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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman al-Balushi Amina al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman nabeel al-yateem alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Change in mean postoperative pain in patients undergoing tonsillectomy with cold water versus usual practice:A pragmatic trial

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 24-28页

作者： Haissan Iftikhar Nida Zahid Adan Zubair Mohammad Wasif nabeel N.Baig Khadijah Abid Muhammad Ozair Awan Muhammad Sohail Awan Department of Otolaryngology Queen Elizabeth HospitalBirminghamUK Department of Surgery Aga Khan University HospitalKarachiPakistan College of Physicians and Surgeons Higher Education CommissionKarachiPakistan Department of UGME Aga Khan UniversityKarachiPakistan

Introduction:Tonsillectomy is one of the most common procedures performed in *** are various methods to perform tonsillectomies(cold and hot).Thermal damage and inflammation of the surrounding tissue using monopolar cautery is said to point to increased pain whereas immediate cooling of the burnt area is thought to reduce pain owing to heat *** objective was to determine the difference in mean post‐tonsillectomy pain scores among patients irrigated with cold water(4℃)and in patients not irrigated with cold *** and Methods:A quasi‐experimental trial was conducted from January 2016 to December 2017 at a tertiary care *** tonsillectomies were carried out with monopolar cautery at a power of 20 *** either received cold water irrigation post tonsillectomy of the tonsillar bed(intervention arm)or no irrigation(control arm).The pain score was measured on Days 0,1,3,5,and *** scores were charted on a visual analog scale on the respective ***:Seventy‐eight patients were included in the *** mean age of our patients was 10.26(4.24)years old in the intervention arm,and 11.95(4.19)years old in the control *** was observed that the pain was significantly lower in patients with cold water irrigation of the tonsillar fossa on Days 1,3,5,and 7(p=0.001).There were no readmissions postprocedure and none of our patients developed any complications ***:In this trial,we report a reduced pain score at all days of observation in the intervention *** of the tonsillar fossa is a safe,cost-effective,and less technically demanding technique that could be employed to reduce postoperative *** studies with randomization,blinding and a larger sample size could further improve on our results.

关键词： cold water tonsillectomy monopoalr tonsillectomy postoperative pain tonsillectomy

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Discharging of PCM in Various Shapes of Thermal Energy Storage Systems:A Review

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Journal of Thermal Science 2023年第3期32卷 1124-1154页

作者： DHAIDAN nabeel HASHIM Hasan ABBAS Abdalrazzaq KHODADADI Jay alMOSAWY Wala al-MOUSAWI Fadhel Engineering Faculty Kerbala UniversityKerbalaIraq Department of Mechanical Engineering Auburn University1418 Wiggins HallAuburnAL 36849-5341USA al-Zahraa University for Women KerbalaIraq

Utilizing the phase change materials in different thermal storage applications attains valuable attention due to the fascinating thermal properties of these *** comprehension of the thermal behaviour of phase change materials during the melting and solidification is considered a significant priority in designing the shape of the different *** this review,analytical,computational and experimental investigations that address solidification/freezing of phase change materials within thermal energy storage systems are *** is placed on the role of the shape of adopted containers encompassing planar,spherical,cylindrical and annular *** storage for solar thermal applications,waste heat recovery,and thermal management of buildings/computing platforms/photovoltaics has been the topics that benefit from these *** all container shapes,the freezing process is controlled initially by natural convection,and a high solidification rate is ***,the conduction dominates the process,and the freezing rate *** temperature and flow of cooling heat transfer fluid affect the solidification process,but the impact of heat transfer fluid temperature is more significant than its flow ***,the freezing time increases with the container’s size and amount of contained *** aspect ratio of the planar and vertical cylindrical cavities substantially influences the discharging time and *** contrast,the orientation of the annular cavity has a lower impact on the discharging process.

