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Evaluation of anti-inflammatory potential of leaf extracts of Skimmia anquetilia

Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 627-630页

作者： Vijender Kumar Zulfiqar Ali Bhat Dinesh Kumar na Khan ia Chashoo Department of Pharmaceutical Sciences University of Kashmir

Objective:To evaluate anti-inflammatory potential of leaf extract of Skimmia anquetilia by invitro and in-vivo anti-inflammatory ***:Acute toxicity study was carried out to determine the toxicity level of different extract using acute toxic class method as described in Organization of Economic Co-operation and Development Guidelines ***(1% w/w) was administered and inflammation was induced in rat *** leaf extracts of Skimmia anquetilia were evaluated for anti-inflammatory activity by in-vitro human red blood cell(HRBC) membrane stabilization method and in-vivo carrangeenan-induced rat paw edema method. Results:The in-vitro membrane stabilizing test showed petroleum ether(PE),chloroform(CE), ethyl acetate(EE),methanol(mE) and aqueous extracts(AE) showed 49.44%,59.39%,60.15%,68.40% and 52.18%protection,respectively as compared to control *** in-vivo results of CE,EE and mE showed 58.20%.60.17%and 67.53%inhibition of inflammation after 6h administration of test drugs in albino *** potency of the leaf extracts of Skimmia anquetilia were compared with standard diclofenac(10 mg/kg) which showed 74.18%protection in in-vitro HRBC membrane stabilization test and 71.64%inhibition in in-vivo carrangeenan-induced rat paw edema model. The mE showed a dose dependent significant(Pmmatory activity in human red blood cell membrane stabilization test and reduction of edema in carrageenan induced rat paw ***:The present investigation has confirmed the anti-inflammatory activity of Skimmia anquetilia due to presence of bioactive phytoconstitutes for the first lime and provide the pharmacological evidence in favor of traditional claim of Skimmia anquetilia as an antiinflammatory agent.

关键词： Skimmia anquetilia Anti-inflammatory Carrageenan Diclofenac Leaf extract Phytochemical analysis

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基于岭估计方法的多谐波源责任划分

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电力系统自动化 2015年第21期39卷 87-92页

作者：贾秀芳岳娜新能源电力系统国家重点实验室华北电力大学河北省保定市071003

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩... 详细信息

电网中受关注母线处的谐波电压是系统中所有谐波源共同作用的结果。在主要谐波源已知的情况下,量化这些谐波源在受关注母线处产生的谐波影响是划分谐波污染责任的前提。首先建立了多谐波源谐波责任划分的多元线性回归模型,考虑到系数矩阵病态情况下传统最小二乘估计无法得出正确结果,因此研究应用了岭估计方法。当谐波电流数据异常或者存在一定相关性时,岭估计方法避免了模型病态导致的错误结果。仿真算例验证了所述方法的有效性以及在系数矩阵病态时相对于传统最小二乘估计的优越性。

关键词：电能质量多谐波源谐波责任最小二乘估计岭估计

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Far-Field Pattern Tolerance Analysis of Reflector Antenna with Random or System Error Based on Interval Arithmetic

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Chinese Journal of Electronics 2018年第3期27卷 641-647页

作者： LI Peng LI na XU Wanye WANG Wei Key Laboratory of Electronic Equipment Structure Design Ministry of Education Xidian University

A novel analytic approach for the research of effect on electromagnetic performance of reflector antennas with deformation, including random processing error and system error caused by external loads(such as wind,gravity, and solar radiation), in panels of the reflector surface is proposed. The deformations are modeled as error intervals, and their impact on the electromagnetic performance, including radiation power pattern and some main electromagnetic characteristics(such as side lobe level,peak power, and half-power beamwidth), are efficiently estimated by Interval analysis(ia). The closed-form equations indicate the relationship between the error interval and the bounds(upper and lower bounds) of the radiated power pattern interval by exploiting the rules of interval arithmetic. Two kinds of surface errors(random and system error) and two shapes of deformation area(bump-like and sector) are taken into account in the numerical examples to assess the validation and effectiveness of the proposed approach. The results of the examples show that the proposed ia-based approach has great capability and effectiveness regarding the traditional statistical method(such as monte-Carlo method).

