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Effects of contrast media on the hepato-pancreato-biliary system

World Journal of Gastroenterology 2009年第38期15卷 4788-4793页

作者： omer Topcu Atilla Kurt Isilay nadir Sema Arici Ayhan Koyuncu Cengiz Aydin Department of General Surgery Faculty of MedicineCumhuriyet University Department of Gastroenterology Numune Hospital Department of Pathology Faculty of MedicineCumhuriyet University

AIM： To determine the effects of high osmolarity contrast media （HOCM） and iso-osmolar contrast media （CM） application, with or without pressure, on hepato-pancreato-biliary （HPB） system. METHODS： Sixty rats were divided into six equal groups as follows： Group i：（0.9% naCl, control）, Group 2：（diatrizoate meglumine na, ionic HOCM, Urographin）, Group 3：（iodixanol, iso-osmolar nonionic CM, Visipaque）; each of which was applied without pressure, whereas the animals of the remaining three groups （1p, 2p, 3p） were subjected to the same CM with pressure. We performed a duodenal puncture and introduced a catheter into the ampulla. After the catheterization, 0.2 mL CM or 0.9% naCI was injected with or without pressure. Blood samples were taken for biochemical evaluations. The histopathological examinations of liver, common bile duct, and pancreas were performed. RESULTS： There were no significant differences between the six groups for blood amylase, alanine aminotransferases, aspartate aminotransferases, bilirubin levels （P 〉 0.05）. Alkaline phosphatase and γ glutamyl transaminase levels were higher （P 〈 0.05） in the Urographin groups （2, 2p） than the Visipaque groups （3, 3p）, or control groups （1, 1p）. Hepatocyte necrosis, portal area inflammation, and Kupffer＇s cell hyperplasia were higher （P 〈 0.05） in the study groups than the control group. However, there were no significant differences （P 〉 0.05） between HOCM （2, 2p） and iso-osmolar CM （3, 3p） groups. Bile duct proliferation and regeneration in the Urographin groups （2, 2p） were significantly higher （P 〈 0.05） than the Visipaque~ groups （3, 3p） or the control groups （1, lp）. Although CM caused minor damage to the pancreas, there were no statistically significant differences （P 〉 0.05） between the groups. Application of the CM with pressure did not cause additional damage to the HPB system. CONCLUSION： Iso-osmolar, non-ionic CM could be more reliable than the ionic HOCM, whereas the application of pressure during the

关键词： Contrast media Liver Pancreas Biliarytract Pressure

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Synthesis,Characterization and Catalytic Activity of Znal Anionic Clay Pillared by α-na_(6)[GaW_(11)O_(39)Fe(H_(2)O)]·18H_(2)O

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Chemical Research in Chinese Universities 1998年第4期14卷 8-10页

作者： Yu, XW Zhang, SY Huang, RD Zhang, SX Wang, eb NE Normal Univ Dept Chem Changchun 130024 Peoples R China

ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅａｎｉｏｎｉｃｃｌａｙｉｓａｌｓｏｃａｌｅｄｌａｙｅｒｅｄｄｏｕｂｌｅｈｙｄｒｏｘｉｄｅ（ｎｏｔｅｄａｓＬＤＨ），ｉｔｓｕｎｉｑｕｅｂａｓｉｃｃａｔａｌｙｔｉｃｆｕｎｃｔｉｏｎ，ｉｎｔｅ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅａｎｉｏｎｉｃｃｌａｙｉｓａｌｓｏｃａｌｅｄｌａｙｅｒｅｄｄｏｕｂｌｅｈｙｄｒｏｘｉｄｅ（ｎｏｔｅｄａｓＬＤＨ），ｉｔｓｕｎｉｑｕｅｂａｓｉｃｃａｔａｌｙｔｉｃｆｕｎｃｔｉｏｎ，ｉｎｔｅｒｅｓｔｉｎｇ“ｍｅｍｏｒｙｅｆｅ...

关键词： Anionic clay Heteropolyanion Catalytic activity

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Fearful imagery induces hyperventilation and dyspnea in medically unexplained dyspnea

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Chinese Medical Journal 2008年第1期121卷 56-62页

作者： HAN Jiang-na ZHU Yuan-jue LUO Dong-mei LI Shun-wei Ilse Van Diest omer Van den Bergh KarelP Van de Woestijne Department of Pneumology Peking Union Medical CollegeHospital Chinese Academy of Medical Sciences Beijing 100730China Department of Psychology University of Leuven B-3000 LeuvenBelgium Department of Pneumology U Z Gasthuisberg B-3000 LeuvenBelgium

