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International Journal of Technology Ma.0}gement 2015年第12期 27-29页

作者： ni na Qingda. Technica. College Qingdao266000

In this resea.ch pa.er, we conduct resea.ch on development trend of contempora.y English educa.ion pa.tern under the qua.ity educa.ion a.d the a.ility oriented ba.kground. In lea.ning, lea.n gra.ma. use ma.ter gra.ma. functions in use ma.y tea.hing experts recommended is effective wa.. In this wa., we ca. fully mobilize students＇ lea.ning gra.ma. effectiveness on the ba.is of ca. ma.e them ha.e more cha.ce to pra.tice. Pa.ticipa.ion ca. ma.e students understa.d, no longer limited to simple memoriza.ion a.d found problems in study a.d communica.ion with ea.h other, to explore the problems a.d effectively improve English lea.ning. The proposed methodology will enha.ce genera. performa.ce of the contempora.y English educa.ion a.d a.tiva.e the students＇ lea.ning pa.sion.

关键词： English Educa.ion Qua.ity Educa.ion a.ility Oriented Tea.hing Development Trend.

Multiple “Omics” da.a.ba.ed bioma.ker screening for hepa.ocellula. ca.cinoma.dia.nosis

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World Journal of Ga.troenterology 2019年第30期25卷 4199-4212页

作者： Xia.-na Liu Da.-ni Cui Yu-Fa.g Li Yun-He Liu Ga.g Liu Lei Liu Institutes of Biomedica. Sciences Fudan University

The huge prognostic difference between ea.ly a.d la.e sta.e hepa.ocellula. ca.cinoma.HCC)is a.cha.lenging dia.nostic ***-fetoprotein is the mostly widely used bioma.ker for HCC used in the clinic,however it’s sensitivity a.d specificity of is not *** development a.d a.plica.ion of multiple biotechnologies,including next genera.ion sequencing,multiple“omics”da.a.tha. include genomics,epigenomics,tra.scriptomics,proteomics,meta.olomics,meta.enomics ha. been used for HCC dia.nostic bioma.ker *** bioma.kers/pa.els/models ha.e been identified a.d va.ida.ed a. different clinica. levels.a.la.ge proportion of these ha.e a.good dia.nostic performa.ce for HCC,especia.ly for ea.ly *** this a.ticle,we reviewed the va.ious HCC bioma.kers derived from“omics”da.a.a.d discussed the a.va.ta.es a.d disa.va.ta.es for dia.nosis HCC.

关键词： Hepa.ocellula. ca.cinoma Dia.nosis Circula.ing tumor cells Exosomes Circula.ing tumor Dna Rna Meta.olomics Protein

The mecha.ica. property a.d corrosion resista.ce of Mg-Zn-Nd a.loy fine wires in vitro a.d in vivo

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Bioa.tive Ma.eria.s 2021年第1期6卷 55-63页

作者： Ming Ga. Di na Xia.gqia. ni Lihui Song Iniobong PEtim Ke Ya.g Lili Ta. Zheng Ma School of Ma.eria.s Science a.d Engineering University of Science and Technology of ChinaShenyang110016China Institute of Meta. Resea.ch Chinese Academy of SciencesShenyang110016China The First Hospita. of China Medica. University Department of Surgical OncologyChina

Tita.ium a.d its a.loy a.e commonly used a. surgica. sta.les in the reconstruction of intestinal tra.t a.d stoma.h,however they ca.not be a.sorbed in huma. body,which ma. ca.se a.series of complica.ions to influence further *** a.d its a.loy ha.e grea. potentia. a. surgica. sta.les,beca.se they ca. be degra.ed in huma. body a.d ha.e good mecha.ica. properties a.d *** this study,Mg-2Zn-0.5Nd(ZN20)a.loy fine wires showed grea. potentia. a. surgica. *** ultima.e tensile strength a.d elonga.ion of ZN20 a.loy fine wires were 248 MPa.a.d 13%,respectively,which could be benefit for the deforma.ion of the surgica. sta.les from U-sha.e to *** bursting pressure of the wire wa. a.out 40 kPa.implying tha. it ca. supply sufficient mecha.ica. support a.ter *** test a.d histologica. a.0}lysis illustra.ed good biocompa.ibility a.d biologica. sa.ety of ZN20 a.loy fine *** residua. tensile stress formed on the outside of ZN20 fine wire during dra.ing would a.celera.e the *** second pha.e ha. a.nega.ive influence on corrosion property due to ga.va.ic *** corrosion ra.e in vitro wa. fa.ter tha. tha. in vivo due to the ca.sule formed on the surfa.e of ZN20 a.loy fine wire.

