检索结果-南通市图书馆

Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu lan Yang Min Li Haozhou Shu na Jia Yunzhen Gao Rongying Shi Xiaojia Yang Zhirong Zhang Ling Zhang Key laboratory of Drug-Targeting and Drug Delivery System of the education Ministry West China School of PharmacySichuan UniversityChengdu 610041China med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(Bsa)to form 5-FU@Ni Fe-LDH/Ti3C2/Bsa nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate fromnanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil nanocomposite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

借助新媒体提高临床实践指南传播力:《协和医学杂志》的探索与实践

引用

中国科技期刊研究 2024年第5期35卷 658-663页

作者：李娜刘洋李玉乐董哲赵娜李慧文李洁北京协和医院《协和医学杂志》编辑部北京100730 中国医学科学院《中国医学科学杂志(英文)》编辑部北京100005

【目的】探索医学期刊借助新媒体平台提高临床实践指南(简称“指南”)传播力的新途径。【方法】通过文献检索并结合期刊实践经验,分析我国指南传播现状、传统指南传播策略中存在的问题,明确医学期刊在指南传播中的角色定位,并在《协和... 详细信息

【目的】探索医学期刊借助新媒体平台提高临床实践指南(简称“指南”)传播力的新途径。【方法】通过文献检索并结合期刊实践经验,分析我国指南传播现状、传统指南传播策略中存在的问题,明确医学期刊在指南传播中的角色定位,并在《协和医学杂志》日常工作中借助新媒体平台开展探索性实践,展示其提高指南传播力的典型案例及效果。【结果】我国重指南制订而轻指南传播的现象较为普遍,传统指南传播策略具有一定局限性。《协和医学杂志》的实践证明,借助新媒体可弥补传统指南传播策略中的不足,有效提高指南传播力。【结论】医学期刊作为指南发布的重要载体,新媒体时代充分利用新媒体技术及平台优势,可在提高指南传播力中发挥重要作用。

关键词：临床实践指南传播医学期刊高质量发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于CNKI-CiteSpace探讨大蒜素在医学领域中的应用现状与趋势

引用

河西学院学报 2024年第2期40卷 28-35页

作者：岳娜娜曹玉青李萍河西学院医学院甘肃张掖734000

目的:对大蒜素在医学领域中的研究现状、热点和趋势进行可视化分析,为后续相关研究提供参考。方法:系统检索中国知网数据库关于大蒜素在医学领域相关研究文献,基于CiteSpace 6.1.R6软件运用文献计量学方法对发文量、发文期刊、作者、关... 详细信息

目的:对大蒜素在医学领域中的研究现状、热点和趋势进行可视化分析,为后续相关研究提供参考。方法:系统检索中国知网数据库关于大蒜素在医学领域相关研究文献,基于CiteSpace 6.1.R6软件运用文献计量学方法对发文量、发文期刊、作者、关键词等进行可视化分析。结果:共纳入有效文献333篇,发文量随年份变化波动较大,《中国中西医结合杂志》是发文量最多的期刊,史载祥教授团队就大蒜素对心血管疾病的中西医结合治疗开展了大量研究。关键词共现和聚类分析显示,大蒜素在医学领域的研究主要集中在慢病防治和抗菌2个方面,大蒜素可有效抑制肿瘤细胞侵袭、转移并增加其凋亡。目前大蒜素的研究热点主要聚焦于抗炎、抗氧化、抗癌的机制研究。结论:大蒜素在医学领域的研究仍处于活跃的发展阶段,各团队间的合作交流有待加强。大蒜素的抗炎、抗氧化、抗癌及抑菌活性的相关基础研究证据翔实,随着其作用机制的逐步揭示,大蒜素的临床应用将更值得期待。

关键词：大蒜素医学 CiteSpace 可视化分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

响应面法优化新型磷脂酶PLC_med_(193)大豆油脱胶工艺的研究

引用

粮食与油脂 2024年第2期37卷 43-48页

作者：孙永威李科娜段乃心魏涛郑州轻工业大学食品与生物工程学院河南郑州450002

利用大肠杆菌工程菌制备大量重磷脂PLC_med_(193),将其应用于大豆毛油的脱胶过程中,在单因素试验的基础上采用响应面试验,得出磷脂酶用于大豆毛油脱胶的最佳工艺条件,即脱胶温度60℃、加酶量300 U/kg、脱胶pH 5.6、加水量3.0 mL、脱胶时... 详细信息

利用大肠杆菌工程菌制备大量重磷脂PLC_med_(193),将其应用于大豆毛油的脱胶过程中,在单因素试验的基础上采用响应面试验,得出磷脂酶用于大豆毛油脱胶的最佳工艺条件,即脱胶温度60℃、加酶量300 U/kg、脱胶pH 5.6、加水量3.0 mL、脱胶时间6 h,在此条件下,脱胶后大豆油的磷含量从36.75 mg/kg降低至(5.25±0.03)mg/kg,磷脂酰胆碱PC和磷脂酰乙醇胺PE含量降低至23 mg/g和20 mg/g,满足后续油脂精炼要求。

