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enhancing Secure Development in Globally Distributed Software Product Lines: A Machine Learning-Powered Framework for Cyber-Resilient Ecosystems

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Computers, Materials & Continua 2024年第6期79卷 5031-5049页

作者： Marya Iqbal Yaser Hafeez nabil Almashfi Amjad Alsirhani Faeiz Alserhani Sadia Ali Mamoona Humayun Muhammad Jamal University Institute of Information Technology PMAS-Arid Agriculture UniversityRawalpindiPakistan Department of Software engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer engineering&Networks College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72388Saudi Arabia Department of Mathematics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

Embracing software product lines(SPLs)is pivotal in the dynamic landscape of contemporary software ***,the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability,underscoring the critical importance of robust cybersecurity *** paper advocates for leveraging machine learning(ML)to address variability management issues and fortify the security of *** the context of the broader special issue theme on innovative cybersecurity approaches,our proposed ML-based framework offers an interdisciplinary perspective,blending insights from computing,social sciences,and ***,it employs ML for demand analysis,dynamic feature extraction,and enhanced feature selection in distributed settings,contributing to cyber-resilient *** experiments demonstrate the framework’s superiority,emphasizing its potential to boost productivity and security in *** digital threats evolve,this research catalyzes interdisciplinary collaborations,aligning with the special issue’s goal of breaking down academic barriers to strengthen digital ecosystems against sophisticated attacks while upholding ethics,privacy,and human values.

关键词： Machine Learning variability management cybersecurity digital ecosystems cyber-resilience

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Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor agents:Mechanisms and implications

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World Journal of Pharmacology 2024年第1期13卷 1-7页

作者： nabil Eid Payal Bhatnagar Department of Anatomy Division of Human BiologySchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia

In this editorial,we comment on a recent publication,which highlights the important findings from the study,including the antitumor and anti-inflammatory effects of isothiocyanates,their underlying mechanisms,and ***,... 详细信息

关键词： Cancer Isothiocyanates Genus Capparis Apoptosis Autophagy Inflammation GC/MS analysis

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The Upper Jurassic sediments,Marib-Shabwa Basin,Yemen:Lithofacies aspects and sequence stratigraphic analysis

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energy Geoscience 2024年第1期5卷 342-357页

作者： mohammed Albaroot mohamed M.Elhossainy nabil M.Al-Areeq Emad A.Abdullah Abdelhamid M.Salman Department of Applied Geology Faculty of Science and EducationUniversity of Saba RegionMaribYemen Department of Geology Faculty of ScienceKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Geology and environment Faculty of Applied SciencesThamar UniversityYemen Department of Mineral Developing and Oil&Gas engineering Academy of EngineeringPeoples’Friendship University of Russia(RUDN University)Moscow117198Russia Department of Geology Faculty of ScienceAssiut UniversityAssiut71516Egypt

The present study is devoted to understanding the evolution of the Upper Jurassic Sab'atayn Formation in the Marib-Shabwa Basin,Yemen,through a sequence stratigraphic analysis based on integrating datasets of sedimentology,seismic sections,and well *** Sab'atayn Formation(Tithonian age)is represented by a series of clastic and evaporites that were deposited under fluvio-deltaic to prodeltaic *** is divided into four members including Yah(at the base),upwards to Seen,Alif,and Safir at the *** third-order depositional sequences were determined for the Tithonian succession which were separated by three sequence *** sequences were classified into their systems tracts signifying several sedimentation patterns of progradational,aggradational,and retrogradational parasequence *** first depositional sequence corresponds to the early-middle Tithonian Yah and Seen units that can be classified into lowstand,transgressive,and highstand systems *** second sequence comprises the late Tithonian Alif unit that can be subdivided into transgressive and highstand systems *** sandy deposits of the Alif Member(highstand deposits)represent the most productive hydrocarbon reservoir in the *** Upper Jurassic sediments in the study area were resulted from a combination of eustatic and tectonic effects.

