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Morphological Evaluation of PLA/Soybean Oil Epoxidized Acrylate Three-Dimensional Scaffold in Bone Tissue Engineering

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Journal of Renewable Materials 2022年第9期10卷 2391-2408页

作者： Mahmood Hameed Majeed nabeel kadhem abd alsaheb Department of Biomedical Engineering Al Nahrain UniversityAl Jadriya BridgeBaghdad64074Iraq

Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease,injury,or congenital *** engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and *** are utilized to attach the right cells and then grow *** prototyping appears to be the most promising technology due to its high level of precision and *** tissue replacement“scaffolding”is a common theme discussed in this *** fused deposition technique was used to construct our scaffold,and a polymer called polylactic acids and soybean oil resin were used to construct our *** samples were then divided into two groups;the first group was left without immersion in the simulated body fluid and served as a control for *** second group was immersed in the simulated body *** results of the Field Emission Scanning Electron Microscope(FESEM),Energy Dispersive X-ray Spectroscopy(EDX)and X-ray diffraction(XRD)were utilized to interpret the surface attachment to ions,elements,and compounds,giving us a new perspective on scaffold *** this study,an innovative method has been used to print therapeutic scaffold that combines fused deposition three-dimensional printing with ultraviolet curing to create a high-quality biodegradable polymeric ***,the results demonstrate that adding soybean oil resin to the PLA increased ion attachment to the surface while also attracting tricalcium phosphate formation on the surface of the scaffold,which is highly promising in bone tissue *** conclusion,the soybean oil resin,which is new in the field of bone tissue engineering,shows magnificent characteristics and is a good replacement biopolymer that replaces many ceramic and polymeric materials used in this field that have poor morphological characteristics.

关键词： Bone tissue engineering polylactic acid soybean oil biodegradable polymers fused deposition modeling scaffold

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Immobilization techniques for beverage production using yeast cell systems: challenges, types, and future perspectives - a mini review

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Food and Health 2024年第4期6卷 27-38页

作者： Syed Sib Tul Hassan Shah Iqra Naeem Aimen Naeem nabeel Khalid Bhutta Fatima Noor Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China School of Biological Sciences University of the PunjabLahorePakistan Laboratory of Anti-allergic Functional Molecules College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang310018China Department of Zoology Government College UniversityFaisalabadPunjabPakistan

Yeast immobilization is a process of physical entrapment of yeast cells using different techniques while maintaining their biological *** fermentation systems have significant advantages over conventional *** highlights that immobilized yeast cell systems have several benefits as compared to free yeast *** immobilized yeast cell systems improve fermentation rates,especially when paired with continuous fermentation and appropriate immobilization *** various immobilization techniques,continuous fermentation processes,yeast metabolic activity related to beverage flavor production,and bioreactor designs is vital for optimizing the use of immobilized yeast cells systems on industrial *** review provides an overview of recent basic research on immobilized yeast cell systems,with a focus on continuous beverage *** this study,different reactor configurations and immobilization techniques are *** study focus on the impacts of immobilization on the yeast cells,and discuss the recent advancements in these *** review concludes with a discussion on the practical applications of immobilized yeast cells and continuous fermentation in beverage production.

关键词： Yeast Cell System Beverages Continuous Fermentation Microbial System

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Big Model Strategy for Bridge Structural Health Monitoring Based on Data-Driven, Adaptive Method and Convolutional Neural Network (CNN) Group

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Structural Durability & Health Monitoring 2024年第6期18卷 763-783页

作者： Yadong Xu Weixing Hong Mohammad Noori Wael A.Altabey Ahmed Silik nabeel S.D.Farhan Nanjing Highway Development Center Changzhou211106China Nanjing Zhixing Information Technology Co. Ltd.Nanjing210000China Department of Mechanical Engineering California Polytechnic State UniversitySan Luis ObispoCA 93405USA Department of Mechanical Engineering Faculty of EngineeringAlexandria UniversityAlexandria21544Egypt Department of Civil Engineering Nyala UniversityP.O.Box 155NyalaSudan School of Civil Engineering University of LeedsLeedsLS29JTUK

This study introduces an innovative“Big Model”strategy to enhance Bridge Structural Health Monitoring(SHM)using a Convolutional Neural Network(CNN),time-frequency analysis,and fine element *** ensemble methods,collaborative learning,and distributed computing,the approach effectively manages the complexity and scale of large-scale bridge *** CNN employs transfer learning,fine-tuning,and continuous monitoring to optimize models for adaptive and accurate structural health assessments,focusing on extracting meaningful features through time-frequency *** integrating Finite Element Analysis,time-frequency analysis,and CNNs,the strategy provides a comprehensive understanding of bridge *** diverse sensor data,sophisticated feature extraction,and advanced CNN architecture,the model is optimized through rigorous preprocessing and hyperparameter *** approach significantly enhances the ability to make accurate predictions,monitor structural health,and support proactive maintenance practices,thereby ensuring the safety and longevity of critical infrastructure.