Background Medically unexplained dyspnea refers to a condition characterized by a sensation of dyspnea and is typically applied to patients presenting with anxiety and hyperventilation without underlying cardiopulmonary pathology. We were interested to know how anxiety triggers hyperventilation and elicits subjective symptoms in those patients. Using an imagery paradigm, we investigated the role of fearful imagery in provoking hyperventilation and in eliciting symptoms, specifically dyspnea. Methods Forty patients with medically unexplained dyspnea and 40 normal subjects matched for age and gender were exposed to scripts and asked to imagine both fearful and restful scenarios, while end-tidal PCO2 （PetCO2） and breathing frequency were recorded and subjective symptoms evaluated. The subject who had PetCO2 falling more than 5 mmHg from baseline and persisting at this low level for more than 15 seconds in the imagination was regarded as a hyperventilation responder. Results In patients with medically unexplained dyspnea, imagination of fearful scenarios, being blocked in an elevator in particular, induced anxious feelings, and provoked a significant fall in PetCO2 （P〈0.05）. Breathing frequency tended to increase. Eighteen out of 40 patients were identified as hyperventilation responders compared to 5 out of 40 normal subjects （P〈0.01）. The patients reported symptoms of dyspnea, palpitation or fast heart beat in the same fearful script imagery. Additionally, PetCO2 fall was significantly correlated with the intensity of dyspnea and palpitation experienced during the mental imagery on one hand, and with anxiety symptoms on the other. Conclusions Fearful imagery provokes hyperventilation and induces subjective symptoms of dyspnea and palpitation in patients with medically unexplained dyspnea.

关键词： medically unexplained dyspnea hyperventilation anxiety dyspnea mental imagery

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Dietary betaine activates hepatic VTGⅡexpression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression

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Journal of Animal Science and Biotechnology 2018年第2期9卷 381-390页

作者： nagmeldin A.omer Yun Hu Yan Hu Abdulrahman A.Idriss Halima Abobaker Zhen Hou Haibo Dong Ruqian Zhao MOE Joint International Research Laboratory of Animal Health&Food Safety Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Key Laboratory of Animal Physiology&Biochemistry Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Jiangsu Collaborative Innovation Centre of Meat Production and Processing Quality and Safety ControlNanjing 210095People’s Republic of China Poultry Institute Chinese Academy of Agriculture SciencesYangzhouJiangsuChina

Background: Vitellogenin(VTG) is a precursor of egg yolk proteins synthesized within the liver of oviparous vertebrates. Betaine is an important methyl donor that is reported to improve egg production of laying hens with an unclear mechanism. In the present study, we fed betaine-supplemented diet(0.5%) to laying hens for 4 wk and investigated its effect on VTGII expression in the ***: Betaine did not affect chicken weight, but significantly(P na was significantly(P na.a.d protein levels. Also, ERα/GR interaction tended to be enhanced in the liver nuclear lysates of betainesupplemented hens as determined by co-immunoprecipitation. Furthermore, dietary betaine supplementation significantly increased(P na methylation of GR gene promoter, GR expression and ERα/GR interaction. Activation of hepatic VTGII expression may contribute, at least partly, to improved egg production in betaine-supplemented hens.

关键词： Betaine Glucocorticoid receptor Hypomethylation Laying hens Vitellogenin

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ASAS J174406+2446.8 is identified as a marginal-contact binary with a possible cool third body

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Research in Astronomy and Astrophysics 2020年第6期20卷 265-272页

作者： Xiang-Dong Shi Sheng-Bang Qian Lin-Jia Li Wei-Wei na Xiao Zhou Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China Yuxi Normal University Yuxi 653100China

ASAS J174406+2446.8 was originally found as aδScuti-type pulsating star with the period P=0.189068 d by ASAS ***,the LAMOST stellar parameters reveal that it is far beyond the red edge of pulsational instability strip on the log g-T diagram ofδScuti pulsating *** understand the physical properties of the variable star,we observed it by the 1.0-m Cassegrain reflecting telescope at Yunnan ***-color light curves in B,V,R_c and I_c bands were obtained and are analyzed by using the W-D *** is found that this variable star is a shallow-contact binary with an eb-type light curve and an orbital period of 0.3781 d rather than aδScuti *** is a W-subtype contact binary with a mass ratio of 1.135(±0.019)and a fill-out factor of 10.4%(±5.6)%.The situation of ASAS J174406+2446.8 resembles those of other eb-type marginal-contact binaries such as UU Lyn,ⅡPer and GW *** of them are at a key evolutionary phase from a semi-detached configuration to a contact system predicted by the thermal relaxation oscillation *** linear ephemeris was corrected by using 303 new determined times of light *** is detected that the O-C curve shows a sinusoidal variation that could be explained by the light-travel-time effect via the presence of a cool red *** present investigation reveals that some of theδScuti-type stars beyond the red edge of pulsating instability strip on the log g-T diagram are misclassified eclipsing *** understand their structures and evolutionary states,more studies are required in the future.

