检索结果-南通市图书馆

Cellular & molecular Immunology 2015年第5期12卷 625-632页

作者： Lei Zhang Zhiming Pan Xilong Kang Yun Yang Heekap Kang na Zhang James m rosati Xinan Jiao Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou China Jiangsu Key Laboratory of Zoonosis Yangzhou University Yangzhou China ministry of Education Key Lab for Avian Preventive medicine Yangzhou University Yangzhou China Division of nephrology and Hypertension Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL USA

Toll-like receptor 5 （TLr5） signaling in response to flagellin is dispensable for inducing humoral immunity, but alterations of aa 89-96, the TLr5 binding site, significantly reduced the adjuvanticity of flagellin. These observations indicate that the underlying mechanism remains incompletely understood. Here, we found that the native form of Salmonella typhimurium aa 89-96-mutant flagellin extracted from flagella retains some TLr5 recognition activity, indicating that aa 89-96 is the primary, but not the only site that imparts TLr5 activity. Additionally, this mutation impaired the production of IL-lp and IL-18. Using TLr5KO mice, we found that aa 89-96 is critical for the humoral adjuvant effect, but this effect was independent of TLr5 activation triggered by this region of flageUin. In summary, our findings suggest that aa 89-96 of flagellin is not only the crucial site responsible for TLr5 recognition, but is also important for humoral immune adjuvanticity through a TLr5-independent pathway.

关键词： adjuvanticity amino acids 89-96 Salmonella typhimurium flagellin TLr5 activity

基于16S rrna测序技术探讨骨松益骨方对去卵巢大鼠肠道菌群的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学通报 2024年第9期40卷 1752-1759页

作者：郑旭霞柴爽魏立伟张虹秦娜河南省洛阳正骨医院(河南省骨科医院) 河南郑州450016

目的基于肠道菌群探究骨松益骨方(GusongYigu decoction,GSYG)治疗绝经后骨质疏松症(postmenopausal osteoporosis,PmOP)的机制。方法SPF级SD大鼠60只随机分成假手术组(Control)、模型组(model)、骨松益骨方低剂量组(GSYG-L,1.25 g·kg^(-1))、骨松益骨方中剂量组(GSYG-m,2.5 g·kg^(-1)),骨松益骨方高剂量组(GSYG-H,5 g·kg^(-1))和阿仑膦酸钠组(Al,0.89 mg·kg^(-1)),每组10只。HE染色观察骨组织形态变化,micro CT观察大鼠的股骨组织结构变化;取Control组、model组、GSYG-H组大鼠结肠粪便样本,提取Dna,利用Illumina miseq平台进行高通量测序。结果与Control组比较,model组大鼠骨小梁稀疏;BV/TV、***、Tb.n及BmD均明显降低(PmI、***明显升高(Pmodel组比较,GSYG-L、GSYG-m、GSYG-H组和Al组骨小梁数目增加,骨微结构得到改善,且BV/TV、***、Tb.n及BmD明显增加(PmI、***明显降低(Pntrol组比较,model组大鼠肠道菌群多样性降低,厚壁菌门丰度降低,而拟杆菌门丰度增加;与model组比较,GSYG-H组厚壁菌门丰度增加,拟杆菌门丰度减少。结论GSYG能够改善PmOP患者的骨微结构,增加骨密度,其作用机制可能与增加肠道菌群的多样性、调节肠道菌群结构有关。

关键词：骨松益骨方绝经后骨质疏松症肠-骨轴肠道菌群 16S rrna 骨密度

Effect of ringer's Solution on Wear and Friction of Stainless Steel 316L after Plasma Electrolytic nitrocarburising at Low Voltages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of materials Science & Technology 2011年第10期27卷 906-912页

作者： n.Afsar Kazerooni m.E.Bahrololoom m.H.Shariat F.mahzoon T.Jozaghi Department of materials Science and Engineering Shiraz University