关键词： Ma.nesium Surgica. sta.le a.0}stomosis Corrosion resista.ce In vivo

Ca.tive chimpa.zee sha.es food with ba.oons

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Current Zoology 2024年第5期70卷 682-684页

作者： Bin Ya.g Ja.es R.a.derson ni-na Gou Ka.-Feng Wa.g Ba.-Guo Li Sha.nxi Key La.ora.ory of Qinling Ecologica. Security Shaanxi Key Laboratory for Animal ConservationShaanxi Institute of ZoologyXi’an710032China Depa.tment of Psychology Kyoto University Graduate School of LettersKyoto606-8501Japan Sha.nxi Key La.ora.ory for a.ima. Conserva.ion and College of Life SciencesNorthwest UniversityXi’an 710069China

Food sha.ing is a.prosocia. beha.ior consisting of the unresisted tra.sfer of monopoliza.le food from a.possessor to a.other individua.(Feistner a.d McGrew 1989;Stevens a.d Gilby 2004).Despite the cost for donors(i.e.,loss of the food),intra.pecifc food sha.ing occurs in va.ious insects,fsh,birds,a.d a.ua.ic,terrestria.,a.d a.borea. ma.ma.s(Liévin‐Ba.in et a..2019;Ca.ter et a..2020).By fa.,most food sha.ing is intra.pecifc,a.d ta.es pla.e while possessors a.e in the process of ***,we describe the rema.ka.le ca.e of a.ca.tive chimpa.zee,Pa. troglodytes,regula.ly dispensing food to a.other prima.e species(ba.oons,Pa.io ha.a.rya.)in a.neighboring *** discuss likely ca.ses a.d functions of this interspecifc a.truistic *** were ma.e in Xi’a. Qinling Wildlife Pa.k,Sha.nxi Province,China(34°02ʹ56.22″N,108°51ʹ48.60″E),where two a.ult chimpa.zees a.d a.group of a.ound 40-50 ba.oons lived in a.ja.ent *** fema.e chimpa.zee(a.a.)wa. the elderly mother of the ma.e(DuoDuo,or DD).a. feeding times,a.a. usua.ly a.e nea. the door to the chimpa.zees’indoor a.ea.a.d she a.most never intera.ted with the ba.oon *** ba.oon group consisted of two one-ma.e *** recorded beha.iors using foca.-a.ima. sa.pling(for informa.ion a.out subjects a.d methods,see Supplementa.y Ma.eria.s).

关键词： ba.oons chimpa.zee food sha.ing

Cornea. ulcer possibly ca.sed by the opportunistic pa.hogen Schizophyllum commune

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International Journal of Ophtha.mology(English edition) 2020年第7期13卷 1164-1166页

作者： Xia.-ning Liu Ya. Cheng Ya.ni Wa.g Jie Wu Cha. Liu na.a. Institute of Ophtha.mology Xi’an First Hospital (First Affiliated Hospital of Northwest University of China)Xi’an 710002Shaanxi ProvinceChina Sha.nxi Key La.ora.ory of Ophtha.mology Shaanxi Institute of OphthalmologyClinical Research Center for Ophthalmic Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina Depa.tment of Ophtha.mology Xi’an First Hospital First Affiliated Hospital of Northwest University of ChinaXi’an 710002Shaanxi ProvinceChina

Dea. Editor,I a. ***-ning Liu,from the Institute of Ophtha.mology of Xi’a. First Hospita. in Xi’a.,Sha.nxi Province,China.I write to present a.ca.e report of cornea. ulcer ca.sed by Schizophyllum commune(***).Mycotic kera.itis is one of the most severe ca.ses of cornea. blindness in developing countries,such a. China.a.d India.1-2].

关键词： ulcer cornea. Ophtha.

Stem cell thera.ies in tendon-bone hea.ing

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World Journal of Stem Cells 2021年第7期13卷 753-775页

作者： Yue Xu Wa.-Xia.Zha.g Li-na Wa.g Yue-Qing Ming Yu-Lin Li Guo-Xin ni School of Sports Medicine a.d Reha.ilita.ion Beijing Sport UniversityBeijing 100084China

Tendon-bone insertion injuries such a. rota.or cuff a.d a.terior crucia.e liga.ent injuries a.e currently highly common a.d *** key method of trea.ing this kind of injury is the reconstruction *** success of this reconstructive process depends on the a.ility of the gra.t to incorpora.e into the ***,there ha. been substa.tia. discussion a.out how to enha.ce the integra.ion of tendon a.d bone through biologica. *** cells like bone ma.row mesenchyma. stem cells(MSCs),tendon stem/progenitor cells,synovium-derived MSCs,a.ipose-derived stem cells,or periosteum-derived periostea. stem cells ca. self-regenera.e a.d potentia.ly differentia.e into different cell types,which ha.e been widely used in tissue repa.r a.d ***,we concentra.e in this review on the current circumsta.ces of tendon-bone hea.ing using stem cell thera.y.

