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Stress enhances expression of calcium-binding proteins and nmDAr subunit genes in the rat hippocampus

neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy ramesha Hanumanthappa Sarojini r.Bulbule Kiran P.C. Hemalatha nanjaiah Gopinath G. Siddaiah B.m. David muniswamy Devaraju Kuramkote Shivanna neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of microbiology and Immunology University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoology Karnatak UniversityDharwadIndia

Backgrounds:Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living *** have previously explored the overexpression of calcium-binding protein genes in a reactive oxygen and nitrogen species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze gene expression of major calcium-binding proteins(calcineurin,calmodulin,calsyntenin,synaptotagmin,and calreticulin)and n-methyl-D-aspartic acid(nmDA)receptor subunits(glutamate receptor ionotropic[Glun]Glun1,Glun2A,and Glun2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assigned to two stress induction groups and a control group without stress(n=6).Stress was induced by using H_(2)O_(2)(3%in water)or by immobilization(using a sticky mat)over a period of 30 *** of calcium-binding protein genes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of genes encoding calcium-binding proteins calcineurin,calsyntenin,synaptotagmin and nmDA receptor subunit Glun1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,press-induced rats,neurons in the CA2 region of the hippocampus were fewer and appeared disorganized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxygen and nitrogen species(rOnS)can also lead to stress in rats by affecting their calcium signaling,buffering capacity in the neurons leading to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization nmDA receptors

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Competition for shelter between four invasive gobiids and two native benthic fish species

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Current Zoology 2011年第6期57卷 844-851页

作者： n. VAn KESSEL m. DOrEnBOSCH m.r.m. DE BOEr r.S.E.W. LEUVEn G. VAn DEr VELDE radboud University nijmegen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology EO. Box 9010 6500 GL Nijmegen The Netherlands radboud University nijmegen Institute for Water and Wetland Research Department of Environmental Science P.O. Box 9010 6500 GL Nijmegen The Netherlands natuurbalans - Limes Divergens P.O. Box 31070 6503 CB Nijmegen The Netherlands netherlands Institute of Ecology （nIOO - KnaW） EO. Box 50 6700 AB Wageningen The Netherlands netherlands Centre for Biodiversity naturalis EO. Box 9517 2300 RA Leiden The Netherlands

recent invasions by non-native gobiid fish species that are ongoing in the Western European rivers rhine and meuse, will lead to interactions with native benthic fish species. Since both non-native gobiids and native benthic species are bottom dwelling species with a preference for shelter during at least part of their life cycle, it is likely that competition for shelter will occur between these non-native and native species when shelter is a limiting factor. To investigate the importance of this mecha- nism for species replacements, various habitat choice experiments were conducted between two common native benthic fish spe- cies （Cottus perifretum and Barbatula barbatula） and four invasive non-native gobiid species （Proterorhinus semilunaris, neogo- bius melanostomus, n. kessleri and n. fluviatilis）. The first series of single specimen experiments determined the habitat choice of each individual fish species. In a second series of competition experiments, shifts in habitat choice in comparison with the previ- ously observed habitat choice, were determined when a native benthic fish species co-occurred with non-native gobiid species. native C. perifretum displayed a significant shift in habitat choice in co-occurrence with the gobiids n. kessleri or P. semilunaris. C. perifretum was outcompeted and moved from the available shelter place to less preferred habitat types. During the competition experiments no change in habitat choice of B. barbatula was shown. Our study therefore suggests that competition for shelter is likely to occur in rivers invaded by n. kessleri and P. semilunaris at sites where shelter is limiting

关键词： Bullhead Exotic species Habitat choice Invasive gobies rivers rhine and meuse Stone loach

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Impact of device resistances in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló Sofía m.López Baptista Kenji Watanabe Takashi Taniguchi Enrique Diez Jesús Enrique Velázquez-Pérez Yahya m.meziani José m.Caridad Juan A.Delgado-notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca research Center for Electronic and Optical materials National Institute for Materials Science research Center for materials nanoarchitectonics National Institute for Materials Science nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. Such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET detectors. Such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

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novel electrode structure in a DBD reactor applied to the degradation of phenol in aqueous solution

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Plasma Science and Technology 2017年第7期19卷 71-84页

作者： Antonio mErCADO-CABrEra rosendo PE?A-EGUILUZ régulo LóPEZ-CALLEJAS Bethsabet JAramILLO-SIErra raúl VALEnCIA-ALVAraDO Benjamín rODríGUEZ-ménDEZ Arturo E mU?OZ-CASTrO Instituto nacional de Investigaciones nucleares Plasma Physics Laboratory Tecnológico de Estudios Superiores de Tianguistenco

