检索结果-南通市图书馆

Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis

World Journal of Gastroenterology 2019年第5期25卷 567-583页

作者： Rim Serhal Nagib Saliba George Hilal Mayssam Moussa Ghada S Hassan Oula El Atat nada alaaeddine Regenerative Medicine Laboratory Faculty of Medicine Saint-Joseph University Surgery Department Faculty of Medicine Saint-Joseph University and Hotel-Dieu de France Cancer and Metabolism Laboratory Faculty of Medicine Campus of Medical Sciences Saint-Joseph University Laboratoire d’Immunologie Cellulaire et Moléculaire Centre Hospitalier de l’Université de Montréal

AIM To investigate the effect of adipose-derived mesenchymal stem cells(ADMSCs)and their conditioned media(CM) on hepatocellular carcinoma(HCC) cell tumorigenesis.METHODS The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit8(commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Protein and mRNA expression was quantified by ELISA and real time PCR, respectively. Migration and invasion rates were performed by Transwell migration and invasion assays. Wound healing was examined to confirm the data obtained from the migration assays.RESULTS Our data demonstrated that when co-culturing HCC cell lines with ADMSCs or treating them with ADMSC CM, the HCC cell proliferation rate was significantly inhibited and the apoptosis rate increased. The decreased proliferation rate was accompanied by an upregulation of P53 and Retinoblastoma mRNA and a downregulation of c-Myc and hTERT mRNA levels. More notably, ADMSCs and their CM suppressed the expression of the two important markers of HCC carcinogenicity, alpha-fetoprotein and Des-gamma-carboxyprothrombin. In addition, the migration and invasion levels of HepG2 and PLC-PRF-5 cells significantly decreased, potentially through increased expression of the tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3.CONCLUSION These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis.

关键词： Hepatocellular carcinoma Adipose-derived mesenchymal stem cells Adipose-derived mesenchymal stem cell conditioned media Proliferation Apoptosis Migration Invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peripartum Cardiomyopathy Complicated by Ventricular Tachycardia during Labor: A Case Report and Literature Review

引用

Open Journal of Obstetrics and Gynecology 2024年第3期14卷 365-380页

作者： nada Alayed Department of Obstetrics and Gynecology College of Medicine King Saud University King Saud University Medical City Riyadh Saudi Arabia

Background: Peripartum cardiomyopathy (PPCM) is a rare disease that typically affects young, healthy women. Because PPCM is associated with significant mortality, timely diagnosis and management are essential. Ventricular tachycardia (VT) is a major complication and contributor to sudden death. Available data on VT in patients with PPCM are limited. Aim: This case report demonstrates the clinical presentation, antenatal care, and management of labor and delivery in a patient with PPCM complicated by VT. Case report: 36-year old patient G4P3 presents at 27 weeks gestation to the emergency department complaining of chest tightness, palpitations, and profuse sweating. Peripartum cardiomyopathy was diagnosed after her last pregnancy a few years prior. Ventricular tachycardia was diagnosed at this visit and treated successfully. The remainder of the pregnancy was uneventful until she had another episode of ventricular tachycardia during labor. Treatment using antiarrhythmics (diltiazem, amiodarone, adenosine) highlights the importance of prompt intervention and the need for a range of therapeutic options. Results: This case demonstrated successful VT management during pregnancy and labor, emphasizing multidisciplinary collaboration, influencing maternal and fetal outcomes positively, providing insights into optimal care strategies. Conclusion: Peripartum cardiomyopathy complicated by ventricular tachycardia is a life-threatening combination. This case highlights the importance of timely diagnosis and management with combined care between cardiologists, maternal fetal medicine specialists and anesthesiologists to prevent morbidities and sudden maternal death.

关键词： Peripartum Cardiomyopathy Ventricular Tachycardia High Risk Pregnancy Antenatal Care Delivery Planning

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Mineralogy and Chemistry Characterization of the New Basaltic Intrusion at Maasser El Chouf/Lebanon

引用

Journal of Geoscience and Environment Protection 2024年第2期12卷 95-106页

作者： Khaled Tarawneh nada Nemhe Amin Shaban Ghaleb Fauor George Njeim Mining and Mineral Department Faculty of Engineering Al Hussein Bin Talal University Ma’an Jordan Faculty of Agricultural Engineering and Veterinary Medicine Lebanese University Dekwaneh Lebanon National Council for Research Beirut Lebanon BeytLeila Guesthouse Maasser el Chouf Lebanon

