检索结果-南通市图书馆

Impact of body mass index on hepatocellular carcinoma recurrence after liver transplantation through long-term follow-up

引用

Hepatobiliary Surgery and Nutrition 2021年第5期10卷 598-609页

作者： nada el-domiaty Faouzi Saliba Vincent Karam Rodolphe Sobesky Wafaa Ibrahim Eric Vibert Gabriella Pittau Khaled Amer Maysaa ASaeed Jihan AShawky Daniel Cherqui RenéAdam Didier Samuel AP-HP Hôpital Paul Brousse Hepato-Biliary CentreINSERM UMR 1193UniversitéParis SaclayVillejuifFrance Tropical Medicine Department Faculty of MedicineZagazig UniversityZagazigEgypt Statistics Department Faculty of Economics and Political ScienceCairo UniversityCairoEgypt Hepato-Biliary and Liver Transplant Department International Medical CenterCairoEgypt

Background:Obesity is associated with increased oncological risk and outcomes but the evidence surrounding the effect of body mass index(BMI)on increased risk of hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)is still *** purpose of this retrospective study of a large cohort of adult patients transplanted for HCC was to investigate the effect of BMI on the incidence of HCC recurrence and ***:Data from 427 adult recipients transplanted for HCC between 2000 and 2017 were *** were classified at time of LT according to the World Health Organization BMI classification into 3 groups;group 1:BMIely 68.6%,47.3%and 40.8%in group 1,73.3%,66.2%and 49.5%in group 2 and 68.8%,57.5%and 47.7%in group 3(log rank P=0.47).Conclusions:Recipient BMI at time of transplant and during follow-up didn’t impact the incidence of HCC recurrence nor long-term patient survival,irrespective to the status of the patients and their tumor characteristic at time of *** present study clearly confirms that obesity should not be considered,when selecting patients with HCC to LT,as a predictive factor of recurrence.

关键词： Hepatocellular carcinoma(HCC) obesity body mass index(BMI) nutrition liver transplantation(LT) hepatocellular carcinoma recurrence(HCC recurrence)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of Real-Time Distributed Denial-of-Service (DDoS) Attacks on Internet of Things (IoT) Networks Using Machine Learning Algorithms

引用

Computers, Materials & Continua 2024年第8期80卷 2139-2159页

作者： Zaed Mahdi nada Abdalhussien Naba Mahmood Rana Zaki Information Technology Center University of TechnologyBaghdad00964Iraq Continuous Education Center University of TechnologyBaghdad00964Iraq Computer Science Department University of TechnologyBaghdad00964Iraq

The primary concern of modern technology is cyber attacks targeting the Internet of *** it is one of the most widely used networks today and vulnerable to ***-time threats pose with modern cyber attacks that pose a great danger to the Internet of Things(IoT)networks,as devices can be monitored or service isolated from them and affect users in one way or *** Internet of Things networks is an important matter,as it requires the use of modern technologies and methods,and real and up-to-date data to design and train systems to keep pace with the modernity that attackers use to confront these *** of the most common types of attacks against IoT devices is Distributed Denial-of-Service(DDoS)*** paper makes a unique contribution that differs from existing studies,in that we use recent data that contains real traffic and real attacks on IoT *** a hybrid method for selecting relevant features,And also how to choose highly efficient *** gives the model a high ability to detect distributed denial-of-service *** model proposed is based on a two-stage process:selecting essential features and constructing a detection model using the K-neighbors algorithm with two classifier algorithms logistic regression and Stochastic Gradient Descent classifier(SGD),combining these classifiers through ensemble machine learning(stacking),and optimizing parameters through Grid Search-CV to enhance system *** were conducted to evaluate the effectiveness of the proposed model using the CIC-IoT2023 and CIC-DDoS2019 *** evaluation demonstrated the potential of our model in robust intrusion detection in IoT networks,achieving an accuracy of 99.965%and a detection time of 0.20 s for the CIC-IoT2023 dataset,and 99.968%accuracy with a detection time of 0.23 s for the CIC-DDoS 2019 ***,a comparative analysis with recent related works highlighted the superiority of our methodology in in

关键词： DDoS Service networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)

引用

Open Journal of Nephrology 2024年第2期14卷 275-293页

作者： Rihab Dkhissi nada el Kadiri Tarik Bouattar Loubna Benamar Naima Ouzeddoun Department of Nephrology-Dialysis-Renal Transplantation IbnSina Hospital Mohammed V University Rabat Morocco

