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Multiplexed imaging detection of live cell intracellular changes in early apoptosis with aggregation-induced emission fluorogens

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Science China Chemistry 2018年第8期61卷 892-897页

作者： Yabin Zhou Haixiang Liu na Zhao Zhiming Wang Michael Z.Michael Ni Xie Ben Zhong Tang Youhong Tang Faculty of Biological Engineering Sichuan University of Science and Engineering Department of Chemistry the Hong Kong University of Science and Technology Centre for nano Scale Science and Technology College of Science and Engineering Flinders University Department of Gastroenterology and Hepatology Flinders Centre for Innovation in Cancer Flinders University AIEgen Biotech Co. Limited

Apoptosis is an important process for maintaining tissue homeostasis and eliminating abnormal cells in multicellular *** in apoptosis often leads to severe diseases such as cancers. Better understanding of its mechanisms and processes is therefore important. Accompanying molecular biology events of apoptosis is a series of cellular morphology changes: nucleus condensation, cell shrinkage and rounding, cell surface blebbing, dynamic blebbing, apoptotic membrane protrusions and nucleus fragmentations and finally, the formation and release of apoptotic bodies. It is difficult to detect cellular changes in the early phase of apoptosis due to the subtle changes at this phase. In the current study, we induced apoptosis in He la cells with H2 O2 and used nuclear dye Hoechst 33258, mitochondria, lysosome and cytoplasmic protein specific aggregation-induced emission fluorogens(AIEgens), TPE-Ph-In, 2 M-DABS and BSPOTPE to successfully perform live cell multiplexed imaging to investigate early apoptosis cellular events. We showed the gradual dissipation of mitochondria membrane potential until it is nondetectable by TPE-Ph-In. Increased mitophagy detected by TPE-Ph-In and 2 M-DABS, condensed nucleus detected by Hoechst33258, increased permeability and/or reduced integrity of nuclear membrane, and increased intracellular vesicles detected by2 M-DABS are some of the early events of apoptosis.

关键词： apoptosis multiplexed imaging He la aggregation-induced emission fluorogens(AIEgens)

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蒙药花锚石油醚萃取物化学成分研究

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中药材 2015年第11期38卷 2321-2323页

作者：邰巴达拉胡拉喜那木吉拉桂荣白梅荣包明兰巴根那内蒙古民族大学蒙医药学院内蒙古通辽028000

目的:研究蒙药花锚的化学成分。方法:用正相、反相硅胶柱层析、Sephadex LH-20等色谱方法进行分离纯化,根据NMR等波谱数据以及结合文献报道的波谱数据鉴定化合物的结构。结果:从蒙药花锚95%乙醇提取物的石油醚萃取部位中分离得到9个化合... 详细信息

目的:研究蒙药花锚的化学成分。方法:用正相、反相硅胶柱层析、Sephadex LH-20等色谱方法进行分离纯化,根据NMR等波谱数据以及结合文献报道的波谱数据鉴定化合物的结构。结果:从蒙药花锚95%乙醇提取物的石油醚萃取部位中分离得到9个化合物,分别鉴定为:1-羟基-2,3,4,6-四甲氧基酮(1)、1-羟基-2,3,5-三甲氧基酮(2)、1-羟基-3,7-二甲氧基酮(3)、1-羟基-3,5,6,7,8-五甲氧基酮(4)、1-羟基-2,3,4,7-四甲氧基酮(5)、1-羟基-3,5-二甲氧基酮(6)、1-羟基-2,3,4,5,7-五甲氧基酮(7)、棕榈酸(8)、β-谷甾醇(9)。结论:其中,化合物3、4、8为首次从花锚属中分离得到,化合物1为首次从蒙药花锚中分离得到。

关键词：花锚化学成分结构鉴定

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Microstructure and electrochemical properties of la0.8-xMMxMg0.2Ni3.1Co0.3Al0.1(x=0,0.1,0.2,0.3)alloys