关键词： Structural Health Monitoring(SHM) bridges big model Convolutional Neural Network(CNN) Finite Element Method(FEM)

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Change in mean postoperative pain in patients undergoing tonsillectomy with cold water versus usual practice:A pragmatic trial

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 24-28页

作者： Haissan Iftikhar Nida Zahid Adan Zubair Mohammad Wasif nabeel N.Baig Khadijah Abid Muhammad Ozair Awan Muhammad Sohail Awan Department of Otolaryngology Queen Elizabeth HospitalBirminghamUK Department of Surgery Aga Khan University HospitalKarachiPakistan College of Physicians and Surgeons Higher Education CommissionKarachiPakistan Department of UGME Aga Khan UniversityKarachiPakistan

Introduction:Tonsillectomy is one of the most common procedures performed in *** are various methods to perform tonsillectomies(cold and hot).Thermal damage and inflammation of the surrounding tissue using monopolar cautery is said to point to increased pain whereas immediate cooling of the burnt area is thought to reduce pain owing to heat *** objective was to determine the difference in mean post‐tonsillectomy pain scores among patients irrigated with cold water(4℃)and in patients not irrigated with cold *** and Methods:A quasi‐experimental trial was conducted from January 2016 to December 2017 at a tertiary care *** tonsillectomies were carried out with monopolar cautery at a power of 20 *** either received cold water irrigation post tonsillectomy of the tonsillar bed(intervention arm)or no irrigation(control arm).The pain score was measured on Days 0,1,3,5,and *** scores were charted on a visual analog scale on the respective ***:Seventy‐eight patients were included in the *** mean age of our patients was 10.26(4.24)years old in the intervention arm,and 11.95(4.19)years old in the control *** was observed that the pain was significantly lower in patients with cold water irrigation of the tonsillar fossa on Days 1,3,5,and 7(p=0.001).There were no readmissions postprocedure and none of our patients developed any complications ***:In this trial,we report a reduced pain score at all days of observation in the intervention *** of the tonsillar fossa is a safe,cost-effective,and less technically demanding technique that could be employed to reduce postoperative *** studies with randomization,blinding and a larger sample size could further improve on our results.

关键词： cold water tonsillectomy monopoalr tonsillectomy postoperative pain tonsillectomy

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Functional plastic films:nano-engineered composite based flexible microwave antennas with near-unity relative visible transmittance

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Light(Advanced Manufacturing) 2024年第2期5卷 95-105页

作者： Cheng Zhang Liang Zhu Chengang Ji Zhilu Ye nabeel Alsaab Minye Yang Yuhui Hu Pai-Yen Chen L.Jay Guo School of Optical and Electronic Information&Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China Department of Electrical and Computer Engineering University of Illinois at ChicagoChicagoIL 60607USA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA

Microwave antennas are essential elements for various applications,such as telecommunication,radar,sensing,and wireless power *** antennas are conventionally manufactured on rigid substrates using opaque materials,such as metal strips,metallic tapes,or epoxy pastes;thus,prohibiting their use in flexible and wearable devices,and simultaneously limiting their integration into existing optoelectronic ***,we demonstrate that mechanically flexible and optically transparent microwave antennas with high operational efficiencies can be readily fabricated using composite nanolayers deposited on common plastic *** composite nanolayer structure consists of an ultra-thin copper-doped silver film sandwiched between two dielectric films of tantalum pentoxide and aluminum *** material and thickness of each constituent layer are judiciously selected such that the whole structure exhibits an experimentally measured averaged visible transmittance as high as 98.94%compared to a bare plastic substrate,and simultaneously,a sheet resistance as low as 12.5Ω/*** representative types of microwave antennas are implemented:an omnidirectional dipole antenna,unidirectional Yagi-Uda antenna,low-profile patch antenna,and Fabry-Pérot cavity *** devices exhibit great mechanical flexibility with bending angle over 70°,high gain of up to 13.6 dBi,and large radiation efficiency of up to 84.5%.The proposed nano-engineered composites can be easily prepared over large areas on various types of substrates and simultaneously overcome the limitations of poor mechanical flexibility,low electrical conductivity,and reduced optical transparency usually faced by other constituent materials for flexible transparent microwave *** demonstrated flexible microwave antennas have various applications ranging from fifth-generation and vehicular communication systems to bio-signal monitors and wearable electronics.

