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红外肝病治疗仪联合抗病毒治疗及强肝丸对老年慢性乙型肝炎患者血清细胞因子、肝纤维化的影响

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中西医结合肝病杂志 2024年第1期34卷 16-19页

作者：史娜宋娟丽尹玉红王静邯郸市传染病医院肝四科河北邯郸056002 邯郸市中心医院肿瘤三科邯郸市丛台区和平街道社区卫生服务中心邯郸市传染病医院CT室

目的:探讨红外肝病治疗仪联合抗病毒治疗及强肝丸对老年慢性乙型肝炎(CHB)患者血清细胞因子、肝纤维化的影响。方法:以2020年12月至2021年12在我院门诊收治的107例老年CHB患者为研究对象,根据治疗方法将患者分为两组,观察组53例和对照... 详细信息

目的:探讨红外肝病治疗仪联合抗病毒治疗及强肝丸对老年慢性乙型肝炎(CHB)患者血清细胞因子、肝纤维化的影响。方法:以2020年12月至2021年12在我院门诊收治的107例老年CHB患者为研究对象,根据治疗方法将患者分为两组,观察组53例和对照组54例。对照组患者采用口服抗病毒药及强肝丸治疗,观察组患者在对照组治疗基础上加用红外肝病治疗仪。比较两组患者的临床疗效、血清学及病毒学指标、肝功能指标、肝纤维化指标、血清细胞因子及不良反应发生率。结果:观察组患者临床总有效率为92.5%,明显高于对照组75.9%,差异有统计学意义(Pna转阴率及HBeAg转阴率明显更高(Pha、PCⅢ、Ⅳ-C水平更低(P0.05)。结论:在抗病毒治疗及强肝丸基础上加用红外肝病治疗仪对老年CHB患者能取得更好的临床效果,能有效促进相关血清学及病毒学指标转阴,改善肝功能及肝纤维化指标,并降低相关炎性因子水平。

关键词：红外肝病治疗仪抗病毒强肝丸慢性乙型肝炎

Synergistic effects of Mg-substitution and particle size of chicken eggshells on hydrothermal synthesis of biphasic calcium phosphate nanocrystals

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Journal of Materials Science & Technology 2020年第1期36卷 27-36页

作者： Wei Cui Qibin Song Huhu Su Zhiqing yang Rui yang na Li Xing Zhang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Department of Plastic Surgery Shengjing Hospital of China Medical UniversityShenyang 110004China

Magnesium(Mg^2+))ion plays important roles in biomineralization of bone,teeth and calcium carbonate ***,chicken eggshells mainly comprising of Mg-calcite nanocrystals(Mg/(Mg+Ca)2.0 mol.%)were used to fabricate biphasic calcium phosphate(BCP),a mixture of hydroxyapatite(ha)and p-tricalcium phosphate(p-TCP)nanocrystals,through hydrothermal reactions at 200℃for 24 *** results indicated thatβ-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite,while ha nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal *** substitution in calcite resulted in formation ofβ-TCP nanocrystals instead of ha crystals through ion-exchange *** samples with different compositions(28.6-77.8 wt.%β-TCP)were produced by controlling particle sizes of eggshells for hydrothermal *** larger particles lead to the larger proportion ofβ-TCP in the BCP ***,Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation *** culture results showed that the BCP products were non-cytotoxic to MC3 T3-E1 cells,which may be used for bone substitute materials in future.

关键词： Hydrothermal reactions Ion-exchange Dissolution-reprecipitation nanocrystals Biphasic calcium phosphate Bone substitute materials

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锈蚀钢骨混凝土梁轴力与剪力计算

工业建筑 2008年第Z1期38卷 513-516页

作者：哈娜王连广东北大学资源与土木工程学院沈阳110004

均布荷载作用下,锈蚀钢骨混凝土梁轴力与交接面的剪力体现了钢骨与混凝土之间的粘结性能,两者都是影响梁承载能力的重要因素。利用弹性理论,结合锈蚀钢骨混凝土梁的受力特征,建立了考虑钢骨锈蚀率影响的轴力微分方程,给出了均布荷载下... 详细信息

均布荷载作用下,锈蚀钢骨混凝土梁轴力与交接面的剪力体现了钢骨与混凝土之间的粘结性能,两者都是影响梁承载能力的重要因素。利用弹性理论,结合锈蚀钢骨混凝土梁的受力特征,建立了考虑钢骨锈蚀率影响的轴力微分方程,给出了均布荷载下轴力与交接面剪力的计算公式。计算结果表明,均布荷载作用下轴力与交接面剪力随着钢骨锈蚀率的增加而减小,随着荷载的增大而增大,且钢骨锈蚀率越大,轴力与交接面剪力下降的也就越快。

关键词：锈蚀钢骨混凝土梁轴力交接面剪力计算公式

Pretreated Oenan the Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils

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Neural Regeneration Research 2019年第9期14卷 1536-1543页

