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Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: A large single center experience

World Journal of Gastrointestinal Endoscopy 2019年第11期11卷 531-540页

作者： Rintaro Hashimoto John G Lee Kenneth J Chang nabil el hage chehade Jason B Samarasena H.H.Chao Comprehensive Digestive Disease Center Division of Gastroenterology and Hepatology Department of Medicine University of CaliforniaIrvine

BACKGROUND Establishing a diagnosis of pancreatic cystic lesions(PCLs)preoperatively still remains ***,endoscopic ultrasound(EUS)-through-the-needle biopsy(EUS-TTNB)using microforceps in PCLs has been made *** To assess the efficacy and safety of EUS-TTNB in the diagnosis of *** We retrospectively collected data of patients with PCLs who underwent both EUS-fine-needle aspiration(FNA)for cytology and EUS-TTNB at our institution since ***-FNA for cytology was followed by EUS-TTNB in the same *** of the cyst location,primary diagnosis,adverse events,and comparison between the cytologic fluid analyses and histopathology was *** success of EUS-TTNB was defined as visible tissue present after *** success was defined as the presence of a specimen adequate to make a histologic or cytologic *** A total of 56 patients(mean age 66.9±11.7,53.6%females)with PCLs were enrolled over the study *** mean cyst size was 28.8 mm(12-85 mm).The EUS-TTNB procedure was technically successful in all patients(100%).The clinical success rate using EUS-TTNB was much higher than standard EUS-FNA,respectively 80.4%(45/56)vs 25%(14/56).Adverse events occurred in 2 patients(3.6%)who developed mild pancreatitis that resolved with medical *** TTNB specimens,23 of 32 cases(71.9%)with intraductal papillary mucinous neoplasm were further differentiated into gastric type(19 patients)and pancreaticobiliary type(4 patients)based on immunochemical *** EUS-TTNB for PCLs was technically feasible and had a favorable safety ***,the diagnostic yield for PCLs was much higher with EUS-TTNB than standard EUS-FNA cytology and fluid carcinoembryonic *** should be considered as an adjunct to EUS-FNA and cytologic analysis in the diagnosis and management of PCLs.

关键词： Pancreatic cyst lesion Endoscopic ultrasound Endoscopic ultrasound-guided fine needle aspiration Cyst fluid Biopsy

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