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Ethnobotanical survey of medicinal plants used in the management of cancer and diabetes

Journal of Traditional Chinese Medicine 2020年第6期40卷 1007-1017页

作者： Garima Singh Ajit kumar Passari Marcy D Momin Sakthivel Ravi Bhim Pratap Singh nachimuthu senthil kumar Department of Biotechnology Mizoram UniversityAizawl 796004India Department of Botany Pachhunga University CollegeAizawl 796001India Departamento de Biologia Molecular y Biotecnologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de Mexico(UNAM)Ciudad de Mexico-04510Mexico Department of Agriculture&Environmental Sciences(AES) National Institute of Food Technology Entrepreneurship&Management(NIFTEM)SonepatHaryanaIndia

OBJECTIVE:To conduct an ethnobotanical survey and document the traditional anticancer and antidiabetic plants used by the local tribes of Mizoram,Northeast ***:A systematic survey was conducted in rural and urban areas of Mizoram by interviewing traditional practitioners,and cancer and diabetes patients.A detailed literature search was carried out using MEDLINE and SCOPUS and available literatures were selected and included in the *** use value(UV)of the selected plants was calculated based on the number of citations per species given by ***:Data was obtained for 201 traditional medicinal plants from Mizoram,Northeast *** plants were from 72 different families and belonged to 140 *** these,103 plants were reported for the first time as possessing either anticancer or antidiabetic potential,and 105 plants were identified that were used for the treatment of both *** plants(Phlogacanthus thysiformis,Solanum gilo and Lobelia angulata)with antidiabetic potential,and six plants(Dillenia scabrella,Circium sinesis,Eupatorium nodiflorum,Pratia begonifolia,Vernonia teres and Plantago erosa)with both as anticancer and antidiabetic potential were documented for the first ***:In this study,we documented several explored and unexplored medicinal plants that may be useful for the management of cancer and *** study suggests that there is a broad scope fordeveloping potent anticancer and antidiabetic agent from the flora of Mizoram,Northeast India.

关键词： Plants medicinal Antineoplastic agents Hypoglycemic agents Ethanobotanical survey Traditional knowledge

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Highlighting novel genes associated with the classical Rett syndrome patient from India

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Genes & Diseases 2022年第6期9卷 1394-1396页

作者： Gomathi Mohan Ranjan Jyoti Sarma Mahalaxmi Iyer nachimuthu senthil kumar Balachandar Vellingiri UGC-RGNF Senior Research Fellow Human Molecular Cytogenetics and Stem Cell LaboratoryDepartment of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia Department of Biotechnology Mizoram University(A Central University)Aizawl 796004MizoramIndia Livestock Farming&Bioresource Technology Tamil NaduIndia Human Molecular Cytogenetics and Stem Cell Laboratory Department of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia

Rett syndrome(RTT)is a rare X-linked brain disorder predominantly in females,caused by mutations in Methyl-CpGBinding Protein2(MECP2)gene with the characteristic features of progressive developmental delay,severe intellectual disability,microcephaly,retarded growth,loss of communication abilities,loss of purposeful hand movements,abnormal walking or gait abnormalities,repetitive hand movements,abnormal breathing,irritability and abnormal behaviours.1 Over the last five years,more than eighty genes related to RTT were found using next generation sequencing.2 Here we presented a comprehensive clinical report of a 38-year-old RTT woman having de novo heterozygous Laminin Subunit Gamma 3 gene(LAMC3)mutation G>A(Chr9:133944387;p.C947Y)links with RTT neurological dysfunctions,brain malformations,reduced brain volume and hypoplasia of corpus *** new finding supports the possibility of targeting LAMC3 gene for rescuing the neuropathology of *** deleterious mutations found in genes such as,CACNA1B(rs4422842),CUBN(rs2271460),GPATCH3(rs779537923),TUBB1(rs463312),KCNJ5(rs768906222),VWA5A(rs551469534),DNAAF1(rs751148678),and PARP1(rs3219145)were unreported in RTT patients.

