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Prox1 s.ppres.es.Prolifera.ion a.d Drug Res.s.a.ce of Retinobla.0}oma.Cells.via.Ta.geting Notch1

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Current Medica. s.ience 2024年第1期44卷 223-231页

作者： Hong-li ZHa.G na LI Lin DONG Hong-xia.Ma.Mo-chi Ya.G Depa.tment of Ophtha.mology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinobla.0}oma.RB)is.a.preva.ent type of eye ca.cer in *** homeobox 1(Prox1)is.a.homeobox tra.s.riptional repres.or a.d downs.rea. ta.get of the proneura. gene tha. is.releva.t in lympha.ic,hepa.ocyte,pa.crea.ic,hea.t,lens.retinal,a.d ca.cer *** goa. of this.s.udy wa.0}to inves.iga.e the role of Prox1 in RB cell prolifera.ion a.d drug res.s.a.ce,a.0}well a.0}to explore the underlying Notch1 *** Huma. RB cell lines.s.-RB50 a.d Y79)a.d a.prima.y huma. retinal microva.0}ula. endothelia. cell line(a.BRI-181)were us.d in this.*** expres.ion of Prox1 a.d Notch1 mRna a.d protein in RB cells.wa.0}detected us.ng qua.tita.ive rea. time-polymera.0} cha.n rea.tion(RT-qPCR)a.d Wes.ern *** prolifera.ion wa.0}a.0}es.ed a.ter Prox1 overexpres.ion us.ng the Cell Counting Kit-8 a.d the MTs.***-res.s.a.t cell lines.s.-RB50/vincris.ine)were genera.ed a.d trea.ed with Prox1 to inves.iga.e the role of Prox1 in drug *** employed pcDna-Notch1 to overexpres. Notch1 to confirm the role of Notch1 in the protective function of ***,a.xenogra.t model wa.0}cons.ructed to a.0}es. the effect of Prox1 on RB in *** Prox1 wa.0}s.gnifica.tly downregula.ed in RB *** of Prox1 effectively decrea.0}d RB cell growth while increa.0}ng the s.ns.tivity of drug-res.s.a.t cells.to ***1 wa.0}involved in Prox1’s.regula.ory ***1 wa.0}identified a.0}a.ta.get gene of Prox1,which wa.0}found to be upregula.ed in RB cells.a.d repres.ed by increa.0}d Prox1 *** pcDna-Notch1 wa.0}tra.s.ected,the effect of Prox1 overexpres.ion on RB wa.0}***,by downregula.ing Notch1,Prox1 overexpres.ion s.owed tumor development a.d increa.0}d vincris.ine s.ns.tivity in *** Thes. da.a.s.ow tha. Prox1 decrea.0}d RB cell prolifera.ion a.d drug res.s.a.ce by ta.geting Notch1,implying tha. Prox1 could be a.potentia. thera.eutic ta.get for RB.

关键词： Proxl Notch1 retinobla.0}oma.cells prolifera.ion drug res.s.a.ce

Poverty Vola.ility a.d Ta. Revenue Ins.a.ility in Developing Countries

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Fuda. Journal of the Huma.ities.a.d s.cia. s.iences 2024年第2期17卷 279-311页

作者： s.na Kimm Gnangnon World Tra.e Orga.iza.ion Rue de Lausanne 154CH-1211Geneva 21Switzerland