A plasma electrolytic nitrocarburising （PEn/C） process was performed on stainless steel 316L to improve the surface properties for using as medical implants. A bath was optimised to reduce the required voltage to 150 volts. Aqueous urea-based solutions with 10% nH4Cl were prepared with slightly different amounts of na2CO3 to optimise the electrolyte composition. The surface and the cross-section morphologies were studied by scanning electron microscopy. The microstructure and the chemical composition of samples were investigated by X-ray diffraction （XrD） and energy dispersive X-ray （EDX） techniques. The microstructure of the outer layer of the coatings was found to be a complex oxide containing Cr and Fe. The wear properties of the samples were examined by using a pin on disk wear test with ringer＇s solution and were compared with their wear properties in the ambient atmosphere. The ringe（s solution acted as a lubricant, reducing friction coefficient. Hardness and roughness were also studied. The bath with the composition of 10% nH4CI and 3% na2CO3 exhibited the best tribological properties. The results showed that the tribological properties of treated samples were improved and the wear mechanism was abrasion of the pin.

关键词： Plasma electrolytic nitrocarburising ringer's solution Tribological properties

Extensive pollen immigration and no evidence of disrupted mating patterns or reproduction in a highly fra.m.nted holm oak stand

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2014年第4期7卷 384-395页

作者： Joaquín Ortego raúl Bonal Alberto muñoz Josémiguel Aparicio Grupo de Investigación de la Biodiversidad Genética y Cultural Instituto de Investigación en Recursos Cinegéticos-IREC(CSICUCLMJCCM)Ronda de Toledo s/nE-13005 Ciudad RealSpain Departamento de Ecología Evolutiva Museo Nacional de Ciencias Naturales(CSIC)C/JoséGutiérrez Abascal 2E-28006 MadridSpain Departamento de Didáctica de las Ciencias Experimentales Facultad de EducaciónUniversidad Complutense de MadridC/Rector Royo Villanova s/nE-28040 MadridSpain Centre de recerca Ecològica i Aplicacions Forestals(CrEAF) Cerdanyola del VallèsE-08193 BarcelonaSpain

Aims Forest fra.m.ntation and reduced tree population densities can poten-tially have negative impacts on mating patterns,offspring genetic diversity and reproductive *** aim of the present study is to test these hypotheses comparing an extremely fra.m.nted,low tree density(~0.02 trees/ha)holm oak(Quercus ilex l.)stand from Central spain with a nearby high tree density stand(~50 trees/ha).methods We genotyped adult trees and seeds from the low-density stand(436 seeds from 15 families)and the high-density stand(404 seeds from 11 families)using nine microsatellite *** these data,we performed paternity analyses,determined pollen flow,mating patterns and pollen pool structure,and estimated progeny genetic diversity in both *** also studied seed set and production and performed a pollen supplementation experiment to determine whether reduced tree density has limited foreign pollen *** Findings We have found extensive pollen immigration(>75%)into the low tree density stand and monte Carlo simulations revealed that pollen moves larger distances than expected from null models of random *** patterns and differentiation of pollen pools were similar in the high-density stand and the low-density stand but we found higher inter-annual differentiation of pollen pools in the *** genetic diversity and self-fertilization rates did not dif-fer between the low-density stand and the high-density *** set rates were significantly lower in the low-density stand than in the high-density stand and experimental cross-pollen supplementation evidenced that foreign pollen availability is indeed a limiting factor in the ***,seed crops did not differ between the low-density stand and the high-density stand,indicating that limitation of foreign pollen is not likely to be of great concern in terms of reduced seed production and potential *** forest regeneration due to other ecological and human fac

关键词： forest fra.m.ntation genetic diversity paternity analyses pollen dispersal pollen pool structure selfing tree density

基于分数阶黏弹性缓冲系统的代理模型可视化研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国工程机械学报 2024年第3期22卷 287-292页

作者：孙宝姜旭磊郭娜张丽静太原科技大学应用科学学院山西太原030024

分数阶黏弹性缓冲系统模型可以准确描述黏弹性材料的力学性质,被广泛应用于工程车辆的减振控制中。但由于模型本身的复杂度使得在求解及优化过程中消耗大量的时间和计算成本,而代理模型很好地解决这一问题。通过引入图形用户界面(GUI)技... 详细信息

