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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo Ding Reng-na Yan Yun Hu Jian-Hua Ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUND Insulin antibodies(ias)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and ias in patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and ia levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive ias(ia level>5%),with a mean ia level of 11.06%(10.39%-11.72%).ia levels were positively correlated with high fasting blood glucose(odds ratio=1.069,Pias was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),Pia levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all Pia antibodies,and ia antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower ia levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

Evaluation of anti-inflammatory potential of leaf extracts of Skimmia anquetilia

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 627-630页

作者： Vijender Kumar Zulfiqar Ali Bhat Dinesh Kumar na Khan ia Chashoo Department of Pharmaceutical Sciences University of Kashmir

Objective:To evaluate anti-inflammatory potential of leaf extract of Skimmia anquetilia by invitro and in-vivo anti-inflammatory ***:Acute toxicity study was carried out to determine the toxicity level of different extract using acute toxic class method as described in Organization of Economic Co-operation and Development Guidelines ***(1% w/w) was administered and inflammation was induced in rat *** leaf extracts of Skimmia anquetilia were evaluated for anti-inflammatory activity by in-vitro human red blood cell(HRBC) membrane stabilization method and in-vivo carrangeenan-induced rat paw edema method. Results:The in-vitro membrane stabilizing test showed petroleum ether(PE),chloroform(CE), ethyl acetate(EE),methanol(ME) and aqueous extracts(AE) showed 49.44%,59.39%,60.15%,68.40% and 52.18%protection,respectively as compared to control *** in-vivo results of CE,EE and ME showed 58.20%.60.17%and 67.53%inhibition of inflammation after 6h administration of test drugs in albino *** potency of the leaf extracts of Skimmia anquetilia were compared with standard diclofenac(10 mg/kg) which showed 74.18%protection in in-vitro HRBC membrane stabilization test and 71.64%inhibition in in-vivo carrangeenan-induced rat paw edema model. The ME showed a dose dependent significant(Pnan induced rat paw ***:The present investigation has confirmed the anti-inflammatory activity of Skimmia anquetilia due to presence of bioactive phytoconstitutes for the first lime and provide the pharmacological evidence in favor of traditional claim of Skimmia anquetilia as an antiinflammatory agent.

关键词： Skimmia anquetilia Anti-inflammatory Carrageenan Diclofenac Leaf extract Phytochemical analysis

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基于岭估计方法的多谐波源责任划分

电力系统自动化 2015年第21期39卷 87-92页

作者：贾秀芳岳娜新能源电力系统国家重点实验室华北电力大学河北省保定市071003

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩... 详细信息

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩阵病态情况下传统最小二乘估计无法得出正确结果,因此研究应用了岭估计方法。当谐波电流数据异常或者存在一定相关性时,岭估计方法避免了模型病态导致的错误结果。仿真算例验证了所述方法的有效性以及在系数矩阵病态时相对于传统最小二乘估计的优越性。

关键词：电能质量多谐波源谐波责任最小二乘估计岭估计

Far-Field Pattern Tolerance Analysis of Reflector Antenna with Random or System Error Based on Interval Arithmetic

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Chinese Journal of Electronics 2018年第3期27卷 641-647页

作者： LI Peng LI na XU Wanye WANG Wei Key Laboratory of Electronic Equipment Structure Design Ministry of Education Xidian University

A novel analytic approach for the research of effect on electromagnetic performance of reflector antennas with deformation, including random processing error and system error caused by external loads(such as wind,gravity, and solar radiation), in panels of the reflector surface is proposed. The deformations are modeled as error intervals, and their impact on the electromagnetic performance, including radiation power pattern and some main electromagnetic characteristics(such as side lobe level,peak power, and half-power beamwidth), are efficiently estimated by Interval analysis(ia). The closed-form equations indicate the relationship between the error interval and the bounds(upper and lower bounds) of the radiated power pattern interval by exploiting the rules of interval arithmetic. Two kinds of surface errors(random and system error) and two shapes of deformation area(bump-like and sector) are taken into account in the numerical examples to assess the validation and effectiveness of the proposed approach. The results of the examples show that the proposed ia-based approach has great capability and effectiveness regarding the traditional statistical method(such as Monte-Carlo method).