关键词： Reflector antenna Interval analysis Random error System error Power pattern

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multi-Class Classification methods of Cost-Conscious LS-SVm for Fault Diagnosis of Blast Furnace

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Journal of Iron and Steel Research International 2011年第10期18卷 17-23,33页

作者： LIU Li-mei WANG An-na SHA mo ZHAO Feng-yun College of Information Science and Engineering Northeastern University Shenyang 110819 Liaoning China

Aiming at the limitations of rapid fault diagnosis of blast furnace, a novel strategy based on cost-conscious least squares support vector machine （LS-SVm） is proposed to solve this problem. Firstly, modified discrete particle swarm optimization is applied to optimize the feature selection and the LS-SVm parameters. Secondly, cost-con- scious formula is presented for fitness function and it contains in detail training time, recognition accuracy and the feature selection. The CLS-SVm algorithm is presented to increase the performance of the LS-SVm classifier. The new method can select the best fault features in much shorter time and have fewer support vectbrs and better general- ization performance in the application of fault diagnosis of the blast furnace. Thirdly, a gradual change binary tree is established for blast furnace faults diagnosis. It is a multi-class classification method based on center-of-gravity formula distance of cluster. A gradual change classification percentage ia used to select sample randomly. The proposed new metbod raises the sped of diagnosis, optimizes the classifieation scraraey and has good generalization ability for fault diagnosis of the application of blast furnace.

关键词： blast furnace fault diagnosis eosc-conscious LS-SVm multi-class classification

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Comparative analysis of robotic vs laparoscopic radical hysterectomy for cervical cancer

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World Journal of Clinical Cases 2019年第20期7卷 3185-3193页

作者： Li Chen Li-Ping Liu na Wen Xiao Qiao Yuan-Guang meng Department of Obstetrics and Gynecology Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology The First Central Hospital of BaodingBaoding 071000Hebei ProvinceChina medical Big Data Center Chinese PLA General HospitalBeijing 100853China

BACKGROUND Cervical cancer is the most common gynecological malignancy,ranking first in female reproductive malignancies with more than 500000 new cases and 275000 deaths each ***,open radical hysterectomy is considered the standard surgical procedure for the treatment of resectable cervical *** latest guidelines from the national Comprehensive Cancer Network and the European Society of Gynecological Oncology suggest that open surgery and laparoscopic surgery(using traditional laparoscopic or robotic techniques)are the main surgical approaches for radical hysterectomy for patients with stage ia2-Iia cervical *** surgery has been increasingly used in abdominal surgery and has shown more beneficial *** To analyse the perioperative conditions,complications,and short-term and longterm effects in patients undergoing robotic radical hysterectomy(RRH)and laparoscopic radical hysterectomy(LRH)to compare their clinical efficacy,safety,and *** The perioperative data of patients undergoing RRH and LRH were extracted and collected from the database of surgical treatments for cervical cancer for statistical *** Of the patients,342 underwent LRH for cervical cancer,and 216 underwent *** total complication rate was 9.65%(20 patients)in the RRH group and 17.59%(60 patients)in the LRH *** complication rate was significantly lower in the RRH group than in the LRH *** was no significant difference in the follow-up period(P=0.658).The total recurrence rates were 15.7%and 12%in the RRH and LRH groups,*** progression-free survival time was 28.91±15.68 mo and 28.34±15.13 mo in the RRH and LRH groups,respectively(P=0.669).The overall survival(OS)rates were 92.13%and 94.45%in the RRH and LRH groups,respectively(P=0.292).The OS time was 29.87±15.92 mo and 29.41±15.14 mo in the RRH and LRH groups,respectively(P=0.732).The survival curves and the progression-free survival curves were not statis

关键词： Cervical cancer Robotic radical hysterectomy Laparoscopy Survival

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Synthesis, insecticidal activities and SAR studies of novel anthranilic diamides containing trifluoroethoxyl substituent and chiral amino acid moieties

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Chinese Chemical Letters 2018年第8期29卷 1254-1256页

作者： Shaa Zhou Sha Zhou Yongtao Xie Xiangde meng Baolei Wang Lixia Xiong na Yang Zhengming Li State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) College of ChemistryNankai University

Ryanodine receptors（RyRs） activator has become one class of popular insecticide because of its unique mode of action. In order to find more new RyRs activators as insecticidal agents, a series of 18 novel chiral anthranilic diamides were designed by introducing the D-alanine acid and D-serine acid esters as well as trifluoroethoxyl group into the anthranilic diamide skeleton and synthesized successfully based on anthranilic diamide and FKI-1033 structures. The structures of the title compounds ia–i and Iia–i were confirmed by melting points,~1H NmR,^（13）C NmR, elemental analysis and specific optical rotation *** preliminary bioassay results indicated that most of the title compounds exhibited considerable larvicidal activities against oriental armyworm at 10 mg/L, especially Ib, Ie and IIh showed remarkable insecticidal activities at 0.5 mg/L. The larvicidal activity against diamondback moth of ia and IId were 80%and 90% respectively at 0.0001 mg/L, which was similar to that of chlorantraniliprole. The relationship between structure and insecticidal activity was analyzed to reveal a possible co-regulated effect of the chiral amino acid ester, halogen atom or cyano group, and trifluoroethyloxyl group of the skeleton structures of the title compounds, which will provide useful information for guiding the design and discovery of new RyRs activators and insecticidal agrochemicals.

