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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo Ding Reng-na Yan Yun Hu Jian-Hua Ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUND Insulin antibodies(ias)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and ias in patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and ia levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive ias(ia level>5%),with a mean ia level of 11.06%(10.39%-11.72%).ia levels were positively correlated with high fasting blood glucose(odds ratio=1.069,Pias was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),Pia levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all Pia antibodies,and ia antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower ia levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

Improving high-temperature oxidation behavior by modifying Al and Co content in Al-Co-Cr-Fe-Ni high-entropy alloy

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Journal of Materials Science & Technology 2022年第34期129卷 115-126页

作者： Timothy Alexander Listyawan Maya Putri Agus tianingrum Young Sang na ka Ram Lim Nokeun Park School of Materials Science and Engineering Yeungnam University280 Daehak-roGyeongbuk 38541Republic of Korea Advanced Metals Division Korea Institute of Materials Science(KIMS)797 ChangwondaeroSeongsan-guChangwonGyeongnam 51508Republic of Korea Institute of Materials Technology Yeungnam University280 Daehak-roGyeongsanGyeongbuk 38541Republic of Korea

Composition modification was introduced to improve the oxidation resistance by varying Al and excluding Co from the Al-Co-Cr-Fe-Ni system. Since adjusting the composition shifted the valence electron concentration(VEC) of the alloys, the dual-phase structure of the alloys is expected to be more stable. At low temperatures(T nated the alloy’s surface. Compared to equiatomic AlCoCrFeNi(5-Equi), nonequiatomic AlCoCrFeNi(5-B 40) and four-component AlCrFeNi(4-B 2013) had better oxidation resistance due to monocrystalline-Al_(2)O_(3)formation. Besides the role of oxide formation, maintaining BCC and B2phases within the alloys is also beneficial to supporting the stable Cr_(2)O_(3)or Al_(2)O_(3).

关键词： High-entropy alloy Alloy design Oxidation Valence electron concentration Phase stability Transmission electron microscope

Advantageous mechanochemical synthesis of copper(Ⅰ)selenide semiconductor,characterization,and properties

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Frontiers of Chemical Science and Engineering 2022年第3期16卷 433-442页

作者： katarína Gáborová Marcela Achimovičová Michal Hegedüs Vladimír Girman Mária kaňuchová Erika Dutková Institute of Geotechnics Slovak Academy of SciencesKošice04001Slovakia Institute of Metallurgy Faculty of MaterialsMetallurgy and RecyclingTechnical UniversityKošice04201Slovakia Synthon s.r.o.Blansko67801Czech Republic Faculty of Science Pavol JozefŠafárik UniversityKošice04154Slovakia Institute of Earth Resources Faculty of MiningEcologyProcess Control and GeotechnologiesTechnical UniversityKošice04200Slovakia

Copper(I)selenide-nanocrystalline semiconductor was synthesized via one-step mechanochemical synthesis after 5 min milling in a planetary ball *** kinetics of synthesis was followed by X-ray powder diffraction analysis and specific surface area measurements of milled 2Cu/Se *** X-ray diffraction confirmed the orthorhombic crystal structure of Cu_(2)Se with the crystallite size∼25 *** surface chemical structure was studied by X-ray photoelectron spectroscopy,whereby the binding energy of the Cu 2p and Se 3d signals corresponded to Cu^(+)and Se^(2−)oxidation *** electron microscopy revealed agglomerated nanocrystals and confirmed their orthorhombic structure,as *** optical properties were studied utilizing ultraviolet-visible spectroscopy and photoluminescence *** direct bandgap energy 3.7 eV indicated a blue-shift phenomenon due to the quantum size *** type of Cu_(2)Se synthesis can be easily adapted to production dimensions using an industrial vibratory *** advantages of mechanochemical synthesis represent the potential for inexpensive,environmentally-friendly,and waste-free manufacturing of Cu_(2)Se.

关键词： Cu_(2)Se berzelianite nanocrystalline semiconductor mechanochemical synthesis planetary ball mill

基于ka波段的海事卫星Global Xpress系统

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数字通信世界 2024年第6期 78-80页

作者：赵娜中国交通通信信息中心北京100011

文章主要介绍了基于ka波段的海事卫星Global Xpress系统的技术特点,着重与传统Vsat业务进行了对比,简单介绍了GX的海事业务。

关键词：第五代海事卫星国际移动卫星公司 Global Xpress 技术特点 Vsat

苯丁酸甘油酯治疗儿童鸟氨酸氨甲酰基转移酶缺乏症1例

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中国当代儿科杂志 2024年第5期26卷 512-517页

作者：杨帆王立瑞李辛胡佳悦应令雯冯碧云李芸芸林卡娜佘佳笑李浩常国营王秀敏上海交通大学医学院附属上海儿童医学中心临床研究病区上海200127 上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科上海200127 云南省德宏州陇川县人民医院儿科云南德宏678700

