检索结果-南通市图书馆

Platelets in hemostasis and thrombosis:Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis

引用

The Journal of Biomedical Research 2015年第6期29卷 437-444页

作者： Yan Hou naadiya carrim Yiming Wang Reid C.Gallant Alexandra Marshall Heyu Ni Department of Laboratory Medicine Keenan Research Centre for Biomedical ScienceLi Ka Shing Knowledge InstituteSt.Michael's Hospital and Toronto Platelet Immunobiology Group Jilin Provincial Center for Disease Control and Prevention Department of Laboratory Medicine and Pathobiology University of Toronto Canadian Blood Services Department of Medicine and Department of Physiology University of Toronto

Platelets are small anucleate cells generated from megakaryocytes in the bone marrow. Although platelet genera- tion, maturation, and clearance are still not fully understood, significant progress has been made in the last 1-2 dec- ades. In blood circulation, platelets can quickly adhere and aggregate at sites of vascular injury, forming the platelet plug （i.e. the first wave of hemostasis）. Activated platelets can also provide negatively charged phosphatidylserine- rich membrane surface that enhances cell-based thrombin generation, which facilitates blood coagulation （i.e. the second wave of hemostasis）. Platelets therefore play central roles in hemostasis. However, the same process of hemostasis may also cause thrombosis and vessel occlusion, which are the most common mechanisms leading to heart attack and stroke following ruptured atherosclerotic lesions. In this review, we will introduce the classical mechanisms and newly discovered pathways of platelets in hemostasis and thrombosis, including fibrinogen-inde- pendent platelet aggregation and thrombosis, and the plasma fibronectin-mediated ＂protein wave＂ of hemostasis that precedes the classical first wave of hemostasis. Furthermore, we briefly discuss the roles of platelets in inflam- marion and atherosclerosis and the potential strategies to control atherothrombosis.

关键词： platelets thrombosis and hemostasis integrin αIIbβ3 fibrinogen fibronectin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platelets and platelet alloantigens:Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia

引用

Genes & Diseases 2015年第2期2卷 173-185页

作者： Brian Vadasz Pingguo Chen Issaka Yougbare Darko Zdravic June Li Conglei Li naadiya carrim Heyu Ni Toronto Platelet Immunobiology Group TorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical ScienceSt.Michael’s HospitalTorontoONCanada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Canadian Blood Services TorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Medicine University of TorontoTorontoONCanada

Platelets play critical roles in hemostasis and *** evidence indicates that they are versatile cells and also involved in many other physiological processes and disease *** and neonatal alloimmune thrombocytopenia(FNAIT)is a life threatening bleeding disorder caused by fetal platelet destruction by maternal alloantibodies developed during *** polymorphisms cause platelet surface protein incompatibilities between mother and fetus,and ultimately lead to maternal *** is the most common cause of intracranial hemorrhage in full-term infants and can also lead to intrauterine growth retardation and *** diagnosis,prevention and treatment of FNAIT is challenging due to insufficient knowledge of the disease and a lack of routine screening as well as its frequent occurrence in first *** the ethical difficulties in performing basic research on human fetuses and neonates,animal models are essential to improve our understanding of the pathogenesis and treatment of *** aim of this review is to provide an overview on platelets,hemostasis and thrombocytopenia with a focus on the advancements made in FNAIT by utilizing animal models.

关键词： Fetal and neonatal alloimmune thrombocytopenia Integrins and GPIb complex Platelets and platelet receptors Thrombosis and hemostasis and Animal models of human disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：