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Rare Metals 2017年第8期36卷 645-650页

作者： na Zhou Wen-Bo Du Pei-Long Zhang Yong-Guo Zhu Zhao-Hui Wang Ke Liu Shu-Bo Li College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China Whole Win Materials Science and Technology Co. LtdBeijing 100083China

The present study aims to improve electrochemical properties of the la-Mg-Ni-based hydrogen storage alloys through partial substitution for la by mischmetal（MM）.The la_（0.8-x）MM_xMg_（0.2）Ni_（3.1）Co_（0.3）Al_（0.1）（x=0,0.1,0.2,0.3）alloys were prepared by inductive melting,and their phase structures and electrochemical properties were studied by X-ray diffraction（XRD）,scanning electron microscope（SEM）,energy-dispersive X-ray spectrometry（EDX）and electrochemical *** show that the alloys mainly consist of la_2Ni_7-type phase,la_5Ni_（19）-type phase,laNi_5-type phase and laNi_3-type *** addition of MM does not change the phase compositions,while it leads to more uniform phase distribution and obviously promotes the formation of la_2Ni_7-type phase which possesses favorable electrochemical *** studies indicate that the substitution for la by MM could effectively improve the high rate dischargeability（HRD）of the alloy electrode,and the optimal value of HRD_（1500）（HRD at 1500 mA·g^（-1））increases from 40.63%（x=0）to 60.55%（x=0.3）.Although the activation properties of the alloy electrodes keep almost unchanged,both the maximum discharge capacity（C_（max））and the cycling stability are significantly improved by MM addition.

关键词： Hydrogen storage alloy Microstructure Discharge capacity High rate dischargeability Cyclingstability

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整数自仿Tiling的Tile数字集(英文)

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工程数学学报 2010年第6期27卷 1129-1132页

作者：薛玉梅李拉娜北京航空航天大学数学与系统科学学院数学、信息与行为教育部重点实验室北京100191

关于由一个扩张矩阵A∈Mn(Z)和数字集D={d1,d2,...,dm}■Zn生成的整数自仿Tiling,已经有很多研究结果。其中一个重要的问题是判定一个数字集在什么条件下能生成一个Tile。在一维情况下,已知结果有:标准数字集,乘积形式数字集,弱乘积形... 详细信息

关于由一个扩张矩阵A∈Mn(Z)和数字集D={d1,d2,...,dm}■Zn生成的整数自仿Tiling,已经有很多研究结果。其中一个重要的问题是判定一个数字集在什么条件下能生成一个Tile。在一维情况下,已知结果有:标准数字集,乘积形式数字集,弱乘积形式数字集都是Tile数字集。在本文中,我们把弱乘积形式的概念推广到高维,并证明它们都是Tile数字集。

关键词：整数自仿Tile 标准数字集乘积形式数字集弱乘积形式数字集

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Sparing lung tissue with virtual block method in VMAT planning for locally advanced non-small cell lung cancer

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Nuclear Science and Techniques 2022年第4期33卷 136-150页

作者： Jia-Yun Chen Da-Quan Wang Xiao-Dong Zhang Qi Fu Xue-na Yan Kuo Men Jian-Rong Dai nan Bi Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTXUSA

This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(la-NSCLC).The previous method was used to manually restrict the angle of the beam passing through,which ignored the location and shape of large targets that varied between different slices and did not block the beamlets *** the previous method,this new virtual block method was used to block the beamlets when necessary by closing the multi-leaf collimator(MLC)at prerequisite *** algorithm for closing the MLC depended on the thickness of the beamlets passing through the lungs and avoided only the entrance radiation ***,this block can be automatically contoured.A retrospective study was performed to compare the VMAT plans with and without the virtual block method for 17 laNSCLC patients,named the block plan(B-plan)/non-block plan(N-plan).All cases were selected in this study because of the large tumor size and unmet dose constraints of the *** addition to the maximum dose constraint for the virtual block,B-plans adopted identical optimization parameters to N-plans for each *** two types of plans were compared in terms of dosimetric indices and plan *** results were statistically analyzed using the Wilcoxon nonparametric signed-rank test.B-plans have advantages in the following dosimetric metrics that have statistical significance(plateral lung;(3)decrease in Dmean/V_(40)of the heart;(4)decrease in esophagus V_(40);(5)reductions in Dmean,V_(5)/V_(10) of normal tissue.B-plans(82.51±7.07)achieved higher-quality scores than N-plans(80.74±7.22).The new virtual block spared the lungs as well as other normal structures in VMAT planning for ***,the block method may decrease the risk of radiation-related toxicity in p