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in developed countries. The aim of this study is to describe the predictive factors for the development of end-stage chronic kidney disease (CKD) in the course of this disease. Material and Methods: This is a retrospective, descriptive, and analytical study including 300 cases of ADPKD collected at the Nephrology Department of Ibn-Sina Hospital in Rabat over a period of 30 years (1993 to 2023). Included in the study are all patients with ADPKD meeting the ultrasound diagnostic criteria. The analysis focused on demographic, clinical, paraclinical, evolutionary data, as well as prognostic factors associated with renal function deterioration. Results: The mean age of patients at diagnosis is 51.53 +/− 17 years [16 - 93] with a male predominance. The median serum creatinine at diagnosis is 15.5 mg/l [10 - 34]. 21% of patients had ESRD (eGFR 300 mg/24h (21%). The most common cystic complication is hemorrhage (12.3%). 21.3% of patients had hepatorenal polycystic disease. In adjusted analysis, the predictive risk factors for the occurrence of ESRD were smoking (p = 0.019), anemia (p Conclusion: ADPKD can progress insidiously to ESRD. Identification and early treatment of predictive factors for poor renal prognosis could contribute to a better outcome for this disease.

关键词： ADPKD ESRD Factors of Poor Renal Prognosis Renal and Extra-Renal Manifestations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Primary Hyperoxaluria Type 1 in Adulthood: Case Series

引用

Open Journal of Nephrology 2024年第3期14卷 350-360页

作者： Sara el Maakoul nada el Kadiri Nabil Hmaidouch Salma Belmokadem Loubna Benamar Tarik Bouattar Naima Ouzeddoun Department of Nephrology Dialysis Renal Transplantation Ibn Sina University Hospital-Rabat Rabat Morocco Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.

关键词： Primary Hyperoxaluria Adulthood Kidney Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peripartum Cardiomyopathy Complicated by Ventricular Tachycardia during Labor: A Case Report and Literature Review

引用

Open Journal of Obstetrics and Gynecology 2024年第3期14卷 365-380页

作者： nada Alayed Department of Obstetrics and Gynecology College of Medicine King Saud University King Saud University Medical City Riyadh Saudi Arabia

Background: Peripartum cardiomyopathy (PPCM) is a rare disease that typically affects young, healthy women. Because PPCM is associated with significant mortality, timely diagnosis and management are essential. Ventricular tachycardia (VT) is a major complication and contributor to sudden death. Available data on VT in patients with PPCM are limited. Aim: This case report demonstrates the clinical presentation, antenatal care, and management of labor and delivery in a patient with PPCM complicated by VT. Case report: 36-year old patient G4P3 presents at 27 weeks gestation to the emergency department complaining of chest tightness, palpitations, and profuse sweating. Peripartum cardiomyopathy was diagnosed after her last pregnancy a few years prior. Ventricular tachycardia was diagnosed at this visit and treated successfully. The remainder of the pregnancy was uneventful until she had another episode of ventricular tachycardia during labor. Treatment using antiarrhythmics (diltiazem, amiodarone, adenosine) highlights the importance of prompt intervention and the need for a range of therapeutic options. Results: This case demonstrated successful VT management during pregnancy and labor, emphasizing multidisciplinary collaboration, influencing maternal and fetal outcomes positively, providing insights into optimal care strategies. Conclusion: Peripartum cardiomyopathy complicated by ventricular tachycardia is a life-threatening combination. This case highlights the importance of timely diagnosis and management with combined care between cardiologists, maternal fetal medicine specialists and anesthesiologists to prevent morbidities and sudden maternal death.

关键词： Peripartum Cardiomyopathy Ventricular Tachycardia High Risk Pregnancy Antenatal Care Delivery Planning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms

引用

Environment & Health 2024年第7期2卷 474-485页

作者： nada J.Daood Daniel P.Russo elena Chung Xuebin Qin Hao Zhu Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms Department of Chemistry and Biochemistry Rowan UniversityGlassboroNew Jersey 08028United States Center for Biomedical Informatics and Genomics Tulane University School of MedicineNew OrleansLouisiana 70112United States Tulane National Primate Research Center Tulane University School of MedicineCovingtonLouisiana 70433United States

Computational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals for their potential ***,few computational modeling studies for immunotoxicity were reported,with few models available for predicting toxicants due to the lack of training data and the complex mechanisms of *** this study,we employed a data-driven quantitative structure–activity relationship(QSAR)modeling workflow to extensively enlarge the limited training data by revealing multiple targets involved in *** this end,a probe data set of 6,341 chemicals was obtained from a high-throughput screening(HTS)assay testing for the activation of the aryl hydrocarbon receptor(AhR)signaling pathway,a key event leading to *** this probe data set against PubChem yielded 3,183 assays with testing results for varying proportions of these 6,341 compounds.100 assays were selected to develop QSAR models based on their correlations to AhR *** individual QSAR models were built for each assay using combinations of four machine-learning algorithms and three molecular fingerprints.5-fold cross-validation of the resulting models showed good predictivity(average CCR=0.73).A total of 20 assays were further selected based on QSAR model performance,and their resulting QSAR models showed good predictivity of potential immunotoxicants from external *** study provides a computational modeling strategy that can utilize large public toxicity data sets for modeling immunotoxicity and other toxicity endpoints,which have limited training data and complicated toxicity mechanisms.

