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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 272-285页

作者： na PANG Dawei ZhANG Shuqian ZhU School of Mathematics Shandong UniversityJinan250100China

This paper investigates the recoil control of the deepwater drilling riser system with nonlinear tension force and energy-bounded friction force under the circumstances of limited network resources and unreliable *** from the existing linearization modeling method,a triangle-based polytope modeling method is applied to the nonlinear riser *** on the polytope model,to improve resource utilization and accommodate random data loss and communication delay,an asynchronous gain-scheduled control strategy under a hybrid event-triggered scheme is *** asynchronous linear parameter-varying system that blends input delay and impulsive update equation is presented to model the nonlinear networked recoil control system,where the asynchronous deviation bounds of scheduling parameters are *** to the Lyapunov-Krasovskii functional method,some solvable conditions of disturbance attenuation analysis and recoil control design are derived such that the resulting networked system is exponentially mean-square stable with prescribed h∞*** obtained numerical results verified that the proposed nonlinear networked control method can achieve a better recoil response of the riser system with less transmission data compared with the linear control method.

关键词： Riser system Recoil control Asynchronous gain-scheduled control Data loss Event-triggered scheme

A Review on nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

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Chemical Research in Chinese Universities 2024年第2期40卷 202-212页

作者： CAO Mengyu XING Xiner ShEN Xiaotong OUYANG Jin na na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of Chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430074P.R.China

Cancer is a leading cause of death worldwide,and a series of strategies has been reported for tumor-specific ***,chemodynamic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimulation,and high ***,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient acidity,tumor hypoxia,low hydrogen peroxide(h2O2),and high glutathione(GSh).Consequently,different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strategies for enhancing CDT through manipulating *** CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials.

关键词： Chemodynamic therapy Tumor microenvironment nanomaterial Manipulating strategy Fenton/Fenton-like reaction

Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

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Particuology 2024年第3期86卷 269-280页

作者： Danping Wu Jiaying Zou Junyi Chen Yan Li na Ma Wei Dai College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China College of Life Sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).however,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood *** this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward *** of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in *** the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different ph values was systematically *** nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred ***,the MSPC exhibited very low toxicity on hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres Sustained-release performance Biocompatibility

A Scalable Pillar Layered Metal-Organic Framework for natural Gas Purification

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Chemical Research in Chinese Universities 2024年第4期40卷 675-681页

作者： LU nan LAN Lan GAO Qiang LI na BU Xian-he School of Materials Science and Engineering Nankai UniversityTianjin300350P.R.China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212003P.R.China

One-step harvest of high-purity methane(Ch_(4))from ternary propane/ethane/methane(C_(3)h_(8)/C_(2)h_(6)/Ch_(4))mixtures remains a desirable yet challenging goal for natural gas ***,adsorbents either suffer from high capacity and selectivity,or are caught in a dilemma of scalable ***,we demonstrate a scalable pillar layered metal-organic framework Ni-MOF for highly efficient one-step Ch_(4)***-MOF exhibits high C_(2)h_(6)and C_(3)h_(8)uptakes of 83.3 and 86.1 cm^(3)/g at 298 K and 100 kPa and remarkable C_(2)h_(6)/Ch_(4)(50/50,volume ratio,21.5)and C_(3)h_(8)/Ch_(4)(50/50,volume ratio,212.0)***,high C_(2)h_(6)(42.2 cm^(3)/g at 10 kPa)and C_(3)h_(8)(64.7 cm^(3)/g at 5 kPa)capacities in the low-pressure region at 298 K were realized on Ni-MOF,suggesting the strong affinities of Ni-MOF towards C_(2)h_(6)and C_(3)h_(8).Furthermore,the dynamic breakthrough experiments revealed that purifying Ch_(4)from natural gas in one-step can be achieved in Ni-MOF with high-purity(>99.8%)and productivity(346.0 cm^(3)/g).Most significantly,the production of Ni-MOF can be scalably synthesized at room temperature,rendering it promising potential for industrial *** combined advantages of exceptional separation performance,scalability,and cycle stability of Ni-MOF pave the way for one-step Ch_(4)purification from natural gas.

关键词： Metal-organic framework Adsorption and separation natural gas purification Scale-up synthesis

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia ZhAO Yan-na YU Xiao-ling YIN Li-ming Department of hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(hTT)group[treated with 1 mg/(kg·d)hTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(phowing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(phe effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(Pht and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

The guest Ch_(3)CN molecule triggers solid-state photochromism in a Cu_(2)I_(2)-based MOF for advanced time-dependent encryption and inkless erasable printing

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Chinese Chemical Letters 2024年第3期35卷 532-537页

作者： Meng-Juan Wang Bo Li Yong-Li Wei Shu-na Zhao Shuang-Quan Zang henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang 473061China

It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention ***,a 2D Cu_(2)I_(2)-based MOF with photoresponsive spiropyran(SP)groups orderly installed on its skeleton is *** structural isomerization from SP to colored merocyanine(MC)form can be triggered by removing the Ch_(3)CN ***,the degree of structural isomerization and the retention time can be adjusted by controlling the amount of Ch_(3)CN guests,exhibiting dynamic photochromic behavior with multicolor states and tunable retention *** on these advantages,time-dependent information encryption is successfully ***,the long retention time(>72 h)of the MC form under daylight conditions in the Ch_(3)CN-removed Cu_(2)I_(2)-based MOF and good repeatability make it promising in various applications,such as temporary calendars,price-cards,billboards,and reusable identity *** work provides a novel design strategy to fabricate multi-functional MOF-based smart materials for challenging applications of time-dependent information encryption and inkless erasable printing.

