by vibrating sample magnetometer(VSM),are found to increase linearly with the incorporation of Gd3+,Pr3+and Sm3+in the product *** CO1-xZnxFe2-yRyO4 photocatalyst sample is found to display a red shift in its absorption,and exhibits outstanding photocatalytic effects in the degradation of MO under ultraviolet(UV)*** is attributed to the reduction of the band gap of cobalt-zinc ferrite due to the presence of rare earth *** in vitro evaluations of the cytotoxic effects of the synthesized nanoparticles were performed on a HeLa cell line.

关键词： Magnetic ferrite Rare earth ions Photocatalyst Cytotoxicity Sol-gel

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Commutators with Finite Spectrum Ⅱ

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Acta Mathematica Sinica,English Series 2009年第5期25卷 815-830页

作者： nadia BOUDI Département

The purpose of this paper is to study derivations d, d′ defined on a Banach algebra A such that the spectrum a（[dx, d′x]） is finite for all x ∈ A. In particular we show that if the algebra is semisimple, then the... 详细信息

关键词： Banach algebras derivations commutators finite spectra socle

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Microscopic Calculations of Core-Polarization Effect on Inelastic Electron Scattering Form Factors for Different Parity States in （14^）

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Journal of Physical Science and Application 2012年第9期2卷 392-397页

作者： nadia mohammad Adeeb Dep. of Physics College of Science University of Baghdad Baghdad Iraq

Inelastic electron scattering form factors has been calculated for different parity for the two （C3） transitions of 14^N for （5.83MeV）（f^π, T = 20） level and, （5.106MeV）（f^π, T = 30） level in the frame work of shell model. The model space wave functions are generated by using the Cohen-Kurath （CK） interaction, where 4He is assumed as a core and ten nucleons are distributed over the lp-shell which forms the model space. Core-polarization effects （CP）（the effects from outside lp-shell model space） are included through the first order perturbation theory. The core-polarization effects increase the form factor to be up near the experimental data which are not sufficient to give a good comparison with the calculating data.

关键词： Nuclear reactions Inelastic form factors (e e') p-shell nuclei different parity states calculated first-ordercore-polarization effects.

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Theoretical investigation on organolanthanide guanidinate complexes

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Journal of Rare Earths 2010年第2期28卷 161-165页

作者： Salima Lakehal nadia Ouddai Laboratory of Chemistry of Materials and Alive:Activity ReactivityFaculty of ScienceUniversity of Batna

Density functional theory (DFT) calculations were carried out on the compounds Cp2Ln-guan for Ln=Y, Lu, Yb, Dy and Gd, [guan=(iPrN)2CN(iPr)2]. The results were compared with the X-ray structures that were available from the literature; the calculations reproduced quite well the experimental structural features in these complexes exhibiting distorted tetrahedron geometry. The calculated evolution of the Ln-guan bond as a function of the cation showed that lanthanide-ligand distances increased with the increa...

关键词： DFT guanidinate organolanthanide HOMO LUMO rare earths

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Mesopancreas:A boundless structure,namely the rationale for dissection of the paraaortic area in pancreaticoduodenectomy for pancreatic head carcinoma

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World Journal of Gastroenterology 2015年第10期21卷 2865-2870页

作者： nadia Peparini Azienda Sanitaria Locale Roma H- Distretto 3 00043 Ciampino (Rome)Italy

This review highlights the rationale for dissection of the 16a2 and 16b1 paraaortic area during pancreaticoduodenectomy(PD)for carcinoma of the head of the *** advances in surgical anatomy of the mesopancreas indicate that the retropancreatic area is not a single entity with well defined boundaries but an anatomical site of embryological fusion of peritoneal layers,and that continuity exists between the neuro lymphovascular adipose tissues of the retropancreaticand paraaortic *** advances in surgical pathology and oncology indicate that,in pancreatic head carcinoma,the mesopancreatic resection margin is the primary site for R1 resection,and that epithelialmesenchymal transition-related processes involved in tumor progression may impact on the prevalence of R1 resection or local recurrence rates after R0 *** concepts imply that mesopancreas resection during PD for pancreatic head carcinoma should be extended to the paraaortic area in order to maximize retropancreatic clearance and minimize the likelihood of an R1 resection or the persistence of residual tumor cells after R0 *** PD for pancreatic head carcinoma,the rationale for dissection of the paraaortic area is to control the spread of the tumor cells along the mesopancreatic resection margin,rather than to control or stage the nodal *** mesopancreatic resection cannot be considered"complete"or"en bloc",it should be"extended as far as possible"or be"maximal",including dissection of16a2 and 16b1 paraaortic areas.

关键词： Pancreatic carcinoma Mesopancreas Mesopancreas res

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