关键词： Reflector antenna Interval analysis Random error System error Power pattern

复方益母片促进早孕妇女人工流产术后恢复临床疗效观察

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中国实用妇科与产科杂志 2024年第7期40卷 752-755页

作者：杨思晨杨梦萍郭亚楠张悦健马小娜北京中医药大学第三临床医学院北京100029 北京中医药大学第三附属医院北京100029

目的观察复方益母片应用于早孕妇女人工流产(induced abortion,ia)术后恢复的临床疗效及安全性。方法将2023年3月至2024年1月就诊于北京中医药大学第三附属医院妇科的70例ia术后妇女按照随机数字表分为治疗组、对照组各35例。两组均常... 详细信息

目的观察复方益母片应用于早孕妇女人工流产(induced abortion,ia)术后恢复的临床疗效及安全性。方法将2023年3月至2024年1月就诊于北京中医药大学第三附属医院妇科的70例ia术后妇女按照随机数字表分为治疗组、对照组各35例。两组均常规口服抗生素预防感染,对照组不再使用其他药物治疗,治疗组加服复方益母片治疗。观察两组疼痛评分、疼痛持续时间、阴道流血量、阴道流血持续时间、术后2周子宫内膜厚度及优势卵泡生成情况、首次月经复潮时间及痛经发生情况,并进行安全性评价。结果术后2 h疼痛评分,两组比较差异无统计学意义(P>0.05)。治疗组第3天、第7天疼痛评分均低于对照组(P0.05),治疗组优势卵泡生成率高于对照组(Pia术后恢复有较好临床疗效。

关键词：复方益母片人工流产术疼痛中医

不同气候环境条件时黑荆和银荆在中国的潜在分布区预测

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东北林业大学学报 2024年第8期52卷 78-84,94页

作者：贺娜王洋刘凌户连荣张知晓马惠芬季梅云南省林业和草原科学院昆明650201

以388个黑荆(Acacia mearnsii)和477个银荆(Acacia dealbata)分布点数据为数据基础,依据筛选出的气候环境因子(黑荆13个、银荆12个)构建黑荆和银荆在中国潜在分布区的评价指标体系;以适生性指数(ia)0A≤0.20(不适生区)、0.20A≤0.40(低... 详细信息

以388个黑荆(Acacia mearnsii)和477个银荆(Acacia dealbata)分布点数据为数据基础,依据筛选出的气候环境因子(黑荆13个、银荆12个)构建黑荆和银荆在中国潜在分布区的评价指标体系;以适生性指数(ia)0A≤0.20(不适生区)、0.20A≤0.40(低适生区)、0.40A≤0.60(较适生区)、0.60A≤1.00(最适生区)为划分依据,运用最大熵模型(MaxEnt3.4.1)和地理信息系统软件(ArcGIS10.5)相结合方法,选择第六次国际耦合模式比较计划(CMIP6)划分的环境模式中两种环境模式(低强迫气候环境条件(SSP1-2.6)、高强迫气候环境条件(SSP5-8.5)),分析黑荆和银荆在中国当前(1950-2020年)及2021-2040年、2041-2060年、2061-2080年、2081-2100年气候环境条件时的潜在分布。结果表明:(1)最大熵模型预测的模型精度均大于0.9,表明模型预测结果极好,可信度极高。(2)影响黑荆分布的主要环境因子为年均温、年降水量、最冷月份最低温、等温性,影响银荆分布的主要环境因子为最冷月份最低温、年均温、最冷季降水量、年降水量。(3)在当前和未来气候环境条件时,黑荆和银荆均适宜在中国的西南和沿海等温暖湿润地区分布,如西藏最南部、云南、贵州、四川南部、福建和台湾地区;而中国西北、东北等冬季严寒地区均为不适生区。