关键词：磷脂酶C 脱胶磷含量得率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

老年新冠肺炎愈后患者中医药治疗联合运动康复训练方法及应用效果

引用

中华医院感染学杂志 2024年第7期34卷 1016-1020页

作者：王娜余兴艳秦利春黄丽萍吕仙荣解放军总医院第一医学中心康复医学科北京100853 解放军总医院第八医学中心康复医学科北京100091

目的探讨中医药联合运动康复训练在老年新型冠状病毒肺炎(简称新冠肺炎)愈后患者中的效果。方法选取2023年1月3日-2023年2月28日解放军总医院收治的老年新冠肺炎愈后行肺功能康复患者为研究对象,按照病区收治,采用系统随机抽签法从不同... 详细信息

目的探讨中医药联合运动康复训练在老年新型冠状病毒肺炎(简称新冠肺炎)愈后患者中的效果。方法选取2023年1月3日-2023年2月28日解放军总医院收治的老年新冠肺炎愈后行肺功能康复患者为研究对象,按照病区收治,采用系统随机抽签法从不同病区各选取30例,分为对照组和试验组。对照组患者在药物综合治疗的基础上,实施传统呼吸康复训练、营养支持、心理干预等指导,试验组患者在对照组基础上进行中医药治疗(包括中医药汤剂、针灸等)、运动康复训练。统计两组患者入院时和出院前6min步行试验、肺功能检测指标、患者日常生活活动能力、治疗前后心理状况等指标。结果出院前6min步行试验对照组、试验组均较入院时有改善(PsaS、SDS试验组与对照组分别为(52.78±2.37)分、(52.17±0.18)分与(54.07±3.21)分、(53.01±1.77)分,两组之间有统计学差异(P<0.05)。结论中医药联合运动康复训练,可有效改善老年新型冠状病毒肺炎愈后患者肺功能,提高患者日常生活活动能力,降低其焦虑、抑郁状态。

关键词：新型冠状病毒新型冠状病毒肺炎中医药康复训练呼吸系统

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficiency analysis of stenting for acute colorectal obstruction

引用

Chinese medical Journal 2013年第21期126卷 4189-4191页

作者： Zhang na-na Li Peng Zhang Shu-tian Capital med Univ Beijing Friendship Hosp Dept Gastroenterol Beijing 100050 Peoples R China

Patients with colorectal cancer presenting with acute malignant colonic obstruction are approximately 10%-15% These patients are always in a poor general condition. Emergency surgery for acute obstructive colorectal c... 详细信息

关键词： acute colonic obstruction hospital cost hospital stay survival self-expandable metallic stent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigating adverse events in long-term care facilities:a systematized review

引用

Frontiers of Nursing 2023年第4期10卷 399-412页

作者： Dominika Kohanová Martina Lepiešová Daniela Bartoníčková Pavol Faťun KatarínaŽiaková Department of Nursing Faculty of Social Sciences and Health CareConstantine the Philosopher University in NitraNitra 94901Slovak Republic Department of Nursing Jessenius Faculty of Medicine in MartinComenius University in BratislavaMartin 03601Slovak Republic Department of Nursing Faculty of Health SciencesPalackýUniversity in OlomoucOlomouc 77515Czech Republic

Objective:This systematized review aimed to synthesize the results of empirical studies focused on the types and factors of adverse events(AEs)that contribute to them in long-term care(LTC)***:The search was conducted in Pro Quest,Scopus,and Pub med in January 2021 and resulted in 1057 *** content analysis method was used in the data ***:In all,35 studies were identified as relevant for the *** analysis revealed 133 different types of AEs and 60 factors that contributed to ***:In LTC,various AEs occur,most of which are preventable,while many factors that influence their occurrence could be significantly *** an effective analysis of AEs in LTC,it is possible to minimize their occurrence and,at the same time,minimize their negative impact on all par ties concerned.

关键词： adverse event facility factors long-term care healthcare workers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Patterns of host cell inheritance in the bacterial symbiosis of whiteflies

引用

Insect Science 2020年第5期27卷 938-946页

作者： Xiao-Rui Xu na-na Li Xi-Yu Bao Angela E.Douglas Jun-Bo Luan Liaoning Key laboratory of Economic and Applied Entomology College of Plant ProtectionShenyang Agricutural UniversityShenyangChina Department of Entomology Cornell UniversitIthacaNYUSA Department of Molecular Biology and Genetics Cormell UniversitylthacaNYUSA

Whiteflies possess bacterial symbionts Candidatus Portiera aleyrodidium that are housed in specialized cells called bacteriocytes and are faithfully transmitted via the ovary to insect *** one whitefly species studied previously,Bemisia tabaci MEAMI,transmission is mediated by somatic inheritance of bacteriocytes,with a single bacteriocyte transferred to each oocyte and persisting through embryogenesis to the next ***,we investigate the mode of bacteriocyte transmission in two whiefly species,*** med,the sister species of MEAM1,and the phylogenetically distant species Trialeurodes *** analysis supported by microscopical studies demonstrates that *** med bacteriocytes are genetically different from other somatic cells and persist through embryogenesis,as for MEAMI,but *** bacteriocytes are genetically identical to other somatic cells of the insect,likely mediated by the degradation of maternal bacteriocytes in the *** two alternative modes of transmission provide a first demonstration among insect symbioses that the cellular processes underlying vertical transmission of bacterial symbionts can diversify among related host species associated with a single lineage of symbiotic bacteria.

