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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Cluster dynamics modeling of niobium and titanium carbide precipitates inα-Fe andγ-Fe

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Chinese Physics B 2022年第2期31卷 509-515页

作者： nadezda Korepanova 顾龙 Mihai Dima 徐瑚珊 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China Institute for Physics and Nuclear Engineering Bucharest 077125Romania School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Paul Scherrer Institute Villigen 5232Switzerland

Kinetic behaviors of niobium and titanium carbide precipitates in iron are simulated with cluster *** simulations,carried out in austenite and ferrite for niobium carbides,and in austenite for titanium carbide,are analyzed for dependences on temperature,solute concentration,and initial cluster *** results are presented for different temperatures and solute concentrations,compared to experimental data *** show little impact of initial cluster distribution beyond a certain relaxation time and that highly dilute alloys with monomers only present a significantly different behavior from denser alloys or ones with different initial cluster distributions.

关键词： cluster dynamics precipitates precipitation kinetics carbides

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Epidural oscillating field stimulation increases axonal regenerative capacity and myelination after spinal cord trauma

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Neural Regeneration Research 2022年第12期17卷 2730-2736页

作者： Maria Bacova Katarina Bimbova Alexandra Kisucka nadezda lukacov. Jan Galik Institute of Neurobiology of Biomedical Research Center Slovak Academy of SciencesSoltesovejKosiceSlovak Republic

Oscillating field stimulation(OFS)with regular alterations in the polarity of electric current is a unique,experimental approach to stimulate,support,and potentially guide the outgrowth of both sensory and motor nerve fibers after spinal cord injury(SCI).In previous experiments,we demonstrated the beneficial effects of OFS in a 4-week survival period after *** this study,we observed the major behavioral,morphological,and protein changes in rats after 15 minutes of T9 spinal compression with a 40 g force,followed by long-lasting OFS(50μA),over a 8-week survival *** groups of rats were analyzed:rats after T9 spinal compression(SCI group);SCI rats subjected to implantation of active oscillating field stimulator(OFS+SCI group);and SCI rats subjected to nonfunctional OFS(nOFS+SCI group).Histopathological analysis of spinal tissue indicated a strong impact of epidural OFS on the reduction of tissue and myelin loss after SCI in the segments adjacent to the lesion *** fluorescent analysis of the most affected areas of spinal cord tissue revealed a higher number of spared axons and oligodendrocytes of rats in the OFS+SCI group,compared with rats in the SCI and nOFS+SCI *** protein levels of neurofilaments(NF-l),growth-associated protein-43(marker for newly sprouted axons),and myelin basic protein in rats were signifiantly increased in the OFS+SCI group than in the nOFS+SCI and SCI *** suggests a supporting role of the OFS in axonal and myelin regeneration after ***,rats in the OFS+SCI group showed great improvements in sensory and motor functions than did rats in the nOFS+SCI and SCI *** these findings suggest that long-lasting OFS applied immediately after SCI can provide a good microenviroment for recovery of damaged spinal tissue by triggering regenreative processes in the acute phase of injury.

关键词： axonal regenerative capacity behavioral assessment epidural stimulation motor recovery myelin regeneration oscillating field stimulation spinal cord injury

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How acute myeloid leukemia(AML)escapes from FMS-related tyrosine kinase 3(FLT3)inhibitors?Still an overrated complication?

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Cancer Drug Resistance 2023年第2期6卷 223-238页

作者： Salvatore Perrone Tiziana Ottone nadezda Zhdanovskaya Matteo Molica Hematology Polo Universitario PontinoS.M.Goretti HospitalLatina 04100Italy Department of Biomedicine and Prevention the University of Rome“Tor Vergata”Rome 00100 Italy Neuro-Oncohematology Santa Lucia FoundationI.R.C.C.S.Rome 00100Italy Hematology Department of Translational and Precision MedicineSapienza UniversityRome 00161Italy Hematology Unit S.Eugenio HospitalASL Roma 2Rome 00144Italy.