关键词： Tendon Bone Stem cell a.terior crucia.e liga.ent Rota.or cuff

Determination of a.ions in lithium-ion ba.teries electrolyte by ion chroma.ogra.hy

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Chinese Chemica. Letters 2016年第6期27卷 864-866页

作者： Bin-He Zhu Cheng-Zhu ni na-ni Wa.g Xun-Ya. Zha. Wei-Qia.g Guo Pei-Min Zha.g Jia.Jie Zha.g Su-Qing Chen Wei-De Lv Ya. Zhu Depa.tment of Chemistry Xixi Campus Zhejiang University Hangzhou 310028 China Depa.tment of Medicine Zhejiang Academy of Traditional Chinese Medicine Hangzhou 310007 China School of Pha.ma.eutica. a.d Chemica. Engineering Taizhou University Taizhou 317000 China Ha.gzhou Voca.ional & Technica. College Hangzhou 310018 China

a.sensitive a.d a.cura.e method ba.ed on ion chroma.ogra.hy wa. esta.lished for determination of five lithium sa.ts in lithium-ion ba.teries electrolytes. Chroma.ogra.hic a.0}lyses were ca.ried out on a. a.ion excha.ge column a. flow ra.e of 1 m L/min. Under the optima. conditions, five ta.get a.ions（BF4^-,PF6^-, TFSI^-, BOB^-a.d FSI^-） exhibited sa.isfa.tory linea.ity with a.correla.ion coefficient of 0.9996. The rela.ive sta.da.d deriva.ions of the ta.get a.ions were less tha. less tha. 0.94%（n = 7）. The limits of detections were in the ra.ge of 0.068–0.29 mg/L with a.era.e spiked recoveries ra.ging from 96.8% to 105.1%.

关键词： Ion chroma.ogra.hy Lithium sa.ts Lithium-ion ba.teries electrolyte

Bio-inspired chira. self-a.semblies promoted neuronal differentia.ion of retinal progenitor cells through a.tiva.ion of meta.olic pa.hwa.

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Bioa.tive Ma.eria.s 2021年第4期6卷 990-997页

作者： na Sun Xia.qiu Dou Zhimin Ta.g Da.da. Zha.g ni ni Jia.ing Wa.g Huiqin Ga. Ya.a. Ju Xia.cha. Da. Cha.gli Zha. Ping Gu Jing Ji Chua.lia.g Feng Sha.gha. Key La.ora.ory of Orbita. Disea.es a.d Ocula. Oncology Department of OphthalmologyNinth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Sta.e Key La. of Meta. Ma.rix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Road 800200240ShanghaiChina

Retinal degenera.ion is a.ma.n cla.s of ocula. *** fa.,retinal progenitor cell(RPC)tra.spla.ta.ion ha. been the most potentia. thera.y for it,in which promoting RPCs neuronal differentia.ion rema.ns a. unmet *** a.dress this issue,innova.ively designed L/D-phenyla.a.ine ba.ed chira. nanofibers(LPG a.d DPG)a.e employed a.d it finds tha. chira.ity of fibers ca. efficiently regula.e RPCs ***,western blot,a.d immunofluorescence a.0}lysis show tha. right-ha.ded helica. DPG nanofibers significa.tly promote RPCs neuronal differentia.ion,wherea. left-ha.ded LPG nanofibers decrea.e this *** effects a.e ma.nly a.cribed to the stereoselective intera.tion between chira. helica. nanofibers a.d retinol-binding protein 4(RBP4,a.key protein in the retinoic a.id(Ra.meta.olic pa.hwa.).The findings of chira.ity-dependent neuronal differentia.ion provide new stra.egies for trea.ment of neurodegenera.ive disea.es via.optimizing differentia.ion of tra.spla.ted stem cells on chira. nanofibers.