关键词： Optically transparent antenna Flexible microwave antenna Transparent conductor Ultra-thin silver Doped silver Wearable optoelectronics

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NEURO FUZZY MODEL FOR PREDICTING THE DYNAMIC CHARACTERISTICS OF BEAMS

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Acta Mechanica Solida Sinica 2014年第1期27卷 85-96页

作者： Imad O.Bachi nabeel abdulrazzaq Zeng He Department of Mechanical Engineering Basrah University Department of Mechanics Engineering Huazhong University of Science and Technology Department of Civil Engineering Basrah University

An adaptive neuro-fuzzy inference system （ANFIS） is introduced to predict the dynamic behavior of beams. The effects of axial forces and large displacements are considered in the analysis. A database of tests for the dynamic characteristics of beams is developed from the experimental tests. The responses of nonlinear vibration force for the single and multiple-stepped beams are calculated from the finite element method （FEM）, experimental tests and neuro-fuzzy model for comparison. The neuro-fuzzy model provides a general framework for the combination of neural networks and fuzzy logic. It is more flexible with more options of incorporating the fuzzy nature of the real-world system and is an useful estimation tool for the dynamic characteristics of beams. Therefore, ANFIS can be a useful tool for dynamic behaviour analysis of multiple-stepped beams subjected to axial loads and large displacement.

关键词： dynamic analysis large displacement neuro-fuzzy finite element beam

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LES of rotating film-cooling performance in a 1-1/2 turbine stage

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Propulsion and Power Research 2019年第2期8卷 85-107页

作者： nabeel Al-Zurfi Adel Nasser Mechanical Engineering Department Faculty of EngineeringUniversity of KufaNajafIraq School of Mechanical Aerospace and Civil EngineeringThe University of ManchesterManchesterM139PLUK

The large eddy simulation method was employed to investigate the film-cooling performance in a low-speed rotor blade of a 1-1/2 turbine *** rotor blade height and axial chord length were 99 mm and 124.3 mm,*** rows of film holes were placed on the rotor blade surface,one each on the pressure and suction *** row had three cylindrical film holes with a diameter of 4 mm and a tangential injection angle of 28°on the pressure side and 361 on the suction *** Reynolds number was fixed at Re=1.92×10^(5)and the coolant-to-mainstream density ratio(DR)was about *** were carried out for three different rotating speeds of 1800,2100,and 2400 rpm with the blowing ratio(BR)varying from 0.3 to *** commercial CFD code STAR-CCM+was used to run the simulations using the WALE subgrid-scale model for modelling the *** results show that on the pressure side,the film coverage and filmcooling effectiveness decrease with increasing rotation number(Ro)and increase with increasing blowing ratio(BR).A higher Ro and lower BR result in a stronger film *** film injection with higher BR produces better film *** film deflects centrifugally where the deflection becomes greater with increasing *** the suction side,the film coverage and film-cooling effectiveness increase with increasing either Ro or BR and a centripetal deflection of the film is *** deflection of the film path could be amplified by either increasing the Ro at a constant BR or decreasing the BR at a constant *** the rotation weakens the film deflection towards the hub on the suction ***,it was found that both rotation number and blowing ratio play significant roles in determining the film-cooling effectiveness distributions of the rotor blade surface.