FMS-related tyrosine kinase 3(FLT3)mutations,present in about 25%-30%of acute myeloid leukemia(AML)patients,constitute one of the most frequently detected mutations in these *** binding of FLT3L to FLT3 activates the phosphatidylinositol 3-kinase(PI3K)and RAS pathways,producing increased cell proliferation and the inhibition of *** types of FLT3 mutations exist:FLT3-ITD and FLT3-TKD(point mutations in D835 and I836 or deletion of codon I836).A class of drugs,tyrosine-kinase inhibitors(TKI),targeting mutated FLT3,is already available with 1st and 2nd generation molecules,but only midostaurin and gilteritinib are currently ***,the emergence of resistance or the selection of clones not responding to FLT3 inhibitors has become an important clinical dilemma,as the duration of clinical responses is generally limited to a few *** review analyzes the insights into mechanisms of resistance to TKI and poses a particular view on the clinical relevance of this *** resistance been overlooked?Indeed,FLT3 inhibitors have significantly contributed to reducing the negative impact of FLT3 mutations on the prognosis of AML patients who are no longer considered at high risk by the European LeukemiaNet(ELN)***,several ongoing efforts to overcome resistance to FLT3-inhibitors will be presented:new generation FLT3 inhibitors in monotherapy or combined with standard chemotherapy,hypomethylating drugs,or IDH1/2 inhibitors,Bcl2 inhibitors;novel anti-human FLT3 monoclonal antibodies(e.g.,FLT3/CD3 bispecific antibodies);FLT3-CAR T-cells;CDK4/6 kinase inhibitor(e.g.,palbociclib).

关键词： Acute myeloid Leukemia FLT3 gilteritinib midostaurin TKI-inhibitor resistance quizartinib sorafenib crenolanib

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长城遗址景区游客评论的可视化对比研究

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当代旅游 2022年第13期 49-51页

作者：林静 nadezda Sorokina 又松大学旅游管理学院

本研究以长城两个遗址景区（八达岭长城和慕天峪长城）为样本，利用其在评论网站猫途鹰（***）上的21000条国外游客评论来进行游客评论的可视化对比研究。利用可视化工具“最小生成树”（Minimum Spanning Tree）和“主题河”（ThemeRi... 详细信息

本研究以长城两个遗址景区（八达岭长城和慕天峪长城）为样本，利用其在评论网站猫途鹰（***）上的21000条国外游客评论来进行游客评论的可视化对比研究。利用可视化工具“最小生成树”（Minimum Spanning Tree）和“主题河”（ThemeRiver）来描述两个景区在游客评论中所呈现的突出特征及特征间关系。结果表明，虽然这两个景区都很受国外游客欢迎，但游客在景区服务、基础设施和风景感知方面存在较显著差异。

关键词：长城可视化在线评论最小生成树主题河

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Characterization of Manmade and Recycled Cellulosic Fibers for Their Application in Building Materials

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Journal of Renewable Materials 2019年第11期7卷 1121-1145页

作者： nadezda Stevulova Viola Hospodarova Adriana Estokova Eva Singovszka Marian Holub Stefan Demcak Jaroslav Briancin Anton Geffert Frantisek Kacik Vojtech Vaclavik Tomas Dvorsky Technical University of Kosice Faculty of Civil EngineeringInstitute of Environmental EngineeringVysokoskolska 404200 KosiceSlovakia Institute of Geotechnics of the Slovak Academy of Sciences Watsonova 4504353 KosiceSlovakia Technical University in Zvolen Faculty of Wood Sciences and TechnologyDepartment of Chemistry and Chemical TechnologiesT.G.Masaryka 2117/2496053 ZvolenSlovakia VSB-Technical University of Ostrava Faculty of Mining and GeologyDepartment of Environmental Engineering17.listopadu 15/217270833 Ostrava-PorubaCzech Republic

The aim of this study was to characterize two types of cellulosic fibers obtained from bleached wood pulp and unbleached recycled waste paper with different cellulose content(from 47.4 percent up to 82 percent),to compare and to analyze the potential use of the recycled fibers for building application,such as plastering *** in the chemical composition,cellulose crystallinity and degree of polymerization of the fibers were *** recycled fibers of lower quality showed heterogeneity in the fiber sizes(width and length),and they had greater surface roughness in comparison to high purity wood pulp *** high purity fibers(cellulose content>80.0 percent)had greater crystallinity and more homogeneous and smooth surfaces than the recycled *** presence of calcite and kaolinite in all of the recycled cellulosic fibers samples was confirmed,whereas only one wood pulp sample contained *** influence of the chemical composition was reflected in the fiber density *** in the chemical composition and cellulose structure of the fibers affected the specific surface area,porosity and thermo physical properties of the *** favorable values of thermal conductivity were reached for the recycled fibers than for the wood pulp *** the suitability of the recycled fibers with inorganic impurities originating from the paper-making processes for their use as fillers in plastering mortars(0.5 wt.%fiber content of the total weight of the filler and binder)confirmed their application by achieving a compressive strength value of 28 day-cured fiber-cement mortar required by the standard as well as by measured more favorable value of capillary water absorption coefficient.