分数阶黏弹性缓冲系统模型可以准确描述黏弹性材料的力学性质,被广泛应用于工程车辆的减振控制中。但由于模型本身的复杂度使得在求解及优化过程中消耗大量的时间和计算成本,而代理模型很好地解决这一问题。通过引入图形用户界面(GUI)技术,开发出一种用户友好的复杂分数阶代理模型可视化实验系统,该系统主要包含实验设计模块、代理模型模块和误差分析模块3大模块。使用时根据需求选择不同的分数阶及代理模型,输入变量取值范围信息,即可得到代理模型拟合效果图以及误差,然后对比分析不同代理模型的误差结果,选择拟合效果最好的代理模型。以maxwell分数阶模型为例,在同等变量选择范围下分析4种代理模型获得的代理效果。结果表明:当施加外力在0~100 n,系统固有频率在0~100 Hz的条件下,决定系数为0.989 7,均方根误差为0.146的混合自适应代理模型为拟合效果最好的代理模型。此系统的开发为代理模型在分数阶黏弹性缓冲系统的计算及优化研究中提供一定的应用价值,解决了复杂分数阶求解计算成本大的问题。

关键词：分数阶代理模型可视化图形用户界面(GUI) 实验系统

Evaluation of high yielding soybean germplasm under water limitation

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2016年第5期58卷 475-491页

作者： Silvas J.Prince mackensie murphy ra.m.nd n.mutava Zhengzhi Zhang na nguyen Yoon Ha Kim Safiullah m.Pathan Grover J.Shannon Babu Valliyodan Henry T.nguyen national Center for Soybean Biotechnology and Division of Plant Sciences University of Missouri

Limited information is available for soybean root traits and their plasticity under drought stress. To date, no studies have focused on examining diverse soybean germ- plasm for regulation of shoot and root response under water limited conditions across varying soil types. In this study, 17 genetically diverse soybean germplasm lines were selected to study root response to water limited conditions in clay （trial 1） and sandy soil （trial 2） in two target environments. Physiological data on shoot traits was measured at multiple crop stages ranging from early vegetative to pod filling. The phenotypic root traits, and biomass accumulation data are collected at pod filling stage. In trial 1, the number of lateral roots and forks were positively correlated with plot yield under water limitation and in trial 2, lateral root thickness was positively correlated with the hill plot yield. Plant Introduction （PI） 578477A and 088444 were found to have higher later root number and forks in clay soil with higher yield under water limitation, in sandy soil, P1458o2o was found to have a thicker lateral root system and higher yield under water limitation. The genotypes identified in this study could be used to enhance drought tolerance of elite soybean cultivars through improved root traits specific to target environments.

关键词： Fibrous root root angle root plasticity root systemarchitecture (rSA) root thickness spectral indices soybean spectralindices total root length water limitation

Anomalous acceleration of ions in a plasma accelerator with an anodic layer

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2018年第3期20卷 95-105页

作者： V m BArDAKOV S D IVAnOV A V KAZAnTSEV n A STrOKIn A n STUPIn Binhao JIAnG Zhenyu WAnG Irkutsk State Transport University Chernyshevsky Str.15664074IrkutskRussia national research Irkutsk Technical University Lermontova Str.83664074IrkutskRussia Department of Electrical Engineering Harbin Institute of TechnologyHarbin 150001People's Republic of China

In a plasma accelerator with an anodic layer(PAAL),we discovered experimentally the effect of‘super-acceleration'of the bulk of the ions to energies W exceeding the energy equivalent to the discharge voltage V_(d).The E×B discharge was ignited in an environment of atomic argon and helium and molecular *** charged argon ions were accelerated most effectively in the case of the largest discharge currents and pressure P of the working *** ions with W〉eV_(d)(e being the electron charge)were only recorded at maximum *** nitrogen was not accelerated to energies W〉e V_(d).Anomalous acceleration is realized in the range of radial magnetic fields on the anode 2.8×10^(–2)≤B_(ra)≤4×10^(–2)*** was also found analytically that the cathode of the accelerator can receive anomalously accelerated *** this case,the value of the potential in the anodic layer becomes higher than the anode potential,and the anode current exceeds some critical *** modeling in terms of the developed theory showed qualitative agreement between modeling data and measurements.