作者： Joon ha Park In Hye Kim Ji Hyeon Ahn YooHun Noh Sung-Su Kim Tae-Kyeong Lee Jae-Chul Lee Bich-na Shin Tae Heung Sim Hyun sam Lee Jeong Hwi Cho In Koo Hwang Il Jun Kang Jong Dai Kim Moo-Ho Won Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym UniversityChuncheonGangwonRepublic of Korea Famenity Company GwacheonGeyonggiRepublic of Korea Department of Neurobiology School of MedicineKangwon National UniversityChuncheonGangwonRepublic of Korea Danchunok Company ChuncheonGangwonRepublic of Korea Department of Histology College of Veterinary MedicineChonbuk National UniversityIksanJeollabuk.doRepublic of Korea Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea Department of Food Science and Nutrition Hallym UniversityChuncheonGangwonRepublic of Korea Division of Food Biotechnology School of BiotechnologyKangwon National UniversityChuncheonGangwonRepublic of Korea

Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ***,neuroprotective mechanisms of OJE have not been fully ***,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral *** treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral *** of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade *** of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,*** investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory *** we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 *** also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ***,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal *** findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 *** experimental plan of this study was rev

关键词： Oenanthe javanica extract transient global cerebral ischemia hippocampus ischemic damage cerebral ischemia neuroprotection glial activation pro-inflammatory cytokines anti-inflammatory cytokines inflammation neural regeneration

Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia

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Neural Regeneration Research 2015年第10期10卷 1604-1611页

作者： Seongkweon Hong Ji Yun Ahn Geum-Sil Cho In Hye Kim Jeong Hwi Cho Ji Hyeon Ahn Joon ha Park Moo-Ho Won Bai Hui Chen Bich-na Shin Hyun-Jin Tae Seung Min Park Jun Hwi Cho Soo Young Choi Jae-Chul Lee Department of Surgery School of Medicine Kangwon National University Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Neuroscience College of Medicine Korea University Department of Neurobiology School of Medicine Kangwon National University Department of Physiology College of Medicine Hallym University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University

Monocarboxylate transporters（MCTs）, which carry monocarboxylates such as lactate across biological membranes, have been associated with cerebral ischemia/reperfusion process. In this study, we studied the effect of ischemic preconditioning（IPC） on MCT4 immunoreactivity after 5 minutes of transient cerebral ischemia in the gerbil. Animals were randomly designated to four groups（sham-operated group, ischemia only group, IPC ＋ sham-operated group and IPC ＋ ischemia group）. A serious loss of neuron was found in the stratum pyramidale of the hippocampal CA1 region（CA1）, not CA2/3, of the ischemia-only group at 5 days post-ischemia; however, in the IPC ＋ ischemia groups, neurons in the stratum pyramidale of the CA1 were well protected. Weak MCT4 immunoreactivity was found in the stratum pyramidale of the CA1 in the sham-operated group. MCT4 immunoreactivity in the stratum pyramidale began to decrease at 2 days post-ischemia and was hardly detected at 5 days post-ischemia; at this time point, MCT4 immunoreactivity was newly expressed in astrocytes. In the IPC ＋ sham-operated group, MCT4 immunoreactivity in the stratum pyramidale of the CA1 was increased compared with the sham-operated group, and, in the IPC ＋ ischemia group, MCT4 immunoreactivity was also increased in the stratum pyramidale compared with the ischemia only group. Briefly, present findings show that IPC apparently protected CA1 pyramidal neurons and increased or maintained MCT4 expression in the stratum pyramidale of the CA1 after transient cerebral ischemia. Our findings suggest that MCT4 appears to play a significant role in the neuroprotective mechanism of IPC in the gerbil with transient cerebral ischemia.

关键词： nerve regeneration monocarboxylate transporters ischemic preconditioning ischemia/ reperfusion injury hippocampus CA1 pyramidal neurons neural regeneration

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

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Neural Regeneration Research 2015年第6期10卷 944-950页

作者： Eun Joo Bae Bai Hui Chen Bing Chun yan Bich na Shin Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn Jae Chul Lee Hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi Cho Yun Lyul Lee Moo-Ho Won Joon ha Park Department of Pediatrics Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Institute of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Surgery School of MedicineKangwon National University Department of Emergency Medicine Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions （CA1-3） between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group, p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

关键词： p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting neural regeneration

Soil Organic Carbon Stocks of Citrus Orchards in Yongchun County Fujian Province China

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Pedosphere 2017年第5期27卷 985-990页

作者： WANG Yixiang WENG Boqi TIAN na ZHONG Zhenmei WANG Mingkuang Institute of Agricultural Ecology Fujian Academy of Agricultural Sciences

Studies related to the quantitation and distribution of soil organic carbon （C） under different land use types can help to fill the knowledge gaps regarding estimation of the amount of C stored in soils at a global scale. Orchards are an important land use type in southern China; the total area （1.15 x 107 ha） of orchards in China comprises approximately 20.5% of the area of all orchards worldwide. We assessed soil organic C stocks （SOCS） in citrus orchards in Yongchun County （consisting of 22 towns）, Fujian Province, China in 1982 and 2010. The southeastern part of the county, an area featuring extensive citrus farming with a gently sloping landscape and low rates of water erosion, had the highest SOCS. In contrast, the lowest SCOS was observed in the northern part of the county, where steep hills with severe erosion problems are common and citrus orchards are sparsely distributed. From 1982 to 2010, the mean SOCS in citrus orchards increased from 22.1 to 41.7 Mg ha-1 which indicated that current management practices such as fertilization, irrigation, and cultivation enhanced soil C stocks. Further in-depth studies on the effects of these practices on C sequestration would be worthwhile and surveys of SOCS throughout Fujian Province are needed, to support efforts to mitigate global C emission.