关键词： Wood pulp waste paper fiber properties characterization compressive strength of mortars

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WOMEN TIN CHINA Shifting Gender Landscapes in the Middle Kingdom

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城市漫步（GBA版） 2018年第9期 36-45页

作者： Erica Martin nadezda Grapes MJgraphics 不详

When began writing this article,my plan was to open with a reterence to a survivor ot sexual misconduct in *** that meant focusing on any numher of university cases,from the overdue retribution for the tragedy of Gao Yan's suicide at Peking University in 1998,to the successful student petition at Guangzhou's Sun Yat-sen Wniversity to dismiss Professor Zhang Peng for sexual assoult on July 10.

关键词： dis Middle sexual

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Characterization of Cellulosic Fibers by FTIR Spectroscopy for Their Further Implementation to Building Materials

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American Journal of Analytical Chemistry 2018年第6期9卷 303-310页

作者： Viola Hospodarova Eva Singovszka nadezda Stevulova Institute of Environmental Engineering Technical University of Ko&#154 ice Ko&#154 ice Slovakia

Nowadays, the material recycling is a growing trend in development of building materials and therefore using of secondary raw materials for production new building materials is in accordance with sustainable development in civil engineering. Therefore, it is increasingly becoming crucial to accelerate the transition from application of non-renewable sources of raw materials to renewable raw materials. One fast renewable resource is natural plant fibers. The use of the cellulosic fibers as environmentally friendly material in building products contributes to the environmental protection and saves non-renewable resources of raw materials. Wood fibers and recycled cellulose fibers of waste paper appear as suited reinforcing elements for cement-based materials. In this paper, there is used application of Fourier transform infrared spectroscopy (FTIR) on cellulose fibers coming from different sources. FTIR spectra of cellulose fiber samples are investigated and compared with reference sample of cellulose.

关键词： Renewable Raw Materials Cellulose Fibers Infrared Spectroscopy

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俄罗斯环境现状与治理措施

俄罗斯环境现状与治理措施

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作者： Noskova nadezda（娜佳）天津科技大学

学位级别：硕士

这篇论文的第一部分包括如下内容:提出研究问题,国内外文献研究综述,科学和技术研究的视角,研究的方法和框架,论文的创新性等。环境安全是人类面临的主要问题之一。它在文学方面的概念被看做是阻止和消除危险的能力。这种危险包括威胁... 详细信息