关键词： stars binaries close-stars binaries eclipsing-stars δScuti-stars individual(ASAS J174406+2446.8)

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Hydrochemical characteristics of aquifers in Northern Gezira State,Central Sudan

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Journal of Southeast University(English Edition) 2003年第3期19卷 270-274页

作者： Adil Elkrail 束龙仓 omer Kheir 郝振纯河海大学水资源环境学院苏丹地质研究部

This paper presents an assessment of the hydrochemical characteristics of groundwater in Northern Gezira State, Central Sudan. The approaches followed here include the chemical analyses for major ions chemistry and construction of hydrochemical maps of total dissolved solids (TDS), sodium (na +), bicarbonate (HCO 3 -), and chloride (Cl -) ions. The hydrochemical characteristics of the groundwater in each aquifer and management consideration are discussed. Sources of major ions in groundwater are analyzed. The hydrochemical maps of important species are constructed. The relationship of groundwater to use is elaborated. High concentrations of the chemical and hydrochemical constituents and the occurrence of calcretes (CaCO 3) in upper zones suggest a long history of evaporation and increasing leachates.

关键词： total dissolved solids hardness aquifer chemical constituents

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Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis

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World Journal of Gastroenterology 2009年第5期15卷 570-577页

作者： Di na Fu-nan Liu Zhi-Feng Miao Zong-Min Du Hui-Mian Xu Department of Oncology The First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM： To determine the inhibitory effect of Astragalus memebranaceushas on gastric cancer cell superna.a.t- induced apoptosis of human peritoneal mesothelial cells. METHODS： Human peritoneal mesothelial cell （HPMC） line HMrSV5 was co-incubated with gastric cancer cell superna.a.t （MKN45） and/or Astragalus memebranaceushas. Morphological changes in gastric cancer cells were observed under phase-contrast microscope. Quantitative cell damage was determined by MTT assay. Apoptosis was determined under transmission electron microscope and quantified by detectinr, acridine orange/ethidium bromide-stained （AO/eb） condensed nuclei under fluorescent microscope or by flow cytometry. Expressions of Bcl-2 and Bax were evaluated with immunostaining.

关键词： Peritoneal carcinomatosis Stomachneoplasm Astragalus plant Mesothelial cell Apoptosis

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Tubeimoside-1 induces TFeb-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3134-3149页

作者： Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu na Zhang Hongbin Deng Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Zhejiang Provincial Key Lab of Geriatrics Department of GeriatricsZhejiang HospitalHangzhou 310013China State Key Laboratory of natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization China Pharmaceutical UniversityNanjing 210009China Qingdao Women and Children’s Hospital Qingdao UniversityQingdao 266034China

Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)*** PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor *** flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 ***-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of ***,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell ***,TBM-1 triggers PD-L1 lysosomal degradation in a TFeb-dependent,autophagy-independent ***-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFeb and lysosome ***,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)*** findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy.

关键词： PD-L1 Immune checkpoint blockade Transcription factor eb Lysosome mTOR

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Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

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Microsystems & nanoengineering 2020年第1期6卷 903-915页

作者： Kyounghwan na Zachariah J.Sperry Jiaao Lu Mihaly Voroslakos Saman S.Parizi Tim M.Bruns Euisik Yoon John P.Seymour Electrical Engineering&Computer Science Department University of MichiganAnn ArborMI 48105USA Biomedical Engineering Department University of MichiganAnn ArborMI 48105USA Biointerfaces Institute University of MichiganAnn ArborMI 48105USA The Neuroscience Institute New York UniversityNew YorkNY 10016USA Center for nanomedicine Institute for Basic Science(IBS)Seoul 03722Korea Graduate Program of nano Biomedical Engineering(nano BME) Yonsei-IBS InstituteYonsei UniversitySeoul 03722Korea Vivian L Smith Department of Neurosurgery University of Texas Health Science CenterHoustonTX 77030USA Department of Electrical and Computer Engineering Rice UniversityHoustonTX 77005USA

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural *** devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of *** demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes(4.5-µm thick)through dura mater and thick *** diamond shuttle has 54%less cross-sectional area than an equivalently stiff silicon shuttle,which we simulated will result in a 37%reduction in blood vessel *** also discovered that higher frequency oscillation of the shuttle(200Hz)significantly reduced tissue compression regardless of the insertion speed,while slow speeds also independently reduced tissue *** and recording performance are demonstrated in rat and feline models,but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

关键词： sectional neural thick

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线性混合模型中方差分量的经验Bayes检验

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中北大学学报（自然科学版） 2013年第3期34卷 218-222页

作者：邵敏娜宁夏大学数学计算机学院宁夏银川750021

给出了含有2个方差分量的线性混合模型中方差分量的Bayes检验的判决函数,利用核估计的方法,构造了相应的经验Bayes(eb)检验的判决函数.在适当的条件下证明了eb判决函数是渐近最优的且有收敛速度.举例验证了定理的正确性.

关键词：线性混合模型方差分量经验Bayes检验收敛速度

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