关键词： carbon emission carbon pool carbon sequestration kriging land use type management practices

均布荷载下锈蚀后预应力钢骨混凝土梁的滑移计算

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东北大学学报（自然科学版） 2010年第2期31卷 281-284页

作者：哈娜王连广王文浩东北大学资源与土木工程学院辽宁沈阳110004 沈阳建筑大学土木工程学院辽宁沈阳110168

利用弹性理论,结合预应力钢骨混凝土梁的受力特征,建立了同时考虑预应力增量和钢材锈蚀率影响的滑移微分方程,给出了均布荷载下梁滑移计算的理论公式.讨论了钢骨锈蚀率、荷载、钢筋锈蚀率及预应力增量对滑移的影响,并给出了计算滑移的... 详细信息

利用弹性理论,结合预应力钢骨混凝土梁的受力特征,建立了同时考虑预应力增量和钢材锈蚀率影响的滑移微分方程,给出了均布荷载下梁滑移计算的理论公式.讨论了钢骨锈蚀率、荷载、钢筋锈蚀率及预应力增量对滑移的影响,并给出了计算滑移的简化公式.计算结果表明,均布荷载下交接面的滑移随着钢骨锈蚀率和荷载的增大而增大,钢筋锈蚀率和预应力增量对梁滑移的影响相对较小.

关键词：钢材锈蚀预应力钢骨混凝土梁滑移计算

大鼠慢性牙周炎与慢性肾衰竭模型的建立及相关性研究

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中华肾脏病杂志 2010年第8期26卷 619-623页

作者：李静桑晓红刘健哈丽娅米娜新疆医科大学第一附属医院肾内科乌鲁木齐830054 新疆医科大学第一附属医院口腔科乌鲁木齐830054

目的用SD大鼠建立慢性牙周炎（CP）和慢性肾衰竭（CRF）动物模型,探讨两种疾病是否相关.方法将40只健康雄性SD大鼠随机分为4组,每组10只：正常对照组、CP组、CRF组和CP＋CRF组.于8周末处死动物,检查记录牙周指标,检测血清中血肌酐（Sc... 详细信息

目的用SD大鼠建立慢性牙周炎（CP）和慢性肾衰竭（CRF）动物模型,探讨两种疾病是否相关.方法将40只健康雄性SD大鼠随机分为4组,每组10只：正常对照组、CP组、CRF组和CP＋CRF组.于8周末处死动物,检查记录牙周指标,检测血清中血肌酐（Scr）、尿素氮（BUN）、白细胞介素（IL）1β、肿瘤坏死因子（TNF）α的含量,观察牙周和肾脏组织病理学改变,进行统计学分析.结果成功建立了CP和CRF动物模型.CP＋CRF组Scr（120.54±21.29）μmol/L,BUN（34.20±14.44）mmol/L;CRF组Scr（93.63±18.82）μmol/***（17.77±4.15）mmol/L,两组间差异有统计学意义（P〈0.05）.肾脏病理显示,CP组肾组织出现炎性改变.CP＋CRF组肾脏炎细胞浸润,PAS、Masson染色评分与CRF组差异有统计学意义.牙周病理显示,CP组、CP＋CRF组出现明显牙周炎,CP＋CRF组附着丧失（AL）（173.60±16.75）μm,CP组AL（124.00±23.87）μm,两组差异有统计学意义（P〈0.05）.CP组、CRF组、CP＋CRF组血清IL-1β、TNF-α水平显著高于正常对照组（P〈0.05）,CP＋CRF组IL-1β显著高于CP组、CRF组（P〈0.05）,CP＋CRF组TNF-α水平高于CP组、CRF组,且与CP组差异有统计学意义（P〈0.05）.2×2析因设计方差分析结果显示,CP与CRF对Scr、BUN、AL的数值具有交互作用（P〈0.05）,且两因素各自对上述指标的主效应显著（P〈0.05）;CP与CRF对IL-1β、TNF-α的数值不具有交互作用（P〉0.05）,但两因素各自对IL-1β、TNF-α的主效应显著（P〈0.05）.结论本模型可在SD大鼠同时显现牙周炎和慢性肾衰竭,CP可加重肾衰竭,两者间有相关性,CP可能通过炎性机制加重肾脏的损害.

关键词：牙周炎肾功能衰竭,慢性大鼠白细胞介素1β 肿瘤坏死因子α