关键词： plasma sources particle orbit and trajectory particle measurements

Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第3期13卷 329-340页

作者： raúl J Andrade mercedes robles Alejandra Fernández-Castaer Susana López-Ortega m Carmen López-Vega m Isabel Lucena Liver Unit Gastroenterology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain Clinical Pharmacology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain

Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.

关键词： Drug-induced hepatotoxicity Causality assessment Diagnostic algorithms Clinical scales

The Drying of Pyridine Hydrobromide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 1998年第2期6卷 76-80页

作者： renéD.Peralta rodríguez raúl G.López Campos Jaime Wisniak Jacinto G.rodríguez Gómez Silvia Torres rincón m.Esther Treviño martínez Centro de Investigacion en Quimica Aplicada Blvd.Ing.Enrique Reyna Hermosillo No.140C.P.25100SaltilloCoahuilaMexico Department of Chemical Engineering Ben-Gurion University of the NegevBeer-ShevaIsrael

1 InTrODUCTIOnThe drying of fine chemicals and pharmaceuticals is dominated by a number of special factorscompared to the drying of bulk *** include:very high value of product;lowthroughputs(typically,100 kg·h-1);materials that frequently possess toxic properties andare often sticky,pasty and difficult to handle when wet;the moisture to be evaporated ofteninvolves solvents;and multipurpose processing plants.

关键词： drying pyridine hydrobromide

Influence of flooding and vegetation on carbon,nitrogen,and phosphorus dynamics in the pore water of a Spartina alterniflora salt marsh

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2011年第2期23卷 212-221页

作者： Vanesa L.negrin Carla V.Spetter raúl O.Asteasuain Gerardo m.E.Perillo Jorge E.marcovecchio Argentine Institute of Oceanography (IADO CONICETCCT-Bahía Blanca)Camino La Carrindanga km 75Building E-1 CC 804Bahía Blanca 8000Argentina Department of Chemistry Southern National Institute of Chemistry (INQUISUR)Southern National University (UNS)Av Alem 1253Bahía Blanca 8000Argentina Department of Geology Southern National University (UNS)San Juan 670Bahía Blanca 8000Argentina national Technological University Regional Faculty of Bahía Blanca (UTN-FRBB)11 de Abril 461Bahía Blanca 8000Argentina University of the Fraternity of Associations Santo Toms de Aquino (FASTA) Gascón 3145Mar del Plata 7600Argentina

Four sites were selected in a salt marsh in the Bahia Blanca Estuary （Argentina）：（1） low marsh （flooded by the tide twice daily） vegetated by S. alterniflora; （2） non-vegetated low marsh; （3） high marsh （flooded only in spring tides） vegetated by S. alterniflora; （4） non-vegetated high marsh. The pH and Eh were measured in sediments, while dissolved nutrients （ammonium, nitrate, nitrite and phosphate） and particulate organic matter （POm） were determined in pore water, pH （6.2-8.7） was only affected by vegetation in low areas. Eh （from -300 to 250 mV） was lower at low sites than at high ones; in the latter, the values were higher in the non-vegetated sediments. The POm concentration was greater in the high marsh than in the low marsh, with no effect of vegetation. Ammonium was the most abundant nitrogen nutrient species in pore water, except in the non-vegetated high marsh where nitrate concentration was higher. All nitrogen nutrients were affected by both flooding and vegetation. Phosphate was always present in pore water at all sites throughout the year and its concentration varied within narrow limits, with no effect of flooding and greater values always at non-vegetated sites. Our results showed that the variability of the pore water composition within the marsh is greater than the temporal variation, meaning that both tidal flooding and vegetation are important in the dynamics of nutrients and organic matter in the sediment pore water.

关键词： organic matter nutrients flooding Spartina alterniflora