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Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway

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Acta Pharmaceutica Sinica B 2019年第2期9卷 279-293页

作者： Shanshan Qi lingyuan Guo Shuzhen Yan Robert j.lee Shuqin Yu Shuanglin Chen jiangsu Province Key laboratory for Microbes and Functional Genomics College of Life SciencesNanjing Normal University College of Pharmacy the Ohio State University Cancer Pharmacology Crown Bioscience Inc. jiangsu Province Key laboratory for Molecular and Medical Biotechnology College of Life SciencesNanjing Normal University

Over recent decades, many studies have reported that hypocrellin A(ha) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined. ha-mediated cytotoxicity and apoptosis in human lung adenocarcinoma A549 cells were evaluated after photodynamic therapy(PDT). A temporal quantitative proteomics approach by isobaric tag for relative and absolute quantitation(iTRAQ) 2 D liquid chromatography with tandem mass spectrometric(lC–MS/MS) was introduced to help clarify molecular cytotoxic mechanisms and identify candidate targets of ha-induced apoptotic cell death. Specific caspaseinhibitors were used to further elucidate the molecular pathway underlying apoptosis in PDT-treated A549 cells. Finally, down-stream apoptosis-related protein was evaluated. Apoptosis induced by ha was associated with cell shrinkage, externalization of cell membrane phosphatidylserine, Dna fragmentation,and mitochondrial disruption, which were preceded by increased intracellular reactive oxygen species(ROS) generations. Further studies showed that PDT treatment with 0.08 mmol/l ha resulted in mitochondrial disruption, pronounced release of cytochrome c, and activation of caspase-3,-9, ***, ha may be a possible therapeutic agent directed toward mitochondria and a promising photodynamic anticancer candidate for further evaluation.

关键词： Hypocrellin A Photodynamic therapy Reactive oxygen species Proteomic lC–MS/MS iTRAQ

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Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal

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journal of Environmental Sciences 2019年第6期31卷 58-65页

作者： jin-Ho Sung Seung-Ki Back Eun-Song lee ha-na jang Yong-Chil Seo Youn-Suk Kang Myong-Hwa lee Department of Environmental Engineering Yonsei University j-E Tech Co. Ltd Department of Environmental Engineering Kangwon National University

Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of particle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine particulates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed.

关键词： Mercury Hybrid filter Activated carbon Coating filter Coal-fired power plant

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Approach for electrodynamic force for compensation in low voltage circuit breaker WP 630-1.2 type

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 393-396页

作者： lU na XU l.j Miedzifiski B Automation School Beijing University of Posts and Telecommunications Beijing 100876 China Electrical Power Engineering Institute Wroclaw University of Technology Wroclaw Poland

Undesirable repulsive force between contact members due to both a current path shrink near a real contact area and/or so-called pinch effect is particularly onerous for power switch applications, and results in either contact floating or bouncing which are associated with an electric arc following contact welding. This problem is of great importance for any circuit breaker especially for compact low voltage vacuum circuit breakers. To avoid contact floating at closure and during any inrush current under short circuit conditions, the electrodynamic repulsive force can be employed successfully if we use a special compensation system flexibly combined with the contact itself. However to select and design the compensation system properly, its efficiency has to be known. This paper presents an approach to obtain the electrodynamic force value depending on different shaped (rectangular, square, circle and arch) copper plates used in the compensator by using ANSYS for current values 40 kA RMS. Curve-fitting was done according to the calculating results, the optimization designing of compensation unit is based on them.

关键词： Compensation. Electrodynamic force. FEM (Finite Element Method)

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Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

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journal of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre larhrib louiza larbi lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Réseau sur le Stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIFCs)in view of the transition from potassium-ion half-cells(KIHCs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIFCs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIFC performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(SEI)formation in KIFCs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries Cross-talk Solid-state batteries Potassium reactivity Electrolyte design Electrode design

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Recurrent basal cell carcinoma of lower lid invading the orbit and whole hemiface reconstructed by rectus abdominis free flap

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International journal of Ophthalmology(English edition) 2013年第3期6卷 413-414页

作者： Dong Hyun ji ha na Park Tae Yoon la Department of Ophthalmology St. Vincent's Hospital College of Medicine the Catholic University of Korea

Dear Sir, I am Dong Hyun ji, from the Department of Ophthalmology of St. Vincent’s Hospital, Suwon, Korea. I write to present a very severely recurrent basal cell carcinoma (BCC) in lower lid invading left orbit and ... 详细信息

关键词： Figure Recurrent basal cell carcinoma of lower lid invading the orbit and whole hemiface reconstructed by rectus abdominis free flap free BCC cell

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Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song ha lee Keun Young jang Seong jae lee jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

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Decomposition of multi-particle azimuthal correlations in Q-cumulant analysis

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Chinese Physics C 2023年第10期47卷 178-196页

作者： l.nađđerđ j.Milošević D.Devetak 王福强 Department of physics "VINČA"Institute of Nuclear Science-National Institute of the Republic of SerbiaUniversity of BelgradeMike Petrovića Alasa 12-14Vinča 11351BelgradeSerbia Strong coupling Physics International Research laboratory Huzhou UniversityHuzhou 313000China College of Science Huzhou UniversityHuzhou 313000China Department of Physics and Astronomy Purdue UniversityIndiana 47907USA

The method of Q-cumulants is a powerful tool for studying the fine details of azimuthal anisotropies in high energy nuclear *** paper presents a new method,based on mathematical induction,to evaluate the analytical form of high-order *** capability of this method is demonstrated via a toy model that uses the elliptic power distribution to simulate the anisotropic emission of particles,quantified in terms of Fourier flow harmonics v_(n).The method can help in studying the large amount of event statistics that can be collected in the future and allow measurements of the very high central moments of the v_(2)*** can,in turn,facilitate progress in understanding the initial geometry,the input to the hydrodynamic calculations of medium expansion in high energy nuclear collisions,and the constraints on it.