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上... 详细信息

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上海儿童医学中心1例诊断为OTCD的患儿资料,并进行相关文献复习。该患儿确诊后使用GPB治疗,随后进行疗效随访和药学监测。患儿,男,6岁6个月,语言发育差,不听指令,脾气暴躁并伴有攻击性行为。监测血氨最高327μmol/L;尿有机酸分析提示尿嘧啶水平升高;头颅磁共振成像示双侧大脑半球广泛异常信号;基因检测发现OTC基因新生突变(c.241T>C,p.S81P)。予以GPB治疗后1、2、3个月左右的血氨分别为43、80、56μmol/L。患儿治疗期间血氨控制良好,未见与药物相关的不良反应,发育落后情况较前改善,可听指令,脾气好转,无攻击性行为。

关键词：苯丁酸甘油酯鸟氨酸氨甲酰基转移酶缺乏症尿素循环障碍高氨血症药学监测儿童

Pareto排序遗传算法及响应面优化在纯电车电池壳体参数设计的工程应用

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机械科学与技术 2024年第5期43卷 819-831页

作者：高媛媛刘娜刘鹏王成诺山东建筑大学机电工程学院济南250101 运输车辆检测、诊断与维修技术交通行业重点实验室济南250300

为解决三元锂电池壳厚重与应力集中的问题。本文利用拉丁超立方法对变密度拓扑优化后参数抽样,利用了Pareto排序多目标遗传算法,选择应力等作为目标函数进行迭代计算。本文利用克里格空间插值法得到各响应图谱以及初步预测的优化方案。... 详细信息

为解决三元锂电池壳厚重与应力集中的问题。本文利用拉丁超立方法对变密度拓扑优化后参数抽样,利用了Pareto排序多目标遗传算法,选择应力等作为目标函数进行迭代计算。本文利用克里格空间插值法得到各响应图谱以及初步预测的优化方案。基于上述结果利用Design-Expert建立了62组响应面数学模型,计算所得帕累托最优为70%,p-value≤0.0001,证明响应面模型的准确性,经仿真计算优化后的结构较原模型各方面性能都有所提升,具有较好的可靠性。

关键词：纯电动汽车多目标遗传算法响应面优化

naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2

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Cellular & Molecular Immunology 2022年第11期19卷 1302-1310页

作者： Qiaoli Peng Runhong Zhou na Liu Hui Wang Haoran Xu Meiqing Zhao Dawei Yang ka-Kit Au Haode Huang Li Liu Zhiwei Chen AIDS Institute Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China national Clinical Research Center for Infectious Diseases HKU AIDS Institute Shenzhen Research LaboratoryThe Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdongPR China Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China Centre for Virology Vaccinology and Therapeutics LimitedThe University of Hong KongHong Kong Special Administrative RegionPR China HKU AIDS Institute Joint Laboratory Department of Clinical Microbiology and Infection ControlThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdongPR China State Key Laboratory of Emerging Infectious Disease The University of Hong KongHong Kong Special Administrative RegionPR China

Mutations in SARS-CoV-2 variants of concern(VOCs)have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies(nabs).How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be *** entry efficiency of individual spike mutations was determined in vitro using pseudotyped ***/c mice were immunized with 2-dose Dna vaccines encoding B.1.1.7,B.1.351,B.1.1.529 and their single *** and humoral immune responses were then compared to determine the impact of individual mutations on *** the B.1.1.7 lineage,Del69–70 and Del 144 in NTD,A570D and P681H in SD1 and S982A and D1118H in S2 significantly increased viral entry,whereas T716I resulted in a *** the B.1.351 lineage,L18F and Del 242–244 in the NTD,K417N in the RBD and A701V in S2 also increased viral entry.S982A weakened the generation of binding *** sera showed reduced cross-neutralization activity against B.1.351,B.1.617.2(Delta)and B.1.1.529(Omicron BA.1).S982A,L18F,and Del 242–244 hindered the induction of cross-nabs,whereas Del 69–70,Del144,R246I,and K417N showed the opposite effects.B.1.351 elicited adequate broad cross-nabs against both B.1.351 and *** immunogens tested,however,showed low neutralization against circulating *** addition,T-cell responses were unlikely affected by mutations tested in the *** conclude that individual spike mutations influence viral infectivity and vaccine *** VOC-targeted vaccines is likely necessary to overcome immune evasion from current vaccines and neutralizing antibodies.