关键词： Virtual block VMAT Normal tissue sparing Lung cancer

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绵羊放牧方式及强度对围封恢复草场牧草细胞壁成分及营养价值的影响

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家畜生态学报 2013年第7期34卷 58-63页

作者：塔娜德庆哈拉那日苏中国农业科学院草原研究所内蒙古呼和浩特010010 内蒙古家畜改良工作站农业部草原资源与生态重点开放实验室内蒙古呼和浩特010010 内蒙古家畜改良工作站内蒙古呼和浩特010010

选取内蒙古自治区典型草原区封育恢复中天然放牧草场,进行毛肉兼用细毛羊的暖季放牧试验。采用2×5完全随机试验设计,设定不同放牧方式(不放牧,连续放牧,四区、五区、六区轮牧)及2种放牧强度(1.0,1.4hm2/***),运用酶分析方法分析比较了... 详细信息

选取内蒙古自治区典型草原区封育恢复中天然放牧草场,进行毛肉兼用细毛羊的暖季放牧试验。采用2×5完全随机试验设计,设定不同放牧方式(不放牧,连续放牧,四区、五区、六区轮牧)及2种放牧强度(1.0,1.4hm2/***),运用酶分析方法分析比较了围封过程中放牧绵羊对封育草场牧草细胞壁成分月动态变化及营养价值的影响。结果表明,整个暖季放牧期内,不同放牧区牧草营养物质含量主要受到放牧方式的显著影响(P<0.05)。具体表现为,不放牧处理牧草细胞壁有机物(OCW)含量始终显著低于各放牧处理,不同放牧处理间没有明显差异;划区轮牧处理牧草始终保持着较高的消化性部分且显著高于连续放牧处理;不放牧处理牧草始终保持着较高的Oa和较低的Ob,而连续放牧处理与其相反,各轮牧处理间没有显著差异;轮牧处理总可消化养分(TDN)和代谢能(ME)含量较高,尤其在牧草生长旺盛期(八月份),六区轮牧放牧场牧草可利用营养物质含量最高,营养价值最高。

关键词：绵羊放牧恢复草场牧草细胞壁划区轮牧

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Western Indian Ocean SST signal and anomalous Antarctic sea-ice concentration variation

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Acta Oceanologica Sinica 2011年第2期30卷 9-13页

作者： LIU na ZHANG Zhanhai CHEN Hongxia LIN Lina First Institute of Oceanography State Oceanic Administration Qingdao 266061 China Key laboratory for Polar Science Polar Research Institute of China Shanghai 200136 ChinaReceived 13 June 2010 accepted 2 December 2010

Teleconnection between El Nino/la Nina-Southern Oscillation （ENSO） phenomenon and anomalous Antarctic sea-ice variation has been studied *** this study,impacts of sea surface temperature in the Indian Ocean on Antarctic sea-ice change were investigated during Janaury 1979 and October *** on previous research results,sea areas in the western Indian Ocean （WIO;50°–70°E,10 °–20 °S） are selected for the *** variables showed 1-10 year interannual timescales by Fast Founer Tranaform （FFT） *** show that i） strong WIO signals emerged in the anomalous changes of Antarctic sea-ice concentration;ii） significant positive correlations occurred around the Antarctic Peninsula,Ross Sea and its northwest peripheral sea region iii） negative correlation occurred in the Indian Ocean section of the Southern Ocean,Amundsen Seas,and the sea area over northern Ross Sea;and iv） the atmospheric anomalies associated with the WIO including wind,meridional heat flux,and surface air temperature over southern high latitudes were the possible factors for the teleconnection.