关键词： quark gluon plasma azimuthal anisotropies Q-cumulants Pfaff transformation

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A nanofilter composed of carbon nanotube-silver composites for virus removal and antibacterial activity improvement

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journal of Environmental Sciences 2016年第4期28卷 275-283页

作者： jun Pyo Kim jae ha Kim jieun Kim Soo No lee han-Oh Park nano Development Team Bioneer Corporation Daejeon 306-220 Republic of Korea

We have developed a new nanofilter using a carbon nanotube-silver composite material that is capable of efficiently removing waterborne viruses and *** nanofilter was subjected to plasma surface treatment to enhance its flow rate,which was improved by approximately 62%.nanoscale pores were obtained by fabricating a carbon nanotube network and using nanoparticle fixation technology for the removal of *** pore size of the nanofilter was approximately 38 nm and the measured flow rate ranged from 21.0 to 97.2 l/（min·m^2）under a pressure of 1–6 kgf/cm^2 when the amount of loaded carbon nanotube-silver composite was 1.0 mg/cm^*** nanofilter was tested against Polio-,Noro-,and Coxsackie viruses using a sensitive real-time polymerase chain reaction assay to detect the presence of viral particles within the *** trace of viruses was found to flow through the nanofilter with carbon nanotube-silver composite loaded above 0.8 mg/cm^***,the surface of the filter has antibacterial properties to prevent bacterial clogging due to the presence of 20-nm silver nanoparticles,which were synthesized on the carbon nanotube surface.

关键词： Carbon nanotube Silver nanoparticle Virus removal nanofilter Water purification

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Massively parallel electro-optic sampling of space-encoded optical pulses for ultrafast multi-dimensional imaging

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light(Science & Applications) 2023年第2期12卷 304-313页

作者： Yongjin na Hyunsoo Kwak Changmin Ahn Seung Eon lee Woojin lee Chu-Shik Kang jungchul lee junho Suh Hongki Yoo jungwon Kim Korea Advanced Institute of Science and Technology(KAIST) Daejeon 34141Korea Korea Research Institute of Standards and Science(KRISS) Daejeon 34113Korea

High-speed and high-resolution imaging of surface profiles is critical for the investigation of various structures and mechanical dynamics of micro-and nano-scale *** particular,recent emergence of various nonlinear,transient and complex mechanical dynamics,such as anharmonic vibrations in mechanical resonators,has necessitated real-time surface deformation imaging with higher axial and lateral resolutions,speed,and dynamic ***,real-time capturing of fast and complex mechanical dynamics has been challenging,and direct time-domain imaging of displacements and mechanical motions has been a missing element in studying full-field structural and dynamic ***,by exploiting the electro-optic sampling with a frequency comb,we demonstrate a line-scan time-of-flight(TOF)camera that can simultaneously measure the TOF changes of more than 1000 spatial coordinates with hundreds megapixels/s pixel-rate and sub-nanometre axial resolution over several millimetres *** unique combination of performances enables fast and precise imaging of both complex structures and dynamics in three-dimensional devices and mechanical resonators.

关键词： deformation dimensional dynamics

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Evaluation of high yielding soybean germplasm under water limitation

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journal of Integrative Plant Biology 2016年第5期58卷 475-491页

作者： Silvas j.Prince Mackensie Murphy Raymond N.Mutava Zhengzhi Zhang na Nguyen Yoon ha Kim Safiullah M.Pathan Grover j.Shannon Babu Valliyodan Henry T.Nguyen national Center for Soybean Biotechnology and Division of Plant Sciences University of Missouri

limited information is available for soybean root traits and their plasticity under drought stress. To date, no studies have focused on examining diverse soybean germ- plasm for regulation of shoot and root response under water limited conditions across varying soil types. In this study, 17 genetically diverse soybean germplasm lines were selected to study root response to water limited conditions in clay （trial 1） and sandy soil （trial 2） in two target environments. Physiological data on shoot traits was measured at multiple crop stages ranging from early vegetative to pod filling. The phenotypic root traits, and biomass accumulation data are collected at pod filling stage. In trial 1, the number of lateral roots and forks were positively correlated with plot yield under water limitation and in trial 2, lateral root thickness was positively correlated with the hill plot yield. Plant Introduction （PI） 578477A and 088444 were found to have higher later root number and forks in clay soil with higher yield under water limitation, in sandy soil, P1458o2o was found to have a thicker lateral root system and higher yield under water limitation. The genotypes identified in this study could be used to enhance drought tolerance of elite soybean cultivars through improved root traits specific to target environments.

关键词： Fibrous root root angle root plasticity root systemarchitecture (RSA) root thickness spectral indices soybean spectralindices total root length water limitation

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