关键词： Sequence stratigraphy Sandstone reservoir Well logs Upper Jurassic Marib-Shabwa Basin Yemen

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Predicting an Optimal Virtual Data Model for Uniform Access to Large Heterogeneous Data

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Data Intelligence 2024年第2期6卷 504-530页

作者： Chahrazed B.Bachir Belmehdi Abderrahmane Khiat nabil Keskes LabRI-SBA Enterprise Information SystemsESI-SBA InstituteFraunhofer IAISAlgeriaGermany

The growth of generated data in the industry requires new efficient big data integration approaches for uniform data access by end-users to perform better business *** virtualization systems,including Ontology-Based Data Access(ODBA)query data on-the-fly against the original data sources without any prior data *** approaches by design use a fixed model e.g.,TABULAR as the only Virtual Data Model-a uniform schema built on-the-fly to load,transform,and join relevant *** other data models,such as GRAPH or DOCUMenT,are more flexible and,thus,can be more suitable for some common types of queries,such as join or nested *** queries are hard to predict because they depend on many criteria,such as query plan,data model,data size,and *** address the problem of selecting the optimal virtual data model for queries on large datasets,we present a new approach that(1)builds on the principal of OBDA to query and join large heterogeneous data in a distributed manner and(2)calls a deep learning method to predict the optimal virtual data model using features extracted from SPARQL ***-implementation of our approach currently leverages state-of-the-art Big Data technologies,Apache-Spark and Graphx,and implements two virtual data models,GRAPH and TABULAR,and supports out-of-the-box five data sources models:property graph,document-based,e.g.,wide-columnar,relational,and tabular,stored in Neo4j,MongoDB,Cassandra,MySQL,and CSV *** experiments show that our approach is returning the optimal virtual model with an accuracy of 0.831,thus,a reduction in query execution time of over 40%for the tabular model selection and over 30%for the graph model selection.

关键词： Data Virtualization Big Data OBDA Deep Learning

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Peritoneo-Vaginal Leaks in Peritoneal Dialysis: A Report of 3 Cases

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Open Journal of Nephrology 2024年第2期14卷 176-184页

作者： Mariam Jdidou Sara Elmakkoul nabil Hmaidouch Naima Ouzeddoun Loubna Benamar Department of Nephrology Dialysis and Renal Transplantation Ibn Sina University Hospital Rabat Morocco

Introduction: Peritoneal dialysis (PD) is an extra-renal purification technique indicated for patients with end-stage kidney disease (ESKD). Although it has many advantages, it also has a number of complications, such as peritoneo-vaginal leakage of dialysate. Cases Reports: Three male patients, aged 70, 50 and 77 respectively, with ESKD were placed on PD. All three patients presented with inadequate drainage and the progressive appearance of bilateral hydrocele, which occurred one year (late leakage), two and four days (early leakage) respectively after the initiation of exchanges. The etiological investigation led to the conclusion of a peritoneo-vaginal leak associated with an inguinal hernia in only one case. The two cases of early leakage were treated by temporary suspension of PD, with a good response in one case and failure in the second, leading to hisdefinitive transfer to hemodialysis (HD);however, the hernia repair enabled immediate resumption of PD in the third patient. Discussion and Conclusion: Peritoneo-vaginal leakage is a rare mechanical complication in PD. The clinical examination plays an essential role in confirming the diagnosis and in the therapeutic decision. If the diagnosis is uncertain, or if there is a clinical need to show the anatomy of the leak, an imaging approach becomes desirable. This complication should not prevent the progression of PD in the management of patients with ESKD.

关键词： Peritoneal Dialysis Peritoneal Leakage Hernia-Peritoneal Scintigraphy

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Mechanistic insights into fasting-induced autophagy in the aging heart

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World Journal of Cardiology 2024年第3期16卷 109-117页

作者： Hannaneh Parvaresh Katarzyna Paczek Md Abdul Alim Al-Bari nabil Eid Department of Biology Faculty of ScienceFerdowsi University of MashhadMashhad ***Iran Department of Chiropractic International Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmacy University of RajshahiRajshahi 6205Bangladesh Department of Anatomy Division of Human BiologySchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins,damaged organelles,and excessive lipids within mammalian cells.A growing body of data indicates that autophagy is reduced in aging *** reduction leads to various diseases,such as myocardial hypertrophy,infarction,and *** studies in animal models of an aging heart showed that fasting-induced autophagy improved cardiac function and *** improvement is related to autophagic clearance of damaged cellular components via either bulk or selective autophagy(such as mitophagy).In this editorial,we summarize the mechanisms of autophagy in normal and aging *** addition,the protective effect of fasting-induced autophagy in cardiac aging has been highlighted.