关键词： Antarctic sea-ice western Indian Ocean sea surface temperature

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论中国蒙医整骨术骨折复位特征、特质及其准则

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中华中医药杂志 2018年第9期33卷 3812-3814页

作者：照那木拉胡达来贾强内蒙古民族大学骨伤科学研究基地通辽028000 通辽市蒙医整骨医院骨伤科通辽028000 北京美晶视界科技有限公司北京100803

为探究中国蒙医整骨术骨折复位的独具特征、独有特质及其独特准则。文章利用生理心理、生物力学原理及方法进行讨论,发现中国蒙医整骨术骨折复位相对于中医正骨术骨折复位更具有"生理愈合-心理恢复"兼顾、"肢体愈合-功能恢复"兼顾独具特... 详细信息

为探究中国蒙医整骨术骨折复位的独具特征、独有特质及其独特准则。文章利用生理心理、生物力学原理及方法进行讨论,发现中国蒙医整骨术骨折复位相对于中医正骨术骨折复位更具有"生理愈合-心理恢复"兼顾、"肢体愈合-功能恢复"兼顾独具特征,生理与心理"动"稳定、静态与动态"动"平衡、作用力与反作用力"动"统一独有特质,因而恪守"身心统一""动静合一""以力对力""反向复位"独特准则。因此它的独具特征、独有特质、独特准则是传继与沿用至今的根本,更是当今骨折复位疗法整体、动态、功能化发展方向。

关键词：蒙医整骨术骨折复位特征特质准则

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Human cytomegalovirus infection is associated with essential hypertension in the Kazakh and Han Chinese populations

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中国病理生理杂志 2015年第10期 1784-1784页

作者： TANG na LI Jia-wei LIU Yong-min ZHONG Hua WANG la-mei HE Fang Department of Pathophysiology/Key laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases Medical College of Shihezi University

AIM:To study the association between cytomegalovirus(CMV)infection and hypertension in Kazakh and Han populations from Xinjiang province,***:The data of 800 Kazakhs(467 hypertension patients and 333 healthy control participants)and 800 Hans(482 hypertension patients and 318 healthy participants)aged 18～84 years old were *** and real-time

关键词： Human cytomegalovirus infection is associated with essential hypertension in the Kazakh and Han Chinese populations CMV

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REE geochemistry of suspended sediments from the rivers around the Yellow Sea and provenance indicators

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Chinese Science Bulletin 2003年第11期48卷 1135-1139页

作者： YANG Shouye LI Congxian C. B. Lee T. K. na laboratory of Marine Geology Tongji UniversityLaboratory of Marine Geology Tongji UniversitySchool of Earth and Environment of Sciences Seoul National UniversitySchool of Earth and Environment of Sciences Seoul National University Shanghai 200092 ChinaShanghai 200092 ChinaSeoul 151-742 KoreaSeoul 151-742 Korea

Rare earth element (REE) compositions of the suspended sediments from the rivers around the Yellow Sea were different in that Korean river sediments (Han, Keum and Yeongsan Rivers) yield stronger fractionations than Chinese river sediments (Changjiang, Huanghe and Yalujiang), shown by obvious enrichments of LREE (light rare earth element) relative to UCC (upper continental crust). Variations of source rock compositions in the drainage basins are responsible for the differences of REE compositions between the river sediments. REE fractionation parameters including (la/Yb)UCC and (Gd/Yb)UCC as well as the ratios of la/Sc and Th/Sc can be treated as proper proxies for identifying the Chinese river sediments from those Korean river matters, and furthermore, for studying the provenances and paleoenvironmental changes of the marginal seas of China.

关键词：地球化学黄海稀有元素 REE 沉积物中国韩国

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