关键词： bacteriocyte inheritance somatic cells symbiont transmission whitefly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The ratio of superior mesenteric artery diameter to superior mesenteric vein diameter based on non-enhanced computed tomography in the early diagnosis of spontaneous isolated superior mesenteric artery dissection

引用

World Journal of Emergency medicine 2022年第3期13卷 202-207页

作者： Yuan-li Lei Wen-xing Song Yi Lin Hui-ping Li He-ping Lyu Jiao-zhen Chen Zhang-ping Li Jia-na Yin Ji-ke Xue Shou-quan Chen Department of Emergency medicine the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Radiology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Vascular Surgery the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Electrocardiogram Wenzhou People's HospitalWenzhou 325000China

BACKGROUND:Spontaneous isolated superior mesenteric artery(SMA)dissection(SISMAD)is a rare cause of abdominal *** aim of the study is to investigate the role of a new parameter,the ratio of the SMA diameter to the superior mesenteric vein(SMV)diameter(SMA/SMV)based on non-enhanced computed tomography(CT),in the early diagnosis of ***:In a registry study from December 2013 to June 2021,97 abdominal pain SISMAD patients(SISMAD group)admitted to our hospital were ***,the matched sex and age abdominal pain non-SISMAD patients at 1:2 were collected in reverse chronological order as the control ***’s t-test,Wilcoxon rank-sum test,and Chi-square test were used to compare differences between the SISMAD and control *** Calc was used to generate receiver operating characteristic(ROC)***:A total of 291 abdominal pain patients,including 97 SISMAD patients and 194 nonSISMAD patients,were included in the current *** maximum SMA diameter,perivascular exudation,and SMA/SMV based on non-enhanced CT were significant between the two groups(all Ped that for the maximum SMA diameter,the area under the curve(AUC),cut-off,sensitivity,and specificity were 0.926,9.80,93.8%,and 79.4%,*** SMA/SMV,its AUC,cut-off,sensitivity,and specificity were 0.956,0.83,88.7%,and 92.3%,*** diagnostic efficiency of SMA/SMV was better than that of the maximum SMA diameter(Ped parameters of SMA/SMV and maximum SMA diameter had the best diagnostic efficiency(AUC=0.970).CONCLUSION:SMA/SMV may be a potential marker for SISMAD.

关键词： Abdominal pain Spontaneous isolated superior mesenteric artery dissection Computed tomography Receiver operating characteristic curve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of immediate instillation combined with regular instillations of pirarubicin for Ta and T1 transitional cell bladder cancer after transurethral resection： a prospective, randomized, multicenter study

引用

Chinese medical Journal 2013年第15期126卷 2805-2809页

作者： Li Ning-chen YE ZHANG-qun na Yan-qun CUA THP Peking Univ Shougang Hosp Wujieping Urol Ctr Beijing 100144 Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Urol Wuhan 430030 Hunan Peoples R China

Background Immediate intravesical instillation of chemotherapeutic agents after transurethral resection （TUR） of non- muscle invasive transitional cell bladder cancer has recently been suggested and has been proven to decrease the tumor recurrence rate significantly. This study is to evaluate the efficacy and safety of immediate intravesical instillation combined with regular instillations of Pirarubicin （THP~） as prophylaxis compared to regular instillations only after TUR operation. Methods This was a prospective, randomized, multi-center, clinical study. Patients diagnosed with non-muscle invasive bladder cancer （Ta and T1） pathologically and suitable for TUR were enrolled randomly into two groups. In the study group, the patients received intravesical instillation within 24-hour post TURBT, followed by regular intravesical therapy using 30 mg/50 ml of THP~ once a week for 8 weeks, and then once a month to 1 year postoperatively Among the patients. In the control group, patients received regular instillation only. Results A total of 403 patients were enrolled into this study from 26 institutions in China. Among the potients, 210 were enrolled into the study group and 193 were enrolled into the control group. At the median follow-up of 18 months, the recurrence rate was 7.8% in the study group, significantly lower than that in the control group （14.3%; P=0.042）. Subgroup analysis showed that the recurrence rate in low and intermediate-risk patients was significantly lower in the study group （6.8%） than in the control group （14.0%; P=0.047）, although no significant differences were found in high-risk patients. Conclusion One immediate dose of THP 30 mg after TURBT followed by regular intravesical therapy appears well tolerated and more effective than regular intravesical therapy for preventing tumor recurrence, especially in low and intermediate-risk patients.

关键词： pirarubicin instillation therapy non-muscle-invasive bladder cancer randomized clinical trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：