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Atrial fibrillation burden and the risk of stroke:A systematic review and dose-response meta-analysis

World Journal of Clinical Cases 2022年第3期10卷 939-953页

作者： Sheng-Yi Yang min Huang Ai-Lian Wang Ge Ge mi ma Hong Zhi Li-na Wang Department of Epidemiology and Biostatistics Southeast UniversityNanjing 210009Jiangsu ProvinceChina Yaohua Community Healthcare Center Nanjing 210046Jiangsu ProvinceChina Department of Cardiology Zhongda HospitalNanjing 210009Jiangsu ProvinceChina School of Public Health Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND The increased stroke risk associated with atrial fibrillation(AF)burden exceeding 5 min is a matter of *** addition,the potential linear or nonlinear relationship between AF burden and stroke risk has been largely *** To determine the association between AF burden>5 min and the increased risk of stroke and explore the potential dose-response relationship between these two *** Sixteen studies from six databases with 53141 subjects(mean age 65 years)were *** studies were observational studies,and one was a randomized controlled trial *** potential nonlinear dose-response association was characterized using a restricted cubic splines regression *** burden for each 1 h and 2 h was associated with an increased risk of *** sequential analysis with a random-effect model was used to evaluate the robustness of the evidence from the included 16 *** AF burden>5 min was associated with an increased risk of clinical AF[adjusted risk ratio(RR)=4.18,95%confidence interval(CI):2.26-7.74].However,no association was found with an increased risk of all-cause mortality(adjusted RR=1.55,95%CI:0.87-2.75).Patients with AF burden>5 min had an increased risk of stroke(adjusted RR=2.49,95%CI:1.79-3.47).Moreover,a dose-response analysis showed that the increased stroke risk was paralleled by an increase in AF burden at a rate of 2.0%per hour(Pnonlinear=0.656,RR=1.02,95%CI:1.01-1.03).Trial sequential analysis provided robust evidence of the association between AF burden>5 min and an increased risk of *** AF burden was a significant risk factor for clinical AF and future stroke.A significant linear association was documented between increased AF burden and risk of future stroke.

关键词： Atrial fibrillation Stroke Dose-response Meta-analysis Risk

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Weekly Weight Gain in Women with Gestational Diabetes Mellitus and Neonatal Birth Weight - China, 2011–2021

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China CDC weekly 2023年第32期5卷 703-709页

作者： nana Liu Jinlang Lyu Haijun Wang Yin Sun Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai ma na Han Yang mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Yuelong Ji Liangkun ma Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College National Clinical Research Center for Obstetric&Gynecologic DiseasesBeijingChina Peking University School of Public Health BeijingChina Beijing Tongzhou maternal and Child Health Hospital BeijingChina Northwest Women’s and Children Hospital Xi’an CityShaanxi ProvinceChina Guiyang maternal and Child Health Hospital Guiyang CityGuizhouChina The Fourth Hospital of Hebei Medical University Shijiazhuang CityHebei ProvinceChina Wenzhou’s People Hospital Wenzhou CityZhejiang ProvinceChina Dong E County People’s Hospital Liaocheng CityShandong ProvinceChina.

What is already known about this topic?Elevated gestational weight gain(GWG)during pregnancy among women diagnosed with gestational diabetes mellitus(GDM)is correlated with an increased instance of large for gestational age(LGA)and ***,it remains uncertain whether managing weekly GWG following a GDM diagnosis positively impacts fetal birth *** is added by this report?Our study found that GWG following GDM diagnosis correlates positively with the risk of LGA and macrosomia among all body mass index(Bmi)subgroups,especially for overweight and obese *** are the implications for public health practice?The results of this research highlight the importance of enforcing a more stringent regulation on GWG on a weekly basis for overweight and obese women diagnosed with GDM,particularly when considering neonatal growth.

关键词： diagnosis fetal pregnancy

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Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021

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China CDC weekly 2023年第9期5卷 189-193,I0001-I0007页

作者： Jinlang Lyu Yin Sun Yuelong Ji nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai ma na Han Yang mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun ma Haijun Wang School of Public Health Peking UniversityBeijing MunicipalityChina Peking Union Medical College Hospital Beijing MunicipalityChina Chinese Academy of Medical Sciences and Peking Union Medical College Beijing MunicipalityChina Tongzhou maternal and Child Health Hospital Beijing MunicipalityChina Northwest Women’s and Children’s Hospital Xi'an CityShaanxi ProvinceChina Guiyang maternal and Child Health Hospital Guiyang CityGuizhou ProvinceChina The Fourth Hospital of Hebei Medical University Shijiazhuang CityHebei ProvinceChina Wenzhou People’s Hospital Wenzhou CityZhejiang ProvinceChina People’s Hospital of Dong’e County Liaocheng CityShandong ProvinceChina.

Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of *** is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,*** are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management.

关键词： diagnosis gestational pregnancy

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Allicin Improves Cardiac Function by Protecting against Apoptosis in Rat Model of Myocardial Infarction

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Chinese Journal of Integrative Medicine 2017年第8期23卷 589-597页

作者： ma Li-na LI Lian-da LI Shao-chun HAO Xin-mei ZHANG Jin-yan HE Ping LI Yi-kui Graduate School Beijing University of Chinese Medicine Laboratory of Academician LI Lian-da Xiyuan HospitalChina Academy of Chinese Medical Sciences School of Basic Medical Sciences Hebei University

Objective：To study the effects of allicin on cardiac function and underlying mechanism in rat model of myocardial infarction（mi）.Methods：Ninety-four Wistar rats were randomly assigned to 6 groups（n=14–16 per group）：sham control group[underwent thoracotomy without left anterior descending（LAD）occlusion and only received an injection of the same amount of citrate buffer],mi control group（subjected to LAD occlusion and only received an injection of same amount of citrate buffer）,positive control group（subjected to LAD occlusion and received an injection of diltiazem hydrochloride at the dose of 1.5 mg/kg）,and mi＋allicin groups（subjected to LAD occlusion and received an injection of allicin at the doses of 1.2,1.8,and 3.6 mg/kg）.All of the drugs were administered intraperitoneally daily for 21 *** infarct area was measured by myocardial ***-eosin staining was used to observe the pathological *** function parameters were assessed by *** myocardial apoptotic index was estimated by terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling *** expression of Bax and Bcl-2 were detected by quantificational real-time polymerase chain reaction and Western ***：Treatment with allicin could attenuate the myocardial infarct area（P〈0.05）and relieve the changes of the *** left ventricular anterior wall diastolic and systolic thicknesses were increased in the allicin-treated groups（P〈0.05）,while there was no significant difference in the left ventricular posterior wall diastolic and systolic thickness（P〉0.05）.The left ventricular internal diameter in systole,ejection fraction,fractional shortening,and stroke volume were dramatically elevated in allicin-treated rats（P〈0.05）.Allicin dose-dependently reduced creatine kinase and lactate dehydrogenase levels（P〈0.05）.The myocardial apoptotic index was also markedly lowered,and Bax expression was significantly decreased,whereas Bcl-2 expression exhib

关键词： allicin myocardial infarction cardiac function apoptosis Bcl-2/Bax

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Glycogen synthase kinase-3β inhibition alleviates NLRP3 inflammasome activation in myocardial infarction

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中国药理学与毒理学杂志 2019年第10期 801-802页

作者： WANG Shu-hui XU Li-na SU Xue-ling ma Yu-ran ZHANG Li-rong HAN Sheng-na School of Basic Medical Sciences Zhengzhou University

OBJECTIVE To investigate the regulatory mechanisms of glycogen synthase kinase-3β(GSK-3β)on NLRP3 inflammasome activation. METHODS We conducted myocardial infarction(mi) model in male Sprague-Dawley(SD) rat during days 2-28. An in vitro investigation was performed using new-born rat/human cardiomyocyte and fibroblast cultures under typical inflammasome stimulation and hypoxia treatment. Further identification for possibility of GSK-3β active NLRP3 inflammasomes, GSK-3β immunoprecipitation was performed from the lysate of inflammasome stimulation-treated rat neonatal fibroblasts(RCFs) with or without GSK-3β inhibitor pretreatment. RESULTS Assessments of cardiac function, histochemical and biochemical assays for cardiac tissues, as well as detection of protein and m Rna expressions in heart tissues, showed that GSK-3β inhibition remarkably improves myocardial dysfunction and prevents remodeling with parallel reduction of the parameters of NLRP3 inflammasome activation after mi. The measurement of primary rats/human cells expounded that GSK-3β inhibition reduce NLRP3 inflammasome activation happens in cardiac fibroblasts, but not in cardiomyocytes. Futhermore, GSK-3β interacts with ASC and GSK-3β inhibition reduces cytoplasmic aggregates of ASC, NLRP3 and caspase-1 formation. CONCLUSION GSK-3β directly mediates NLRP3 inflammasome activation causing cardiac dysfunction in mi.

