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Expression and significance of homeodomain protein Cdx2 in gastric carcinoma and precancerous lesions

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World Journal of Gastroenterology 2012年第25期18卷 3296-3302页

作者： Rong Qin na-na wang Jing Chu Xian wang Departmentof Pathology Basic Medical CollegeAnhui Medical UniversityHefei 230032Anhui ProvinceChina

AIM： To investigate the expression and significance of caudal-related homeobox transcription factor （Cdx2） in gastric carcinoma （GC） and precancerous lesions. METHODS： The expression of Cdx2 in GC, precancer- ous lesions and normal gastric mucosa were detected using immunohistochemical method. Hematoxylin and eosin staining, alcian blue/periodic acid-schiff and high iron diamine/alcian blue staining were used to classify intestinal metaplasia （IM） and GC. RESULTS： Cdx2 was not detected in normal gas- tric mucosa. Cdx2 expression was detected in 87.1% （101/116） of IM, 50% （36/72） of dysplasia and 48.2% （41/85） of GC. The Cdx2-expressing cells in IM were more prevalent than in dysplasia and carcinoma （P 〈 0.05）. There was no relationship between Cdx2 ex- pression and the classification of IM or the degree of dysplasia. Expression of Cdx2 was significantly higher in intestinal-type carcinoma than in diffuse and mixed- type carcinoma （P 〈 0.05）. Positive expression of Cdx2was mainly found in moderately to well differentiated GC. There was a negative association between nuclear Cdx2 expression and lymph node metastasis and tumor, nodes, metastasis stage of GC （P 〈 0.05）. The patients with Cdx2-positive expression showed a higher survival rate than those with Cdx2-negative expression （P = 0.038）. Multivariate analysis revealed that the expres- sion of Cdx2 and lymph node metastasis were indepen- dent prognostic indicators of GC （P 〈 0.05）.

关键词： Caudal-related homeobox transcription fac-tor Stomach neoplasm Intestinal metaplasia Dyspla-sia Immunohistochemistry

Sky-blue perovskite light-emitting diodes based on quasi-two-dimensional layered perovskites

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Chinese Chemical Letters 2017年第1期28卷 29-31页

作者： Lu Cheng Yu Cao Rui Ge Ying-Qiang Wei na-na wang Jian-Pu wang Wei Huang Key Laboratory of Flexible Electronics & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing University of Posts & Telecommunications

A mixed organic（4-phenylbutylamine, 4-PBA） and inorganic（cesium, Cs） cations are used to deposit quasi-two-dimensional layered perovskites. This layered perovskites exhibit good film coverage as twodimensional perovskites and high emission performance close to three-dimensional organic–inorganic hybrid perovskites. Light-emitting diodes（LEDs） are fabricated by using solution process based on the quasi-two-dimensional layered perovskites. The perovskite LEDs exhibit a sky-blue emission with electroluminescence peak at 491 nm and a low turn on voltage at 2.9 V. The maximum external quantum efficiency reaches 0.015% at brightness of 186 cd/m^2.

关键词： Perovskite light-emitting diodes Quasi-2D Sky-blue emission Morphology Solution process

Three-dimensional evaluation of upper anterior alveolar bone dehiscence after incisor retraction and intrusion in adult patients with bimaxillary protrusion malocclusion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 990-997页

作者： Qing-yuan GUO Shi-jie ZHANG Hong LIU Chun-ling wang Fu-lan WEI Tao LV na-na wang Dong-xu LIU Department of Orthodontics Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University Jinan 250012 China Department of Stomatology the Second Hospital of Shandong University Jinan 250033 China

Objective:The purpose of this study was to evaluate three-dimensional(3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum ***:Twenty adult patients with bimaxillary dentoalveolar protrusion had the four first premolars *** were placed to provide maximum anchorage for upper incisor retraction and intrusion.A computed tomography(CT) scan was performed after placement of the miniscrews and *** 3D reconstructions of pre-and post-CT data were used to assess the dehiscence of upper anterior alveolar ***:The amounts of upper incisor retraction at the edge and apex were(7.64±1.68) and(3.91±2.10) mm,respectively,and(1.34±0.74) mm of upper central incisor *** alveolar bone height losses at labial alveolar ridge crest(LAC) and palatal alveolar ridge crest(PAC) were 0.543 and 2.612 mm,respectively,and the percentages were(6.49±3.54)% and(27.42±9.77)%,*** shape deformations of LAC-labial cortex bending point(LBP) and PAC-palatal cortex bending point(PBP) were(15.37±5.20)° and(6.43±3.27)°,***:Thus,for adult patients with bimaxillary protrusion,mechanobiological response of anterior alveolus should be taken into account during incisor retraction and *** of maximum anchorage might lead to upper anterior alveolar bone loss.