The importance of this study is to identify the newly reordered and recognized basaltic intrusion for the first time in Maasser El Chouf in Lebanon. The recorded basaltic intrusion cut the Jurassic-Lower Cretaceous rock in this area. Necessary field inspection, geology, mineralogy and chemical tests were carried out on 8 basalt samples to determine their mineralogy, petrography and chemical composition. Representative samples have been tested with polarizing microscope, X-ray diffraction (XRD) and X-ray fluorescence (XRF). Petrographic and mineralogical studies show that the basalt is characterized by presence mainly of calcic-plagioclase feldspar, pyroxene-augite and olivine minerals. Secondary minerals of iron oxides also present (ilmenite and magnetite). The most appeared property is the alteration of olivine mineral to iddingsite that indicated highly weathered process. The composition of the basaltic samples reflects ultrabasic-basic type (Basanite-Tholeiitic basalt). The existence of volcanic activity occurred mostly with Pliocene age (< 2 Ma) as indicated by previous studies for similar basalt in Lebanon. Possibly, these boulders have been carried up from some deeper intrusive magmatic body under very active tension zones. Volcanism of Lebanon basalts belong to the alkaline olivine basalt, suite generally associated with tension, rifting and block faulting movements of the continental crust. Most of the volcanisms in Lebanon and in Harrat Ash Shaam Basalt from Syria and Palestine through Jordan to Saudi Arabia are related and connected to the opening of the Red Sea Rift System, making the area with tremendous volcanic tectonic activities.

关键词： Lebanon Basalt Intrusion Basanite Alteration Alkaline Olivine Basalt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of the Characteristics of the Municipal Solid Waste Compost in Lebanon

引用

Journal of Geoscience and Environment Protection 2024年第5期12卷 17-39页

作者： Rana Sawaya Jalal Halwani nada Nehme Hiba Alawiye Walaa Diab Water & Environment Science Lab Lebanese University Tripoli Lebanon Faculty of Sciences Lebanese University Hadath Lebanon Faculty of Agriculture Engineering and Veterinary Sciences Lebanese University Dekwaneh Lebanon

Waste management is crucial due to the fast increase of human population, causing an increase in solid waste generation which if not properly managed causes environmental problems. Around 57% of the wastes generated from homes are made up of green material (fruits, vegetables…). Thus, reusing and recycling green wastes through composting is one way of reducing the waste load to landfills. Composting is the transformation of raw organic materials into organic soil amendments that provide nutrients to crops and enhance the tilth, fertility, and productivity of soils. Aerobic windrow composting system at Sukomi Greensite facility located at Karantina is performed, where materials biodegrade under controlled conditions to produce compost. However, assessment of the quality of the compost is fundamental in order to determine its usages. Thus, regular testing of physical, chemical and biological parameters was performed for adequate monitoring purposes. The basic objective of this study was to determine the characteristics of the Lebanese municipal solid waste compost on a yearly basis and compare these characteristics amongst the years. Hence, each parameter was tested and compared to the BNQ international Canadian standards for proper classification of the compost and adequate identification of its usages. The preliminary data obtained were statistically diagnosed through principal component analysis by Spadv55 software. All the data reflected the normal content value of the studied parameters with minor differences between the years except for year 2007 which demonstrated higher levels of Potassium, Phosphate, Lead and Cadmium. The characteristics of the compost enabled it to be used as a soil amendment on all types of agricultural and landscape commodities at the adequate dosages and proper timing. This data will additionally reflect the efficiency of the solid waste management practices adopted via highlighting the importance of the implementation of the integrated solid waste management practices.

关键词： Composting Organic Material Lebanon Contamination Solid Waste Management

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)

引用

Open Journal of Nephrology 2024年第2期14卷 275-293页

作者： Rihab Dkhissi nada El Kadiri Tarik Bouattar Loubna Benamar Naima Ouzeddoun Department of Nephrology-Dialysis-Renal Transplantation IbnSina Hospital Mohammed V University Rabat Morocco

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in developed countries. The aim of this study is to describe the predictive factors for the development of end-stage chronic kidney disease (CKD) in the course of this disease. Material and Methods: This is a retrospective, descriptive, and analytical study including 300 cases of ADPKD collected at the Nephrology Department of Ibn-Sina Hospital in Rabat over a period of 30 years (1993 to 2023). Included in the study are all patients with ADPKD meeting the ultrasound diagnostic criteria. The analysis focused on demographic, clinical, paraclinical, evolutionary data, as well as prognostic factors associated with renal function deterioration. Results: The mean age of patients at diagnosis is 51.53 +/− 17 years [16 - 93] with a male predominance. The median serum creatinine at diagnosis is 15.5 mg/l [10 - 34]. 21% of patients had ESRD (eGFR 300 mg/24h (21%). The most common cystic complication is hemorrhage (12.3%). 21.3% of patients had hepatorenal polycystic disease. In adjusted analysis, the predictive risk factors for the occurrence of ESRD were smoking (p = 0.019), anemia (p Conclusion: ADPKD can progress insidiously to ESRD. Identification and early treatment of predictive factors for poor renal prognosis could contribute to a better outcome for this disease.