关键词： Rotor blade Large eddy simulation Film-cooling effectiveness Turbulence Rotation Subgrid-scale

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Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation:a multi-institutional,retrospective study

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Stroke & Vascular Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Mantziaris Sam Dayawansa Zhiyuan Xu Stylianos Pikis Selcuk Peker Yavuz Samanci Gokce D Ardor Ahmed M nabeel Wael A Reda Sameh R Tawadros Khaled abdelkarim Amr M N El-Shehaby Reem M Emad Eldin Ahmed H Elazzazi Nuria Martínez Moreno Roberto MartínezÁlvarez Roman Liscak Jaromir May David Mathieu Jean-Nicolas Tourigny Manjul Tripathi Akshay Rajput Narendra Kumar Rupinder Kaur Piero Picozzi Andrea Franzini Herwin Speckter Wenceslao Hernandez Anderson Brito Ronald E Warnick Juan Alzate Douglas Kondziolka Greg N Bowden Samir Patel Jason Sheehan Department of Neurological Surgery Hospices Civils de LyonLyonFrance Department of Neurological Surgery University of VirginiaCharlottesvilleVirginiaUSA Department of Neurosurgery Koc University School of MedicineIstanbulTurkey Gamma-knife Center Nasser institute HospitalCairoEgypt Neurosurgery Department Benha UniversityBenhaEgypt Departments of Neurosurgery Ain Shams UniversityCairoEgypt Department of Clinical Oncology Ain Shams UniversityCairoEgypt Department of Radiation Oncology National Cancer InstituteCairo UniversityGizaEgypt Faculty of Medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Department of Radiosurgery Rúber Internacional HospitalMadridSpain Department of Stereotactic and Radiation Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia Radiation Therapy PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominican Gamma Knife Center and Radiology Department CEDIMATSanto DomingoDominican Republic Gamma Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of Radiation Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Background Cerebral cavernous malformations(CCMs)frequently manifest with *** radiosurgery(SRS)has been employed for CCM not suitable for *** effect on reducing haemorrhage risk is still *** aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic *** This retrospective multicentric study included CCM with at least one haemorrhage treated with single-session *** annual haemorrhagic rate(AHR)was calculated before and after *** event analysis and Cox regression were used to evaluate factors associated with *** radiation effects(AREs)and occurrence of new neurological deficits were *** The study included 381 patients (median age:37.5 years(Q1–Q3:25.8–51.9))with 414 *** AHR from diagnosis to SRS excluding the first haemorrhage was 11.08 per 100 CCM-years and was reduced to 2.7 per 100 CCM-years after *** recurrent event analysis,SRS,HR 0.27(95%CI 0.17 to 0.44),p13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 and the presence of DVA,HR 2.08(95%CI 1.00 to 4.31),p=0.049 were factors associated with higher probability of post-SRS ***-SRS haemorrhage was symptomatic in 22 out of 381(5.8%)patients,presenting with transient(15/381)or permanent(7/381)neurological *** occurred in 11.1%(46/414)CCM and was responsible for transient neurological deficit in 3.9%(15/381)of the patients and permanent deficit in 1.1%(4/381)of the *** doses>13 Gy and CCM volume>0.7 cc were associated with increased risk of ARE.

关键词： doses haemorrhagic diagnosis

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Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

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BIOCELL 2022年第3期46卷 677-687页

作者： abdELKADER HASSANI SITI ASLINA HUSSAIN MOTHANNA SADIQ AL-QUBAISI MOHAMED LAKHDER BELFAR HAKIM BELKHALFA HAMID HAMMAD ENEZEI HAMID ZENTOU WISAM nabeel IBRAHIM abd ALMONEM DOOLAANEA Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University MalaysiaKuantanMalaysia Department of Chemical and Environmental Engineering University Putra MalaysiaSerdang43400Malaysia Department of Chemistry Faculty of Mathematics and Material SciencesUniversity of kasdi MurbahOuarglaAlgeria UPM-MAKNA Cancer Research Laboratory Institute of BioscienceUniversity Putra MalaysiaSerdangMalaysia Scientific and Technical Research Center in Physicochemical Analysis Bou-IsmailTipazaAlgeria Department of Oral&Maxillofacial Surgery College of DentistryUniversity of AnbarRamadiIraq Department of Biomedical Sciences College of Health SciencesQU HealthQatar UniversityDohaQatar Pharmaceutical Research Unit QU HealthQatar UniversityDohaQatar

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin(Cur)through nanoformulation with gum Arabic(GA)as a coating agent through an efficient synthetic *** antioxidant properties of the developed nanoparticles(Cur/GANPs)were assessed through several in vitro assays,such asβ-carotene bleaching activity,DPPH,and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensinconverting enzyme(ACE).The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer(MCF7,MDA-MB231),liver cancer(HepG2),and colon cancer(HT29)*** prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of–15 *** Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500μg/*** Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations ***,the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of ***,Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.

关键词： Curcumin Gum arabic Nanoparticles Cancer cells Antioxidants

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