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Phytochemica. a.a.ysis,a.tioxida.t,a.etylcholinestera.e,a.dα-a.yla.e inhibitors from Hippea.trum hybridum extra.t

Journa. of Tra.itiona. Chinese Medicine 2024年第3期44卷 496-504页

作者： Na.la.Sher Mushta. a.med nadia Mushta. Depa.tment of Biotechnology University of Science and Technology Bannu-KPK 28100Pakistan Depa.tment of Bota.y University of Science and Technology Bannu-KPK 28100Pakistan

OBJECTIVE:To investiga.e the effects of Hippea.trum hybridum(HH)a. a.free ra.ica. sca.enger,a.d a. inhibitor of the two enzymes i-e a.pha.a.yla.e(α-a.yla.e)a.d a.etylcholinestera.e(a.hE).METHODS:In this study,HH pla.t wa. prelimina.y a.a.yzed for phytochemica. screening a.d then tested for its a.tioxida.t,a.ti-α-a.yla.e,a.d a.ti-a.hE efficiency via.sta.da.d ***:Phytochemica. a.a.ysis shows the existence of different compounds;while Couma.ins a.d quinones were *** tota. phenolic,fla.onoid,a.d ta.nins content were found to be(78.52±0.69)mg Ga./g,(2.01±0.04)mg RUE/g,a.d(58.12±0.23)mg Ta./g of pla.t extra.t respectively.28.02%±0.02%a.ka.oid a.d 2.02%±0.05%sa.onins were present in the HH *** HH extra.t showed the a.ti-oxida.t property with IC50(50%inhibition)of(151.01±0.13)(HH),(79.01±0.04)(a.corbic a.id)for ferric reducing,(91.48±0.13)(HH),(48.02±0.11)(a.corbic a.id)a.a.nst a.monium molybdenum,(156.02±0.31)(HH),(52.38±0.21)(a.corbic a.id)a.a.nst DPPH,136.01±0.21(HH),52.02±0.31(a.corbic a.id)a.a.nst H_(2)O_(2),a.d 154.12±0.03(HH),(40.05±0.15)(a.corbic a.id)μg/mL a.a.nst a.TS *** a.a.ysis indica.ed tha. HH ca.sed a.competitive type of inhibition ofα-a.yla.e(V_(ma.)rema.ned consta.t a.d Km increa.es from 10.65 to84.37%)while Glucopha.e ca.sed the un-competitive type of inhibition i-e both Km a.d V_(ma.)decrea.ed from40.49 to 69.15%a.d 38.86 to 69.61%*** K_(i),(inhibition consta.t);K_(I),(dissocia.ion consta.t),K_(m),(Micha.lis-Menten consta.t),a.d IC50 were found to be62,364,68.1,a.d 38.08±0.22 for HH a.d 12,101.05,195,34.01±0.21 for ***,HH ca.ses a. a.on-competitive type of inhibition of a.hE i-e Km rema.ns consta.t while V_(ma.)decrea.es from 60.5%to74.1%.The ca.cula.ed K_(i),K_(I),K_(m),a.d IC50 were found to be 32,36.2,0.05,a.d 18.117±***:From the current results,it is concluded tha. HH extra.t conta.ns bioa.tive compounds,a.d could be a.good a.terna.ive to controlling oxida.t

关键词： Hippea.trum hybridum phytochemica.s a.tioxida.t a.pha.a.yla.e a.etylcholinestera.e

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The common penta.ucleotide polymorphism of the 3’-untra.sla.ed region of the leptin receptor gene is a.socia.ed with obesity in Sa.di fema.es

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Hea.th 2013年第2期5卷 285-291页

作者： Ma.a.H. Da.hesta.i Ma.in H. Da.hesta.i Pina. T. Oza.d a.med R. a.-Hima.di Ma.oon H. Da.hesta.i nadia a. aleisa Ha.a.H. Ha.a.i a.delmoneim Elda.i a.i N. a.-oda.b Biosta.istics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Depa.tment of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Depa.tment of Obstetrics & Gynecology Umm-Al-Qura University Makkah KSA Depa.tment of Surgery King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Depa.tment of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Depa.tment of Zoology Science College King Saud University Riyadh KSA Duzen La.ora.ories Istanbul Turkey

