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杭州地区臭氧污染及台风烟花过程影响

中国环境科学 2024年第3期44卷 1195-1203页

作者：张嘉月康娜邵生成牛彧文程昊张佳欣浩翔杲先亮齐冰南京信息工程大学中国气象局气溶胶-云-降水重点开放实验室江苏南京210044 金华市气象局浙江金华321000 浙江省气象科学研究所浙江杭州310056 力合科技(湖南)股份有限公司湖南长沙410000 杭州市气象局浙江杭州310051

为探究杭州地区臭氧的污染问题及影响因素,利用2018~2021年杭州地区空气质量、气象要素,选取2021年杭州台风烟花中后期后向轨迹数据与臭氧小时数据,进行后向轨迹聚类及潜在源区域分析.结果表明:2018~2021年杭州地区总体空气质量改善良好... 详细信息

为探究杭州地区臭氧的污染问题及影响因素,利用2018~2021年杭州地区空气质量、气象要素,选取2021年杭州台风烟花中后期后向轨迹数据与臭氧小时数据,进行后向轨迹聚类及潜在源区域分析.结果表明:2018~2021年杭州地区总体空气质量改善良好,臭氧污染一直较为严重,主要集中在每年的4~10月份.臭氧污染与相对湿度呈负相关性,温度呈正相关性,同时风速对臭氧的生成和扩散也有一定的影响.以2021年台风烟花为例,台风期间降雨量大,风速强,各污染物浓度下降,台风过境后,高温低湿促使了臭氧浓度的上升.对2021年7月25~30日(台风过境后)进行聚类与潜在源分析,得到7条气团传输路径,主要气团来自西北方向,途经江西、湖北等地区.而WPSCF和WCWT的臭氧浓度高值区的一致性较好,臭氧污染受一定的区域传输影响,主要受金华、上饶、南昌、武汉等城市影响,涉及浙江、江西、湖北3个省份.

关键词：空气质量臭氧后向轨迹来源分析杭州影响因素

Statistical Characteristics of Austral Summer Cyclones in Southern Ocean

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Journal of Ocean University of China 2012年第2期11卷 118-128页

作者： LIU na FU Gang KUO Ying-Hwa Department of Marine Meteorology Ocean University of ChinaQingdao 266100P.R.China national Center for Atmospheric Research Mesoseale and Microscale Meteorology DivisionBoulder 80307USA

Characteristics of cyclones and explosively developing cyclones (or 'bombs') over the Southern Ocean in austral summer (December, January and February) from 2004 to 2008 are analyzed by using the Final Analysis (FNL) data produced by the national Centers for Environmental Prediction (NCEP) of the United States. Statistical results show that both cyclones and explosively developing cyclones frequently develop in January, and most of them occur within the latitudinal zone between 55°S and 70°S. These cyclones gradually approach the Antarctic Continent from December to February. Generally cyclones and bombs move east-southeastward with some exceptions of northeastward movement. The lifetime of cyclones is around 2-6 d, and the horizontal scale is about 1000 km. Explosive cyclones have the lifetime of about 1 week with the horizontal scale reaching up to 3000 km. Compared with cyclones developed in the Northern Hemisphere, cyclones over the southern ocean have much higher occurrence frequency, lower central pressure and larger horizontal scale, which may be caused by the unique geographical features of the Southern Hemisphere.

关键词： cyclone explosive cyclone Southern Hemisphere lifetime

Biomimetic Crawling Motion of Soft and Slender Gel-worm

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Chinese Chemical Letters 2006年第10期17卷 1394-1396页

作者： Song Miao LIANG Jian XU Li na ZHANG Department of Chemistry Wuhan University Wuhan 430072 State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080

Inspired by the locomotion of terrestrial limbless animals, the present work attempt to study the motion of biomimetic system based on poly（vinyl alcohol） / dimethylsulfoxide gel. The system was operated in air by employing a non-contacted DC electric field. The results showed that the gel exhibited a long-range snail-like motion and had a very fast response rate.

关键词： Polymer gel electric field motion poly (vinyl alcohol) dimethylsulfoxide

胡兰贵运用芪脉地黄汤治疗慢性肾小球肾炎经验撷菁

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山东中医杂志 2024年第6期43卷 635-638页

作者：马倩张维亮申娜陈小慧邓树文刘洋胡娜胡兰贵(指导) 广州中医药大学广东广州510120 山西省中医药研究院山西太原030012 山西中医药大学山西太原030024 不详

胡兰贵教授认为慢性肾小球肾炎发病以外邪侵袭为引,病机以脾肾两虚为本,湿热、瘀血为标,三焦气滞为要。临床治疗本病,胡教授遵循“以脉为根”“以平为期”“守变相参”的辨证思维,应用健脾益肾、清热除湿、活血化瘀之芪脉地黄汤治之,并... 详细信息