关键词： containers freezing phase change materials phase transformation solidification

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Effect evaluation of shale types on hydrocarbon potential using well logs and crossplot approach,Halewah oilfield,Sab'atayn Basin,Yemen

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Energy Geoscience 2022年第2期3卷 202-210页

作者： nabeel A.S.al al-Azazi A.S.A.E.alsrory Mohammed albaroot Oil and Gas Engineering Department Faculty of Oil and MineralsShabwah UniversityShabwaYemen Geophysics Administration Yemen Company for Investment in Oil&MineralsSana'aYemen Applied Geology Department Faculty of SciencesSaba University RegionMaribYemen

Log-analysts typically distinguish three types of shale distribution in clastic reservoirs,that is,laminated,dispersed and structural distribution,which tend to influence the effective porosity and permeability of *** alif Member is made up of sandstone interbedded with some shale,with shale dominating on top and at the *** sedimentary formations,the gamma ray log normally reflects the shale *** gamma ray log and neutron-density porosity crossplot is used to estimate a reservoir's shale volume(Vsh),according to which the alif Member is divided into three *** addition,shale types are recognized by neutron-density porosity crossplot,and the correlation coefficients of gamma ray log-based Vsh and neutron-density porosity-based Vsh are suggested to be *** Vsh and shale types of the three zones are compared against the reservoir's potential to yield *** major oil intervals mainly concentrate in shaly sand and sandstone zones of dispersed and laminated shale *** third zone,the lowermost interval,contains pure shale of laminated type and is considered out of reservoir standards in hydrocarbon production due to its excessive shale *** assessment of shale type distribution and Vsh by crossplot approach could not furnish correct information to evaluate massive shale intervals.

关键词： Shale type distribution Shale volume(Vsh) Shaly sandstone reservoir alif member Sab'atayn Basin Yemen

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COVID-19 pandemic and the cyberthreat landscape:Research challenges and opportunities

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Digital Communications and Networks 2023年第1期9卷 211-222页

作者： Heba Saleous Muhusina Ismail Saleh HalDaajeh Nisha Madathil Saed alrabaee Kim-Kwang Raymond Choo nabeel al-Qirim Information Systems and Security College of ITUnited Arab Emirates UniversityAl AinUnited Arab Emirates Department of Information Systems and Cyber Security The University of Texas at San AntonioSan AntonioTX78249USA College of Technological Innovations(CIT) Zayed UniversityUAE

although cyber technologies benefit our society,there are also some related cybersecurity *** example,cybercriminals may exploit vulnerabilities in people,processes,and technologies during trying times,such as the ongoing COVID-19 pandemic,to identify opportunities that target vulnerable individuals,organizations(e.g.,medical facilities),and *** this paper,we examine the various cyberthreats associated with the COVID-19 *** also determine the attack vectors and surfaces of ***,we will discuss and analyze the insights and suggestions generated by different cyberattacks against individuals,organizations,and systems.

关键词： COVID-19 Cyberattacks Security and privacy Mitigation Potential solutions

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Morphological Evaluation of PLA/Soybean Oil Epoxidized Acrylate Three-Dimensional Scaffold in Bone Tissue Engineering

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Journal of Renewable Materials 2022年第9期10卷 2391-2408页

作者： Mahmood Hameed Majeed nabeel Kadhem Abd alsaheb Department of Biomedical Engineering Al Nahrain UniversityAl Jadriya BridgeBaghdad64074Iraq

Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease,injury,or congenital *** engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and *** are utilized to attach the right cells and then grow *** prototyping appears to be the most promising technology due to its high level of precision and *** tissue replacement“scaffolding”is a common theme discussed in this *** fused deposition technique was used to construct our scaffold,and a polymer called polylactic acids and soybean oil resin were used to construct our *** samples were then divided into two groups;the first group was left without immersion in the simulated body fluid and served as a control for *** second group was immersed in the simulated body *** results of the Field Emission Scanning Electron Microscope(FESEM),Energy Dispersive X-ray Spectroscopy(EDX)and X-ray diffraction(XRD)were utilized to interpret the surface attachment to ions,elements,and compounds,giving us a new perspective on scaffold *** this study,an innovative method has been used to print therapeutic scaffold that combines fused deposition three-dimensional printing with ultraviolet curing to create a high-quality biodegradable polymeric ***,the results demonstrate that adding soybean oil resin to the PLA increased ion attachment to the surface while also attracting tricalcium phosphate formation on the surface of the scaffold,which is highly promising in bone tissue *** conclusion,the soybean oil resin,which is new in the field of bone tissue engineering,shows magnificent characteristics and is a good replacement biopolymer that replaces many ceramic and polymeric materials used in this field that have poor morphological characteristics.