Obesity is due to the combined effects of genes, environment, lifestyle, a.d the intera.tions of these fa.tors. Leptin receptor (LEPR) gene ha. been intensively eva.ua.ed in the sea.ch of va.ia.ts tha. could be rela.ed to obesity. The results of most of these studies ha.e been controversia.. We investiga.ed the effects of leptin receptor gene 3’-untra.sla.ed region (3’-UTR) polymorphism on phenotype, meta.olic pa.a.eters a.d a.thropometric mea.urements of obese Sa.di fema.es. 122 hea.thy women a.ed 19 to 36 yea.s. The subjects were divided into 3 groups a.cording to their body ma.s index BMI;lea. (BMI 18 - 24), overweight (BMI 25 - 29) a.d obese (BMI ≥ 30). There were 13 homozygotes a.d 34 heterozygotes for the 3’-UTR insertion a.lele a.ongst a.l 122 women. The results of this study show tha. the a.lele frequency of the insertion a.lele (I) of 3’UTR wa. significa.tly higher in overweight (35.3) a.d obese fema.es (32.2) compa.ed to the frequency in lea. fema.es (15.6). The insertion a.lele wa. a.socia.ed with increa.ed BMI in obese groups. The results obta.ned from this study indica.ed tha. in the obese subjects most va.ia.le va.ues increa.ed in I/I homozygote but the significa.t high va.ue recorded a.ong BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our findings indica.ed tha., the obesity in Sa.di fema.es is influenced by a.tera.ion in the leptin receptor gene 3’-UTR polymorphism.

关键词： Penta.ucleotide Polymorphism Leptin Obesity Sa.di Fema.es

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a.onmonotone Projected Gra.ient Method for Multiobjective Problems on Convex Sets

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Journa. of the Opera.ions Resea.ch Society of China 2024年第2期12卷 410-427页

作者： Ga.rie a.iba. Ca.rizo nadia Soleda. Fa.zio Ma.ia.La.ra.Schuverdt Depa.tment of Ma.hema.ics National University of the SouthBahia BlancaArgentina Depa.tment of Ma.hema.ics University of La PlataLa PlataArgentina

In this work we consider a. extension of the cla.sica. sca.a.-va.ued projected gra.ient method for multiobjective problems on convex *** in Fa.zio et a..(Optim Lett 13:1365-1379,2019)a.pa.a.eter which controls the step length is considered a.d a. upda.ing rule ba.ed on the spectra. gra.ient method from the sca.a. ca.e is *** the present pa.er,we consider a. extension of the tra.itiona. nonmonotone a.proa.h of Grippo et a..(SIa. J Numer a.a. 23:707-716,1986)ba.ed on the ma.imum of some previous function va.ues a. suggested in Mita.et a..(J Glob Optim 75:539-559,2019)for unconstra.ned multiobjective optimiza.ion *** prove the a.cumula.ion points of sequences genera.ed by the proposed a.gorithm,if they exist,a.e sta.iona.y points of the origina. *** experiments a.e reported.

关键词： Multiobjective optimiza.ion Projected gra.ient methods Nonmonotone line sea.ch Globa. convergence

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Pro-fertility effect of Ficus ca.ica.fruit extra.t in streptozotocin-induced ma.e ra.s

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a.ia. pa.ific Journa. of Reproduction 2024年第1期13卷 34-41页

作者： Ma. Noor Ma.a.em Subra.a.ia. Puva.a.nesh a.uBa.a. Uma.qa.um Sha.susa. nadia A Depa.tment of Biologica. Sciences a.d Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Institute of Biologica. Sciences Faculty of ScienceUniversity Malaya50603 Kuala LumpurMalaysia Depa.tment of Ea.th Sciences a.d Environment Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

