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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

A public database of thermoelectric materials and system-identified material representation for data-driven discovery

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npj Computational Materials 2022年第1期8卷 2064-2074页

作者： Gyoung s.na Hyunju Chang Korea Research Institute of Chemical Technology DaejeonRepublic of Korea

Thermoelectric materials have received much attention as energy harvesting devices and power ***,discovering novel high-performance thermoelectric materials is challenging due to the structural diversity and complexity of the thermoelectric materials containing alloys and *** the efficient data-driven discovery of novel thermoelectric materials,we constructed a public dataset that contains experimentally synthesized thermoelectric materials and their experimental thermoelectric *** the collected dataset,we were able to construct prediction models that achieved R^(2)-scores greater than 0.9 in the regression problems to predict the experimentally measured thermoelectric properties from the chemical compositions of the ***,we devised a material descriptor for the chemical compositions of the materials to improve the extrapolation capabilities of machine learning *** on transfer learning with the proposed material descriptor,we significantly improved the R^(2)-score from 0.13 to 0.71 in predicting experimental ZTs of the materials from completely unexplored material groups.

关键词： properties alloys system

Modal parameter identification and damping ratio estimation from the full-scale measurements of a typical Tibetan wooden structure

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 681-695页

作者： Dai Lu Yang na s.s.Law Yang Qingshan school of Civil Engineering Beijing Jiaotong University

Tibetan heritage buildings have a high historical and cultural value. They have endured adverse environmental loadings over hundreds of years without significant damage. However, there are few reports on their structural characteristics under normal environmental loadings and their behavior under dynamic loadings. In this research, a typical Tibetan wooden wall-frame building is selected to study its dynamic characteristics. Field measurements of the structure were conducted under environmental excitation to collect acceleration responses. The stochastic subspace identification （ssI） method was adopted to calculate the structural modal parameters and obtain the out-of-plane vibration characteristics of the slab and frames. The results indicated that the wall-frame structure had a lower out-of-plane stiffness and greater in-plane stiffness due to the presence of stone walls. Due to poor identified damping ratio estimates from the ssI method, a method based on the variance upper bound was proposed to complement the existing variance lower bound method for estimating the modal damping ratio to address the significant damping variability obtained from different points and measurements. The feasibility of the proposed method was illustrated with the measured data from the floor slab of the structure. The variance lower and upper bound methods both provided consistent results compared to those from the traditional ssI method.

关键词： Tibetan wooden structure field test modal parameters damping ratio variance upper/lower bound

Deformation behavior of laser bending of circular sheet metal

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Chinese Optics Letters 2011年第5期9卷 47-51页

作者： Q.nadeem s.J.na Department of Mechanical Engineering KAIST

The application of a thermal source in non-contact forming of sheet metal has long been used. However, the replacement of this thermal source with a laser beam promises much greater controllability of the process. This yields a process with strong potential for application in aerospace, shipbuilding, automobile, and manufacturing industries, as well as the rapid manufacturing of prototypes and adjustment of misaligned components. Forming is made possible through laser-induced non-uniform thermal stresses. In this letter, we use the geometrical transition from rectangular to circle-shaped specimen and ring-shaped specimen to observe the effect of geometry on deformation in laser forming. We conduct a series of experiments on a wide range of specimen geometries. The reasons for this behavior are also analyzed. Experimental results are compared with simulated values using the software ABAQUs. The utilization of line energy is found to be higher in the case of laser forming along linear irradiation than along curved ones. We also analyze the effect of strain hindrance. The findings of the study may be useful for the inverse problem, which involves acquiring the process parameters for a known target shape of a wide range of complex shape geometries.

关键词： Deformation behavior of laser bending of circular sheet metal

Predicting thermoelectric properties from chemical formula with explicitly identifying dopant effects

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npj Computational Materials 2021年第1期7卷 964-974页

作者： Gyoung s.na seunghun Jang Hyunju Chang Korea Research Institute of Chemical Technology DaejeonSouth Korea

Dopants play an important role in synthesizing materials to improve target materials properties or stabilize the *** particular,the dopants are essential to improve thermoelectic performances of the ***,existing machine learning methods cannot accurately predict the materials properties of doped materials due to severely nonlinear relations with their materials ***,we propose a unified architecture of neural networks,called DopNet,to accurately predict the materials properties of the doped *** identifies the effects of the dopants by explicitly and independently embedding the host materials and the *** our evaluations,DopNet outperformed existing machine learning methods in predicting experimentally measured thermoelectric properties,and the error of DopNet in predicting a figure of merit(ZT)was 0.06 in mean absolute *** particular,DopNet was significantly effective in an extrapolation problem that predicts ZTs of unknown materials,which is a key task to discover novel thermoelectric materials.