关键词： Chiral anthranilic diamides Trifluoroethoxyl Synthesis Insecticidal activity Ryanodine receptor

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白芷近缘野生种兴安白芷的生药学研究

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华西药学杂志 2011年第2期26卷 155-157页

作者：王娜马逾英卢晓琳张利成都中医药大学药学院四川成都610075

目的对兴安白芷进行系统的生药学研究以区别于其他白芷类药材。方法按照常规生药学方法进行来源、性状、显微鉴定,按《中国药典》2005年版白芷项下方法进行薄层鉴别与含量测定。结果找出了兴安白芷在生药性状、组织构造及化学成分上的... 详细信息

目的对兴安白芷进行系统的生药学研究以区别于其他白芷类药材。方法按照常规生药学方法进行来源、性状、显微鉴定,按《中国药典》2005年版白芷项下方法进行薄层鉴别与含量测定。结果找出了兴安白芷在生药性状、组织构造及化学成分上的主要特征。结论为白芷种质资源的评价提供了参考依据。

关键词：兴安白芷生药学鉴定

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Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes

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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo Ding Reng-na Yan Yun Hu Jian-Hua ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUND Insulin antibodies(ias)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and ias in patients with type 2 diabetes mellitus(T2Dm).mETHODS This cross-sectional,retrospective study included 1863 patients with T2Dm who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and ia levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive ias(ia level>5%),with a mean ia level of 11.06%(10.39%-11.72%).ia levels were positively correlated with high fasting blood glucose(odds ratio=1.069,Pias was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),Pia levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all Pia antibodies,and ia antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower ia levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

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Design, Synthesis, Biological Evaluation and SARs of Novel N-Substituted Sulfoximfnes as Potential Ryanodine Receptor modulators

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Chinese Journal of Chemistry 2018年第2期36卷 129-133页

作者： Yongtao Xie Sha Zhou Yuxin Li Shaa Zhou minggui Chen Baolei Wang Lixia Xiong na Yang Zhengming Li State Key Laboratory of Elemento-Organic Chemistry Department of Chemistry Collaborative innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 China

The sulfoximine group has been evaluated as a pharmacophore. Introducing the sulfoximine structure into medicinal compounds as exciting motifs has brought opportunities in drug discovery. In order to develop new ryanodine receptor （RyR） modulators, a series of phthalamides containing sulfoximine derivatives were designed, synthesized, and evaluated against oriental armyworm and diamondback moth for their insecticidal activities. These studies helped to elucidate the electronic and structural requirements around the sulfoximine motif for insecticidal activity. All new structures were synthesized and characterized by ^1H NmR, ^13C NmR, HRmS and bioassay and a preliminary structure-activity relationship （SAR） was discussed. The biological assessment indicated that most title compounds showed good to excellent larvicidal activities. Compounds la, le, and If gave excellent insecticidal activity against oriental armyworm, which showed 100% larvicidal activity at 0.5 mg/L. All compounds showed 100% larvicidal activity at 0.1 mg/L against diamondback moth. In particular, the larvicidal activities of le, If, and lh at 0.0001 mg/L were 50%, 20%, and 40%, respectively, reaching an activity as high as that of the commercial flubendiamide （40%, 0.0001mg/L）. Therefore, ia, Ie, If and Ih could be considered as new lead structures for the development of new ryanodine receptor （RyR） modulators.

关键词： sulfoximines SAR insecticidal activity ryanodine receptor

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不同电离层格网产品的精度分析

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大地测量与地球动力学 2017年第8期37卷 849-855页

作者：陈秀德贾小林朱永兴程娜长安大学地质工程与测绘学院西安市雁塔路126号710054 西安测绘研究所西安市雁塔路中段1号710054 中国科学院上海天文台上海市南丹路80号200030

利用全球部分IGS站实测数据,精确提取测站天顶方向的总电子含量,以此作为评估基准,对国内外5家分析中心和2家综合中心(IGS,international GNSS service和iGmAS,international GNSS monitoring&assessment system)的全球电离层格网(global ionosphere maps,GIm)产品在全球范围内的符合精度进行评估。结果表明,不同机构不同类型的GIm产品精度在不同范围的符合精度略有不同。

关键词： GIm iGmAS VTEC CAS IPP

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