关键词：黑荆银荆气候环境变化潜在分布区中国

Multi-Class Classification Methods of Cost-Conscious LS-SVM for Fault Diagnosis of Blast Furnace

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Journal of Iron and Steel Research International 2011年第10期18卷 17-23,33页

作者： LIU Li-mei WANG An-na SHA Mo ZHAO Feng-yun College of Information Science and Engineering Northeastern University Shenyang 110819 Liaoning China

Aiming at the limitations of rapid fault diagnosis of blast furnace, a novel strategy based on cost-conscious least squares support vector machine （LS-SVM） is proposed to solve this problem. Firstly, modified discrete particle swarm optimization is applied to optimize the feature selection and the LS-SVM parameters. Secondly, cost-con- scious formula is presented for fitness function and it contains in detail training time, recognition accuracy and the feature selection. The CLS-SVM algorithm is presented to increase the performance of the LS-SVM classifier. The new method can select the best fault features in much shorter time and have fewer support vectbrs and better general- ization performance in the application of fault diagnosis of the blast furnace. Thirdly, a gradual change binary tree is established for blast furnace faults diagnosis. It is a multi-class classification method based on center-of-gravity formula distance of cluster. A gradual change classification percentage ia used to select sample randomly. The proposed new metbod raises the sped of diagnosis, optimizes the classifieation scraraey and has good generalization ability for fault diagnosis of the application of blast furnace.

关键词： blast furnace fault diagnosis eosc-conscious LS-SVM multi-class classification

基于网络药理学和分子对接探讨保和丸“异病同治”小儿厌食症和功能性消化不良的分子机制

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中医康复 2024年第8期1卷 41-48页

作者：赵纳任翔宇葛慧张慧敏山东中医药大学山东济南250014 广安门医院济南医院山东济南250012 山东中医药大学附属济南市中医医院山东济南250012

目的:采用网络药理学和分子对接探讨保和丸“异病同治”小儿厌食症(infantile anorexia, ia)和功能性消化不良(functional dyspepsia, FD)的潜在分子机制。方法:通过TCMSP数据库及PubMed与中国知网收集保和丸活性成分及靶点;利用DisGeNE... 详细信息

目的:采用网络药理学和分子对接探讨保和丸“异病同治”小儿厌食症(infantile anorexia, ia)和功能性消化不良(functional dyspepsia, FD)的潜在分子机制。方法:通过TCMSP数据库及PubMed与中国知网收集保和丸活性成分及靶点;利用DisGeNET、DrugBank、GeneCards等数据库检索与ia和FD相关的疾病靶点;并得到保和丸与ia和FD的交集靶点;使用Cytoscape 3.9.0软件构建“药物-成分-靶点”网络图;基于STRING平台建立蛋白质互作网络;应用R语言进行GO功能及KEGG通路富集分析;采用CB-Dock2平台对关键成分与有效靶点进行分子对接研究。结果:共得到保和丸与ia和FD交集靶点161个,筛选出木犀草素、槲皮素、汉黄芩素、β-谷甾醇、山奈酚、柚皮素6种核心成分,以及TP53、MAPK1、AKT1、MAPK3、BCL2、ESR1 6个核心靶点。GO和KEGG结果显示,通过调控脂质与动脉粥样硬化、PI3K/AKT、内分泌抵抗、IL-17、TNF等信号通路,发挥治疗ia和FD的药理作用。在分子对接验证中,所有结合能均小于-5.0kcal·mol-1,结合能小于-7.0kcal·mol-1的有68组,占66.67%。结论:保和丸核心成分在治疗ia和FD的过程中发挥出“异病同治”作用,体现保和丸具有“多成分、多靶点、多通路、多途径”的作用特点,为进一步研究保和丸的临床应用提供理论基础。