关键词： Aging Autophagy Heart Fasting Mitophagy

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A new hydrophobic deep eutectic solvent composed of menthol and tris(2-ethylhexyl) phosphate for solvent bar microextraction of parabens from biological fluids

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Emerging Contaminants 2024年第2期10卷 135-145页

作者： nabil N.AL-Hashimi Husam Abed Alfattah Khaleel I.Assaf Asma A.Fakhoury Saja H.Hamed Amjad H.El-Sheikh Khairi M.Fahelelbom The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutical ChemistryP.O.Box 330127Zarqa13133Jordan The Hashemite University Faculty of ScienceDepartment of ChemistryP.O.Box 150459Zarqa13115Jordan Al-Balqa Applied University Faculty of ScienceDepartment of Chemistry19117 Al-SaltJordan The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutics and Pharmaceutical TechnologyP.O.Box 330127Zarqa13133Jordan Al Ain University College of PharmacyDepartment of Pharmaceutical SciencesP.O.Box 64141Al AinAl AinUnited Arab Emirates

Parabens are antimicrobial preservatives with extensive applications in cosmetics,toiletries,pharmaceuticals,and *** the legitimate concerns relating to their potential to disrupt multiple endocrine functions,it becomes imperative to prioritize the development of innovative bioanalytical techniques for effectively monitoring their presence in biological *** this study,an efficient solvent bar microextraction(SBME)was established,utilizing new hydrophobic deep eutectic solvents(DEs)to determine methylparaben and propylparaben in urine and plasma *** DEs comprising menthol and tris(2-ethylhexyl)phosphate(M-TEHP)at various molar ratios were synthesized for the first time to enhance the extraction capacity and promote the eco-friendliness of the DE used as an extraction ***-transform infrared(FT-IR)and proton nuclear magnetic resonance(1H NMR)spectroscopies were employed to confirm and investigate the properties of the successful synthesis(M-TEHP)DE at a molar ratio of 1:*** synthesized DE exhibits low microbial toxicity and can be considered an eco-friendly solvent for ***,quantum-chemical calculations were utilized to predict synthesized DE's structure and interaction energy with selected *** influential operational factors of DE-SBME on the extraction efficiency(EE%)of both parabens were evaluated using response surface methodology based on central composite design,and a total of 30 extraction tests were conducted to determine the optimal *** optimized DE-SBME,in combination with HPLC-DAD,exhibited low detection limits(0.54–0.91μg L^(−1)),excellent linearity(R^(2)≥0.9993),precise results(RSDs≤7.6%),satisfactory recoveries(92–97%)and negligible matrix ***,it had remarkable effectiveness and applicability in determining selected parabens in real urine and plasma samples.

关键词： Hydrophobic deep eutectic solvent Solvent bar microextraction Parabens Response surface methodology and central composite design HPLC-DAD Urine and plasma

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Possible Cortical Spreading Depression Recorded Intraoperatively Following a Generalized Seizure: Illustrative Case

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Neuroscience & Medicine 2024年第3期15卷 119-128页

作者： Greg Schaublin Romina Shirka nabil Azar Callan Broderick Jayson Neil George R. Lee Kiara Ebinger Real Time Neuromonitoring Associates Nashville USA Real Time Tele-Epilepsy Consultants Nashville USA Seastnan Medical LLC Kansas City USA Midwest Neurosurgery Associates Kansas City USA Research Medical Center Kansas City USA