胡兰贵教授认为慢性肾小球肾炎发病以外邪侵袭为引,病机以脾肾两虚为本,湿热、瘀血为标,三焦气滞为要。临床治疗本病,胡教授遵循“以脉为根”“以平为期”“守变相参”的辨证思维,应用健脾益肾、清热除湿、活血化瘀之芪脉地黄汤治之,并强调在疾病后期以膏方巩固收功。附验案1则。

关键词：慢性肾小球肾炎芪脉地黄汤脾肾两虚湿热瘀血三焦气滞胡兰贵

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Two-dimensional tungstate nanosheets for constructing novel photochromic hydrogel with ultrahigh flexibility

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Journal of Materiomics 2018年第2期4卷 144-148页

作者： na Liu Sai Liu Fengxia Geng College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China

A hydrogel possessing interesting photochromic behaviors was developed by in situ ultraviolet(UV)irradiation-assisted polymerization of an aqueous solution of N-isopropylacrylamide monomer in the presence of cesium tungstate *** this process,a hierarchical porous network structure was finely constructed while showing ultrahigh *** importantly,the newly prepared hydrogel retained the photochromic properties of the cesium tungstate *** color transitions could be readily controlled by UV laser irradiation and were completely reversible via laser exposure or dark *** nanocomposite hydrogel with its excellent photochromic properties and ultrahigh flexibility will have great applications in flexible photochromic *** synthetic procedure is simple and has promises to be extended to developing other hydrogels with various new functionalities.

关键词： nanocomposite hydrogel Photochromic Tungstate nanosheets

Myeloid sarcoma of the colon as initial presentation in acute promyelocytic leukemia:A case report and review of the literature

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World Journal of Clinical Cases 2021年第21期9卷 6017-6025页

作者： Lei Wang Da-Li Cai na Lin Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Myeloid sarcoma(MS)rarely occurs in acute promyelocytic leukemia(APL)at onset,but it can develop in relapse cases,especially after APL treated with alltrans retinoic acid(ATRA).Therefore little is known about the clinical features and suitable treatment for APL related MS due to the rarity of the disease,although this may be different from the treatment and prognosis of MS in the relapse *** our best knowledge,this is the second case report of APL initial presentation as colon *** SUMMARY A 77-year-old woman complained of intermittent right lower abdominal pain,black stool,and difficult defecation for 2 *** examination showed diffuse tenderness during deep palpation and an anemic *** findings showed positivity for fecal occult blood testing;white blood cell count:3.84×109/L;hemoglobin:105 g/L;platelet count:174×109/L;and negativity for tumor *** enhanced computed tomography showed a space occupying lesion in the colon(1.9 cm).Fibrocolonoscopy revealed a polypoid and ulcerated mass measuring 2.5 *** tumor was *** our surprise,MS was confirmed by ***/RARαfusion gene was detected in colon specimens by fluorescent in situ hybridization and real-time reverse transcription polymerase chain reaction,which was consistent with the bone *** was diagnosed as having APL related MS.A smooth and unobstructed intestinal wall was found by fibrocolonoscopy,and continuous molecular remission was confirmed in both the bone marrow and colon after four courses of ATRA+arsenic trioxide(ATO).ATRA+ATO showed a favorable therapeutic response for both APL and *** Early use of ATRA can benefit APL patients,regardless of whether MS is the first or recurrent manifestation.

关键词： Acute promyelocytic leukemia Myeloid sarcoma All-trans retinoic acid Extramedullary disease Colon Fluorescent in situ hybridization Case report

龙牡皮炎方对特应性皮炎小鼠氧化应激的干预作用

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中国实验方剂学杂志 2024年第5期30卷 88-95页

作者：马梦茜吴思琪王清滢李亚琴汪津禾郎娜任建勋中国中医科学院西苑医院北京100091

目的:本研究观察龙牡皮炎方对2,4-二硝基氯苯(DNCB)诱导特应性皮炎(AD)的BALB/c小鼠模型氧化应激的干预作用并探讨其机制。方法:采用BALB/c小鼠背部皮肤DNCB致敏的方法建立AD模型。雄性BALB/c小鼠40只,随机分为空白组、模型组、维生素C... 详细信息