关键词： Alveolar bone loss Adult patients Computed tomography Three-dimensional registration

Association between mandibular posterior alveolar morphology and growth pattern in a Chinese population with normal occlusion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 25-32页

作者： Min HAN Rong-yang wang Hong LIU Xiu-juan ZHU Fu-lan WEI Tao LV na-na wang Li-hua HU Guo-ju LI Dong-xu LIU Chun-ling wang Department of Orthodontics Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University Jinan 250012 China Department of Radiology Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University Jinan 250012 China

Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal ***:Forty-five patients with normal occlusion(23 males,22 females) were included in this *** these patients,20 displayed the vertical growth pattern,and 20 had the horizontal growth pattern,while the remaining patients displayed the average growth *** of the patients underwent dental cone beam computed tomography(CBCT),which included the region of the mandibular posterior teeth and the alveolar.A linear regression analysis and a correlation analysis between the facial height index(FHI) and the alveolar bone morphology were ***:The inclination of the molars,the thickness of the cortical bone,and the height of the mandibular bone differed significantly between patients with the horizontal growth pattern and those with the vertical growth pattern(Pnation of the molars;the FHI and the thickness of the cortical bone;and the FHI and the height of the mandibular ***:The mandibular posterior tooth-alveolar bone complex morphology may be affected by growth patterns.

关键词： Cone beam computed tomography (CBCT) Growth pattern Alveolar morphology Normal occlusion

Decentralized Optimal Control and Stabilization of Interconnected Systems With Asymmetric Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 698-707页

作者： na wang Xiao Liang Hongdan Li Xiao Lu the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266000China the School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China the College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266000China

The paper addresses the decentralized optimal control and stabilization problems for interconnected systems subject to asymmetric *** with previous work,a closed-loop optimal solution to the control problem and sufficient and necessary conditions for the stabilization problem of the interconnected systems are given for the first *** main challenge lies in three aspects:Firstly,the asymmetric information results in coupling between control and estimation and failure of the separation ***,two extra unknown variables are generated by asymmetric information(different information filtration)when solving forward-backward stochastic difference ***,the existence of additive noise makes the study of mean-square boundedness an *** adopted technique is proving and assuming the linear form of controllers and establishing the equivalence between the two systems with and without additive noise.A dual-motor parallel drive system is presented to demonstrate the validity of the proposed algorithm.

关键词： Asymmetric information decentralized control forwardbackward stochastic difference equations interconnected system stalibization

Dynamic Response Impact of Vehicle Braking on Simply Supported Beam Bridges with Corrugated Steel Webs Based on Vehicle-Bridge Coupled Vibration Analysis

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3467-3493页

作者： Yan wang Siwen Li na Wei School of Civil Engineering Zhengzhou UniversityZhengzhou450001China

A novel approach for analyzing coupled vibrations between vehicles and bridges is presented,taking into account spatiotemporal effects and mechanical phenomena resulting fromvehicle *** modeling and solution of bridge vibrations induced by vehicle deceleration are realized using this *** method’s validity and reliability are substantiated through numerical examples.A simply supported beam bridge with a corrugated steel web is taken as an example and the effects of parameters such as the initial vehicle speed,braking acceleration,braking location,and road surface roughness on the mid-span displacement and impact factor of the bridge are *** results show that vehicle braking significantly amplifies mid-span displacement and impact factor responses in comparison to uniform vehicular motion across the ***,the influence of wheelto-bridge friction forces is of particular significance and cannot be *** the vehicle initiates braking near the middle of the span,both the mid-span displacement and impact factor of the bridge exhibit substantial increases,further escalating with higher braking *** favorable road surface conditions,the midspan displacement and the impact factor during vehicle braking may exceed the design values stipulated by *** is important to note that road surface roughness exerts a more pronounced effect on the impact factor of the bridge in comparison to the effects of vehicle braking.