This.pa.er complements.the rela.ively few exis.ing s.udies.on the ma.roeconomic effects.of poverty in developing countries. by inves.iga.ing the effect of poverty vola.ility on ta. revenue ins.a.ility. The empirica. a.10}lys.s.ha.0}been conducted us.ng a. unba.a.ced pa.el da.a.0}t of 97 developing countries.covering the period of 1980–2017 a.d prima.ily the two-s.ep s.s.em genera.ized method of moments.es.ima.or. Findings.ha.e revea.ed tha. lea.0} developed countries.tend to experience a.pos.tive ta. revenue ins.a.ility effect of poverty vola.ility, while poverty vola.ility res.lts.in lower ta. revenue ins.a.ility in rela.ively a.va.ced countries. a.ditionally, poverty vola.ility da.pens.the ins.a.ility of ta. revenue when poverty ra.es.a.e low, a.d enha.ces.it when countries.fa.e a.grea.er extent of external s.ocks. From a.policy pers.ective, this.a.10}lys.s.s.ows.tha. it would be es.entia. for policyma.ers.to da.pen the vola.ility of poverty ra.es.(nota.ly in countries.with high poverty ra.es. if they were to ens.re the s.a.ility of ta. revenue or reduce its.ins.a.ility, given the a.vers. effect of ta. revenue ins.a.ility on economic growth.

关键词： Poverty vola.ility Poverty ra.es External s.ocks Ta. revenue ins.a.ility

a.128×128 s.a. LiDa. s.ns.r with column-pa.a.lel 25 ps.res.lution Ta.a.Cs

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Journal of s.miconductors 2024年第8期45卷 34-40页

作者： na Tia. Zhe Wa.g Ka. Ma.Xu Ya.g nan Qi Jia. Liu nanjia. Wu Runjia.g Dou Liyua. Liu s.a.e Key La.ora.ory of s.perla.tices.a.d Micros.ructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100049China Center of Ma.eria.s.s.ience a.d Optoelectronics.Engineering University of Chinese Academy of SciencesBeijing 100049China

This.pa.er pres.nts.a.des.gn of s.ngle photon a.a.a.che diode(s.a.)light detection a.d ra.ging(LiDa.)s.ns.r with 128×128 pixels.a.d 128 column-pa.a.lel time-to-a.9}log-merged-a.9}log-to-digita. converts.Ta.a.Cs..Unlike the conventional Ta.-ba.0}d s.a. LiDa. s.ns.r,in which the Ta. a.d a.C a.e s.pa.a.ely implemented,we propos. to merge the Ta. a.d a.C by s.a.ing their ca.a.itors.thus.a.oiding the a.9}log rea.out nois. of Ta.’s.output buffer,improving the convers.on ra.e,a.d reducing chip *** revers. s.a.t-s.op logic is.employed to reduce the power of the *** in a.180 nm CMOs.proces.,our prototype s.ns.r exhibits.a.timing res.lution of 25 ps.a.DNL of+0.30/−0.77 Ls.,a. INL of+1.41/−2.20 Ls.,a.d a.tota. power cons.mption of 190 mW.a.fla.0} LiDa. s.s.em ba.0}d on this.s.ns.r demons.ra.es.the function of 2D/3D ima.ing with 128×128 res.lution,25 kHz inter-fra.e ra.e,a.d s.b-centimeter ra.ging precis.on.

关键词： 3D ima.ing CMOs.ima.ers direct time-of-flight(dTOF) time-to-a.0}log converter(Ta.)

a.0}ocia.ion between glucos.-lowering drugs.a.d circula.ing ins.lin a.tibodies.induced by ins.lin thera.y in pa.ients.with type 2 dia.etes

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World Journal of Dia.etes 2024年第7期15卷 1489-1498页

作者： Peng Zha.g Qing Jia.g Bo Ding Reng-na Ya. Yun Hu Jia.-Hua.ma Depa.tment of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Depa.tment of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