关键词： Chira. structures Self-a.sembly nanofibers Retinal progenitor cell Neuronal differentia.ion

The novel long noncoding Rna LOC283070 is involved in the tra.sition of LNCa. cells into a.drogen-independent cells via.its intera.tion with PHB2

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a.ia. Journal of a.drology 2018年第5期20卷 511-517页

作者： Ying Zha.g Li-na Wa.g Ya.ni Lin Yua.-Xin Xing Yu Shi Jia. Zha. Wei-Wen Chen Bo Ha. Depa.tment of Biochemistry a.d Molecula. Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Jinan 250012 China Depa.tment of Clinica. La.ora.ory Medicine The Second Hospital of Shandong University Jinan 250033 China School of Medicine Cheeloo College of Medicine Shandong University Jinan 250012 China Depa.tment of Thora.ic Surgery Qilu Hospital of Shandong University Jinan 250012 China Key La.ora.ory for Experimenta. Tera.ology of the Ministry of Educa.ion a.d Depa.tment of Pa.hology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Depa.tment of Pa.hology Qilu Hospital of Shandong University Jinan 250012 China

We sought to investiga.e the underlying mecha.ism of a.tion of the long noncoding Rna （IncRna） LOC283070 in the development of a.drogen independence in prosta.e ca.cer. The intera.tions between LOC283070 a.d ta.get proteins were investiga.ed by Rna pull-down a.d Rna-binding protein immunoprecipita.ion （RIP） a.sa.s. Subceilula. fra.tionation a.d qua.tita.ive reverse tra.scription-polymera.e cha.n rea.tion （qRT-PCR） were used to detect the subcellula. loca.iza.ion of LOC283070. Western blotting wa. performed to detect the expression of prohibitin 2 （PHB2）. Lucifera.e a.tivity a.sa.s were performed to eva.ua.e the effects of LOC283070 a.d PHB2 on the a.drogen receptor （a.） signaling pa.hwa.. a.methyl thia.olyl tetra.olium （MTT） a.sa. a.d a.growth curve a.sa. were used to test cell via.ility. Flow cytometry wa. performed to a.0}lyze cell cycles. a.tra.swell a.sa. wa. employed to test cell migra.ion. We identified PHB2 a. a. intera.tion pa.tner of LOC283070 in the pull-down a.d RIP experiments. Furthermore, we confirmed tha. the enrichment of L0C283070 with PHB2 in a.drogen-independent LNCa. （LNCa.-a.） cells wa. much grea.er tha. tha. in LNCa. cells. Moreover, the expression of PHB2 wa. not significa.tly different between the two cell lines, a.d the expression of LOC283070 in the nuclei of the LNCa.-a. cells wa. significa.tly grea.er tha. tha. in the LNCa. cells. In vitro da.a.revea.ed tha. PHB2 overexpression significa.tly inhibited a. a.tivity a.d cell prolifera.ion a.d migra.ion a.d induced a.cumula.ion of prosta.e ca.cer cells in GO/G1 pha.e. Moreover, the overexpression of LOC283070 fully a.roga.ed the effects of PHB2 overexpression. In conclusion, we found tha. LOC283070 ca. bind to PHB2 loca.ed in the nucleus a.d inhibit its effect, a.d this is one of the mecha.isms by which LOC283070 is involved in the tra.sition of LNCa. cells into a.drogen-independent cells.

关键词： a.drogen-dependent prosta.e ca.cer a.drogen-independent prosta.e ca.cer LOC283070 long noncoding Rna prohibitin 2

Vita.in D a.d selenium for type 2 dia.etes mellitus with Ha.himoto’s thyroiditis:Dosa.e a.d dura.ion insights

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World Journal of Dia.etes 2024年第8期15卷 1824-1828页

作者： Yun-Feng Yu Xue-Li Sha.ggua. Da.-ni Ta. Li-na Qin Rong Yu School of Tra.itional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

This letter discusses the publica.ion by Feng et ***,selenium,a.d vita.in D a.e closely a.socia.ed with thyroid hormone production in huma.s;however,the effica.y of selenium a.d vita.in D supplementa.ion for type 2 dia.etes mellitus(T2DM)pa.ients with Ha.himoto’s thyroiditis(HT)rema.ns *** the retrospective study we discuss herein,the a.thors highlighted significa.t improvements in thyroid function,thyroid a.tibodies,blood glucose,a.d blood lipid in T2DM pa.ients with HT following a.dition of vita.in D a.d selenium to their a.tidia.etic regimens,underscoring the va.ue of these *** tea. is currently enga.ed in resea.ch exploring the rela.ionship between micronutrients a.d HT,a.d we ha.e obta.ned inva.ua.le insights from the a.orementioned *** on this resea.ch a.d current litera.ure,we recommend a.regimen of 4000 IU/da. of vita.in D a.d 100-200μg/da. of selenium for over three months to six months for pa.ients with HT,pa.ticula.ly for those with concurrent T2DM.

关键词： Vita.in D Selenium Type 2 dia.etes mellitus Ha.himoto’s thyroiditis Dosa.e Dura.ion