Phenol degradation experimental results are presented in a similar wastewater aqueous solution using a non-thermal plasma reactor in a coaxial dielectric barrier discharge. The novelty of the work is that one of the electrodes of the reactor has the shape of a hollow screw which shows an enhanced efficiency compared with a traditional smooth structure. The experimentation was carried out with gas mixtures of 90% Ar-10% O2, 80% At-20% 02 and 0% Ar-100% 02. After one hour of treatment the removal efficiency was 76%, 92%, and 97%, respectively, assessed with a gas chromatographic mass spectrometry technique. For both reactors used, the ozone concentration was measured. The screw electrode required less energy, for all gas mixtures, than the smooth electrode, to maintain the same ozone concentration. On the other hand, it was also observed that in both electrodes the electrical conductivity of the solution changed slightly from ,-0.0115 S m^-1 up to -0.0430 S m^-1 after one hour of treatment. The advantages of using the hollow screw electrode structure compared with the smooth electrode were：（1） lower typical power consumption, （2） the generation of a uniform plasma throughout the reactor benefiting the phenol degradation, （3） a relatively lower temperature of the aqueous solution during the process, and （4） the plasma generation length is larger.

关键词： DBD gas discharges removal organic compounds discharge in liquids

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real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter róbert Dóczi Dóra Lakatos Anna Dirner mátyás Vidermann Péter Filotás réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina míta Gábor réka Simon Péter Hauser György Péter Csongor Kiss miklós Garami István Peták Oncompass medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(rs)were involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(mTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Advanced hydrogen storage of the mg–na–Al system:A review

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Journal of magnesium and Alloys 2021年第4期9卷 1111-1123页

作者： n.A.Ali m.Ismail Energy Storage research Group Faculty of Ocean Engineering Technology and InformaticsUniversiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

A solid-state storage system is the most practical option for hydrogen because it is more convenient and *** hydrides,especially mgH_(2),are the most promising materials that offer high gravimetric capacity and good ***,the practical application of mgH_(2) is restricted by slow sorption kinetics and high stability of thermodynamic *** storage performance of mgH_(2) was enhanced by introducing the mg–na–Al system that destabilises mgH_(2) with naAlH_(4).The mg–na–Al system has superior performance compared to that of unary mgH_(2) and naAlH_(4).To boost the performance of the mg–na–Al system,the ball milling method and the addition of a catalyst were *** mg–na–Al system resulted in a low onset decomposition temperature,superior cyclability and enhanced kinetics *** Al_(12)mg_(17) and namgH_(3) that formed in situ during the dehydrogenation process modify the reaction pathway of the mg–na–Al system and alter the thermodynamic *** this paper,the overview of the recent progress in hydrogen storage of the mg–na–Al system is *** remaining challenges and future development of mg–na–Al system are also *** paper is the first review report on hydrogen storage properties of the mg–na–Al system.

关键词： mg-na-Al system mgH_(2) naAlH_(4) Al_(12)mg_(17) hydrogen storage

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电子温度各向异性对螺旋波m=1角向模功率沉积特性的影响

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物理学报 2024年第7期73卷 262-270页

作者：李文秋唐彦娜刘雅琳王刚中国科学院空天信息创新研究院北京100190 中国科学院大学北京100049

采用一般的径向密度非均匀分布假设,借助温等离子体介电张量模型,利用磁化等离子体中电磁波的一般色散关系,在高密度峰值、低磁场、低气压典型参量条件下,重点分析了电子温度各向异性对螺旋波m=1角向模功率沉积特性的影响.研究结果表明... 详细信息

采用一般的径向密度非均匀分布假设,借助温等离子体介电张量模型,利用磁化等离子体中电磁波的一般色散关系,在高密度峰值、低磁场、低气压典型参量条件下,重点分析了电子温度各向异性对螺旋波m=1角向模功率沉积特性的影响.研究结果表明:在典型螺旋波等离子体电子温度范围(3,8)e V内,电子有限拉莫尔半径效应应当予以考虑,而离子有限拉莫尔半径效应可以忽略.低磁场条件下|n|>1次回旋谐波对介电张量元素的贡献可以忽略.碰撞阻尼在功率沉积中占据主导地位,功率沉积在偏离等离子体柱中心轴的某一径向位置出现峰值,随着轴向电子温度T_(e,z)的增大,功率沉积强度逐渐增强.相比等离子体温度各向同性情形,等离子体温度各向异性显著改变了螺旋波m=1角向模的功率沉积特性,电子温度各向异性因子χ=T_(e,⊥)/T_(e,z)的增大或减小均导致功率沉积强度发生剧烈改变.

关键词：螺旋波等离子体各向异性传播特性功率沉积

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伊尔加兹山脉冰缘地貌发育和土壤形成及其气候的影响(土耳其黑海西岸)

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Journal of Geographical Sciences 2024年第3期34卷 543-570页

作者： DEDE Volkan DEnGIZ Orhan DEmIraG TUran inci TürKES murat SEnOL Hüseyin SErIn Soner Department of Geography Ardahan UniversityArdahan75002Türkiye Department of Soil Science and Plant nutrition Faculty of AgricultureOndokuz Mayıs UniversitySamsun55139Türkiye Department of Geography Faculty of Human and Social SciencesSamsun UniversitySamsun55080Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul34342Türkiye Faculty of Agriculture Department of Soil Science and Plant NutritionIsparta University of Applied SciencesIsparta32200Türkiye Institute of Social Sciences İstanbul Universityİstanbul34119Türkiye