关键词： myocardial infarction glycogen synthase kinase 3 cardiac fibroblasts NLRP3 inflammasome ASC

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Effects of moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) on chronic atrophic gastritis in rats

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Journal of Traditional Chinese Medicine 2020年第5期40卷 827-835页

作者： Liu mi Shen Jiacheng Liu Caichun Zhong Huan Yang Qing Shu Wenna ma mingzhu Dong Jiyang Yang Zongbao Chang Xiaorong She Chang Yu Shu College of Acupuncture&Moxibustion and Tui-na Hunan University of Chinese MedicineChangsha 410208China Liuyang Hospital of Chinese Medicine Liuyang 410300China Department of Traditional Chinese Medicine Department of Electronic ScienceXiamen UniversityXiamen 361005China Department of Electronic Science Fujian Provincial Key Laboratory for Plasma and Magnetic ResonanceXiamen UniversityXiamen 361005China City University of Hong Kong Hong Kong 999077China Changsha Hospital of Traditional Chinese Medicine(Changsha Eighth Hospital) Changsha 410002China Tat Chee Avenue KowloonHong Kong 999077China

OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their ***:Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40%ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks,followed by daily treatment with moxibustion or acupuncture for 2 *** examination,Western blotting of cytokines[epidermal growth factor(EGF),EGF receptor(EGFR),extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK)],and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and ***:Moxibustion and acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and *** moxibustion treatment regulated the expression of EGF and *** that were increased in gastric tissue by CAG induction(alanine,nicotinamide adenine dinucleotide phosphate,uracil Dna glycosylase,lactate,glycerol and adenosine)were restored to normal levels after moxibustion treatment;acupuncture treatment only normalized the levels of adenosine monophosphate and ***:Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)can significantly improve the condition of CAG in *** treatments exert their effects on CAG through different mechanisms.

关键词： Gastritis,atrophic Moxibustion Acupuncture Metabolomics Proton magnetic resonance spectroscopy

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污灌区地下水硝酸盐污染来源的氮同位素示踪

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地球科学（中国地质大学学报） 2012年第2期37卷 350-356页

作者：张翠云张胜马琳娜殷密英中国地质科学院水文地质环境地质研究所河北石家庄050061

为了识别石家庄市南部污灌区地下水硝酸盐污染来源,采集5种潜在污染源和19组地下水样用于化学和氮同位素分析.灌溉污水NH4+的δ15N值较低(4.0‰),施化肥土壤和粪堆下土壤NO3-的δ15N值分别为1.4‰和12.4‰;仅施厩肥的蔬菜种植区下伏近30... 详细信息

为了识别石家庄市南部污灌区地下水硝酸盐污染来源,采集5种潜在污染源和19组地下水样用于化学和氮同位素分析.灌溉污水NH4+的δ15N值较低(4.0‰),施化肥土壤和粪堆下土壤NO3-的δ15N值分别为1.4‰和12.4‰;仅施厩肥的蔬菜种植区下伏近30m厚包气带沉积物NO3-的δ15N分布显示,来自动物粪便的NO3-已运移到11.5m以下包气带,均值10.9‰;污水灌溉农田下伏厚层包气带沉积物样品分析结果指示,土壤层下伏包气带沉积物δ15N值变幅较小,均值5.7‰.污灌区内除一深井外,其他水井地下水硝酸盐浓度变化在52.6～124.5mg/L之间,均值79.72mg/L,δ15N值变化在5.3‰～8.3‰之间,均值7.0‰.污灌区地下水的δ15N值较污灌区土壤层下伏包气带沉积物的δ15N值高,表明地下水NO3-除了来自灌溉的污水外,还有δ15N值更高的其他来源,这些来源主要是人和动物粪便.利用线性混合模型计算,污灌区地下水NO3-来自灌溉的污水,约占76%,而来自人和动物粪便的NO3-约占24%.为控制污灌区地下水NO3-浓度进一步增长,不仅要加强污水灌溉管理,还要加强人和动物粪便的管理.

关键词：氮同位素硝酸盐污染地下水污灌区包气带水文地质环境地球化学

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Glycemic control predicts the risk of hepatic fibrosis in biopsy-proven naFLD:a possible mediating role for leukemia inhibitory factor?