关键词： Bone tissue engineering polylactic acid soybean oil biodegradable polymers fused deposition modeling scaffold

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LES of rotating film-cooling performance in a 1-1/2 turbine stage

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Propulsion and Power Research 2019年第2期8卷 85-107页

作者： nabeel al-Zurfi Adel Nasser Mechanical Engineering Department Faculty of EngineeringUniversity of KufaNajafIraq School of Mechanical Aerospace and Civil EngineeringThe University of ManchesterManchesterM139PLUK

The large eddy simulation method was employed to investigate the film-cooling performance in a low-speed rotor blade of a 1-1/2 turbine *** rotor blade height and axial chord length were 99 mm and 124.3 mm,*** rows of film holes were placed on the rotor blade surface,one each on the pressure and suction *** row had three cylindrical film holes with a diameter of 4 mm and a tangential injection angle of 28°on the pressure side and 361 on the suction *** Reynolds number was fixed at Re=1.92×10^(5)and the coolant-to-mainstream density ratio(DR)was about *** were carried out for three different rotating speeds of 1800,2100,and 2400 rpm with the blowing ratio(BR)varying from 0.3 to *** commercial CFD code STAR-CCM+was used to run the simulations using the WalE subgrid-scale model for modelling the *** results show that on the pressure side,the film coverage and filmcooling effectiveness decrease with increasing rotation number(Ro)and increase with increasing blowing ratio(BR).A higher Ro and lower BR result in a stronger film *** film injection with higher BR produces better film *** film deflects centrifugally where the deflection becomes greater with increasing *** the suction side,the film coverage and film-cooling effectiveness increase with increasing either Ro or BR and a centripetal deflection of the film is *** deflection of the film path could be amplified by either increasing the Ro at a constant BR or decreasing the BR at a constant *** the rotation weakens the film deflection towards the hub on the suction ***,it was found that both rotation number and blowing ratio play significant roles in determining the film-cooling effectiveness distributions of the rotor blade surface.

关键词： Rotor blade Large eddy simulation Film-cooling effectiveness Turbulence Rotation Subgrid-scale

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Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

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BIOCELL 2022年第3期46卷 677-687页

作者： ABDELKADER HASSANI SITI ASLINA HUSSAIN MOTHANNA SADIQ al-QUBAISI MOHAMED LAKHDER BELFAR HAKIM BELKHalFA HAMID HAMMAD ENEZEI HAMID ZENTOU WISAM nabeel IBRAHIM ABD alMONEM DOOLAANEA Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University MalaysiaKuantanMalaysia Department of Chemical and Environmental Engineering University Putra MalaysiaSerdang43400Malaysia Department of Chemistry Faculty of Mathematics and Material SciencesUniversity of kasdi MurbahOuarglaAlgeria UPM-MAKNA Cancer Research Laboratory Institute of BioscienceUniversity Putra MalaysiaSerdangMalaysia Scientific and Technical Research Center in Physicochemical Analysis Bou-IsmailTipazaAlgeria Department of Oral&Maxillofacial Surgery College of DentistryUniversity of AnbarRamadiIraq Department of Biomedical Sciences College of Health SciencesQU HealthQatar UniversityDohaQatar Pharmaceutical Research Unit QU HealthQatar UniversityDohaQatar

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin(Cur)through nanoformulation with gum Arabic(GA)as a coating agent through an efficient synthetic *** antioxidant properties of the developed nanoparticles(Cur/GANPs)were assessed through several in vitro assays,such asβ-carotene bleaching activity,DPPH,and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensinconverting enzyme(ACE).The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer(MCF7,MDA-MB231),liver cancer(HepG2),and colon cancer(HT29)*** prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of–15 *** Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500μg/*** Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations ***,the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of ***,Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.