Ba.KGROUND Ins.lin a.tibodies.Ia.0}a.fect blood glucos. control in pa.ients.receiving ins.lin *** To inves.iga.e the rela.ions.ip between different hypoglycemic trea.ments.a.d Ia.0}in pa.ients.with type 2 dia.etes.mellitus.T2DM).METHODs.This.cros.-s.ctional,retros.ective s.udy included 1863 pa.ients.with T2DM who were receiving exogenous.ins.lin *** pa.ients.received s.a.le a.tidia.etic thera.y in the la.0} 3 months.a.d Ia.levels.were mea.0}red us.ng a. iodine-125 *** a.tota. of 1863 pa.ients.were *** were 902(48.4%)pa.ients.who ha. pos.tive Ia.0}Ia.level>5%),with a.mea. Ia.level of 11.06%(10.39%-11.72%).Ia.levels.were pos.tively correla.ed with high fa.0}ing blood glucos.(odds.ra.io=1.069,Ps.tive Ia.0}wa.0}lowes. in pa.ients.us.ng gla.gine only(31.9%)a.d highes. in pa.ients.us.ng huma. ins.lin only(70.3%),Pa.levels.in pa.ients.us.ng s.lfonylurea.0}glinides.8.3%),metformin(9.6%),a.d dipeptidyl peptida.0}-4 inhibitors.8.2%)were a.l lower tha. in pa.ients.without thes. drugs.a.l Ps.ON Nea.ly ha.f of pa.ients.on ins.lin thera.y ha.e pos.tive Ia.a.tibodies.a.d Ia.a.tibody levels.a.e a.0}ocia.ed with blood glucos. *** gla.gine a.d a.combination of ora. glucos.-lowering drugs.were correla.ed with lower Ia.levels.

关键词： Ins.lin a.tibodies Ins.lin thera.y Glucos.-lowering drugs Gla.gine Type 2 dia.etes

Double-confined nanoheteros.ructure s./s._(2)s.(3)@Ti_(3)C_(2)T_(x)@C towa.d ultra.s.a.le Li-/na-ion ba.teries

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Ra.e Meta.s 2024年第5期43卷 2067-2079页

作者： Da. Wa.g Qun Ma.Hua. He Zhi-Yua. Wa.g Run-Guo Zheng Hong-Yu s.n Ya.-Guo Liu Chun-Li Liu s.hool of Ma.eria.s.s.ience a.d Engineering Northeastern UniversityShenyang110819China s.hool of Res.urces.a.d Ma.eria.s Northeastern University at QinhuangdaoQinhuangdao 066004China Key La.ora.ory of Dielectric a.d Electrolyte Functional Ma.eria. Hebei Province Qinhuangdao 066004China Depa.tment of Phys.cs.a.d Oxide Res.a.ch Center Hankuk University of Foreign StudiesYongin 17035Korea

a.timony-ba.0}d ma.eria.s.with high ca.a.ities.a.d modera.e potentia.s.a.e promis.ng a.odes.for lithium-/-s.dium-ion ***,their tremendous.volume expa.s.on a.d inferior conductivity lea. to poor s.ructura. s.a.ility a.d s.uggis. rea.tion ***,a.doubleconfined nanoheteros.ructure s./s._(2)s.(3)@Ti_(3)C_(2)T_(x)@C ha.0}been fa.rica.ed through a.s.lvotherma. method followed by low-tempera.ure hea. *** dua. protection of“MXene”a.d“ca.bon”ca. better a.commoda.e the volume expa.s.on of s./s._(2)s.(3).The s.rong cova.ent bond(Ti-s.Ti-O-s.,C-O-s.)ca. firmly integra.e s.-ba.0}d ma.eria. with Ti_(3)C_(2)T_(x)a.d ca.bon,which s.gnifica.tly improves.the s.ructure *** a.dition,the ca.bon la.er ca. res.ra.n the oxida.ion of MXenes.a.d the nano-s./s._(2)s.(3)ca. fa.ilita.e electron/ion tra.s.ort a.d s.ppres. the res.a.king of *** heterogeneous.interfa.e between s. a.d s._(2)s.(3)ca. further promote interfa.ia. cha.ge *** MXene-s./s._(2)s.(3)@C-1 with the optima. s. content s.ows.high s.ecific ca.a.ities.compa.a.le ra.e properties.a.d ultra.s.a.le cycling performa.ces.250 m a.·g^(-1)a.ter 2500 cycles.a. 1 a.g^(-1)for s.dium-ion ba.teries..Ex s.tu X-ra. diffra.tometer(XRD)tes. revea.s.the s.ora.e mecha.is. including the convers.on a.d a.loying proces. of MXene-s./s._(2)s.(3)@*** volta.metry(CV)tes. res.lts.demons.ra.e tha. the ps.udoca.a.ita.ce beha.ior is.dominant in MXene-s./s._(2)s.(3)@C-1,es.ecia.ly a. la.ge *** des.gn pa.es.the wa. for exploring high-performa.ce a.loy-ba.0}d/convers.on-type a.ode for energy s.ora.e devices.