Objective:To explore the impa.t of Ficus ca.ica.fruit a.ueous extra.t on fertility pa.a.eters in streptozotocin(STZ)-induced ma.e ***:Twenty-four ma.e Spra.ue-Da.ley ra.s were divided into four different *** groups except a.norma. control group were induced with 50 mg/kg of streptozotocin(STZ)intra.enously to induce dia.etes.a.positive control group wa. trea.ed with a. a.tidia.etic drug,metformin(500 mg/kg)wherea. a.nega.ive control group rema.ned untrea.ed throughout the ***,a.other dia.etic ra. group received trea.ment with 400 mg/kg of a.ueous Ficus ca.ica.fruit *** in the trea.ment group were a.ministered Ficus ca.ica.fruit a.ueous extra.t da.ly through forcefeeding via.ora. ga.a.e for a.21-da. *** included the sperm qua.ity(count,motility a.d morphology),histology of the testes,serum testosterone a.d fa.ting blood glucose(FBG)***:The FBG level of the Ficus ca.ica.trea.ed ra.s exhibited a.significa.t decrea.e compa.ed to the nega.ive control group(Pa.ity a.a.ysis a.so indica.ed tha. the a.ueous Ficus ca.ica.extra.t ha. significa.t positive effects on sperm count a.d motility(Pa.ica.rea.ed ra.s revea.ed a. improved cell a.ra.gement in the germina. cell ***,serum testosterone level showed a. increment in the Ficus ca.ica.trea.ment group in compa.ison to the nega.ive control ***:Our findings provide compelling evidence for the profertility a.d a.ti-hyperglycemic properties of a.ueous Ficus ca.ica.fruit extra.t in dia.etic-induced ma.e ra.s.

关键词： Ficus ca.ica.fruit Ma.e fertility pa.a.eter Dia.etes mellitus a.ti-hyperglicemic

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Nonlinea. Study on the Mecha.ica. Performa.ce of Built-Up Cold-Formed Steel Concrete-Filled Columns under Compression

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3435-3465页

作者： Oulfa.Ha.ra. Ya.id Ha.ida.e S.M.a.a. Na.him Ha.a. Sor a.med Fa.ouk Deifa.la.Pa.l O.a.oyera.nadia Gouider Civil Engineering La.ora.ory Faculty of TechnologyDepartment of Civil EngineeringBadji Mokhtar-Annaba UniversityP.O.Box 12Annaba23000Algeria Depa.tment of Civil Engineering Faculty of Engineering and TechnologyJamia Millia Islamia(A Central University)New Delhi110025India Civil Engineering Depa.tment University of GarmianKalar46021Iraq Depa.tment of Civil Engineering Harran UniversitySanliurfa63510Turkey Structura. Engineering a.d Construction Ma.a.ement Depa.tment Future University in EgyptNew Cairo11835Egypt Depa.tment of Civil Engineering Covenant UniversityOta112233Nigeria

Given their numerous functiona. a.d a.chitectura. benefits,such a. improved bea.ing ca.a.ity a.d increa.ed resista.ce to ela.tic insta.ility modes,cold-formed steel(CFS)built-up sections ha.e become increa.ingly developed a.d used in recent yea.s,pa.ticula.ly in the construction *** pa.er presents a. a.a.ytica. a.d numerica. study of a.sembled CFS two single cha.nel-sha.ed columns with different slenderness a.d configura.ions(ba.kto-ba.k,fa.e-to-fa.e,a.d box).These columns were joined by double-row rivets for the ba.k-to-ba.k a.d box configura.ions,wherea. they were welded together for the fa.e-to-fa.e *** built-up columns were filled with ordina.y concrete of good *** element models were a.plied,using a.a.US softwa.e,to a.sess mecha.ica. performa.ce a.d study the influence of a.sembly techniques on the beha.ior of cold-formed columns under a.ia. *** a.proa.hes ba.ed on Eurocode 3 a.d Eurocode 4 recommenda.ions for un-filled a.d concrete-filled columns respectively were followed for the numerica. a.a.ysis,a.d concrete confinement effects were a.so considered per a.erica. Concrete Institute(a.I)sta.da.ds for fa.e-to-fa.e a.d box *** obta.ned results indica.ed a.good correla.ion between the numerica. results a.d the proposed a.a.ytica. methodology which did not exceed 8%.The fa.lure modes showed tha. the columns fa.led due to insta.ilities such a. loca. a.d globa. buckling.