关键词： SARS-CoV-2 Variants of Concern Single mutation neutralizing antibody T cell responses vaccine immunogenicity

Experimental study of the mass transfer behavior of carbon dioxide absorption into ternary phase change solution in a packed tower

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Chinese Journal of Chemical Engineering 2022年第3期35卷 135-142页

作者： Yihan Yin Aoqian Qiu Hongxia Gao Yanqing na Zhiwu Liang Joint International Center for CO_(2)Capture and Storage(iCCS) Provincial Hunan Key Laboratory for Cost-effective Utilization of Fossil Fuel Aimed at Reducing Carbon-dioxide EmissionsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Phase change absorbents for CO_(2)are of great interest because they are expected to greatly reduce the heat energy consumption during the regeneration *** with other phase change absorbents,monoethanolamine(MEA)-sulfolane-water is inexpensive and has a fast absorption *** is one of the most promising solvents for large-scale industrial ***,this study investigates the mass transfer performance of this phase change system in the process of CO_(2)absorption in a packed *** comparing the phase change absorbent and the ordinary absorbent,it is concluded that the use of MEA/sulfolane phase change absorbent has significantly improved mass transfer efficiency compared to a single MEA absorbent at the same *** the 4 mol·L^(-1)MEA/5 mol·L^(-1)sulfolane system,the CO_(2)loading of the upper liquid phase after phase separation is almost zero,while the volume of the lower liquid phase sent to the desorption operation is about half of the total volume of the absorbent,which greatly reduces the energy *** study also investigates the influence of operating parameters such as lean CO_(2)loading,gas and liquid flow rates,CO_(2)partial pressure,and temperature on the volumetric mass transfer coefficient(K_(G)α_(V)).The research shows that K_(G)α_(V) increases with increasing liquid flow rate and decreases with the increase of lean CO_(2)loading and CO_(2)partial pressure,while the inert gas flow rate and temperature have little effect on K_(G)α_(V).In addition,based on the principle of phase change absorption,a predictive equation for the K_(G)α_(V) of MEA-sulfolane in the packed tower was *** K_(G)α_(V) obtained from the experiment is consistent with the model prediction,and the absolute average deviation(AAD)is 7.8%.

关键词： Monoethanolamine-sulfolane-water Phase change solution Mass transfer Packed tower

复方益母片促进早孕妇女人工流产术后恢复临床疗效观察

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中国实用妇科与产科杂志 2024年第7期40卷 752-755页

作者：杨思晨杨梦萍郭亚楠张悦健马小娜北京中医药大学第三临床医学院北京100029 北京中医药大学第三附属医院北京100029

目的观察复方益母片应用于早孕妇女人工流产(induced abortion,ia)术后恢复的临床疗效及安全性。方法将2023年3月至2024年1月就诊于北京中医药大学第三附属医院妇科的70例ia术后妇女按照随机数字表分为治疗组、对照组各35例。两组均常... 详细信息

目的观察复方益母片应用于早孕妇女人工流产(induced abortion,ia)术后恢复的临床疗效及安全性。方法将2023年3月至2024年1月就诊于北京中医药大学第三附属医院妇科的70例ia术后妇女按照随机数字表分为治疗组、对照组各35例。两组均常规口服抗生素预防感染,对照组不再使用其他药物治疗,治疗组加服复方益母片治疗。观察两组疼痛评分、疼痛持续时间、阴道流血量、阴道流血持续时间、术后2周子宫内膜厚度及优势卵泡生成情况、首次月经复潮时间及痛经发生情况,并进行安全性评价。结果术后2 h疼痛评分,两组比较差异无统计学意义(P>0.05)。治疗组第3天、第7天疼痛评分均低于对照组(P0.05),治疗组优势卵泡生成率高于对照组(Pia术后恢复有较好临床疗效。

关键词：复方益母片人工流产术疼痛中医

Complete androgen insensitivity syndrome caused by the c.2678C>T mutation in the androgen receptor gene:A case report

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World Journal of Clinical Cases 2021年第35期9卷 11036-11042页

作者： ka-na Wang Qing-Qing Chen Yi-Lin Zhu Chun-Lin Wang Department of Pediatrics The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Androgen insensitivity syndrome is an X-linked recessive genetic disease caused by mutations in the androgen receptor gene(AR).However,the underlying molecular mechanisms for the majority of AR variants remain *** this study,we identified a point variant in three patients with complete androgen insensitivity syndrome(CAIS),summarized the correlation analysis,and performed a literature *** SUMMARY The proband was raised as a *** infancy,she was first referred to hospital with a right inguinal *** revealed the absence of a uterus and ovaries,and a testis-like structure located at the inguinal *** diagnostic workup detected a 46,XY karyotype,and fluorescence in situ hybridization analysis showed the presence of the SRY *** analysis revealed the excised tissue to be *** years later,she was admitted to our hospital with a lack of breast *** pubic hair and breasts were Tanner stage *** had normal female external *** hormone tests showed normal testosterone levels,low estradiol levels,and high gonadotropin *** two siblings underwent similar examinations,and all three had a rare hemizygous missense mutation in AR:c.2678C>*** vitro functional analyses revealed decreased nuclear translocation in AR-c.2678C>T mutation *** This case of CAIS was caused by an AR variant(c.2678C>T).Functional studies showed impaired nuclear translocation ability of the mutant protein.

关键词： Androgen insensitivity syndrome 46 XY disorders of sex development Variants Androgen receptor gene Ligand-binding domain Case report