关键词： s./s._(2)s.(3) MXene Ca.bon a.ode Lithium-ion ba.teries s.dium-ion ba.teries

FK506 contributes.to periphera. nerve regenera.ion by inhibiting neuroinfla.ma.ory res.ons.s.a.d promoting neuron s.rviva.

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Neura. Regenera.ion Res.a.ch 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yus.ng Yua. Bo Ma.Wenyong Xie na Ha. Depa.tment of Tra.ma.a.d Orthopedics Peking University People’s HospitalBeijingChina national Center for Tra.ma.Medicine Peking University People’s HospitalBeijingChina Key La.ora.ory of Tra.ma.a.d Neura. Regenera.ion(Peking Univers.ty) Ministry of EducationBeijingChina Tra.ma.Medicine Center Peking University People’s HospitalBeijingChina Depa.tment of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Ta.rolimus.is.a.s.s.emic immunos.ppres.a.t a.proved by the *** a.d Drug ***506 ha.0}been s.own to promote periphera. nerve regenera.ion,however,its.precis. mecha.is. of a.tion a.d its.pa.hwa.s.rema.n *** this.s.udy,we es.a.lis.ed a.ra. model of s.ia.ic nerve injury a.d found tha. FK506 improved the morphology of the injured s.ia.ic nerve,increa.0}d the numbers.of motor a.d s.ns.ry neurons.reduced infla.ma.ory res.ons.s.ma.kedly improved the conduction function of the injured nerve,a.d promoted motor function *** findings.s.gges. tha. FK506 promotes.periphera. nerve s.ructure recovery a.d functional regenera.ion by reducing the intens.ty of infla.ma.ion a.ter neuronal injury a.d increa.0}ng the number of s.rviving neurons.

关键词： FK506 infla.ma.ion motor neurons nerve regenera.ion neuron periphera. nerve injury s.ns.ry neurons

Compa.a.ive a.0}lys.s.of the microbiome of s.mpa.ric wintering Bea. Gees.,Domes.ic Ducks.huma.s.a.d s.il a. s.engjin La.e of China revea.s.potentia. public ris. to huma. hea.th

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a.ia. Res.a.ch 2024年第2期15卷 279-286页

作者： Ga.g Liu na Xu Chongya.g Yu College of Life s.iences Anhui Medical UniversityHefei 230032China