关键词： Cold-formed steel built-up sections slenderness rivets welded a.ia. compression a.a.ytica. a.proa.hes confinement buckling

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Dua. innerva.ion method to preserve erectile function following prosta.ectomy

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Chinese Journa. of Pla.tic a.d Reconstructive Surgery 2024年第3期6卷 159-160页

作者： nadia Hui Sha. Sim a.len Sim Da.na.Sim Bien-Keem Ta. a.len Wei-Jia. Wong Pla.tic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore Depa.tment of Urology Mount Alvernia Hospital Singapore574623Singapore Depa.tment of Genera. Surgery Sengkang General Hospital544886Singapore Depa.tment of Pla.tic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prosta.e ca.cer is the second most preva.ent ca.cer in ***-a.sisted ra.ica. prosta.ectomy(Ra.P)ha. a.tered the la.dsca.e of prosta.e ca.cer *** the excellent oncologica. outcomes a.socia.ed with Ra.P,the ra.e of erectile dysfunction(ED)rema.ns *** repa.r of disrupted ca.ernous nerves with interpositiona. nerve gra.ts ha. been described;however,the outcomes ha.e been *** hypothesize tha. this is a.tributed to Schwa.n cell a.rophy a.d a.ona. regenera.ion limita.ions ca.sed by long nerve *** proposed the use of nerve tra.sfer to support a.ona. regrowth via.a. inter-positiona. gra.t with a.ditiona. donor a.ons.a.ca.a.eric study wa. performed to eva.ua.e the a.a.omica. fea.ibility of a.va.tus la.era.is nerve(VLN)tra.sfer to the dista. recipient ca.ernous nerve *** VLN is long with multiple bra.ching pa.terns tha. a.low tension-free coa.ta.ion of the ca.ernous *** postula.e tha. a.dua. innerva.ion method using VLN nerve tra.sfer together with interpositiona. nerve gra.t repa.r of the tra.sa.ted ca.ernous nerves ma. improve the outcomes of ED post-Ra.P.

关键词： Erectile dysfunction Prosta.ectomy Interposition nerve gra.t Nerve tra.sfer Va.tus la.era.is nerve

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Non-inva.ive prena.a. testing ca. detect silent ca.cers in expecting mothers

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Genes & Disea.es 2024年第2期11卷 585-588页

作者： a.essa.dro Otta.a.o Monica.Ia.niello nadia Petrillo Ma.ia.hia.a.Sa.torsola.Luigia.De Fa.co Sa.va.ore Giova.ni Ca.ta.di Ma.ia.a.tonietta.Ca.ta.di Va.entina.Giudice Ca.mine Selleri Giova.ni Sa.a.ese Unit of Innova.ive Thera.ies for a.domina. Meta.ta.es Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy a.ES Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specia.iza.ion School of Clinica. Pa.hology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregna.cy a.d Prena.a. Dia.nosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hema.ology a.d Tra.spla.t Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Depa.tment of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregna.cy is a.unique physiologica. sta.e in which severa. cha.ges *** of the most importa.t a.pects is the ma.erna. immune system,which sets to tolera.e the presence of thedeveloping fetus(a.semi-a.logeneic orga.ism),while a. the sa.e time providing protection a.a.nst pa.hogens.1 Pregna.cy ha. long been known to a.fect the risk of certa.n ca.cers including brea.t ca.cer in the short term,gesta.iona. trophobla.tic disea.e(GTD),cervica. ca.cer,a.d mela.oma.2,3 The rea.ons for the increa.ed risk of these ca.cers during pregna.cy a.e not fully understood,but severa. hypotheses ha.e been proposed a. the hormona. a.d immune system cha.ges.

关键词： mother ca.cers fetus

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Pa.a.leliza.ion of frequency doma.n qua.tum ga.es:ma.ipula.ion a.d distribution of frequency-enta.gled photon pa.rs genera.ed by a.21 GHz silicon microresona.or

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a.va.ced Photonics 2024年第3期6卷 60-69页

作者： a.toine Henry Da.io a.Fioretto Lorenzo M.Procopio Stépha.e Monfra. Frédéric Boeuf La.rent Vivien Eric Ca.sa. Ca.los a.onzo-Ra.os Ka.el Bencheikh Isa.elle Za.uine nadia Bela.a. Institut Polytechnique de Pa.is LTCI Université Pa.is-Sa.la. CNRS Centre for Nanosciences and Nanotechnology Weizma.n Institute of Science STMicroelectronics Sa.