关键词：网络药理学分子对接保和丸小儿厌食症功能性消化不良

痤疮丙酸杆菌通过辅助性T淋巴细胞17炎症通路致寻常痤疮的机制研究进展

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实用皮肤病学杂志 2024年第4期17卷 226-230页

作者：王羽侬孙娅楠任星周娜王毅北京中医药大学第三附属医院皮肤科北京100029 中国中医科学院医学实验中心

寻常痤疮是一种常见的慢性炎症性皮肤病,皮脂分泌旺盛、毛囊角化过度、皮肤菌群失调和局部免疫炎症反应是寻常痤疮发生的重要因素。近年来对痤疮发生机制的研究成果包括:痤疮丙酸杆菌(***)生物膜形成与体内毒力因子增强有关;***多样性下... 详细信息

寻常痤疮是一种常见的慢性炎症性皮肤病,皮脂分泌旺盛、毛囊角化过度、皮肤菌群失调和局部免疫炎症反应是寻常痤疮发生的重要因素。近年来对痤疮发生机制的研究成果包括:痤疮丙酸杆菌(***)生物膜形成与体内毒力因子增强有关;***多样性下降,令ⅠA1型***占主导地位,从而诱导辅助性T淋巴细胞17(Th17)通路激活,角质形成细胞、成纤维细胞、单核细胞和皮脂细胞在痤疮炎症反应中发挥核心作用。该文就***诱发Th17炎症通路激活导致痤疮的发病机制进行综述。

关键词：痤疮痤疮丙酸杆菌 Th17细胞炎症发病机制

Comparative analysis of robotic vs laparoscopic radical hysterectomy for cervical cancer

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World Journal of Clinical Cases 2019年第20期7卷 3185-3193页

作者： Li Chen Li-Ping Liu na Wen Xiao Qiao Yuan-Guang Meng Department of Obstetrics and Gynecology Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology The First Central Hospital of BaodingBaoding 071000Hebei ProvinceChina Medical Big Data Center Chinese PLA General HospitalBeijing 100853China

BACKGROUND Cervical cancer is the most common gynecological malignancy,ranking first in female reproductive malignancies with more than 500000 new cases and 275000 deaths each ***,open radical hysterectomy is considered the standard surgical procedure for the treatment of resectable cervical *** latest guidelines from the national Comprehensive Cancer Network and the European Society of Gynecological Oncology suggest that open surgery and laparoscopic surgery(using traditional laparoscopic or robotic techniques)are the main surgical approaches for radical hysterectomy for patients with stage ia2-Iia cervical *** surgery has been increasingly used in abdominal surgery and has shown more beneficial *** To analyse the perioperative conditions,complications,and short-term and longterm effects in patients undergoing robotic radical hysterectomy(RRH)and laparoscopic radical hysterectomy(LRH)to compare their clinical efficacy,safety,and *** The perioperative data of patients undergoing RRH and LRH were extracted and collected from the database of surgical treatments for cervical cancer for statistical *** Of the patients,342 underwent LRH for cervical cancer,and 216 underwent *** total complication rate was 9.65%(20 patients)in the RRH group and 17.59%(60 patients)in the LRH *** complication rate was significantly lower in the RRH group than in the LRH *** was no significant difference in the follow-up period(P=0.658).The total recurrence rates were 15.7%and 12%in the RRH and LRH groups,*** progression-free survival time was 28.91±15.68 mo and 28.34±15.13 mo in the RRH and LRH groups,respectively(P=0.669).The overall survival(OS)rates were 92.13%and 94.45%in the RRH and LRH groups,respectively(P=0.292).The OS time was 29.87±15.92 mo and 29.41±15.14 mo in the RRH and LRH groups,respectively(P=0.732).The survival curves and the progression-free survival curves were not statis

关键词： Cervical cancer Robotic radical hysterectomy Laparoscopy Survival