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Self-assembly of artificial architectures in living cells-design and applications

Science China Chemistry 2022年第1期65卷 31-47页

作者： Xiaolei Sun Yuhang Dong Yujie Liu nachuan song Feng Li Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(Ministry of Eeducation)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

Self-assembly exists widely in natural living system and artificial synthetic material *** of self-assemblies of artificial architectures in living cells can be used to explore the molecular physicochemical fundamentals and operating mechanisms of living system,and consequently promote the development of *** order to mimic naturally occurring self-assemblies and realize controllable functions,great efforts have been devoted to constructing dynamic assembly of artificial architectures in living cells by responding to intracellular specific stimuli,which can be used to regulate morphology,behaviors and fate of living *** review highlights the recent progress on artificial self-assembly in living *** molecular fundamentals and characteristics of intracellular environment that can induce the self-assembly of artificial architectures are introduced,and the representative work on dynamic artificial self-assembly in living cells is sketched ***,intracellular stimuli-mediated pathways of artificial assembly in living cells are categorized,biological effects caused by intracellular self-assembly are summarized,and biomedical applications focusing on therapy and imaging are *** the end,the perspective and challenges of artificial self-assembly in living cells are fully *** is believed that the grand advances on artificial self-assembly in living cells will contribute to elaborating the molecular mechanisms in cells,and further promoting the biologically and medically-related applications in the future.

关键词： self-assembly stimulus responsiveness biomaterials biomedicine

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Engineering CRISPR/Cas-based nanosystems for therapeutics, diagnosis and bioimaging

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Chinese Chemical Letters 2023年第10期34卷 67-75页

作者： nachuan song Shuai Li Zhaoyue Lv Xiaohui Ding Feng Li Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Zhejiang Institute of Tianjin University Ningbo 315201China

CRISPR/Cas system has been utilized to rationally manipulate intracellular genes,and it has been engineered as versatile and efficient gene editing tools with precise site-specificity and excellent targeting ability for therapeutics,diagnostics,and ***,the evolution and application of CRISPR/Cas systems were sketched *** works were exemplified to illustrate the design principles of CRISPR/Cas ***,the delivery vectors of CRISPR/Cas system especially DNA nanomaterials-based vectors were categorized and *** nanomaterials are suitable for CRISPR/Cas system delivery via base pairing due to its sequence programmability and *** the applications of CRISPR/Cas in diagnosis and genomic imaging were *** the end of the review,the challenges and opportunities of CRISPR/Cas systems were deeply *** envision that the grant advances on CRISPR/Cas systems will promote the development of interdisciplinary fields in chemistry,biology and medicine.

关键词： CRISPR/Cas DNA nanotechnology DNA nanomaterials Cancer therapy Diagnosis Bioimaging

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