关键词： materials properties explicitly

Evaluation of anti-inflammatory potential of leaf extracts of skimmia anquetilia

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 627-630页

作者： Vijender Kumar Zulfiqar Ali Bhat Dinesh Kumar na Khan ia Chashoo Department of Pharmaceutical sciences University of Kashmir

Objective:To evaluate anti-inflammatory potential of leaf extract of skimmia anquetilia by invitro and in-vivo anti-inflammatory ***:Acute toxicity study was carried out to determine the toxicity level of different extract using acute toxic class method as described in Organization of Economic Co-operation and Development Guidelines ***(1% w/w) was administered and inflammation was induced in rat *** leaf extracts of skimmia anquetilia were evaluated for anti-inflammatory activity by in-vitro human red blood cell(HRBC) membrane stabilization method and in-vivo carrangeenan-induced rat paw edema method. Results:The in-vitro membrane stabilizing test showed petroleum ether(PE),chloroform(CE), ethyl acetate(EE),methanol(ME) and aqueous extracts(AE) showed 49.44%,59.39%,60.15%,68.40% and 52.18%protection,respectively as compared to control *** in-vivo results of CE,EE and ME showed 58.20%.60.17%and 67.53%inhibition of inflammation after 6h administration of test drugs in albino *** potency of the leaf extracts of skimmia anquetilia were compared with standard diclofenac(10 mg/kg) which showed 74.18%protection in in-vitro HRBC membrane stabilization test and 71.64%inhibition in in-vivo carrangeenan-induced rat paw edema model. The ME showed a dose dependent significant(Pstabilization test and reduction of edema in carrageenan induced rat paw ***:The present investigation has confirmed the anti-inflammatory activity of skimmia anquetilia due to presence of bioactive phytoconstitutes for the first lime and provide the pharmacological evidence in favor of traditional claim of skimmia anquetilia as an antiinflammatory agent.

关键词： skimmia anquetilia Anti-inflammatory Carrageenan Diclofenac Leaf extract Phytochemical analysis

肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤与肾透明细胞癌的鉴别诊断价值

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临床放射学杂志 2025年第1期44卷 133-137页

作者：张小梅李娜赵艳王滔乐山市人民医院放射医学科 614000

目的探讨肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤(AMLmf)与肾透明细胞癌(ccRCC)的鉴别诊断价值。方法回顾性分析经手术和病理证实的ccRCC患者55例共56个病灶,AMLmf患者20例共22个病灶,通过形态学分析两组肿瘤差异,测量肿瘤的肾外夹... 详细信息

目的探讨肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤(AMLmf)与肾透明细胞癌(ccRCC)的鉴别诊断价值。方法回顾性分析经手术和病理证实的ccRCC患者55例共56个病灶,AMLmf患者20例共22个病灶,通过形态学分析两组肿瘤差异,测量肿瘤的肾外夹角并定量分析两组间的差异。结果假包膜、劈裂征及“冰激凌蛋筒征”对AMLmf与ccRCC的鉴别有统计学差异(P<0.05);两组肿瘤的肾外较大夹角及较小夹角值间差异有统计学意义。受试者工作特征(ROC)曲线分析显示肾外较大夹角、肾外较小夹角、劈裂征、“冰激凌蛋筒征”及假包膜鉴别AMLmf与ccRCC的曲线下面积(AUC)值分别为0.925、0.983、0.638、0.727、0.731,五种指标联合的AUC值为0.996,明显高于单一指标。结论肾外夹角、假包膜、劈裂征及“冰激凌蛋筒征”有助于AMLmf与ccRCC的鉴别诊断,联合五种影像学特征的诊断效能更高。

关键词：体层摄影术 X线计算机肾外夹角肾乏脂肪血管平滑肌脂肪瘤肾透明细胞癌

Chung＇s Law of the Iterated Logarithm for subfractional Brownian Motion

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Acta Mathematica sinica,English series 2017年第6期33卷 839-850页

作者： na na LUAN school of Insurance and Economics University of International Business and Economics Beijing 100029 P. R. China

Let XH = {xH（t）,t ∈ R＋} be a subfractional Brownian motion in Rd. We provide asufficient condition for a self-similar Gaussian process to be strongly locally nondeterministic and show that XH has the property of strong local nondeterminism. Applying this property and a stochastic integral representation of XH, we establish Chung＇s law of the iterated logarithm for XH.

关键词： subfractional Brownian motion self-similar Gaussian processes small ball probability,Chung's law of the iterated logarithm

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基于岭估计方法的多谐波源责任划分

电力系统自动化 2015年第21期39卷 87-92页

作者：贾秀芳岳娜新能源电力系统国家重点实验室华北电力大学河北省保定市071003

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩... 详细信息

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩阵病态情况下传统最小二乘估计无法得出正确结果,因此研究应用了岭估计方法。当谐波电流数据异常或者存在一定相关性时,岭估计方法避免了模型病态导致的错误结果。仿真算例验证了所述方法的有效性以及在系数矩阵病态时相对于传统最小二乘估计的优越性。

关键词：电能质量多谐波源谐波责任最小二乘估计岭估计