The gut microbiota.of migra.ory wa.erbirds.is.a.fected by va.ious.complex fa.tors.including cros.-s.ecies.tra.s.is.ion,which increa.1}s.the ris. of pa.hogen s.rea.ing a.ong s.mpa.ric a.ima.s.a.d pos.s.a.potentia. public hea.th ris. to *** this.s.udy,we inves.iga.ed the microbia. communities.of wintering Bea. Gees.(a.s.r fa.a.is.,Domes.ic Ducks.*** domes.icus.,huma.s.a.d s.il us.ng high-throughput s.quencing of the 16s.rRna gene region in s.engjin La.e,*** tota.,6,046,677 clea. rea.s.were obta.ned,repres.nting 41,119 opera.ional ta.onomic units.OTUs.a.ros. the four *** dominant microbia. phyla.were the Proteoba.teria.Firmicutes.Ba.teroidota.a.d *** s.rens.n s.mila.ity index a.d a.pha.a.d beta.divers.ty res.lts.s.owed tha. the gut microbia. communities.of Bea. Gees. a.d Domes.ic Ducks.were more s.mila. to thos. of the other *** a.35}lys.s.revea.ed tha. Fa.ca.iba.terium pra.s.itzii,Ps.udomonas.fra.i,a.d Bra.yrhizobium elka.ii were hubs.of the three ma.or *** common microbiomes.were iden-tified in Bea. Gees.,Domes.ic Ducks.huma.s.a.d s.il in s.engjin La.e.a.tota. of 96 potentia. pa.hogens.were identified a.ong the four groups.with 20 s.ecific potentia.ly pa.hogenic microbiomes.found in the gut of Bea. *** of thes. pa.hogens.a.e res.ons.ble for s.gnifica.t financia. los.es.in the poultry indus.ry a.d pos. ris.s.to huma. *** pneumonia.,Morga.ella.morga.ii,Es.herichia.coli,a.d Ra.s.onia.ins.dios. a.e potentia. core pa.hogens.found in the four groups.a. s.engjin La.e tha. ca. ca.s. dis.a.1}s.in huma.s.a.d a.-ima.s.a.d fa.ilita.e cros.-s.ecies.tra.s.is.ion through va.ious.***,huma.s.a.e a. ris. of con-tra.ting thes. pa.hogens.from migra.ory birds.beca.s. of their frequent conta.t with domes.ic ***,further s.udies.a.e required to explore the potentia. pa.hogenic s.ecies.a.d tra.s.is.ion pa.hwa.s.a.ong s.mpa.ric wintering Bea. Gees.,Domes.ic Ducks.huma.s.a.d s.il.

关键词： Microbiome Migra.ory wa.erbird Pa.hogens Poultry s.mpa.ric s.ecies

Nonaqueous.pota.1}ium-ion full-cells.Ma.ping the progres. a.d identifying mis.ing puzzle pieces

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Journal of Energy Chemis.ry 2024年第6期93卷 384-399,I0010页

作者： Ba.re La.hrib Louiza.La.bi Lénaïc Ma.ec Univers.te de Pa. et des.Pa.s.de l’a.our E2S UPPACNRSIPREMPauFrance Univers.téde Ha.te-a.s.ce Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Univers.téde s.ra.0}ourg F-67081 StrasbourgFrance Rés.a. s.r le s.ocka.e Electrochimique de l’Energie CNRS FR3459AmiensFrance Ins.itut des.Ma.éria.x Jea. Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This.review a.dres.es.the growing interes. for pota.0}ium-ion full-cells.KIFCs.in view of the tra.s.tion from pota.0}ium-ion ha.f-cells.KIHCs.towa.d commercia. K-ion ba.teries.KIBs..It focus.s.on the key pa.a.eters.of KIFCs.s.ch a.0}the electrode/electrolyte interfa.es.cha.lenge,ma.or ba.riers.a.d recent a.va.cements.in *** s.ra.egies.for enha.cing KIFC performa.ce,including interfa.es.co ntrol,electrolyte optimiza.ion,electrodes.ca.a.ity ra.io,electrode ma.eria. s.reening a.d electrode des.gn,a.e *** review highlights.the need to eva.ua.e KIBs.in full-cell configura.ions.a.0}ha.f-cell res.lts.a.e s.rongly impa.ted by the K meta. *** a.s. empha.0}zes.the importa.ce of unders.a.ding s.lid electrolyte interpha.0}(s.I)forma.ion in KIFCs.a.d explores.promis.ng nonaqueous.a.0}well a.0}qua.0}a.d a.l-s.lid-s.a.e electrolytes.*** review thus.pa.es.the wa. for pra.tica.,cos.-effective,a.d s.a.a.le KIBs.a.0}energy s.ora.e s.s.ems.by offering ins.ghts.a.d guida.ce for future res.a.ch.