关键词： Corrugated steel web girder bridges simply supported beam bridges vehicle-bridge coupled vibration braking impact factor

A New Encrypted Traffic Identification Model Based on VAE-LSTM-DRN

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Computers, Materials & Continua 2024年第1期78卷 569-588页

作者： Haizhen wang Jinying Yan na Jia College of Computer and Control Engineering Qiqihar UniversityQiqihar161006China Heilongjiang Key Laboratory of Big Data Network Security Detection and Analysis Qiqihar UniversityQiqiharChina

Encrypted traffic identification pertains to the precise acquisition and categorization of data from traffic datasets containing imbalanced and obscured *** extraction of encrypted traffic attributes and their subsequent identification presents a formidable *** existing models have predominantly relied on direct extraction of encrypted traffic data from imbalanced datasets,with the dataset’s imbalance significantly affecting the model’s *** the present study,a new model,referred to as UD-VLD(Unbalanced Dataset-VAE-LSTM-DRN),was proposed to address above *** proposed model is an encrypted traffic identification model for handling unbalanced *** encoder of the variational autoencoder(VAE)is combined with the decoder and Long-short term Memory(LSTM)in UD-VLD model to realize the data enhancement processing of the original unbalanced *** enhanced data is processed by transforming the deep residual network(DRN)to address neural network gradient-related ***,the data is classified and *** UD-VLD model integrates the related techniques of deep learning into the encrypted traffic recognition technique,thereby solving the processing problem for unbalanced *** UD-VLD model was tested using the publicly available Tor dataset and VPN *** UD-VLD model is evaluated against other comparative models in terms of accuracy,loss rate,precision,recall,F1-score,total time,and ROC *** results reveal that the UD-VLD model exhibits better performance in both binary and multi classification,being higher than other encrypted traffic recognition models that exist for unbalanced ***,the evaluation performance indicates that the UD-VLD model effectivelymitigates the impact of unbalanced data on traffic *** can serve as a novel solution for encrypted traffic identification.

关键词： Data enhancement LSTM deep residual network VAE

Microstructure and room temperature fracture toughness of Nb-Si-based alloys with Sr addition

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Rare Metals 2024年第8期43卷 3904-3912页

作者： Yong-Lin Huang Li-na Jia Bin Kong Yue-Ling Guo na wang School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Nb-Si-based alloys show great potential to surpass the widely used Ni-based *** element Sr is widely applied in aluminum and magnesium alloys,but reports about the effects of Sr on Nb-Si-based alloys are quite ***,Nb-Si-based alloys with nominal compositions of Nb-15Si-24Ti-4Cr-2Al-2Hf-0/0.05/0.15Sr(at%)were prepared by directional solidification and heat *** microstructural characterization and room temperature fracture toughness of Nb-Si-based alloy were systematically *** show that all these alloys consist of Nb_5Si_3 phase embedded within Nb solid solution(Nb_(ss)) *** Nb_(5)Si_(3) phase becomes refined and more discontinuous after adding minor *** for the fracture toughness,0.05 at% and 0.15 at% Sr additions do not cause significant *** discontinuous and refining mechanism of Sr element was studied,and the analysis of toughness decreasing with Sr addition reveals that the size of Nb_(ss) phase plays a crucial role in determining the fracture toughness.

关键词： Nb-Si alloy Refinement Discontinuous Fracture toughness Nb_(ss)

Survey on Fake Information Generation,Dissemination and Detection

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Chinese Journal of Electronics 2024年第3期33卷 573-583页

作者： Wanqiu CUI Dawei wang na HAN School of national Security People's Public Security University of China Big Data Center of The Ministry of Public Security

The current booming development of the Internet has put the public in an era of information overload,in which false information is mixed and spread *** phenomenon has seriously disturbed the social network ***,a substantial amount of research is beginning to be devoted to the effective management of fake *** analyze the abnormal characteristics of fake information from its mechanism of generation and *** view of different exceptional features,we systematically sort out and evaluate the existing studies on false content *** commonly used public datasets,metrics,and performance are categorized and compared,hoping to provide a basis and guidance for related *** study found that the current active social platforms show different *** future direction should point to mining platform features of multi-domain sources,multi-data forms,and multi-language heterogeneity to provide more valuable clues for fake information.

关键词： Fake information Abnormal characteristics Detection methods Public datasets