这篇论文的第一部分包括如下内容:提出研究问题,国内外文献研究综述,科学和技术研究的视角,研究的方法和框架,论文的创新性等。环境安全是人类面临的主要问题之一。它在文学方面的概念被看做是阻止和消除危险的能力。这种危险包括威胁社会生活各个方面的部分。俄罗斯及其区域生态安全格局的要素之一是国家环保政策。按照政治文献给出的定义,政策是组织监管并控制公司的范围,在经济,思想,法律,文化,宗教,环境等其他相似领域也有占有一个特殊的位置。环境政策是一项旨在保护和改善环境的政策,它要求合理利用和复兴自然资源,保护社会发展,并且确保人类和环境的安全性和它的栖息地正常运作。按照"国家安全概念",俄罗斯是最大的国家,在全球进程中起重要作用。这有利于形成一个多极世界构造的思想,以及国际化流程的多边管理思想的发展机制。一个国家未来的成功直接依赖于自然遗产。这方面的国家政策应该有效力的,这非常重要。在过去的十年俄罗斯重新定义了确保环境安全的方法并设计了新的计划来应对环境问题。这个政策有一个重要特征,那就是形成国内新的环境管理体系会在西方国家形成一个相当大的影响。在过去的十年里,市场社会应用的各种体制机制在俄罗斯被传承和采纳。本文的写作目的是研究现代俄罗斯的环境政策在形成和实施过程中的影响性质。这一研究目的的实现需要解决如下目标:--确立全球环境对国家立场影响的重要议题;--分析全球因素在形成生态环境领域的影响规模和特点;--确定俄罗斯联邦的环境政策的内容和性质对环境的影响主要作用;--评估存在的问题和实施俄罗斯联邦环境政策的有效性。该研究的目的是形成和实施俄罗斯国家环保政策的过程。目的是研究俄罗斯联邦在环保领域实施政策的基本原则,对一些发达国家经验的合理利用,并且确定结束本国环境危机的方法。这项研究的结果提供了在全球化背景下,在生态学领域方面有关俄罗斯政策问题的知识增量。其中一些在进一步的研究可被使用。其中,分析了全球化发展在生态学领域的趋势和它们对国家政策的影响,依靠降低全球化进程下环境政策降低的可能性,从国家现实政策的立场上分析环境立法演化,环境竞争力的定义被看做是二十一世纪俄罗斯环境政策的发展前景。在分析中使用的研究方法是一套科学合理的规则和模式。其中包括:结构和功能,体制,系统性,比较,社会学,历史和定量的方法等方面的知识。在研究方法的选择方面,参考国内外的学科经典,以及方法方式的相关参考。在分析全球化生态进程趋势和当代世界环境政策发展趋势时,我采用了比较分析,社会学和历史学的方法。在这些研究方法的辅助下,可以识别出现代环境政策的主要趋势,以及一些国家的国际水平。为了研究俄罗斯环境部门的财政情况,我构建了一个数学模型,通过分析得到结论。第二章我论文的第二部分是研究中用到的相关理论基础。本章包括国内外相关研究的概况,环境政策的概况,以及它的形成和实施。环境政策是一个包含经济,法律,教育和其他措施的系统,它的目的是为了控制环境状况和和确保该国合理利用自然资源。环境政策的框架分为以下几个层次:-国际-国家(民族)-区域-本地而且,在当前的社会经济条件下,很多注意力集中在个别经济主体(尤其是工业企业)的环境政策的形成和实施上,他们是环境污染的主要贡献者。在过去的十年,环境政策及其相关问题已经变成一个非常热门的话题,一些国内外学者都在积极研究他们。W.贝克,D.米度,B.卡门,N.V.摩西,R.英格哈特,G.肯尼在全球化方面的基础工作包括,从政治方面评估了环境问题在我们这个时代的其他全球性问题中的作用,解释了他们之间的相互关系和相互作用。这一基本工作体现了我们现代社会是一个"风险社会"。正如哈贝马斯展示的一样,在这个社会,政治和政策的界限正在扩大。新的角色交织在公众中,并潜伏在政策相互作用的活动中。在E.多布森,G.V.科索沃,A.I考斯汀,E.I.格鲁斯卡瓦的研究中展示了,环境政治的演变和评估"磨合问题"的主要阶段。在夫门库的作品中,对环境和政治的论述进行了细节的描述。作者把他的起源与人们对环境影响的风险规模联系起来,详细探讨危言耸听的论述和可持续发展的论述。在生态经济学领域,可持续发展理论的概念方面的重大意义被大量刊登在他的刊物上。A.I.阔斯提娜,N.V.舒丽妮,V.A.斯泥瓦研究了境政策的结构和与其他政策的联系以及环境进程的形态.环保问题是一个非常迫切,并且和全球经济的领导者之一的中国有关。中国,地域辽阔,是世界上人口最多的国家的领导人之一。针对日益严重的环境问题的背景下,中国学者正试图全面学习导致环境恶化的成因和因素,以证据为基础,国家和社会来采取合适的政策保护环境。这个问题在DiXin X.,Chunye C.,Baoding X.,Guanfen M.,Zhihong X.,Bing W.,Guangsheng Z.,Ming Z.,Hongy

关键词：俄罗斯环境政策环境安全环境管理

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Isolation of γδT cells from mouse small intestine

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Open Journal of Immunology 2013年第4期3卷 221-223页

作者： nadezda Snegireva Marina Gavrilova Ekaterina Sidorova Mechnikov Institute of Vaccine and Sera of RAMS Moscow Russia

Gamma/delta T cells (γδТ cells) are among the first lymphoid cells appearing in the ontogenesis. Many of γδТ cells are located in the small intestine/lamina propria of mice and human, where they cooperate with different cells (B-1 cells, in particular) and influence their activity. However, such interactions are studied rather scanty, and the functional role of γδТ cells in the intestine?is not yet fully elucidated. To study the interactions of mouse γδТ cells with other cells it is necessary to have purified cell populations. Unfortunately, most approaches used for isolation of human γδТ cells are not suitable for isolation of mouse γδТ cells. The aim of the present study is the modification of the method of mouse intestinal γδТ cell isolation in the quantities sufficient for the in vivo and in vitro experiments.

关键词： Gamma/Delta T Cells Small Intestine Intraepithelial Lymphocytes Magnetic Separation

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