关键词： RTT lighting delay

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Novel technique(Ramalingam technique)of port site retrograde intra renal surgery through exteriorized ureter during laparoscopy

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Asian Journal of Urology 2023年第3期10卷 372-375页

作者： Manickam Ramalingam Kallappan senthil Sivasankaran nachimuthu Urology Department Hindusthan HospitalCoimbatoreIndia

Occurrence of significant sized renal calculi along with ureteric pathology is not *** presented two patients:one with significant sized renal calculi along with lower ureteric stricture,and second case with significant sized renal calculi with primary obstructive mega ureter needing surgery for both the renal calculi and ureteric *** both patients laparoscopy was done,and the ureter was mobilised and divided just above the level of the pathology and exteriorised through the nearest sited port,and retrograde intra-renal surgery(RIRS)was done using flexible ureteroscope and *** laparoscopy was resumed,and ureteric reimplantation directly into the bladder or with a Boari flap was *** entire procedure was completed in a single *** novel technique of exteriorizing the ureter through the laparoscopic port site for flexible ureteroscopy in a case of lower ureteric pathology with renal stone is an advantageous option to manage both pathologies in a single *** has a better stone clearance than shock wave lithotripsy and less morbidity than percutaneous nephrolithotomy(PCNL).

关键词： ureter surgery bladder

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Laparoscopic adenomectomy in BPH--Does it have a role today?

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Asian Journal of Urology 2018年第1期5卷 37-41页

作者： Ramalingam Manickam Sivasankaran nachimuthu senthil Kallappan Mizar GPai Uro-Nephro Centre Ganga Medical Centre&HospitalsRamnagarCoimbatoreIndia

Symptomatic benign prostatic hyperplasia(BPH)is managed medically worldwide,but transurethral resection of prostate(TURP)is the gold standard in refractory *** laser enucleation of prostate(HoLEP),laser vaporization are other options which are widely *** in larger glands which are more than 80 g,open adenomectomy is still *** adenomectomy is a minimally invasive option in such *** article explains about different techniques in minimally invasive adenomectomy and the role for this procedure *** simple prostatectomy(LSP)has a place in symptomatic,larger prostatic adenoma in the hands of experienced laparoscopic surgeons when open simple prostatectomy is needed.

关键词： Prostate BPH Adenomectomy Laparoscopy

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Neobladder as content in inguinal herniationd-A rare late complication

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Asian Journal of Urology 2020年第1期7卷 73-75页

作者： senthil Kallappan Manickam Ramalingam Sivasankaran nachimuthu Thilak Ganesapandi Department of Urology Ganga Medical Centre and Hospitals Pvt Ltd Ringgold Standard InstitutionRamnagarCoimbatoreTamil NaduIndia

Dear editor,Secondary inguinal herniation of intraperitoneal content represents a late complication following radical *** presenta case of an inguinoscrotal hernia withStuder ileal neobladder as a content following post radical cystectomy for bladder cancer 10 years *** revealed herniation of Studer ileal neobladder along with few ileal ***-bladder in hernial sac was reduced and reinforcement with prolene meshwas *** our knowledge this is the first case report on neobladder herniation into the scrotum.

关键词： bladder herniation complication

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Isolation and Partial Evaluation of a Potential Indigenous Yeast Strain <i>Pichia kudriavzevii</i>from a Traditional Rice Beer—“Gora” Prepared by the Koloi Tribes of Tripura

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Advances in Microbiology 2019年第9期9卷 824-841页

作者： Sushanta Ghosh Surajit De Mandal Nandita Nath David L. Kaipeng Lovely Rahaman senthil kumar nachimuthu Bipin kumar Sharma Department of Microbiology Tripura University Suryamaninagar India Department of Biotechnology Mizoram University Aizawl India

As per tradition from hundreds of years the Koloi tribes of Tripura are preparing “Gora”-therice based fermented beer which is very good in taste and aroma applying their traditional indigenous brewing techniques. In this study, an attempt has been made to identify the indigenous yeast which is the main causative agent for fermentation and to investigate its fermentation ability with an industrial Saccharomyces cerevisiaes train. After investigation based on culture dependent phenotypic characteristics like-staining and biochemical characterization, primarily the responsible yeast species was determined as Pichia kudriavzevii and further confirmed followed by 18S rRNA ribotyping and the sequences was deposited at Gene bank and NCBI bearing specific accession number. In the comparative analysis, it has been found a significant similarities in all aspects of nutritional and alcohol percentages with the industrial strain in laboratory condition. The alcohol percentage in the rice beer “Gora” measured 6.40 ± 0.008% v/v. The study may be the first scientific investigation of its kind about this indigenous yeast strain isolated from “Gora” of this Indo-Burma biodiversity region and may provide sufficient background and potentiality for promoting these kinds of indigenous alcoholic beverages for small scale commercialization to strengthen the rural livelihood as well as to maintain immaterial cultural heritage.

关键词： Beer Yeast Fermentation 18S rRNA

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