关键词： K-ion full-cells Pota.0}ium-ion ba.teries Cros.-ta.k s.lid-s.a.e ba.teries Pota.0}ium rea.tivity Electrolyte des.gn Electrode des.gn

Ca.bon a.loca.ion in Picea.jezoens.s.a.a.ta.ion s.ra.egies.of a.non-treeline s.ecies.a. its.upper eleva.ion limit

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Fores. Ecos.s.ems 2024年第3期11卷 347-357页

作者： Renka. Dong na Li Ma.-He Li Yu Cong Ha.bo Du Deca. Ga. Hong s.He Key La.ora.ory of Geogra.hica. Proces.es.a.d Ecologica. s.curity in Cha.gba. Mounta.ns Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun130024China s.hool of natura. Res.urces University of MissouriColumbiaMO65211USA s.is. Federa. Ins.itute for Fores. Snow and Landscape Research WSL8903BirmensdorfSwitzerland Northea.0} Ins.itute of Geogra.hy a.d a.ricultura. Ecology Chinese Academy of SciencesChangchun130102China s.hool of Life s.ience Hebei UniversityBaoding071002China

Unders.a.ding the phys.ologica. a.a.ta.ions.of non-treeline trees.to environmenta. s.res. is.importa.t to unders.a.d future s.ifts.in s.ecies.compos.tion a.d dis.ribution of current treeline *** a.m of the pres.nt s.udy wa.0}to elucida.e the mecha.is.s.of the forma.ion of the upper eleva.ion limit of non-treeline tree s.ecies.Picea.jezoens.s.a.d the ca.bon a.loca.ion s.ra.egies.of the s.ecies.on Cha.gba. *** employed the^(13)C in s.tu puls. la.eling technique to tra.e the dis.ribution of photos.nthetica.ly a.0}imila.ed ca.bon in Picea.jezoens.s.a. different eleva.ional pos.tions.tree s.ecies.a. its.upper eleva.ion limit(Ts.UE,1,700 m a.s.l.)under treeline ecotone;tree s.ecies.a. a.lower eleva.ion pos.tion(Ts.LE,1,400 m a.s.l.).We a.35}lyzed^(13)C a.d the non-s.ructura. ca.bohydra.e(Ns.)concentra.ions.in va.ious.tis.ues.following *** findings.revea.ed a.s.gnifica.t s.ift in ca.bon a.loca.ion in Ts.UE compa.ed to *** wa.0}a.pronounced increa.0} inδ^(13)C a.loca.ion to belowground components.roots.s.il,s.il res.ira.ion)in Ts.UE compa.ed to ***,the C flow ra.e within the pla.t-s.il-a.mos.here s.s.em wa.0}fa.0}er,a.d the C res.dence time in the pla.t wa.0}s.orter in *** trends.indica.e enha.ced C s.nk a.tivity in belowground tis.ues.in Ts.UE,with newly a.0}imila.ed C being preferentia.ly directed there,s.gges.ing a.more cons.rva.ive C a.loca.ion s.ra.egy by *** a. higher eleva.ions.under ha.s.er *** a.s.ra.egy,prioritizing C s.ora.e in roots.likely a.ds.in withs.a.ding winter cold s.res. a. the expens. of a.oveground growth during the growing s.a.0}n,lea.ing to reduced growth of Ts.UE compa.ed to *** res.lts.of the pres.nt s.udy s.ed light on the a.a.tive mecha.is.s.governing the upper eleva.ion limits.of non-treeline trees.a.d enha.ces.our unders.a.ding of how non-treeline s.ecies.might res.ond to ongoing clima.e cha.ge.

关键词： ^(13)C puls. la.eling Ca.bon dis.ribution Non-s.ructura. ca.bohydra.es.Ns.) Non-treeline s.ecies s.nk a.tivity s.res.ful environments Upper eleva.ion limit