目的:本研究观察龙牡皮炎方对2,4-二硝基氯苯(DNCB)诱导特应性皮炎(AD)的BALB/c小鼠模型氧化应激的干预作用并探讨其机制。方法:采用BALB/c小鼠背部皮肤DNCB致敏的方法建立AD模型。雄性BALB/c小鼠40只,随机分为空白组、模型组、维生素C组(0.5×10^(-3)g·kg^(-1))及龙牡皮炎方组(26 g·kg^(-1))。除空白组外,模型组、维生素C组和龙牡皮炎方组小鼠分别采用背部外涂不同浓度DNCB致敏的方法诱导AD,空白组予基质外涂。分别于2%DNCB致敏后7 d及0.2%DNCB致敏后24 d开始灌胃给药,连续21 d。实验结束后直接观察各组小鼠皮损变化;采用酶联免疫吸附测定法(ELISA)检测各组小鼠血清中白细胞介素(IL)-4,肿瘤坏死因子(TNF)-α、免疫球蛋白E(Ig E)、活性氧(ROS)的水平;总抗氧化能力测定试剂盒-微量法(ABTS法)测定血清抗氧化能力(TAOC)的水平;采用苏木素-伊红(HE)染色观察皮损部位病理形态学改变;免疫组化法检测皮损部位胸腺基质淋巴细胞生成素(TSLP)表达;蛋白免疫印迹法(Western blot)检测背部皮损部位丝聚蛋白(FLG)的表达。结果:与空白组比较,模型组小鼠皮损评分显著增高(P<0.01),HE染色显示皮肤损伤部位出现AD的特征性病理改变,同时皮损处TSLP表达明显增加及FLG表达降低(P<0.05);血清中TNF-α、IL-4、Ig E、ROS含量升高,同时TAOC活性下降(P<0.01)。与模型组比较,龙牡皮炎方组小鼠皮损评分显著下降,皮损病理明显改善;同时皮损组织中TSLP表达降低及FLG表达上升(P<0.05);此外龙牡皮炎方组小鼠血清中TNF-α、IL-4、Ig E和ROS含量相比模型组也有不同程度降低(P<0.05,P<0.01),且TAOC活性上升(P<0.01)。结论:AD氧化应激程度与皮损严重程度、细胞炎症因子水平具有明显的关联性。龙牡皮炎方可通过促进ROS清除,提升TAOC而抑制氧化应激,从而改善BALB/c小鼠AD样皮损,保护皮肤屏障,降低炎症反应。

关键词：特应性皮炎龙牡皮炎方氧化应激实验研究机制

Modeling the rail surface unevenness of a high-precision radio telescope

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Research in Astronomy and Astrophysics 2017年第3期17卷 13-22页

作者： na Li Peng Li Jiang Wu Bao-Yan Duan School of Mechanical and Electronic Engineering Xidian University Xi'an 710071 China

This study proposed a coarse-fine mixed model for describing the rail surface unevenness of an ultra-large fully steerable radio telescope （Qi Tai Telescope） with a diameter of 110 meters. The rail surface unevenness includes information on error arising from two different scales, i.e., the long-period- short-change and the short-period-long-change. Consequently, in this study an idea of a mixed model was proposed, in which trigonometric and fractal functions were, respectively, used to describe infor- mation on error from two scales. Key parameters were determined by using the least squares method and the wavelet transform method, and finally, a specific mathematical expression of the model was obtained by optimization. To validate the effectiveness of the new modeling method, the mixed model was then used to describe the rails of the Green Bank Telescope, the Large Millimeter Telescope, and a radio telescope in Miyun, Beijing. A comparative study revealed that the maximum error was less than 15 %, thus the result was superior to those of existing modeling methods.

关键词： magnetic fields -- radiation mechanisms: general - instrumentation: adaptive optics -methods: numerical - telescopes

Whole-cell matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for rapid identification of bacteria cultured in liquid media

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Science China(Life Sciences) 2011年第1期54卷 48-53页

作者： ZHOU na WANG na XU Bin WANG Jie FANG JunJian DONG FangTing HE Kun YANG XiaoHong Pharmaceutical Department of Jilin University Changchun 130021 China national Center of Biomedical Analysis Beijing 100850 China

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been used for many years to rapidly identify whole bacteria. However, no consistent methodology exists for the rapid identification of bacteria cultured in liquid media. Thus, in this study we explored the use of MALDI-TOF MS analysis for rapid identification of cells cultured in liquid media. We determined that 2,5-dihydroxybenzoic acid (50 mg mL-1, 50% acetonitrile, 0.1% trifluoroacetic acid) was the best matrix solution for MALDI-TOF MS for this type of study. Moreover, the tested strains were successfully differentiated by principal component analysis, and the main characteristics of the mass peaks for each species were found in mixed culture samples. In addition, we found that the minimum number of cells for detection was 1.8×103. In conclusion, our findings suggest that MS-based techniques can be developed as an auxiliary method for rapidly and accurately identifying bacteria cultured in liquid media.

关键词： MALDI-TOF MS bacteria PCA identification