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iLIVER 2022年第1期1卷 30-34页

作者： Feng Gong Kenneth I.Zheng Liang-Jie Tang Gang Li Rafael S.Rios Ou-Yang Huang Yang-Yang Li Christopher D.Byrne Giovanni Targher man mi na He Hong-Lei ma ming-Hua Zheng Xi'an Medical University China naFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Southampton national Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly The First Affiliated Hospital of Xi'an Medical University Xi'anChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Background:Despite the clear link between nonalcoholic fatty liver disease(naFLD)and type 2 diabetes mellitus,little is understood about how glycemic control impacts histological *** aimed to investigate the deeper association between hemoglobin A1c(HbA1c)and the histologic severity of liver ***:A total of 568 adults with biopsy-proven naFLD from the PERSONS cohort in Wenzhou were *** association between mean HbA1c and hepatic histological features was investigated with ordinal logistic *** additive models were used to identify the non-linear relationship between HbA1c and increased fibrosis stage(stage F3).Causal mediation analysis was performed to calculate the indirect effect of the relationship between HbA1c and hepatic fibrosis mediated by ***:Every 1%increase in mean HbA1c was associated with 16%higher odds of increased fibrosis stage(odds ratio 1.16,95%CI 1.04–1.30),even after adjustment for confounding *** was a non-linear association between HbA1c and increased fibrosis stage(stage F3),and the HbA1c inflection point was 9.2%.In particular,the ORs on the left and right sides of this inflection point were 2.1(95%CI 1.4–3.3)and 0.1(95%CI 0–4.8),respectively.7%of the association(OR 1.07,95%CI 1.01–1.12)between HbA1c and liver fibrosis was mediated by leukemia inhibitory ***:Glycemic control predicts severity of hepatic fibrosis and leukemia inhibitory factor plays an intermediary role between them,and thus optimizing glycemic control may be a means of modifying the risk of fibrosis progression in naFLD.

关键词： naFLD Leukemia inhibitory factor Hepatic fibrosis

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苦豆碱对缺氧/复氧损伤的人脐静脉内皮细胞保护机制研究

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天然产物研究与开发 2020年第9期32卷 1592-1598页

作者：马会军朱米娜杜燕西安市第一医院心血管内科西安710002

苦豆碱(aloperine,ALO)是一种具有抗炎、抗肿瘤及抗感染功效的生物碱,但其对人脐静脉内皮细胞缺氧/复氧损伤的影响尚不明确。本研究利用人脐静脉内皮细胞建立了体外缺氧/复氧损伤的细胞模型,对细胞进行分组处理:对照组、缺氧/复氧损伤... 详细信息

苦豆碱(aloperine,ALO)是一种具有抗炎、抗肿瘤及抗感染功效的生物碱,但其对人脐静脉内皮细胞缺氧/复氧损伤的影响尚不明确。本研究利用人脐静脉内皮细胞建立了体外缺氧/复氧损伤的细胞模型,对细胞进行分组处理:对照组、缺氧/复氧损伤组、苦豆碱(20、50和100μmol/L)预处理组。对细胞活力、细胞内乳酸盐脱氢酶(LDH)、丙二醛(MDA)和超氧化物歧化酶(SOD)活性,细胞内白细胞介素-1β(IL-1β)和肿瘤坏死因子α(TNF-α),以及内质网应激相关蛋白GRP78,XBP-1和凋亡相关蛋白CHOP的表达进行了检测。我们发现与缺氧/复氧损伤组相比,苦豆碱预处理能显著提高细胞活力和SOD活性、降低LDH活性、MDA含量以及IL-1β和TNF-α的水平(P<0.05)。另外,苦豆碱预处理还显著下调缺氧/复氧损伤引起的GRP78、XBP-1和CHOP水平的上升(P<0.05)。本研究证实苦豆碱能够提高细胞抗脂质过氧化反应的能力、降低炎症因子水平、抑制内质网应激引起的细胞凋亡,改善缺氧/复氧损伤引起的内皮细胞损伤。

关键词：苦豆碱人脐静脉内皮细胞缺氧/复氧炎症内质网应激

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数据驱动的公路桥梁网络全寿命抗震韧性评估

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吉林大学学报（工学版） 2023年第6期53卷 1695-1701页

作者：刘振亮赵存宝吴云鹏马迷娜马龙双石家庄铁道大学安全工程与应急管理学院石家庄050043 河北省大型结构健康诊断与控制研究所石家庄050043

首先,提出了综合考虑各种因素(网络拓扑结构、桥梁性能退化、地震动等)和不确定性的公路桥梁网络抗震韧性评估框架。然后,分析了网络拓扑结构、桥梁抗震性能和路段功能特点,建立了震后公路桥梁网络时变功能模拟方法。接着,提出了基于人... 详细信息

首先,提出了综合考虑各种因素(网络拓扑结构、桥梁性能退化、地震动等)和不确定性的公路桥梁网络抗震韧性评估框架。然后,分析了网络拓扑结构、桥梁抗震性能和路段功能特点,建立了震后公路桥梁网络时变功能模拟方法。接着,提出了基于人工神经网络的公路桥梁地震易损性快速分析方法。最后,以美国旧金山地区公路桥梁网络为例,采用本文方法分析了地震发生前、后公路桥梁网络的功能变化,据此揭示了全寿命服役期内抗震韧性的演化规律。结果表明,本文建立的数据驱动易损性模型拟合优度可达0.73,可以代替需要大量动力时程分析的易损性分析方法,且公路桥梁网络抗震韧性评估结果准确可靠,可以为防灾减灾提供决策依据。

关键词：交通运输系统工程公路桥梁网络抗震韧性数据驱动易损性全寿命性能

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