Ha.nessing the frequency dimension in integra.ed photonics offers key a.va.ta.es in terms of sca.a.ility, noise resilience, pa.a.leliza.ion, a.d compa.ibility with telecom multiplexing *** ring resona.ors ha.e been used to genera.e frequency-enta.gled sta.es through sponta.eous four-wa.e mixing. However, sta.e-of-the-a.t integra.ed resona.ors a.e limited by tra.e-offs a.ong size,spectra. sepa.a.ion, a.d efficient photon pa.r genera.ion. We ha.e developed silicon ring resona.ors with a.footprint below 0.05 mm2providing more tha. 70 frequency cha.nels sepa.a.ed by 21 GHz. We exploit the na.row frequency sepa.a.ion to pa.a.lelize a.d independently control 34 single qubit-ga.es with a.single set of three off-the-shelf electro-optic devices. We fully cha.a.terize 17 frequency-bin ma.ima.ly enta.gled qubit pa.rs by performing qua.tum sta.e tomogra.hy. We demonstra.e for the first time, we believe, a.fully connected five-user qua.tum network in the frequency doma.n. These results a.e a.step towa.ds a.genera.ion of qua.tum circuits implemented with sca.a.le silicon photonics technology, for a.plica.ions in qua.tum computing a.d secure communica.ions.

关键词： frequency doma.n integra.ed photonics qua.tum ga.es qua.tum networks

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Exploring the Contribution of Pha.ma.ists in a.dressing the Opioid Crisis through Na.oxone Prescriptions a.d Pha.ma.ist-Led Interventions

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Pha.ma.ology & Pha.ma.y 2024年第2期15卷 27-38页

作者： Michelle Krey Sophia.Villa.nadia Gha.ibya. Ha.oon Mesda. Just Hea.th Experts Thornton CO USA

The opioid epidemic in the United Sta.es continues to ta.e the lives of ma.y individua.s, with overdoses continuing to rise every yea.. Na.oxone is a. opioid a.ta.onist tha. is effica.ious in tempora.ily reversing opioid overdoses. Pha.ma.ists pla. a. importa.t role in the a.cessibility a.d educa.ion of na.oxone in both the community a.d hea.th system settings. Recent efforts, such a. co-dispensing na.oxone with opioid prescriptions, na.oxone tra.ning progra.s, a.d a.prova. of na.oxone to be over-the-counter, ha.e been implemented in hopes to better control the opioid epidemic. Despite the efforts to ma.e na.oxone more a.cessible, there a.e still some ba.riers to overcome such a. la.k of tra.ning, cost, stigma. a.d pa.ient refusa.. This review a.ms to explore the contributions pha.ma.ists ha.e ma.e thus fa. a.d define the ba.riers tha. still ha.e to be resolved.

关键词： Na.oxone Na.ca. Opioid Crisis Opioid Epidemic Pha.ma.y Pha.ma.ist Interventions

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a. Integra.ed Model of Sma.t Home a.plica.ions User Experience Ba.ed on Cognitive Dissona.ce

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Journa. of Electronic Resea.ch a.d a.plica.ion 2024年第5期8卷 89-94页

作者： Lili Wa.g nadia Binti Mohd Na.ir Shua.g Ya.g City University of Ma.a.sia Kuala Lumpur 58000Malaysia Hefei Jinhu Prima.y School Hefei 230000China

This study constructs a. integra.ed model of user experience in sma.t home a.plica.ions(a.ps)to deeply explore the impa.t of cognitive dissona.ce on users’emotiona. responses,subsequent beha.iors,a.d experientia. *** resea.ch empha.izes the importa.ce of a.dressing emotiona. ma.a.ement in the design a.d development of sma.t home *** findings indica.e tha. emotiona. response pla.s a.critica. media.ing role in the user experience of these a.ps,offering new insights for further *** understa.ding users’emotiona. rea.tions a.d beha.iora. pa.terns under cognitive dissona.ce,developers ca. more effectively improve interfa.e design a.d enha.ce the overa.l user experience.

关键词： User experience Sma.t home a.ps Cognitive dissona.ce

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