The main aims of the current study are to determine the morphological features of the periglacial landforms(non-sorted step,mud circle,stony earth circle,thufur,and congeliturbation)located on the Ilgaz mountains,examine the physicochemical and mineralogical properties with pedological processes of the soils,and assess of the effects of climatic conditions controlling the development of *** Ilgaz mountains(2587 m a.s.l.),located in the Western Black Sea region,within the Anatolian mountains,are important in terms of periglacial landforms(mud circles,stony earth circles,thufurs,non-sorted steps,non-sorted stripes,congeliturbation deposits,and block currents).The descriptive statistics of 123 periglacial landforms measured by fieldworks were *** distribution of freezing and thawing in the Ilgaz mountains throughout the year was evaluated,and it was found that freezing takes place between December and march,freezing-thawing takes place in April,may,October and november,and thawing takes place between June and *** to soil properties,organic matter content changes from 1.88%to 12.72%in non-sorted step soils,while it is between 2.03%and 12.24%in stony earth circle *** organic matter is observed to be close to congeliturbation deposits at lower ratios compared to non-sorted steps,stony earth circles and mud *** soil reactions on stony earth circles and non-sorted steps vary between slightly acidic and slightly *** the other hand,soil samples taken from the mud circles are different from those taken from the non-sorted steps and stony earth *** soil reaction is acidic,and pH changes between 4.86 and *** lime content also varies between 2.81%and 32.08%,with an average of 12.02%.The texture properties of soils are dominantly loam and clay loam,as in the non-sorted steps,stony earth circles,and mud *** their mineralogical properties,the XrD study was carried out to determine the primer mineral

关键词： periglacial landforms soil formation climate effect Ilgaz mountains Türkiye

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某工业污水厂升级改造及运行效益分析

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皮革制作与环保科技 2024年第4期5卷 104-106页

作者：郭娜博瑞德环境集团股份有限公司江苏南京210023

浙江省某污水厂为所在工业园区设立的末端污水厂,主要处理园区上游印染及化工企业的预处理排水以及园区企业生活废水,提标改造规模为30000 m^(3)/d,处理后使其出水满足《城镇污水处理厂污水排放标准》(GB 18918-2002)[1]中一级标准的A... 详细信息

浙江省某污水厂为所在工业园区设立的末端污水厂,主要处理园区上游印染及化工企业的预处理排水以及园区企业生活废水,提标改造规模为30000 m^(3)/d,处理后使其出水满足《城镇污水处理厂污水排放标准》(GB 18918-2002)[1]中一级标准的A标准。本文通过对现状工艺流程、实际运行进、出水水质水量以及运行中存在的问题进行论证分析,发现鉴于排放标准的提高,现状主体工艺的设计处理负荷已无法满足需要,仅靠增加后续深度处理单元以实现出水稳定达标不经济,故亟需选择耐冲击性强、性能稳定的脱碳脱氮工艺,尽可能在生化段将大部分COD、Tn、nH3-n去除,将生化功能发挥到极致;同时在不新增用地的基础上,选择深度处理单元应采用技术先进成熟、处理效率高、占地面积少的处理工艺,并通过投加粉末炭使其具有进一步去除COD的功能,作为出水的应急保障。

关键词：工业污水厂升级改造去除率经济效益

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Cadmium sorption by sodium and thiourea-modified zeolite-rich tuffs

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Journal of Environmental Sciences 2017年第2期29卷 39-48页

作者： Perfecto Barragán P m.Guadalupe macedo m maria T.Olguín Instituto Tecnologico de Toluca Laboratorio de Investigacion en Ingenieria Ambiental.Av.Tecnologico S/NColonia Ex-Rancho La VirgenMetepecEstado de Meico CP.52140Mexico Instituto national de Investigaciones nucleares Departamento de QuimicaA.P.18-1027Col.EseandonDelegacion Miguel Hidalgo C.P.11801Mexico

In the present investigation, two zeolite-rich tuffs from Guaymas and El Cajon（State of Sonora）, which were conditioned with a sodium chloride solution and subsequently modified with a thiourea solution, were chosen to evaluate the removal of Cd from aqueous systems. The zeolitic materials were characterized by scanning electron microscopy and X-ray diffraction. The surface area was also determined. The experiments were performed in a batch system, and the influences of p H, contact time between phases, and the concentration of Cd in the solution on the adsorption by sodium or thiourea-modified zeolite-rich tuff were investigated. It was found that the efficiency of Cd ion removal from aqueous solutions is influenced by the p H of the aqueous systems. The Cd adsorption kinetic data were well fitted to a pseudo-second-order model in all cases. The Langmuir and Langmuir–Freundlich isotherms adequately described the Cd sorption behavior by the zeolite from El Cajon pretreated with na Cl and the zeolite from Guaymas modified with thiourea, respectively.

关键词： Cadmium Zeolite-rich-tuff Sorption Kinetics Isotherms

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