关键词： Stimuli-responsive materials Spiropyran Solid-state photochromism Time-dependent encryption Inkless erasable printing

Effect of Maternal DEhP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein

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Biomedical and Environmental Sciences 2024年第3期37卷 315-319页

作者： ZhANG Yun Bo LI Jiang Li TIAN Jie na Xiao Lin Department of Environmental hygiene Public Health CollegeHarbin Medical UniversityHarbin 150081HeilongjiangChina

Lipid metabolism refers to the biochemical processes involved in synthesising,storing,utilising,and breaking down lipids in living *** are essential for various physiological functions,including energy storage,insulation,protection of organs,and the formation of cell *** in lipid metabolism can lead to a number of health issues,such as atherosclerosis,obesity,and type 2 diabetes,etc.[1].Environmental factors,genetics,and lifestyle factors are some of the factors that can contribute to the development of ***,there is a growing academic interest in the impact of environmental factors.

关键词： Lipid metabolism organs

Optimal Operation Strategy of Electricity-hydrogen Regional Energy System under Carbon-Electricity Market Trading

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Energy Engineering 2024年第3期121卷 619-641页

作者： Jingyu Li Mushui Wang Zhaoyuan Wu Guizhen Tian na Zhang Guangchen Liu Inner Mongolia Key Laboratory of Electrical Energy Conversion Transmission and Control Inner Mongolia University of TechnologyHohhot010080China School of Electric Power Inner Mongolia University of TechnologyHohhot010080China School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing102206China

Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction ***,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-hydrogen(P2h)technology,focusing on participating in combined carbon-electricity market *** study introduces an innovative Electro-hydrogen Regional Energy System(EhRES)in this *** system integrates renewable energy sources,a P2h system,cogeneration units,and energy storage *** core purpose of this integration is to optimize renewable energy utilization and minimize carbon *** study aims to formulate an optimal operational strategy for EhRES,enabling its dynamic engagement in carbon-electricity market *** initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with ***,an analysis is conducted to examine the operational mode of EhRES as it participates in carbon-electricity market ***,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the hydrogen Fuel Cell(hFC).This facilitates the establishment of an optimal operational model for EhRES,aiming to minimize the overall operating *** simulation example illustrates that the coordinated operation of EhRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system *** result carries significant implications for attaining advantages in both low-carbon and economic aspects.

关键词： Regional energy system electro-hydrogen coupling carbon-electricity market step carbon trading coordination and optimization

Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients

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World Journal of Psychiatry 2024年第3期14卷 370-379页

作者： hong-Xun Yuan Li-na Zhang Gang Li Li Qiao Intensive Care Unit Peking University International HospitalBeijing 102206China Central Operating Room The Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing 100020China

BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term *** remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical *** To compare the neuroprotective effects of dexmedetomidine and propofol for sedation during prolonged mechanical ventilation in patients without brain *** Patients who underwent mechanical ventilation for>72 h were randomly assigned to receive sedation with dexmedetomidine or *** Richmond Agitation and Sedation Scale(RASS)was used to evaluate sedation effects,with a target range of-3 to *** primary outcomes were serum levels of S100-βand neuron-specific enolase(NSE)every 24 *** secondary outcomes were remifentanil dosage,the proportion of patients requiring rescue sedation,and the time and frequency of RASS scores within the target *** A total of 52 and 63 patients were allocated to the dexmedetomidine group and propofol group,*** data were comparable between *** significant differences were identified between groups within the median duration of study drug infusion[52.0(IQR:36.0-73.5)h vs 53.0(IQR:37.0-72.0)h,P=0.958],the median dose of remifentanil[4.5(IQR:4.0-5.0)μg/kg/h vs 4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the median percentage of time in the target RASS range without rescue sedation[85.6%(IQR:65.8%-96.6%)vs 86.7%(IQR:72.3%-95.3),P=0.592],and the median frequency within the target RASS range without rescue sedation[72.2%(60.8%-91.7%)vs 73.3%(60.0%-100.0%),P=0.880].The proportion of patients in the dexmedetomidine group who required rescue sedation was higher than in the propofol group with statistical significance(69.2%vs 50.8%,P=0.045).Serum S100-βand NSE levels in the propofol group were higher than in the dexmedetomidine group with statistical significance during the first six and five days of mechanical ventilation,respectively(all P<0.05).CONCLUSION Dexmedetomidine demonstrated

关键词： Dexmedetomidine Propofol Sedation Prolonged mechanical ventilation Brain protective

Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

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Chinese Chemical Letters 2024年第6期35卷 445-450页

作者： Leichen Wang Anqing Mei na Li Xiaohong Ruan Xu Sun Yu Cai Jinjun Shao Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou 221116China Center for Rehabilitation Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient singlet oxygen(^(1)O_(2))***,bromine or iodine atoms are introduced on the aza-borondipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient~1O_(2) ***,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthesized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor *** to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(Φ_(Δ))of 66% which was superior to similar brominated photosensitizers previously *** encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conversion efficiency(η)of 43.0% under 660 nm *** vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h *** the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.

关键词： Unexpected bromination Aza-BODIPY Photodynamic therapy Photothermal therapy Synergetic therapy