关键词： Immunotoxicity QSAR Machine learning Aryl hydrocarbon receptor Data mining

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

调查TikTok食品广告对意大利年轻人购买意愿的影响

调查TikTok食品广告对意大利年轻人购买意愿的影响

引用

作者： nada Fanotto 华东师范大学

学位级别：硕士

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Dunbar Syndrome and Hypoxic Hepatitis: An Unusual Presentation

引用

Open Journal of Gastroenterology 2024年第6期14卷 226-232页

作者： Hajar Cherkaoui Ismail Chaouech Yousra el Abidi Haroun Robleh Asmae Lamine Maria Lahlali nada Lahmidani Amine Mekkaoui Mounia elyousfi Dafr Allah Benajah Adil Ibrahimi Mohammed el Abkari Nizar Bouardi Mohammed Maaroufi Hakima Abid Department of Gastroenterology University Hospital Hassan II Fez Morocco Faculty of Medicine and Pharmacy Fez Morocco Department of Radiology University Hospital Hassan II Fez Morocco

Hypoxic hepatitis, also known as ischemic hepatitis, is characterized by acute hepatocellular injury due to inadequate oxygen delivery to the liver. Celiac trunk stenosis can lead to hepatic ischemia and subsequent liver damage. We present the case of an 81-year-old patient with a history of hypertension, ischemic heart disease, hypothyroidism, and biliary lithiasis, who developed hypoxic hepatitis secondary to Dunbar syndrome and a stenosis of the superior mesenteric artery. The patient improved symptoms and liver function tests with conservative management, including intravenous fluids and supportive care. Long-term management involved continued antiplatelet therapy and statins, with consideration of further interventions for celiac trunk stenosis. This case underscores the importance of recognizing Dunbar syndrome as well as superior mesentery trunk stenosis as a potential cause of hypoxic hepatitis. It highlights the need for multidisciplinary management in such cases.

关键词： Dunbar Syndrome Hypoxic Hepatitis Stenosis of Mesentery Artery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the Impact of Direct-Acting Antivirals on Hepatitis-Linked Cirrhosis: A Comprehensive Analysis of Fibrosis, Child Score, and Disease Progression

引用

Open Journal of Gastroenterology 2024年第6期14卷 203-212页

作者： Hajar Cherkaoui Maryam elkhayari Maria Lahlali Asmae Lamine nada Lahmidani Amine Mekkaoui Mounia elyousfi Dafr Allah Benajah Mohammed el Abkari Adil Ibrahimi Hakima Abid Department of Hepato-Gastroenterology Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy of Fez USMBA Fez Morocco

The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).

关键词： Post-Viral Cirrhosis C Pegylated Interferon Direct Acting Antivirals Sustained Viral Response Child Score Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mineralogy and Chemistry Characterization of the New Basaltic Intrusion at Maasser el Chouf/Lebanon

引用

Journal of Geoscience and Environment Protection 2024年第2期12卷 95-106页

作者： Khaled Tarawneh nada Nemhe Amin Shaban Ghaleb Fauor George Njeim Mining and Mineral Department Faculty of Engineering Al Hussein Bin Talal University Ma’an Jordan Faculty of Agricultural Engineering and Veterinary Medicine Lebanese University Dekwaneh Lebanon National Council for Research Beirut Lebanon BeytLeila Guesthouse Maasser el Chouf Lebanon

The importance of this study is to identify the newly reordered and recognized basaltic intrusion for the first time in Maasser el Chouf in Lebanon. The recorded basaltic intrusion cut the Jurassic-Lower Cretaceous rock in this area. Necessary field inspection, geology, mineralogy and chemical tests were carried out on 8 basalt samples to determine their mineralogy, petrography and chemical composition. Representative samples have been tested with polarizing microscope, X-ray diffraction (XRD) and X-ray fluorescence (XRF). Petrographic and mineralogical studies show that the basalt is characterized by presence mainly of calcic-plagioclase feldspar, pyroxene-augite and olivine minerals. Secondary minerals of iron oxides also present (ilmenite and magnetite). The most appeared property is the alteration of olivine mineral to iddingsite that indicated highly weathered process. The composition of the basaltic samples reflects ultrabasic-basic type (Basanite-Tholeiitic basalt). The existence of volcanic activity occurred mostly with Pliocene age (elong to the alkaline olivine basalt, suite generally associated with tension, rifting and block faulting movements of the continental crust. Most of the volcanisms in Lebanon and in Harrat Ash Shaam Basalt from Syria and Palestine through Jordan to Saudi Arabia are related and connected to the opening of the Red Sea Rift System, making the area with tremendous volcanic tectonic activities.

关键词： Lebanon Basalt Intrusion Basanite Alteration Alkaline Olivine Basalt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：