关键词： Curcumin Gum arabic Nanoparticles Cancer cells Antioxidants

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Using the Taguchi Method and Grey Relational Analysis to Optimize the Performance of a Solar Air Heater

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Energy Engineering 2021年第5期118卷 1425-1438页

作者： Manar B.al-Hajji nabeel Abu Shaban Shahnaz al Khalil Ayat al-Jarrah Department of Mechanical Engineering School of EngineeringThe University of JordanAmmanJordan Department of Mechanical Engineering Faculty of Engineering and Technology Al-Zaytonah University of JordanAmmanJordan Department of Mechatronics Engineering Faculty of EngineeringThe Hashemite UniversityZarqa’Jordan

Solar energy is regarded as one of the promising renewable energy sources in the *** main aim of this study is to use the Taguchi-Grey relational grade analysis to optimize the performance of two Solar Air Heaters(SAHs).A typical Grey–Taguchi method was *** Orthogonal Array,Signal-to-Noise ratio,Grey Relational Grade,and Analysis of Variance were employed to investigate the performance characteristics of *** observations were made in agreement with Jordanian climate 32°00′N latitude and 36°00′E longitude with a solar intensity of 500 W\m^(2).The operating factors selected for optimization are the tilt angle(T)with three levels(0°,22°,45°),inlet velocity(V)with two levels(1.2,1.8 m/s),and absorber plate material(M)with two levels(aluminum,wood).In this study,the Grey–Taguchi approach is validated by performing 12 individual *** results show that the process factors sequence required for a maximum SAH efficiency(SAHµ)is V>T>*** this approach,we combined the Orthogonal Array design with Grey Relational *** a result of that,the level of each operating conditions which optimizes both process responses(Temperature difference,ΔT and Solar air heater efficiency,SAHµ)can be specified with a minimum number of tests compared with classic Grey Relational *** optimal operating conditions of a SAH for multiple performance characteristics are determined as T2,M2,and V2,respectively,which are in congruence with the experimental results.

关键词： Solar air heater collector efficiency thermal efficiency grey-taguchi method robust design

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A numerical study of anti-vortex film-cooling holes designs in a 1-1/2 turbine stage using LES

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Propulsion and Power Research 2019年第4期8卷 275-299页

作者： nabeel al-Zurfi ali Turan Adel Nasser Ahmed alhusseny Department of Mechanical Engineering Faculty of EngineeringUniversity of KufaNajafIraq Visiting Researcher Department of MechanicalAerospace and Civil EngineeringSchool of EngineeringFaculty of Science and EngineeringThe University of ManchesterManchesterM139PLUK Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and EngineeringThe University of ManchesterManchesterM139PLUK

The primary focus of the present study is to investigate the impact of anti-vortex holes design on the film-cooling performance in a film-cooled rotor blade model using the large eddy simulation method(LES).One row of the film holes was positioned on the pressure surface of the rotor *** row had three cylindrical holes(the main hole in the present study)with a diameter(D)of 4 mm and a tangential injection angle of 28 *** main hole supplemented with the addition of two symmetrical side holes(anti-vortex holes),which branch out from the same main *** positions for the anti-vortex side holes were considered;namely:upstream to the outlet of the main hole;in line with the main hole;and downstream of the main *** Reynolds number was fixed at Re Z 1.92105 and the speed of the rotor blade was taken to be 1800 *** blowing ratio varied from 1.0 to 5.0 and the density ratio of coolant to mainstream was *** to the base hole,the film cooling performance of the all anti-vortex cases showed obvious improvement at all blowing *** middle stream side holes and downstream side holes each demonstrated good film cooling performance at all blowing ratios,while the upstream side holes perform well only at a lower blowing *** presence of side holes can restrain the CRVP(counter rotating vortex pairs)intensity of the main hole and reduce the coolant lift-off,improving the film coverage and film cooling *** downstream side holes can perform better in reducing the CRVP intensity.

关键词： Rotor blade Large eddy simulation Film-cooling effectiveness Turbulence Rotation Anti-vortex hole

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