Background: We present a compelling case fitting the phenomenon of cortical spreading depression detected by intraoperative neurophysiological monitoring (IONM) following an intraoperative seizure during a craniotomy for revascularization. Cortical spreading depression (CSD, also called cortical spreading depolarization) is a pathophysiological phenomenon whereby a wave of depolarization is thought to propagate across the cerebral cortex, creating a brief period of relative neuronal inactivity. The relationship between CSD and seizures is unclear, although some literature has made a correlation between seizures and a cortical environment conducive to CSD. Methods: Intraoperative somatosensory evoked potentials (SSEPs) and electroencephalography (EEG) were monitored continuously during the craniotomy procedure utilizing standard montages. Electrophysiological data from pre-ictal, ictal, and post-ictal periods were recorded. Results: During the procedure, intraoperative EEG captured a generalized seizure followed by a stepwise decrease in somatosensory evoked potential cortical amplitudes, compelling for the phenomenon of CSD. The subsequent partial recovery of neuronal function was also captured electrophysiologically. Discussion: While CSD is considered controversial in some aspects, intraoperative neurophysiological monitoring allowed for the unique analysis of a case demonstrating a CSD-like phenomenon. To our knowledge, this is the first published example of this phenomenon in which intraoperative neurophysiological monitoring captured a seizure, along with a stepwise subsequent reduction in SSEP cortical amplitudes not explained by other variables.

关键词： Cortical Spreading Depression Electroencephalography Intraoperative Neurophysiological Monitoring Seizure

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Primary Hyperoxaluria Type 1 in Adulthood: Case Series

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Open Journal of Nephrology 2024年第3期14卷 350-360页

作者： Sara El Maakoul Nada El Kadiri nabil Hmaidouch Salma Belmokadem Loubna Benamar Tarik Bouattar Naima Ouzeddoun Department of Nephrology Dialysis Renal Transplantation Ibn Sina University Hospital-Rabat Rabat Morocco Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.

关键词： Primary Hyperoxaluria Adulthood Kidney Disease

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Substitution of Aggregates in Concrete and Mortar with Coltan Mining Waste: Mechanical, environmental, and Economic Impact Case Study

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Journal of Minerals and Materials Characterization and engineering 2024年第2期12卷 139-163页

作者： Alinabiwe Nyamuhanga Ally Élodie Ruffine Zang Masika Muhiwa Grâce Manjia Marcelline Blanche Ursula Joyce Merveilles Pettang Nana Ngapgue François Bella nabil Chrispin Pettang Laboratory engineering Civil and Mechanics Doctoral Research Unit for Engineering and Applications University of Yaound&#233 I Yaound&#233 Cameroon Department of Civil engineering Faculty of Applied Sciences and Technologies Free University of Great Lakes Countries (ULPGL) Goma DRC Department of Civil engineering National Advanced School of Engineering of Yaoundé University of Yaoundé I Yaoundé Cameroon Department of Civil engineering Fotso Victor University Institute of Technology University of Dschang Bandjoun Cameroon FIMAS Laboratory Faculty of Technologies Tahri Mohamed University Bechar Algeria

The mining process involves drilling and excavation, resulting in the production of waste rock and tailings. The waste materials are then removed and stored in designated areas. This study aims to evaluate the mechanical strength and the environmental and economic impact of using Coltan Mining Waste (CMW) as a substitute for aggregates in concrete and mortar production. To achieve this, the CMW needs to be characterised. The Dreux Gorisse method was primarily used to produce concrete with a strength of 20 MPa at 28 days. The mortars, on the other hand, were formulated according to the NF P 18-452 standard. The environmental impact of using CMW as substitutes for natural aggregates in the production of concrete and mortar was analysed using SimaPro software. The results showed that mortars and concrete made with CMW have comparable compressive strengths to the reference mortar and concrete;reduce the negative impact on ecosystem quality, human health, resources, and climate change. It has also been shown that the substitution of aggregates by CMW reduces the cost of concrete and mortar as a function of the distance from the aggregate footprint.

关键词： Aggregate Coltan Mining Waste Concrete Mortar Mechanical Strength Life Cycle Analysis

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