关键词： ADPKD ESRD Factors of Poor Renal Prognosis Renal and Extra-Renal Manifestations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spinal dural arteriovenous fistula:a comprehensive review of the history,classification systems,management,and prognosis

引用

Chinese Neurosurgical Journal 2024年第1期10卷 48-56页

作者： Ali Alkhaibary Ahoud Alharbi nada Alnefaie Hajar Alammar Alshaymaa M.Arishy Noor Alghanim Yazeed M.Aldhfyan Arwa Albaiahy Yahya H.Khormi Wael Alshaya Saad AlQahatani Ahmed Aloraidi Ahmed Alkhani Sami Khairy College of Medicine King Saud Bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia King Abdullah International Medical Research Center RiyadhSaudi Arabia Division of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityMinistry of National Guard-Health AffairsRiyadhSaudi Arabia Department of Neurosurgery National Neurosciences InstituteKing Fahad Medical CityRiyadhSaudi Arabia College of Medicine Jazan UniversityJazanSaudi Arabia Department of Neurosurgery King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Department of Surgery Faculty of MedicineJazan UniversityJazanSaudi Arabia

Spinal dural arteriovenous fistulas account for the majority of spinal vascular malformations.They are typically located in the thoracolumbar region and are diagnosed in the middle-aged and elderly populations.Although spinal dural arteriovenous fistulas have been postulated to be acquired,their exact development remains uncertain.Typically,the arteriovenous shunt is situated close to the spinal nerve root,inside the dura mater,where the blood from the radiculomeningeal artery and radicular vein intermix.Throughout history,there have been multiple classification systems of spinal arteriovenous shunts since 1967.Those were mainly based on the evolution of diagnostic studies as well as the treatment of these lesions.Such classification systems have undergone significant changes over the years.Unlike intracranial dural arteriovenous fistula,spinal dural arteriovenous fistula is progressive in nature.The neurological manifestations,due to venous congestion,tend to be insidious as well as non-specific.These include sensory deficits,such as paresthesia,bilateral and/or unilateral radicular pain affecting the lower limbs,and gait disturbances.Spinal dural arteriovenous fistulas can be suspected on magnetic resonance imaging/magnetic resonance angiography and confirmed by digital subtraction angiography(DSA).The management includes surgery,endovascular therapy,and in selected cases,radiotherapy.The treatment goal of spinal dural arteriovenous fistula is to halt the progression of the disease.The prognosis depends on both the duration of symptoms as well as the clinical condition prior to therapy.The present article comprehensively reviews the pathophysiology,changes in classification systems,natural history,clinical manifestations,radiological features,management,and prognosis.

关键词： Connection Endovascular Myelopathy Vascular

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Multi-Task Deep Learning Framework for Simultaneous Detection of Thoracic Pathology through Image Classification

引用

Journal of Computer and Communications 2024年第4期12卷 153-170页

作者： nada Al Zahrani Ramdane Hedjar Mohamed Mekhtiche Mohamed Bencherif Taha Al Fakih Fattoh Al-Qershi Muna Alrazghan Department of Computer Engineering College of Computer and Information Sciences King Saud University Riyadh Saudi Arabia Department of Information System College of Computer and Information Sciences King Saud University Riyadh Saudi Arabia Department of Software Engineering College of Computer and Information Sciences King Saud University Riyadh Saudi Arabia

Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’s ability to breathe normally. Some notable examples of such diseases encompass pneumonia, lung cancer, coronavirus disease 2019 (COVID-19), tuberculosis, and chronic obstructive pulmonary disease (COPD). Consequently, early and precise detection of these diseases is paramount during the diagnostic process. Traditionally, the primary methods employed for the detection involve the use of X-ray imaging or computed tomography (CT) scans. Nevertheless, due to the scarcity of proficient radiologists and the inherent similarities between these diseases, the accuracy of detection can be compromised, leading to imprecise or erroneous results. To address this challenge, scientists have turned to computer-based solutions, aiming for swift and accurate diagnoses. The primary objective of this study is to develop two machine learning models, utilizing single-task and multi-task learning frameworks, to enhance classification accuracy. Within the multi-task learning architecture, two principal approaches exist soft parameter sharing and hard parameter sharing. Consequently, this research adopts a multi-task deep learning approach that leverages CNNs to achieve improved classification performance for the specified tasks. These tasks, focusing on pneumonia and COVID-19, are processed and learned simultaneously within a multi-task model. To assess the effectiveness of the trained model, it is rigorously validated using three different real-world datasets for training and testing.

关键词： Pneumonia Thoracic Pathology COVID-19 Deep Learning Multi-Task Learning

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Unraveling the Impact of Direct-Acting Antivirals on Hepatitis-Linked Cirrhosis: A Comprehensive Analysis of Fibrosis, Child Score, and Disease Progression

引用

Open Journal of Gastroenterology 2024年第6期14卷 203-212页

作者： Hajar Cherkaoui Maryam Elkhayari Maria Lahlali Asmae Lamine nada Lahmidani Amine Mekkaoui Mounia Elyousfi Dafr Allah Benajah Mohammed El Abkari Adil Ibrahimi Hakima Abid Department of Hepato-Gastroenterology Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy of Fez USMBA Fez Morocco

The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).

关键词： Post-Viral Cirrhosis C Pegylated Interferon Direct Acting Antivirals Sustained Viral Response Child Score Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dunbar Syndrome and Hypoxic Hepatitis: An Unusual Presentation

引用

Open Journal of Gastroenterology 2024年第6期14卷 226-232页

作者： Hajar Cherkaoui Ismail Chaouech Yousra El Abidi Haroun Robleh Asmae Lamine Maria Lahlali nada Lahmidani Amine Mekkaoui Mounia Elyousfi Dafr Allah Benajah Adil Ibrahimi Mohammed El Abkari Nizar Bouardi Mohammed Maaroufi Hakima Abid Department of Gastroenterology University Hospital Hassan II Fez Morocco Faculty of Medicine and Pharmacy Fez Morocco Department of Radiology University Hospital Hassan II Fez Morocco

Hypoxic hepatitis, also known as ischemic hepatitis, is characterized by acute hepatocellular injury due to inadequate oxygen delivery to the liver. Celiac trunk stenosis can lead to hepatic ischemia and subsequent liver damage. We present the case of an 81-year-old patient with a history of hypertension, ischemic heart disease, hypothyroidism, and biliary lithiasis, who developed hypoxic hepatitis secondary to Dunbar syndrome and a stenosis of the superior mesenteric artery. The patient improved symptoms and liver function tests with conservative management, including intravenous fluids and supportive care. Long-term management involved continued antiplatelet therapy and statins, with consideration of further interventions for celiac trunk stenosis. This case underscores the importance of recognizing Dunbar syndrome as well as superior mesentery trunk stenosis as a potential cause of hypoxic hepatitis. It highlights the need for multidisciplinary management in such cases.

关键词： Dunbar Syndrome Hypoxic Hepatitis Stenosis of Mesentery Artery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Dual Attention Encoder-Decoder Text Summarization Model

引用

Computers, Materials & Continua 2023年第2期74卷 3697-3710页

作者： nada Ali Hakami Hanan Ahmed Hosni Mahmoud Jazan University Computer Science DepartmentCollege of Computer Science and Information TechnologyJazanSaudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

A worthy text summarization should represent the fundamental content of the document.Recent studies on computerized text summarization tried to present solutions to this challenging problem.Attention models are employed extensively in text summarization process.Classical attention techniques are utilized to acquire the context data in the decoding phase.Nevertheless,without real and efficient feature extraction,the produced summary may diverge from the core topic.In this article,we present an encoder-decoder attention system employing dual attention mechanism.In the dual attention mechanism,the attention algorithm gathers main data from the encoder side.In the dual attentionmodel,the system can capture and producemore rational main content.The merging of the two attention phases produces precise and rational text summaries.The enhanced attention mechanism gives high score to text repetition to increase phrase score.It also captures the relationship between phrases and the title giving them higher score.We assessed our proposed model with or without significance optimization using ablation procedure.Our model with significance optimization achieved the highest performance of 96.7%precision and the least CPU time among other models in both training and sentence extraction.

关键词： Text summarization attention model phrase significance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：